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Items: 1 to 50 of 86

1.

Slow infection due to lowering amount of intact versus empty particles is a characteristic feature of Coxsackievirus B5, dictated by the structural proteins.

Turkki P, Laajala M, Stark M, Vandesande H, Sallinen-Dal Maso H, Shroff S, Sävneby A, Galitska G, Lindberg AM, Marjomäki V.

J Virol. 2019 Aug 2. pii: JVI.01130-19. doi: 10.1128/JVI.01130-19. [Epub ahead of print]

PMID:
31375587
2.

Extracellular Albumin and Endosomal Ions Prime Enterovirus Particles for Uncoating That Can Be Prevented by Fatty Acid Saturation.

Ruokolainen V, Domanska A, Laajala M, Pelliccia M, Butcher SJ, Marjomäki V.

J Virol. 2019 Aug 13;93(17). pii: e00599-19. doi: 10.1128/JVI.00599-19. Print 2019 Sep 1.

PMID:
31189702
3.

A Common Receptor Found for Echoviruses.

Laajala M, Marjomäki V.

Trends Microbiol. 2019 Jun;27(6):475-477. doi: 10.1016/j.tim.2019.03.010. Epub 2019 Apr 16.

PMID:
31003872
4.

Antiviral Agents From Fungi: Diversity, Mechanisms and Potential Applications.

Linnakoski R, Reshamwala D, Veteli P, Cortina-Escribano M, Vanhanen H, Marjomäki V.

Front Microbiol. 2018 Oct 2;9:2325. doi: 10.3389/fmicb.2018.02325. eCollection 2018. Review.

5.

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells.

Ifie E, Russell MA, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik DL, Morgan NG, Richardson SJ.

Diabetologia. 2018 Nov;61(11):2344-2355. doi: 10.1007/s00125-018-4704-1. Epub 2018 Aug 3.

6.

Novel activities of safe-in-human broad-spectrum antiviral agents.

Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D.

Antiviral Res. 2018 Jun;154:174-182. doi: 10.1016/j.antiviral.2018.04.016. Epub 2018 Apr 23. Review.

PMID:
29698664
7.

A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.

Saarinen NVV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomäki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A, Honkimaa A, Hankaniemi MM, Flodström-Tullberg M, Hyöty H, Hytönen VP, Laitinen OH.

Sci Rep. 2018 Jan 8;8(1):33. doi: 10.1038/s41598-017-18495-4.

8.

Structural characterization of site-modified nanocapsid with monodispersed gold clusters.

Stark MC, Baikoghli MA, Lahtinen T, Malola S, Xing L, Nguyen M, Nguyen M, Sikaroudi A, Marjomäki V, Häkkinen H, Cheng RH.

Sci Rep. 2017 Dec 6;7(1):17048. doi: 10.1038/s41598-017-17171-x.

9.

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.

Bulanova D, Ianevski A, Bugai A, Akimov Y, Kuivanen S, Paavilainen H, Kakkola L, Nandania J, Turunen L, Ohman T, Ala-Hongisto H, Pesonen HM, Kuisma MS, Honkimaa A, Walton EL, Oksenych V, Lorey MB, Guschin D, Shim J, Kim J, Than TT, Chang SY, Hukkanen V, Kulesskiy E, Marjomaki VS, Julkunen I, Nyman TA, Matikainen S, Saarela JS, Sane F, Hober D, Gabriel G, De Brabander JK, Martikainen M, Windisch MP, Min JY, Bruzzone R, Aittokallio T, Vähä-Koskela M, Vapalahti O, Pulk A, Velagapudi V, Kainov DE.

Viruses. 2017 Sep 25;9(10). pii: E271. doi: 10.3390/v9100271.

10.

Optimized production and purification of Coxsackievirus B1 vaccine and its preclinical evaluation in a mouse model.

Hankaniemi MM, Laitinen OH, Stone VM, Sioofy-Khojine A, Määttä JAE, Larsson PG, Marjomäki V, Hyöty H, Flodström-Tullberg M, Hytönen VP.

Vaccine. 2017 Jun 27;35(30):3718-3725. doi: 10.1016/j.vaccine.2017.05.057. Epub 2017 Jun 1.

PMID:
28579231
11.

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months.

Pelliccia M, Andreozzi P, Paulose J, D'Alicarnasso M, Cagno V, Donalisio M, Civra A, Broeckel RM, Haese N, Jacob Silva P, Carney RP, Marjomäki V, Streblow DN, Lembo D, Stellacci F, Vitelli V, Krol S.

Nat Commun. 2016 Nov 30;7:13520. doi: 10.1038/ncomms13520.

12.

Regulation of kynurenine biosynthesis during influenza virus infection.

Gaelings L, Söderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomäki V, De Brabander J, Matikainen S, Nyman TA, Bamford DH, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, Kainov DE.

FEBS J. 2017 Jan;284(2):222-236. doi: 10.1111/febs.13966. Epub 2016 Dec 14.

13.

Echovirus 1 internalization negatively regulates epidermal growth factor receptor downregulation.

Huttunen M, Turkki P, Mäki A, Paavolainen L, Ruusuvuori P, Marjomäki V.

Cell Microbiol. 2017 Mar;19(3). doi: 10.1111/cmi.12671. Epub 2016 Oct 20.

PMID:
27665309
14.

Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy.

Vähätupa M, Prince S, Vataja S, Mertimo T, Kataja M, Kinnunen K, Marjomäki V, Uusitalo H, Komatsu M, Järvinen TA, Uusitalo-Järvinen H.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4898-4909. doi: 10.1167/iovs.16-19212.

15.

Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice.

Pajari AM, Päivärinta E, Paavolainen L, Vaara E, Koivumäki T, Garg R, Heiman-Lindh A, Mutanen M, Marjomäki V, Ridley AJ.

Oncotarget. 2016 Jul 12;7(28):43907-43923. doi: 10.18632/oncotarget.9724.

16.

A Novel Open and Infectious Form of Echovirus 1.

Myllynen M, Kazmertsuk A, Marjomäki V.

J Virol. 2016 Jul 11;90(15):6759-70. doi: 10.1128/JVI.00342-16. Print 2016 Aug 1.

17.

Infectious Entry Pathway of Enterovirus B Species.

Marjomäki V, Turkki P, Huttunen M.

Viruses. 2015 Dec 7;7(12):6387-99. doi: 10.3390/v7122945. Review.

18.

Hydrophobic pocket targeting probes for enteroviruses.

Martikainen M, Salorinne K, Lahtinen T, Malola S, Permi P, Häkkinen H, Marjomäki V.

Nanoscale. 2015 Nov 7;7(41):17457-67. doi: 10.1039/c5nr04139b.

PMID:
26440968
19.

His-tagged norovirus-like particles: A versatile platform for cellular delivery and surface display.

Koho T, Ihalainen TO, Stark M, Uusi-Kerttula H, Wieneke R, Rahikainen R, Blazevic V, Marjomäki V, Tampé R, Kulomaa MS, Hytönen VP.

Eur J Pharm Biopharm. 2015 Oct;96:22-31. doi: 10.1016/j.ejpb.2015.07.002. Epub 2015 Jul 10.

PMID:
26170162
20.

Cannabinoid receptor 1 and acute resistance exercise--In vivo and in vitro studies in human skeletal muscle.

Pekkala S, Wiklund P, Hulmi JJ, Pöllänen E, Marjomäki V, Munukka E, Pierre P, Mouly V, Mero A, Alén M, Cheng S.

Peptides. 2015 May;67:55-63. doi: 10.1016/j.peptides.2015.03.007. Epub 2015 Mar 18.

PMID:
25796352
21.

Permeability changes of integrin-containing multivesicular structures triggered by picornavirus entry.

Soonsawad P, Paavolainen L, Upla P, Weerachatyanukul W, Rintanen N, Espinoza J, McNerney G, Marjomäki V, Cheng RH.

PLoS One. 2014 Oct 9;9(10):e108948. doi: 10.1371/journal.pone.0108948. eCollection 2014.

22.

Compensation of missing wedge effects with sequential statistical reconstruction in electron tomography.

Paavolainen L, Acar E, Tuna U, Peltonen S, Moriya T, Soonsawad P, Marjomäki V, Cheng RH, Ruotsalainen U.

PLoS One. 2014 Oct 3;9(10):e108978. doi: 10.1371/journal.pone.0108978. eCollection 2014.

23.

Raman spectroscopic signatures of echovirus 1 uncoating.

Ruokola P, Dadu E, Kazmertsuk A, Häkkänen H, Marjomäki V, Ihalainen JA.

J Virol. 2014 Aug;88(15):8504-13. doi: 10.1128/JVI.03398-13. Epub 2014 May 21.

24.

Quantitative analysis of dynamic association in live biological fluorescent samples.

Ruusuvuori P, Paavolainen L, Rutanen K, Mäki A, Huttunen H, Marjomäki V.

PLoS One. 2014 Apr 11;9(4):e94245. doi: 10.1371/journal.pone.0094245. eCollection 2014.

25.

Reply to "heparan sulfate in baculovirus binding and entry of Mammalian cells".

Makkonen KE, Turkki P, Laakkonen JP, Ylä-Herttuala S, Marjomäki V, Airenne KJ.

J Virol. 2014 Apr;88(8):4609-10. doi: 10.1128/JVI.00083-14. No abstract available.

26.

Coxsackievirus A9 infects cells via nonacidic multivesicular bodies.

Huttunen M, Waris M, Kajander R, Hyypiä T, Marjomäki V.

J Virol. 2014 May;88(9):5138-51. doi: 10.1128/JVI.03275-13. Epub 2014 Feb 26.

27.

Nanomolar pyrophosphate detection in water and in a self-assembled hydrogel of a simple terpyridine-Zn2+ complex.

Bhowmik S, Ghosh BN, Marjomäki V, Rissanen K.

J Am Chem Soc. 2014 Apr 16;136(15):5543-6. doi: 10.1021/ja4128949. Epub 2014 Feb 6.

PMID:
24494632
28.

Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice.

Koho T, Koivunen MR, Oikarinen S, Kummola L, Mäkinen S, Mähönen AJ, Sioofy-Khojine A, Marjomäki V, Kazmertsuk A, Junttila I, Kulomaa MS, Hyöty H, Hytönen VP, Laitinen OH.

Antiviral Res. 2014 Apr;104:93-101. doi: 10.1016/j.antiviral.2014.01.013. Epub 2014 Jan 28.

PMID:
24485896
29.

Site-specific targeting of enterovirus capsid by functionalized monodisperse gold nanoclusters.

Marjomäki V, Lahtinen T, Martikainen M, Koivisto J, Malola S, Salorinne K, Pettersson M, Häkkinen H.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1277-81. doi: 10.1073/pnas.1310973111. Epub 2014 Jan 13.

30.

Automatic detection and analysis of cell motility in phase-contrast time-lapse images using a combination of maximally stable extremal regions and Kalman filter approaches.

Kaakinen M, Huttunen S, Paavolainen L, Marjomäki V, Heikkilä J, Eklund L.

J Microsc. 2014 Jan;253(1):65-78. doi: 10.1111/jmi.12098. Epub 2013 Nov 26.

31.

The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features.

Nieminen T, Toivanen PI, Rintanen N, Heikura T, Jauhiainen S, Airenne KJ, Alitalo K, Marjomäki V, Ylä-Herttuala S.

Biochim Biophys Acta. 2014 Jan;1840(1):454-63. doi: 10.1016/j.bbagen.2013.10.005. Epub 2013 Oct 8.

PMID:
24112971
32.

6-o- and N-sulfated syndecan-1 promotes baculovirus binding and entry into Mammalian cells.

Makkonen KE, Turkki P, Laakkonen JP, Ylä-Herttuala S, Marjomäki V, Airenne KJ.

J Virol. 2013 Oct;87(20):11148-59. doi: 10.1128/JVI.01919-13. Epub 2013 Aug 7.

33.

Cell susceptibility to baculovirus transduction and echovirus infection is modified by protein kinase C phosphorylation and vimentin organization.

Turkki P, Makkonen KE, Huttunen M, Laakkonen JP, Ylä-Herttuala S, Airenne KJ, Marjomäki V.

J Virol. 2013 Sep;87(17):9822-35. doi: 10.1128/JVI.01004-13. Epub 2013 Jul 3.

34.

Human parvovirus B19 induced apoptotic bodies contain altered self-antigens that are phagocytosed by antigen presenting cells.

Thammasri K, Rauhamäki S, Wang L, Filippou A, Kivovich V, Marjomäki V, Naides SJ, Gilbert L.

PLoS One. 2013 Jun 12;8(6):e67179. doi: 10.1371/journal.pone.0067179. Print 2013.

35.

Echovirus 1 entry into polarized Caco-2 cells depends on dynamin, cholesterol, and cellular factors associated with macropinocytosis.

Krieger SE, Kim C, Zhang L, Marjomaki V, Bergelson JM.

J Virol. 2013 Aug;87(16):8884-95. doi: 10.1128/JVI.03415-12. Epub 2013 Jun 5.

36.

Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway.

Siljamäki E, Rintanen N, Kirsi M, Upla P, Wang W, Karjalainen M, Ikonen E, Marjomäki V.

PLoS One. 2013;8(2):e55465. doi: 10.1371/journal.pone.0055465. Epub 2013 Feb 5.

37.

ADC measurements in diffuse large B-cell lymphoma and follicular lymphoma: a DWI and cellularity study.

Wu X, Pertovaara H, Dastidar P, Vornanen M, Paavolainen L, Marjomäki V, Järvenpää R, Eskola H, Kellokumpu-Lehtinen PL.

Eur J Radiol. 2013 Apr;82(4):e158-64. doi: 10.1016/j.ejrad.2012.11.021. Epub 2012 Dec 17.

PMID:
23254159
38.

BioImageXD: an open, general-purpose and high-throughput image-processing platform.

Kankaanpää P, Paavolainen L, Tiitta S, Karjalainen M, Päivärinne J, Nieminen J, Marjomäki V, Heino J, White DJ.

Nat Methods. 2012 Jun 28;9(7):683-9. doi: 10.1038/nmeth.2047.

PMID:
22743773
39.

Single-cell analysis of population context advances RNAi screening at multiple levels.

Snijder B, Sacher R, Rämö P, Liberali P, Mench K, Wolfrum N, Burleigh L, Scott CC, Verheije MH, Mercer J, Moese S, Heger T, Theusner K, Jurgeit A, Lamparter D, Balistreri G, Schelhaas M, De Haan CA, Marjomäki V, Hyypiä T, Rottier PJ, Sodeik B, Marsh M, Gruenberg J, Amara A, Greber U, Helenius A, Pelkmans L.

Mol Syst Biol. 2012 Apr 24;8:579. doi: 10.1038/msb.2012.9.

40.

Efficient gene therapy based targeting system for the treatment of inoperable tumors.

Wirth T, Pikkarainen JT, Samaranayake HD, Lehtolainen-Dalkilic P, Lesch HP, Airenne KJ, Marjomäki V, Ylä-Herttuala SP.

J Gene Med. 2012 Apr;14(4):221-30. doi: 10.1002/jgm.2619.

PMID:
22411578
41.

Women with and without metabolic disorder differ in their gut microbiota composition.

Munukka E, Wiklund P, Pekkala S, Völgyi E, Xu L, Cheng S, Lyytikäinen A, Marjomäki V, Alen M, Vaahtovuo J, Keinänen-Kiukaanniemi S, Cheng S.

Obesity (Silver Spring). 2012 May;20(5):1082-7. doi: 10.1038/oby.2012.8. Epub 2012 Jan 30.

42.

Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway.

Rintanen N, Karjalainen M, Alanko J, Paavolainen L, Mäki A, Nissinen L, Lehkonen M, Kallio K, Cheng RH, Upla P, Ivaska J, Marjomäki V.

Mol Biol Cell. 2012 Feb;23(3):448-63. doi: 10.1091/mbc.E11-06-0548. Epub 2011 Dec 7.

43.

Echovirus 1 infection depends on biogenesis of novel multivesicular bodies.

Karjalainen M, Rintanen N, Lehkonen M, Kallio K, Mäki A, Hellström K, Siljamäki V, Upla P, Marjomäki V.

Cell Microbiol. 2011 Dec;13(12):1975-95. doi: 10.1111/j.1462-5822.2011.01685.x. Epub 2011 Sep 22.

PMID:
21899700
44.

Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration.

Mai A, Veltel S, Pellinen T, Padzik A, Coffey E, Marjomäki V, Ivaska J.

J Cell Biol. 2011 Jul 25;194(2):291-306. doi: 10.1083/jcb.201012126. Epub 2011 Jul 18.

45.

Capillary enlargement, not sprouting angiogenesis, determines beneficial therapeutic effects and side effects of angiogenic gene therapy.

Korpisalo P, Hytönen JP, Laitinen JT, Laidinen S, Parviainen H, Karvinen H, Siponen J, Marjomäki V, Vajanto I, Rissanen TT, Ylä-Herttuala S.

Eur Heart J. 2011 Jul;32(13):1664-72. doi: 10.1093/eurheartj/ehq433. Epub 2010 Dec 7.

PMID:
21138938
46.

Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin.

Heikkilä O, Susi P, Tevaluoto T, Härmä H, Marjomäki V, Hyypiä T, Kiljunen S.

J Virol. 2010 Apr;84(7):3666-81. doi: 10.1128/JVI.01340-09. Epub 2010 Jan 20.

47.

Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1.

Jokinen J, White DJ, Salmela M, Huhtala M, Käpylä J, Sipilä K, Puranen JS, Nissinen L, Kankaanpää P, Marjomäki V, Hyypiä T, Johnson MS, Heino J.

EMBO J. 2010 Jan 6;29(1):196-208. doi: 10.1038/emboj.2009.326. Epub 2009 Nov 19.

48.

Clathrin-independent entry of baculovirus triggers uptake of E. coli in non-phagocytic human cells.

Laakkonen JP, Mäkelä AR, Kakkonen E, Turkki P, Kukkonen S, Peränen J, Ylä-Herttuala S, Airenne KJ, Oker-Blom C, Vihinen-Ranta M, Marjomäki V.

PLoS One. 2009;4(4):e5093. doi: 10.1371/journal.pone.0005093. Epub 2009 Apr 7.

49.

Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels.

Korpisalo P, Karvinen H, Rissanen TT, Kilpijoki J, Marjomäki V, Baluk P, McDonald DM, Cao Y, Eriksson U, Alitalo K, Ylä-Herttuala S.

Circ Res. 2008 Nov 7;103(10):1092-9. doi: 10.1161/CIRCRESAHA.108.182287. Epub 2008 Oct 2.

50.

A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes.

Karjalainen M, Kakkonen E, Upla P, Paloranta H, Kankaanpää P, Liberali P, Renkema GH, Hyypiä T, Heino J, Marjomäki V.

Mol Biol Cell. 2008 Jul;19(7):2857-69. doi: 10.1091/mbc.E07-10-1094. Epub 2008 Apr 30.

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