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Items: 29

1.

ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases.

Anwar T, Liu X, Suntio T, Marjamäki A, Biazik J, Chan EYW, Varjosalo M, Eskelinen EL.

Cells. 2019 May 17;8(5). pii: E475. doi: 10.3390/cells8050475.

2.

Platelet response to a small molecule inhibitor of α2β1 integrin is associated with ITGA2 C807T dimorphism.

Nissinen L, Rappu P, Ollikka P, Nieminen J, Marjamäki A, Heino J.

Platelets. 2016 Jun;27(4):378-80. doi: 10.3109/09537104.2015.1095877. Epub 2015 Nov 10.

PMID:
26556301
3.

Sulfonamide inhibitors of α2β1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation.

Nissinen L, Ojala M, Langen B, Dost R, Pihlavisto M, Käpylä J, Marjamäki A, Heino J.

Pharmacol Res Perspect. 2015 Jun;3(3):e00146. doi: 10.1002/prp2.146. Epub 2015 May 15.

4.

Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation.

Nissinen L, Koivunen J, Käpylä J, Salmela M, Nieminen J, Jokinen J, Sipilä K, Pihlavisto M, Pentikäinen OT, Marjamäki A, Heino J.

J Biol Chem. 2012 Dec 28;287(53):44694-702. doi: 10.1074/jbc.M111.309450. Epub 2012 Nov 6.

5.

Heparin-like polysaccharides reduce osteolytic bone destruction and tumor growth in a mouse model of breast cancer bone metastasis.

Pollari S, Käkönen RS, Mohammad KS, Rissanen JP, Halleen JM, Wärri A, Nissinen L, Pihlavisto M, Marjamäki A, Perälä M, Guise TA, Kallioniemi O, Käkönen SM.

Mol Cancer Res. 2012 May;10(5):597-604. doi: 10.1158/1541-7786.MCR-11-0482. Epub 2012 Apr 20.

6.

Fluorescent small molecule probe to modulate and explore α2β1 integrin function.

Koivunen JT, Nissinen L, Käpylä J, Jokinen J, Pihlavisto M, Marjamäki A, Heino J, Huuskonen J, Pentikäinen OT.

J Am Chem Soc. 2011 Sep 21;133(37):14558-61. doi: 10.1021/ja206086c. Epub 2011 Aug 30.

PMID:
21863823
7.

A small-molecule inhibitor of integrin alpha2 beta1 introduces a new strategy for antithrombotic therapy.

Nissinen L, Pentikäinen OT, Jouppila A, Käpylä J, Ojala M, Nieminen J, Lipsanen A, Lappalainen H, Eckes B, Johnson MS, Lassila R, Marjamäki A, Heino J.

Thromb Haemost. 2010 Feb;103(2):387-97. doi: 10.1160/TH09-06-0358. Epub 2009 Dec 1.

PMID:
20126829
8.

O-sulfated bacterial polysaccharides with low anticoagulant activity inhibit metastasis.

Borgenström M, Wärri A, Hiilesvuo K, Käkönen R, Käkönen S, Nissinen L, Pihlavisto M, Marjamäki A, Vlodavsky I, Naggi A, Torri G, Casu B, Veromaa T, Salmivirta M, Elenius K.

Semin Thromb Hemost. 2007 Jul;33(5):547-56.

PMID:
17629853
9.

Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function.

Käpylä J, Pentikäinen OT, Nyrönen T, Nissinen L, Lassander S, Jokinen J, Lahti M, Marjamäki A, Johnson MS, Heino J.

J Med Chem. 2007 May 31;50(11):2742-6. Epub 2007 Apr 21.

PMID:
17447751
10.

Conserved structural, pharmacological and functional properties among the three human and five zebrafish alpha 2-adrenoceptors.

Ruuskanen JO, Laurila J, Xhaard H, Rantanen VV, Vuoriluoto K, Wurster S, Marjamäki A, Vainio M, Johnson MS, Scheinin M.

Br J Pharmacol. 2005 Jan;144(2):165-77.

11.

Molecular mechanisms of ligand-receptor interactions in transmembrane domain V of the alpha2A-adrenoceptor.

Peltonen JM, Nyrönen T, Wurster S, Pihlavisto M, Hoffrén AM, Marjamäki A, Xhaard H, Kanerva L, Savola JM, Johnson MS, Scheinin M.

Br J Pharmacol. 2003 Sep;140(2):347-58. Epub 2003 Aug 18.

12.

Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish.

Ruuskanen JO, Xhaard H, Marjamäki A, Salaneck E, Salminen T, Yan YL, Postlethwait JH, Johnson MS, Larhammar D, Scheinin M.

Mol Biol Evol. 2004 Jan;21(1):14-28. Epub 2003 Aug 29.

PMID:
12949138
13.

Phenoxybenzamine binding reveals the helical orientation of the third transmembrane domain of adrenergic receptors.

Frang H, Cockcroft V, Karskela T, Scheinin M, Marjamäki A.

J Biol Chem. 2001 Aug 17;276(33):31279-84. Epub 2001 Jun 6.

14.

Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine.

Nyrönen T, Pihlavisto M, Peltonen JM, Hoffrén AM, Varis M, Salminen T, Wurster S, Marjamäki A, Kanerva L, Katainen E, Laaksonen L, Savola JM, Scheinin M, Johnson MS.

Mol Pharmacol. 2001 May;59(5):1343-54.

PMID:
11306720
15.

Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304.

Cockcroft V, Frang H, Pihlavisto M, Marjamäki A, Scheinin M.

J Neurochem. 2000 Apr;74(4):1705-10.

16.

Three-dimensional models of alpha(2A)-adrenergic receptor complexes provide a structural explanation for ligand binding.

Salminen T, Varis M, Nyrönen T, Pihlavisto M, Hoffrén AM, Lönnberg T, Marjamäki A, Frang H, Savola JM, Scheinin M, Johnson MS.

J Biol Chem. 1999 Aug 13;274(33):23405-13.

17.

Chloroethylclonidine and 2-aminoethyl methanethiosulfonate recognize two different conformations of the human alpha(2A)-adrenergic receptor.

Marjamäki A, Frang H, Pihlavisto M, Hoffrén AM, Salminen T, Johnson MS, Kallio J, Javitch JA, Scheinin M.

J Biol Chem. 1999 Jul 30;274(31):21867-72.

18.

A series of 6-(omega-methanesulfonylthioalkoxy)-2-N-methyl- 1,2,3, 4-tetrahydroisoquinolines: cysteine-reactive molecular yardsticks for probing alpha2-adrenergic receptors.

Heinonen P, Koskua K, Pihlavisto M, Marjamäki A, Cockcroft V, Savola JM, Scheinin M, Lönnberg H.

Bioconjug Chem. 1998 May-Jun;9(3):358-64.

PMID:
9576810
19.

Chloroethylclonidine binds irreversibly to exposed cysteines in the fifth membrane-spanning domain of the human alpha2A-adrenergic receptor.

Marjamaki A, Pihlavisto M, Cockcroft V, Heinonen P, Savola JM, Scheinin M.

Mol Pharmacol. 1998 Mar;53(3):370-6.

PMID:
9495800
20.

Alpha2-adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase.

Pohjanoksa K, Jansson CC, Luomala K, Marjamäki A, Savola JM, Scheinin M.

Eur J Pharmacol. 1997 Sep 17;335(1):53-63.

PMID:
9371546
21.
22.

Subtype specific recognition of human alpha2C2 adrenergic receptor using monoclonal antibodies against the third intracellular loop.

Liitti S, Närvä H, Marjamäki A, Hellman J, Kallio J, Jalkanen M, Matikainen MT.

Biochem Biophys Res Commun. 1997 Apr 7;233(1):166-72.

PMID:
9144416
23.

Molecular pharmacology of alpha 2-adrenoceptor subtypes.

Aantaa R, Marjamäki A, Scheinin M.

Ann Med. 1995 Aug;27(4):439-49. Review.

PMID:
8519505
24.

Use of a hollow fiber bioreactor for large-scale production of alpha 2-adrenoceptors in mammalian cells.

Ala-Uotila S, Marjamäki A, Matikainen MT, Jalkanen M.

J Biotechnol. 1994 Sep 30;37(2):179-84.

PMID:
7765455
25.

Similar ligand binding in recombinant human alpha 2 C2-adrenoceptors produced in mammalian, insect and yeast cells.

Marjamäki A, Pohjanoksa K, Ala-Uotila S, Sizmann D, Oker-Blom C, Kurose H, Scheinin M.

Eur J Pharmacol. 1994 Mar 15;267(1):117-21.

PMID:
7911432
26.

Coupling of human alpha 2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells.

Jansson CC, Marjamäki A, Luomala K, Savola JM, Scheinin M, Akerman KE.

Eur J Pharmacol. 1994 Jan 15;266(2):165-74.

PMID:
7908883
27.

Use of recombinant human alpha 2-adrenoceptors to characterize subtype selectively of antagonist binding.

Marjamäki A, Luomala K, Ala-Uotila S, Scheinin M.

Eur J Pharmacol. 1993 Aug 15;246(3):219-26.

PMID:
7901041
28.

Comparison of four in situ hybridization methods, based on digoxigenin- and biotin-labelled probes, in detecting HPV DNA in male condylomata acuminata.

Lassus J, Niemi KM, Marjamäki A, Syrjänen S, Kartamaa M, Lehmus A, Krohn K, Ranki A.

Int J STD AIDS. 1992 May-Jun;3(3):196-203.

PMID:
1319747
29.

Stable expression of recombinant human alpha 2-adrenoceptor subtypes in two mammalian cell lines: characterization with [3H]rauwolscine binding, inhibition of adenylate cyclase and RNase protection assay.

Marjamäki A, Ala-Uotila S, Luomala K, Perälä M, Jansson C, Jalkanen M, Regan JW, Scheinin M.

Biochim Biophys Acta. 1992 Mar 16;1134(2):169-77.

PMID:
1313304

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