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Items: 17


GPCR-independent activation of G proteins promotes apical cell constriction in vivo.

Marivin A, Morozova V, Walawalkar I, Leyme A, Kretov DA, Cifuentes D, Dominguez I, Garcia-Marcos M.

J Cell Biol. 2019 May 6;218(5):1743-1763. doi: 10.1083/jcb.201811174. Epub 2019 Apr 4.


Atypical activation of the G protein Gαq by the oncogenic mutation Q209P.

Maziarz M, Leyme A, Marivin A, Luebbers A, Patel PP, Chen Z, Sprang SR, Garcia-Marcos M.

J Biol Chem. 2018 Dec 21;293(51):19586-19599. doi: 10.1074/jbc.RA118.005291. Epub 2018 Oct 23.


Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.

Leyme A, Marivin A, Maziarz M, DiGiacomo V, Papakonstantinou MP, Patel PP, Blanco-Canosa JB, Walawalkar IA, Rodriguez-Davila G, Dominguez I, Garcia-Marcos M.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10319-E10328. doi: 10.1073/pnas.1707992114. Epub 2017 Nov 13.


When Heterotrimeric G Proteins Are Not Activated by G Protein-Coupled Receptors: Structural Insights and Evolutionary Conservation.

DiGiacomo V, Marivin A, Garcia-Marcos M.

Biochemistry. 2018 Jan 23;57(3):255-257. doi: 10.1021/acs.biochem.7b00845. Epub 2017 Oct 16.


Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.

de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M.

Nat Commun. 2017 May 18;8:15163. doi: 10.1038/ncomms15163.


Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling.

Parag-Sharma K, Leyme A, DiGiacomo V, Marivin A, Broselid S, Garcia-Marcos M.

J Biol Chem. 2016 Dec 30;291(53):27098-27111. doi: 10.1074/jbc.M116.764431. Epub 2016 Nov 18.


Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease.

Marivin A, Leyme A, Parag-Sharma K, DiGiacomo V, Cheung AY, Nguyen LT, Dominguez I, Garcia-Marcos M.

Sci Signal. 2016 Apr 12;9(423):ra37. doi: 10.1126/scisignal.aad2429.


GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.

Leyme A, Marivin A, Garcia-Marcos M.

J Biol Chem. 2016 Apr 8;291(15):8269-82. doi: 10.1074/jbc.M115.691550. Epub 2016 Feb 17.


Evolutionary Conservation of a GPCR-Independent Mechanism of Trimeric G Protein Activation.

Coleman BD, Marivin A, Parag-Sharma K, DiGiacomo V, Kim S, Pepper JS, Casler J, Nguyen LT, Koelle MR, Garcia-Marcos M.

Mol Biol Evol. 2016 Mar;33(3):820-37. doi: 10.1093/molbev/msv336. Epub 2015 Dec 10.


Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin.

Leyme A, Marivin A, Perez-Gutierrez L, Nguyen LT, Garcia-Marcos M.

J Cell Biol. 2015 Sep 28;210(7):1165-84. doi: 10.1083/jcb.201506041. Epub 2015 Sep 21.


Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.

Aznar N, Midde KK, Dunkel Y, Lopez-Sanchez I, Pavlova Y, Marivin A, Barbazán J, Murray F, Nitsche U, Janssen KP, Willert K, Goel A, Abal M, Garcia-Marcos M, Ghosh P.

Elife. 2015 Jun 30;4:e07091. doi: 10.7554/eLife.07091.


Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseases.

Leyme A, Marivin A, Casler J, Nguyen LT, Garcia-Marcos M.

J Biol Chem. 2014 Aug 8;289(32):21818-27. doi: 10.1074/jbc.M114.549790. Epub 2014 Jun 30.


[IAP and Rho finally connected].

Dubrez L, Marivin A, Berthelet J.

Med Sci (Paris). 2014 Mar;30(3):231-3. doi: 10.1051/medsci/20143003003. Epub 2014 Mar 31. French. No abstract available.


cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation.

Marivin A, Berthelet J, Cartier J, Paul C, Gemble S, Morizot A, Boireau W, Saleh M, Bertoglio J, Solary E, Dubrez L.

Oncogene. 2014 Nov 27;33(48):5534-45. doi: 10.1038/onc.2013.499. Epub 2013 Nov 25.


[IAPs: a central element in the NF-κB activating signaling pathway].

Cartier J, Marivin A, Berthelet J, Dubrez L.

Med Sci (Paris). 2012 Jan;28(1):69-75. doi: 10.1051/medsci/2012281019. Epub 2012 Jan 27. Review. French.


The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress.

Marivin A, Berthelet J, Plenchette S, Dubrez L.

Cells. 2012 Oct 10;1(4):711-37. doi: 10.3390/cells1040711.


Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.

Cartier J, Berthelet J, Marivin A, Gemble S, Edmond V, Plenchette S, Lagrange B, Hammann A, Dupoux A, Delva L, Eymin B, Solary E, Dubrez L.

J Biol Chem. 2011 Jul 29;286(30):26406-17. doi: 10.1074/jbc.M110.191239. Epub 2011 Jun 8.

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