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The structural basis of T-cell receptor (TCR) activation: An enduring enigma.

Mariuzza RA, Agnihotri P, Orban J.

J Biol Chem. 2020 Jan 24;295(4):914-925. doi: 10.1074/jbc.REV119.009411. Epub 2019 Dec 17. Review.


How Natural Killer Cell Receptors Stick to Cell-Cell Adhesion Proteins.

Karade SS, Mariuzza RA.

Structure. 2019 Feb 5;27(2):209-210. doi: 10.1016/j.str.2019.01.007.


Antigenicity and Immunogenicity of Differentially Glycosylated Hepatitis C Virus E2 Envelope Proteins Expressed in Mammalian and Insect Cells.

Urbanowicz RA, Wang R, Schiel JE, Keck ZY, Kerzic MC, Lau P, Rangarajan S, Garagusi KJ, Tan L, Guest JD, Ball JK, Pierce BG, Mariuzza RA, Foung SKH, Fuerst TR.

J Virol. 2019 Mar 21;93(7). pii: e01403-18. doi: 10.1128/JVI.01403-18. Print 2019 Apr 1.


Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites.

Rangarajan S, He Y, Chen Y, Kerzic MC, Ma B, Gowthaman R, Pierce BG, Nussinov R, Mariuzza RA, Orban J.

J Biol Chem. 2018 Oct 12;293(41):15991-16005. doi: 10.1074/jbc.RA118.003832. Epub 2018 Aug 22.


Identification of the fungal ligand triggering cytotoxic PRR-mediated NK cell killing of Cryptococcus and Candida.

Li SS, Ogbomo H, Mansour MK, Xiang RF, Szabo L, Munro F, Mukherjee P, Mariuzza RA, Amrein M, Vyas JM, Robbins SM, Mody CH.

Nat Commun. 2018 Feb 21;9(1):751. doi: 10.1038/s41467-018-03014-4.


Insights into the Structural Basis of Antibody Affinity Maturation from Next-Generation Sequencing.

Mishra AK, Mariuzza RA.

Front Immunol. 2018 Feb 1;9:117. doi: 10.3389/fimmu.2018.00117. eCollection 2018. Review.


Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.

Yang X, Chen G, Weng NP, Mariuzza RA.

J Biol Chem. 2017 Nov 10;292(45):18618-18627. doi: 10.1074/jbc.M117.810382. Epub 2017 Sep 20.


Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8+ TCR Repertoires to Immunodominant Viral Antigens.

Chen G, Yang X, Ko A, Sun X, Gao M, Zhang Y, Shi A, Mariuzza RA, Weng NP.

Cell Rep. 2017 Apr 18;19(3):569-583. doi: 10.1016/j.celrep.2017.03.072.


The Cell Wall Lipid PDIM Contributes to Phagosomal Escape and Host Cell Exit of Mycobacterium tuberculosis.

Quigley J, Hughitt VK, Velikovsky CA, Mariuzza RA, El-Sayed NM, Briken V.

mBio. 2017 Mar 7;8(2). pii: e00148-17. doi: 10.1128/mBio.00148-17.


Kinetic and thermodynamic studies of the interaction between activating and inhibitory Ly49 natural killer receptors and MHC class I molecules.

Romasanta PN, Curto LM, Sarratea MB, Noli Truant S, Antonoglou MB, Fernández Lynch MJ, Delfino JM, Mariuzza RA, Fernández MM, Malchiodi EL.

Biochem J. 2017 Jan 1;474(1):179-194. doi: 10.1042/BCJ20160876. Epub 2016 Nov 9.


Global mapping of antibody recognition of the hepatitis C virus E2 glycoprotein: Implications for vaccine design.

Pierce BG, Keck ZY, Lau P, Fauvelle C, Gowthaman R, Baumert TF, Fuerst TR, Mariuzza RA, Foung SKH.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):E6946-E6954. doi: 10.1073/pnas.1614942113. Epub 2016 Oct 26.


Structural Insights into the Inhibitory Mechanism of an Antibody against B7-H6, a Stress-Induced Cellular Ligand for the Natural Killer Cell Receptor NKp30.

Xu X, Narni-Mancinelli E, Cantoni C, Li Y, Guia S, Gauthier L, Chen Q, Moretta A, Vély F, Eisenstein E, Rangarajan S, Vivier E, Mariuzza RA.

J Mol Biol. 2016 Nov 6;428(22):4457-4466. doi: 10.1016/j.jmb.2016.09.011. Epub 2016 Sep 20.


Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice.

Keck ZY, Wang Y, Lau P, Lund G, Rangarajan S, Fauvelle C, Liao GC, Holtsberg FW, Warfield KL, Aman MJ, Pierce BG, Fuerst TR, Bailey JR, Baumert TF, Mariuzza RA, Kneteman NM, Foung SK.

Hepatology. 2016 Dec;64(6):1922-1933. doi: 10.1002/hep.28850. Epub 2016 Oct 28.


Activity Augmentation of Amphioxus Peptidoglycan Recognition Protein BbtPGRP3 via Fusion with a Chitin Binding Domain.

Wang WJ, Cheng W, Luo M, Yan Q, Yu HM, Li Q, Cao DD, Huang S, Xu A, Mariuzza RA, Chen Y, Zhou CZ.

PLoS One. 2015 Oct 19;10(10):e0140953. doi: 10.1371/journal.pone.0140953. eCollection 2015.


Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope.

Yang X, Gao M, Chen G, Pierce BG, Lu J, Weng NP, Mariuzza RA.

J Biol Chem. 2015 Nov 27;290(48):29106-19. doi: 10.1074/jbc.M115.691311. Epub 2015 Oct 1.


A positive cooperativity binding model between Ly49 natural killer cell receptors and the viral immunoevasin m157. KINETIC AND THERMODYNAMIC STUDIES.

Romasanta PN, Curto LM, Urtasun N, Sarratea MB, Chiappini S, Miranda MV, Delfino JM, Mariuzza RA, Fernández MM, Malchiodi EL.

J Biol Chem. 2015 Aug 14;290(33):20098-9. doi: 10.1074/jbc.A113.532929. No abstract available.


Pre-T-cell receptor binds MHC: Implications for thymocyte signaling and selection.

Yang X, Mariuzza RA.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8166-7. doi: 10.1073/pnas.1510127112. Epub 2015 Jul 1. No abstract available.


Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.

He Y, Rangarajan S, Kerzic M, Luo M, Chen Y, Wang Q, Yin Y, Workman CJ, Vignali KM, Vignali DA, Mariuzza RA, Orban J.

J Biol Chem. 2015 Aug 7;290(32):19796-805. doi: 10.1074/jbc.M115.663799. Epub 2015 Jun 24.


Expression, crystallization and X-ray diffraction analysis of a complex between B7-H6, a tumor cell ligand for the natural cytotoxicity receptor NKp30, and an inhibitory antibody.

Xu X, Li Y, Gauthier L, Chen Q, Vivier E, Mariuzza RA.

Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):697-701. doi: 10.1107/S2053230X15006755. Epub 2015 May 20.


Peptidoglycan recognition protein-peptidoglycan complexes increase monocyte/macrophage activation and enhance the inflammatory response.

De Marzi MC, Todone M, Ganem MB, Wang Q, Mariuzza RA, Fernández MM, Malchiodi EL.

Immunology. 2015 Jul;145(3):429-42. doi: 10.1111/imm.12460. Epub 2015 Apr 16.


Structural basis for penetration of the glycan shield of hepatitis C virus E2 glycoprotein by a broadly neutralizing human antibody.

Li Y, Pierce BG, Wang Q, Keck ZY, Fuerst TR, Foung SK, Mariuzza RA.

J Biol Chem. 2015 Apr 17;290(16):10117-25. doi: 10.1074/jbc.M115.643528. Epub 2015 Mar 3.


Selection of the lamprey VLRC antigen receptor repertoire.

Holland SJ, Gao M, Hirano M, Iyer LM, Luo M, Schorpp M, Cooper MD, Aravind L, Mariuzza RA, Boehm T.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14834-9. doi: 10.1073/pnas.1415655111. Epub 2014 Sep 16.


Structural basis for recognition of cellular and viral ligands by NK cell receptors.

Li Y, Mariuzza RA.

Front Immunol. 2014 Mar 26;5:123. doi: 10.3389/fimmu.2014.00123. eCollection 2014. Review.


T cell receptor bias for MHC: co-evolution or co-receptors?

Rangarajan S, Mariuzza RA.

Cell Mol Life Sci. 2014 Aug;71(16):3059-68. doi: 10.1007/s00018-014-1600-9. Epub 2014 Mar 17. Review.


A positive cooperativity binding model between Ly49 natural killer cell receptors and the viral immunoevasin m157: kinetic and thermodynamic studies.

Romasanta PN, Curto LM, Urtasun N, Sarratea MB, Chiappini S, Miranda MV, Delfino JM, Mariuzza RA, Fernández MM, Malchiodi EL.

J Biol Chem. 2014 Feb 21;289(8):5083-96. doi: 10.1074/jbc.M113.532929. Epub 2013 Dec 30. Erratum in: J Biol Chem. 2015 Aug 14;290(33):20098-9.


Structure-based design of altered MHC class II-restricted peptide ligands with heterogeneous immunogenicity.

Chen S, Li Y, Depontieu FR, McMiller TL, English AM, Shabanowitz J, Kos F, Sidney J, Sette A, Rosenberg SA, Hunt DF, Mariuzza RA, Topalian SL.

J Immunol. 2013 Nov 15;191(10):5097-106. doi: 10.4049/jimmunol.1300467. Epub 2013 Oct 9.


Structural and biophysical insights into the role of CD4 and CD8 in T cell activation.

Li Y, Yin Y, Mariuzza RA.

Front Immunol. 2013 Jul 22;4:206. doi: 10.3389/fimmu.2013.00206. eCollection 2013.


Genetic Association of Peptidoglycan Recognition Protein Variants with Inflammatory Bowel Disease.

Zulfiqar F, Hozo I, Rangarajan S, Mariuzza RA, Dziarski R, Gupta D.

PLoS One. 2013 Jun 19;8(6):e67393. doi: 10.1371/journal.pone.0067393. Print 2013.


Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex.

Li Y, Wang Q, Chen S, Brown PH, Mariuzza RA.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11505-10. doi: 10.1073/pnas.1303300110. Epub 2013 Jun 26.


Uptake and intracellular trafficking of superantigens in dendritic cells.

Ganem MB, De Marzi MC, Fernández-Lynch MJ, Jancic C, Vermeulen M, Geffner J, Mariuzza RA, Fernández MM, Malchiodi EL.

PLoS One. 2013 Jun 14;8(6):e66244. doi: 10.1371/journal.pone.0066244. Print 2013.


Recognition of the Thomsen-Friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor.

Luo M, Velikovsky CA, Yang X, Siddiqui MA, Hong X, Barchi JJ Jr, Gildersleeve JC, Pancer Z, Mariuzza RA.

J Biol Chem. 2013 Aug 9;288(32):23597-606. doi: 10.1074/jbc.M113.480467. Epub 2013 Jun 19.


Structural insights into the evolution of the adaptive immune system.

Deng L, Luo M, Velikovsky A, Mariuzza RA.

Annu Rev Biophys. 2013;42:191-215. doi: 10.1146/annurev-biophys-083012-130422. Epub 2013 Feb 28. Review.


Structural basis for self-recognition by autoimmune T-cell receptors.

Yin Y, Li Y, Mariuzza RA.

Immunol Rev. 2012 Nov;250(1):32-48. doi: 10.1111/imr.12002. Review.


Sugar-binding proteins from fish: selection of high affinity "lambodies" that recognize biomedically relevant glycans.

Hong X, Ma MZ, Gildersleeve JC, Chowdhury S, Barchi JJ Jr, Mariuzza RA, Murphy MB, Mao L, Pancer Z.

ACS Chem Biol. 2013 Jan 18;8(1):152-60. doi: 10.1021/cb300399s. Epub 2012 Oct 8.


Structural insights into the editing of germ-line-encoded interactions between T-cell receptor and MHC class II by Vα CDR3.

Deng L, Langley RJ, Wang Q, Topalian SL, Mariuzza RA.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14960-5. doi: 10.1073/pnas.1207186109. Epub 2012 Aug 28.


Identification of multiple RIG-I-specific pathogen associated molecular patterns within the West Nile virus genome and antigenome.

Shipley JG, Vandergaast R, Deng L, Mariuzza RA, Fredericksen BL.

Virology. 2012 Oct 10;432(1):232-8. doi: 10.1016/j.virol.2012.06.009. Epub 2012 Jul 7.


Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.

Yin Y, Wang XX, Mariuzza RA.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5405-10. doi: 10.1073/pnas.1118801109. Epub 2012 Mar 19.


Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.

Wang XX, Li Y, Yin Y, Mo M, Wang Q, Gao W, Wang L, Mariuzza RA.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15960-5. doi: 10.1073/pnas.1109438108. Epub 2011 Sep 7.


Cis-trans interactions of cell surface receptors: biological roles and structural basis.

Held W, Mariuzza RA.

Cell Mol Life Sci. 2011 Nov;68(21):3469-78. doi: 10.1007/s00018-011-0798-z. Epub 2011 Aug 24. Review.


Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6.

Li Y, Wang Q, Mariuzza RA.

J Exp Med. 2011 Apr 11;208(4):703-14. doi: 10.1084/jem.20102548. Epub 2011 Mar 21.


Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.

Yin Y, Li Y, Kerzic MC, Martin R, Mariuzza RA.

EMBO J. 2011 Mar 16;30(6):1137-48. doi: 10.1038/emboj.2011.21. Epub 2011 Feb 4.


The interaction with H-2D(d) in cis is associated with a conformational change in the Ly49A NK cell receptor.

Back J, Angelov GS, Mariuzza RA, Held W.

Front Immunol. 2011 Oct 11;2:55. doi: 10.3389/fimmu.2011.00055. eCollection 2011.


Crystal structure of staphylococcal enterotoxin G (SEG) in complex with a mouse T-cell receptor {beta} chain.

Fernández MM, Cho S, De Marzi MC, Kerzic MC, Robinson H, Mariuzza RA, Malchiodi EL.

J Biol Chem. 2011 Jan 14;286(2):1189-95. doi: 10.1074/jbc.M110.142471. Epub 2010 Nov 8.


Assessing energetic contributions to binding from a disordered region in a protein-protein interaction .

Cho S, Swaminathan CP, Bonsor DA, Kerzic MC, Guan R, Yang J, Kieke MC, Andersen PS, Kranz DM, Mariuzza RA, Sundberg EJ.

Biochemistry. 2010 Nov 2;49(43):9256-68. doi: 10.1021/bi1008968.


A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey.

Deng L, Velikovsky CA, Xu G, Iyer LM, Tasumi S, Kerzic MC, Flajnik MF, Aravind L, Pancer Z, Mariuzza RA.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13408-13. doi: 10.1073/pnas.1005475107. Epub 2010 Jul 8.


Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates.

Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z.

Biol Chem. 2010 Jul;391(7):753-60. doi: 10.1515/BC.2010.091. Review.


Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells.

Li Y, Depontieu FR, Sidney J, Salay TM, Engelhard VH, Hunt DF, Sette A, Topalian SL, Mariuzza RA.

J Mol Biol. 2010 Jun 18;399(4):596-603. doi: 10.1016/j.jmb.2010.04.037. Epub 2010 Apr 24.


The multiple mechanisms of T cell receptor cross-reactivity.

Yin Y, Mariuzza RA.

Immunity. 2009 Dec 18;31(6):849-51. doi: 10.1016/j.immuni.2009.12.002.


Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis.

Back J, Malchiodi EL, Cho S, Scarpellino L, Schneider P, Kerzic MC, Mariuzza RA, Held W.

Immunity. 2009 Oct 16;31(4):598-608. doi: 10.1016/j.immuni.2009.07.007. Epub 2009 Oct 8.


High-affinity lamprey VLRA and VLRB monoclonal antibodies.

Tasumi S, Velikovsky CA, Xu G, Gai SA, Wittrup KD, Flajnik MF, Mariuzza RA, Pancer Z.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12891-6. doi: 10.1073/pnas.0904443106. Epub 2009 Jul 22.

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