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Items: 1 to 50 of 105

1.

Structure and Dynamics of a Site-Specific Labeled Fc Fragment with Altered Effector Functions.

Gallagher DT, McCullough C, Brinson RG, Ahn J, Marino JP, Dimasi N.

Pharmaceutics. 2019 Oct 21;11(10). pii: E546. doi: 10.3390/pharmaceutics11100546.

2.

2D J-correlated proton NMR experiments for structural fingerprinting of biotherapeutics.

Brinson RG, Marino JP.

J Magn Reson. 2019 Oct;307:106581. doi: 10.1016/j.jmr.2019.106581. Epub 2019 Aug 20.

PMID:
31499472
3.

Incorporating perspective analysis into critical thinking performance assessments.

Mejía A, Mariño JP, Molina A.

Br J Educ Psychol. 2019 Sep;89(3):456-467. doi: 10.1111/bjep.12297. Epub 2019 Jun 27.

PMID:
31243770
4.

Single-Molecule 3D Images of "Hole-Hole" IgG1 Homodimers by Individual-Particle Electron Tomography.

Lei D, Liu J, Liu H, Cleveland TE 4th, Marino JP, Lei M, Ren G.

Sci Rep. 2019 Jun 20;9(1):8864. doi: 10.1038/s41598-019-44978-7.

5.

Engineering ClpS for selective and enhanced N-terminal amino acid binding.

Tullman J, Callahan N, Ellington B, Kelman Z, Marino JP.

Appl Microbiol Biotechnol. 2019 Mar;103(6):2621-2633. doi: 10.1007/s00253-019-09624-2. Epub 2019 Jan 24.

PMID:
30675637
6.

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics.

Brinson RG, Marino JP, Delaglio F, Arbogast LW, Evans RM, Kearsley A, Gingras G, Ghasriani H, Aubin Y, Pierens GK, Jia X, Mobli M, Grant HG, Keizer DW, Schweimer K, Ståhle J, Widmalm G, Zartler ER, Lawrence CW, Reardon PN, Cort JR, Xu P, Ni F, Yanaka S, Kato K, Parnham SR, Tsao D, Blomgren A, Rundlöf T, Trieloff N, Schmieder P, Ross A, Skidmore K, Chen K, Keire D, Freedberg DI, Suter-Stahel T, Wider G, Ilc G, Plavec J, Bradley SA, Baldisseri DM, Sforça ML, Zeri ACM, Wei JY, Szabo CM, Amezcua CA, Jordan JB, Wikström M.

MAbs. 2019 Jan;11(1):94-105. doi: 10.1080/19420862.2018.1544454. Epub 2018 Dec 22.

7.

Selective suppression of excipient signals in 2D 1H-13C methyl spectra of biopharmaceutical products.

Arbogast LW, Delaglio F, Tolman JR, Marino JP.

J Biomol NMR. 2018 Dec;72(3-4):149-161. doi: 10.1007/s10858-018-0214-1. Epub 2018 Nov 27.

PMID:
30483914
8.

Heterologous recombinant expression of non-originator NISTmAb.

Kashi L, Yandrofski K, Preston RJ, Arbogast LW, Giddens JP, Marino JP, Schiel JE, Kelman Z.

MAbs. 2018 Aug/Sep;10(6):922-933. doi: 10.1080/19420862.2018.1486355. Epub 2018 Jul 30.

9.

Non-Uniform Sampling for All: More NMR Spectral Quality, Less Measurement Time.

Delaglio F, Walker GS, Farley KA, Sharma R, Hoch JC, Arbogast LW, Brinson RG, Marino JP.

Am Pharm Rev. 2017 May/Jun;20(4). pii: 339681. Epub 2017 Jun 30. No abstract available.

10.

Invasive Insular Thyroid Carcinoma Presenting as Nonparalytic Dysphonia.

Raggio BS, Barton BM, Grant MC, Fornadley JA, Marino JP.

Ochsner J. 2017 Winter;17(4):438-441.

11.

Multivariate Analysis of Two-Dimensional 1H, 13C Methyl NMR Spectra of Monoclonal Antibody Therapeutics To Facilitate Assessment of Higher Order Structure.

Arbogast LW, Delaglio F, Schiel JE, Marino JP.

Anal Chem. 2017 Nov 7;89(21):11839-11845. doi: 10.1021/acs.analchem.7b03571. Epub 2017 Oct 14.

12.

Application of 2D-NMR with room temperature NMR probes for the assessment of the higher order structure of filgrastim.

Brinson RG, Ghasriani H, Hodgson DJ, Adams KM, McEwen I, Freedberg DI, Chen K, Keire DA, Aubin Y, Marino JP.

J Pharm Biomed Anal. 2017 Jul 15;141:229-233. doi: 10.1016/j.jpba.2017.03.063. Epub 2017 Apr 4.

13.

Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells.

Wajdner HE, Farrington J, Barnard C, Peachell PT, Schnackenberg CG, Marino JP Jr, Xu X, Affleck K, Begg M, Seward EP.

Physiol Rep. 2017 Mar;5(5). pii: e13166. doi: 10.14814/phy2.13166.

14.

A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp.

Altieri AS, Ladner JE, Li Z, Robinson H, Sallman ZF, Marino JP, Kelman Z.

Nucleic Acids Res. 2016 Nov 16;44(20):10015. Epub 2016 Sep 12. No abstract available.

15.

A Molecular Model for Lithium's Bioactive Form.

Briggs KT, Giulian GG, Li G, Kao JPY, Marino JP.

Biophys J. 2016 Jul 26;111(2):294-300. doi: 10.1016/j.bpj.2016.06.015.

16.

A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp.

Altieri AS, Ladner JE, Li Z, Robinson H, Sallman ZF, Marino JP, Kelman Z.

Nucleic Acids Res. 2016 Jul 27;44(13):6232-41. doi: 10.1093/nar/gkw351. Epub 2016 May 3. Erratum in: Nucleic Acids Res. 2016 Nov 16;44(20):10015.

17.

Precision and robustness of 2D-NMR for structure assessment of filgrastim biosimilars.

Ghasriani H, Hodgson DJ, Brinson RG, McEwen I, Buhse LF, Kozlowski S, Marino JP, Aubin Y, Keire DA.

Nat Biotechnol. 2016 Feb;34(2):139-41. doi: 10.1038/nbt.3474. No abstract available.

18.

Applying Thymine Isostere 2,4-Difluoro-5-Methylbenzene as a NMR Assignment Tool and Probe of Homopyrimidine/Homopurine Tract Structural Dynamics.

Brinson RG, Miller JT, Kahn JD, Le Grice SF, Marino JP.

Methods Enzymol. 2016;566:89-110. doi: 10.1016/bs.mie.2015.05.009. Epub 2015 Jun 30.

19.

Application of Natural Isotopic Abundance ¹H-¹³C- and ¹H-¹⁵N-Correlated Two-Dimensional NMR for Evaluation of the Structure of Protein Therapeutics.

Arbogast LW, Brinson RG, Marino JP.

Methods Enzymol. 2016;566:3-34. doi: 10.1016/bs.mie.2015.09.037. Epub 2015 Nov 2.

PMID:
26791974
20.

2D (1)H(N), (15)N Correlated NMR Methods at Natural Abundance for Obtaining Structural Maps and Statistical Comparability of Monoclonal Antibodies.

Arbogast LW, Brinson RG, Formolo T, Hoopes JT, Marino JP.

Pharm Res. 2016 Feb;33(2):462-75. doi: 10.1007/s11095-015-1802-3. Epub 2015 Oct 9.

PMID:
26453189
21.

Mapping monoclonal antibody structure by 2D 13C NMR at natural abundance.

Arbogast LW, Brinson RG, Marino JP.

Anal Chem. 2015 Apr 7;87(7):3556-61. doi: 10.1021/ac504804m. Epub 2015 Mar 9.

PMID:
25728213
22.

Detection of contaminating enzymatic activity in plant-derived recombinant biotechnology products.

Brinson RG, Giulian GG, Kelman Z, Marino JP.

Anal Chem. 2014 Dec 2;86(23):11508-12. doi: 10.1021/ac503864m. Epub 2014 Nov 18.

PMID:
25393810
23.

The epidemiology of dysphonia in the aging population.

Marino JP, Johns MM 3rd.

Curr Opin Otolaryngol Head Neck Surg. 2014 Dec;22(6):455-9. doi: 10.1097/MOO.0000000000000098. Review.

PMID:
25160616
24.

Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.

Seo K, Rainer PP, Shalkey Hahn V, Lee DI, Jo SH, Andersen A, Liu T, Xu X, Willette RN, Lepore JJ, Marino JP Jr, Birnbaumer L, Schnackenberg CG, Kass DA.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1551-6. doi: 10.1073/pnas.1308963111. Epub 2014 Jan 22. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6115.

25.

Probing the intracellular glutathione redox potential by in-cell NMR spectroscopy.

Rhieu SY, Urbas AA, Bearden DW, Marino JP, Lippa KA, Reipa V.

Angew Chem Int Ed Engl. 2014 Jan 7;53(2):447-50. doi: 10.1002/anie.201308004. Epub 2013 Nov 29. Erratum in: Angew Chem Int Ed Engl. 2014 Mar 10;53(11):2797.

PMID:
24288118
26.

TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses.

Cohen HB, Briggs KT, Marino JP, Ravid K, Robson SC, Mosser DM.

Blood. 2013 Sep 12;122(11):1935-45. doi: 10.1182/blood-2013-04-496216. Epub 2013 Aug 1.

27.

The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.

Washburn DG, Holt DA, Dodson J, McAtee JJ, Terrell LR, Barton L, Manns S, Waszkiewicz A, Pritchard C, Gillie DJ, Morrow DM, Davenport EA, Lozinskaya IM, Guss J, Basilla JB, Negron LK, Klein M, Willette RN, Fries RE, Jensen TC, Xu X, Schnackenberg CG, Marino JP Jr.

Bioorg Med Chem Lett. 2013 Sep 1;23(17):4979-84. doi: 10.1016/j.bmcl.2013.06.047. Epub 2013 Jun 26.

PMID:
23886683
28.

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.

Thalji RK, McAtee JJ, Belyanskaya S, Brandt M, Brown GD, Costell MH, Ding Y, Dodson JW, Eisennagel SH, Fries RE, Gross JW, Harpel MR, Holt DA, Israel DI, Jolivette LJ, Krosky D, Li H, Lu Q, Mandichak T, Roethke T, Schnackenberg CG, Schwartz B, Shewchuk LM, Xie W, Behm DJ, Douglas SA, Shaw AL, Marino JP Jr.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3584-8. doi: 10.1016/j.bmcl.2013.04.019. Epub 2013 Apr 16.

PMID:
23664879
29.

Enantioselective synthesis of dihydro-1H-benzindoles.

Silveira GP, Marino JP.

J Org Chem. 2013 Apr 5;78(7):3379-83. doi: 10.1021/jo302798j. Epub 2013 Mar 22.

PMID:
23480349
30.

In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor.

Podolin PL, Bolognese BJ, Foley JF, Long E 3rd, Peck B, Umbrecht S, Zhang X, Zhu P, Schwartz B, Xie W, Quinn C, Qi H, Sweitzer S, Chen S, Galop M, Ding Y, Belyanskaya SL, Israel DI, Morgan BA, Behm DJ, Marino JP Jr, Kurali E, Barnette MS, Mayer RJ, Booth-Genthe CL, Callahan JF.

Prostaglandins Other Lipid Mediat. 2013 Jul-Aug;104-105:25-31. doi: 10.1016/j.prostaglandins.2013.02.001. Epub 2013 Feb 19.

PMID:
23434473
31.

Molecular determinants of HIV-1 NCp7 chaperone activity in maturation of the HIV-1 dimerization initiation site.

Aduri R, Briggs KT, Gorelick RJ, Marino JP.

Nucleic Acids Res. 2013 Feb 1;41(4):2565-80. doi: 10.1093/nar/gks1350. Epub 2012 Dec 28.

32.

Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice.

Morgan LA, Olzinski AR, Upson JJ, Zhao S, Wang T, Eisennagel SH, Hoang B, Tunstead JR, Marino JP Jr, Willette RN, Jucker BM, Behm DJ.

J Cardiovasc Pharmacol. 2013 Apr;61(4):291-301. doi: 10.1097/FJC.0b013e31827fe59c.

PMID:
23232840
33.

Formation of dAMP-glycerol and dAMP-Tris derivatives by Thermococcus kodakaraensis DNA primase.

Chemnitz Galal W, Pan M, Giulian G, Yuan W, Li S, Edwards JL, Marino JP, Kelman Z, Hurwitz J.

J Biol Chem. 2012 May 11;287(20):16220-9. doi: 10.1074/jbc.M111.338160. Epub 2012 Mar 16.

34.

Soluble epoxide hydrolase inhibition exerts beneficial anti-remodeling actions post-myocardial infarction.

Kompa AR, Wang BH, Xu G, Zhang Y, Ho PY, Eisennagel S, Thalji RK, Marino JP Jr, Kelly DJ, Behm DJ, Krum H.

Int J Cardiol. 2013 Jul 15;167(1):210-9. doi: 10.1016/j.ijcard.2011.12.062. Epub 2012 Jan 10.

PMID:
22236509
35.

Structural characterization of the viral and cRNA panhandle motifs from the infectious salmon anemia virus.

Brinson RG, Szakal AL, Marino JP.

J Virol. 2011 Dec;85(24):13398-408. doi: 10.1128/JVI.06250-11. Epub 2011 Oct 12.

36.

Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists.

Thalji RK, Aiyar N, Davenport EA, Erhardt JA, Kallal LA, Morrow DM, Senadhi S, Burns-Kurtis CL, Marino JP Jr.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4104-7. doi: 10.1016/j.bmcl.2010.05.072. Epub 2010 Jun 9.

PMID:
20542694
37.

Revisiting plus-strand DNA synthesis in retroviruses and long terminal repeat retrotransposons: dynamics of enzyme: substrate interactions.

Fabris D, Marino JP, Le Grice SF.

Viruses. 2009 Dec;1(3):657-77. doi: 10.3390/v1030657. Epub 2009 Nov 4.

38.

The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages.

Marino JP Jr, Kallander LS, Ma C, Oh HJ, Lee D, Gaitanopoulos DE, Krawiec JA, Parks DJ, Webb CL, Ziegler K, Jaye M, Thompson SK.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5617-21. doi: 10.1016/j.bmcl.2009.08.036. Epub 2009 Aug 13.

PMID:
19717304
39.

SHAMS: combining chemical modification of RNA with mass spectrometry to examine polypurine tract-containing RNA/DNA hybrids.

Turner KB, Yi-Brunozzi HY, Brinson RG, Marino JP, Fabris D, Le Grice SF.

RNA. 2009 Aug;15(8):1605-13. doi: 10.1261/rna.1615409. Epub 2009 Jun 17.

40.
41.

Dissecting structural transitions in the HIV-1 dimerization initiation site RNA using 2-aminopurine fluorescence.

Lee HW, Briggs KT, Marino JP.

Methods. 2009 Oct;49(2):118-27. doi: 10.1016/j.ymeth.2009.05.006. Epub 2009 May 19.

42.

Probing anomalous structural features in polypurine tract-containing RNA-DNA hybrids with neomycin B.

Brinson RG, Turner KB, Yi-Brunozzi HY, Le Grice SF, Fabris D, Marino JP.

Biochemistry. 2009 Jul 28;48(29):6988-97. doi: 10.1021/bi900357j.

43.

Designing point mutants to detect structural coupling in a heterotrimeric G protein alpha-subunit by NMR spectroscopy.

Abdulaev NG, Mao X, Ramon E, Ngo T, Mysliwy J, Marino JP, Ridge KD.

Photochem Photobiol. 2009 Mar-Apr;85(2):431-6. doi: 10.1111/j.1751-1097.2008.00522.x. Epub 2009 Feb 11.

PMID:
19222798
44.

Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists.

Morales-Ramos AI, Mecom JS, Kiesow TJ, Graybill TL, Brown GD, Aiyar NV, Davenport EA, Kallal LA, Knapp-Reed BA, Li P, Londregan AT, Morrow DM, Senadhi S, Thalji RK, Zhao S, Burns-Kurtis CL, Marino JP Jr.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6222-6. doi: 10.1016/j.bmcl.2008.09.102. Epub 2008 Oct 2.

PMID:
18926700
46.

Structural probing of the HIV-1 polypurine tract RNA:DNA hybrid using classic nucleic acid ligands.

Turner KB, Brinson RG, Yi-Brunozzi HY, Rausch JW, Miller JT, Le Grice SF, Marino JP, Fabris D.

Nucleic Acids Res. 2008 May;36(8):2799-810. doi: 10.1093/nar/gkn129. Epub 2008 Apr 9.

47.

High-resolution NMR analysis of the conformations of native and base analog substituted retroviral and LTR-retrotransposon PPT primers.

Yi-Brunozzi HY, Brinson RG, Brabazon DM, Lener D, Le Grice SF, Marino JP.

Chem Biol. 2008 Mar;15(3):254-62. doi: 10.1016/j.chembiol.2008.01.012.

48.

New crystal structures of ColE1 Rom and variants resulting from mutation of a surface exposed residue: Implications for RNA-recognition.

Struble EB, Ladner JE, Brabazon DM, Marino JP.

Proteins. 2008 Aug;72(2):761-8. doi: 10.1002/prot.21965.

PMID:
18260113
49.

Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.

Marino JP Jr, Fisher PW, Hofmann GA, Kirkpatrick RB, Janson CA, Johnson RK, Ma C, Mattern M, Meek TD, Ryan MD, Schulz C, Smith WW, Tew DG, Tomazek TA Jr, Veber DF, Xiong WC, Yamamoto Y, Yamashita K, Yang G, Thompson SK.

J Med Chem. 2007 Aug 9;50(16):3777-85. Epub 2007 Jul 18.

PMID:
17636946
50.

Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.

Stavenger RA, Cui H, Dowdell SE, Franz RG, Gaitanopoulos DE, Goodman KB, Hilfiker MA, Ivy RL, Leber JD, Marino JP Jr, Oh HJ, Viet AQ, Xu W, Ye G, Zhang D, Zhao Y, Jolivette LJ, Head MS, Semus SF, Elkins PA, Kirkpatrick RB, Dul E, Khandekar SS, Yi T, Jung DK, Wright LL, Smith GK, Behm DJ, Doe CP, Bentley R, Chen ZX, Hu E, Lee D.

J Med Chem. 2007 Jan 11;50(1):2-5.

PMID:
17201404

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