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Items: 36

1.

Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study.

Cohen S, Roy J, Lachance S, Delisle JS, Marinier A, Busque L, Roy DC, Barabé F, Ahmad I, Bambace N, Bernard L, Kiss T, Bouchard P, Caudrelier P, Landais S, Larochelle F, Chagraoui J, Lehnertz B, Corneau S, Tomellini E, van Kampen JJA, Cornelissen JJ, Dumont-Lagacé M, Tanguay M, Li Q, Lemieux S, Zandstra PW, Sauvageau G.

Lancet Haematol. 2019 Nov 5. pii: S2352-3026(19)30202-9. doi: 10.1016/S2352-3026(19)30202-9. [Epub ahead of print]

PMID:
31704264
2.

Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments.

Labelle C, Marinier A, Lemieux S.

Bioinformatics. 2019 Jul 15;35(14):i464-i473. doi: 10.1093/bioinformatics/btz335.

3.

Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.

Toulouse JL, Yachnin BJ, Ruediger EH, Deon D, Gagnon M, Saint-Jacques K, Ebert MCCJC, Forge D, Bastien D, Colin DY, Vanden Eynde JJ, Marinier A, Berghuis AM, Pelletier JN.

ACS Omega. 2019 Jun 10;4(6):10056-10069. doi: 10.1021/acsomega.9b00640. eCollection 2019 Jun 30.

4.

Genetic characterization of ABT-199 sensitivity in human AML.

Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D'Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G.

Leukemia. 2019 Jul 12. doi: 10.1038/s41375-019-0485-x. [Epub ahead of print]

PMID:
31300747
5.

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G.

Cancer Cell. 2019 Jul 8;36(1):84-99.e8. doi: 10.1016/j.ccell.2019.06.003.

PMID:
31287994
6.

Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.

Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A.

J Med Chem. 2019 Aug 22;62(16):7400-7416. doi: 10.1021/acs.jmedchem.9b00186. Epub 2019 Aug 5.

PMID:
31246024
7.

Identification of Allosteric Inhibitors against Active Caspase-6.

Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc AC.

Sci Rep. 2019 Apr 2;9(1):5504. doi: 10.1038/s41598-019-41930-7.

8.

Mild and Diazo-Free Synthesis of Trifluoromethyl-Cyclopropanes Using Sulfonium Ylides.

Cyr P, Flynn-Robitaille J, Boissarie P, Marinier A.

Org Lett. 2019 Apr 5;21(7):2265-2268. doi: 10.1021/acs.orglett.9b00557. Epub 2019 Mar 18.

PMID:
30883143
9.

Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition.

Moison C, Lavallée VP, Thiollier C, Lehnertz B, Boivin I, Mayotte N, Gareau Y, Fréchette M, Blouin-Chagnon V, Corneau S, Lavallée S, Lemieux S, Marinier A, Hébert J, Sauvageau G.

Blood Adv. 2019 Feb 26;3(4):552-563. doi: 10.1182/bloodadvances.2018028480.

10.

Diagnostic Accuracy of Procalcitonin for Early Aspiration Pneumonia in Critically Ill Patients with Coma: A Prospective Study.

Legriel S, Grigoresco B, Martel P, Henry-Lagarrigue M, Lvovschi V, Troché G, Amara M, Jacq G, Bruneel F, Bernard M, Marinier A, Bedos JP; PCT INHAL study group.

Neurocrit Care. 2019 Apr;30(2):440-448. doi: 10.1007/s12028-018-0623-8.

PMID:
30267280
11.

Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.

Lavallée VP, Chagraoui J, MacRae T, Marquis M, Bonnefoy A, Krosl J, Lemieux S, Marinier A, Pabst C, Rivard GÉ, Hébert J, Sauvageau G.

Leukemia. 2018 Jun;32(6):1349-1357. doi: 10.1038/s41375-018-0069-1. Epub 2018 Feb 23.

PMID:
29550835
12.

Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.

Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny Y, Lemieux S, Marinier A, Hébert J, Sauvageau G.

Clin Cancer Res. 2017 Nov 15;23(22):6969-6981. doi: 10.1158/1078-0432.CCR-17-1259. Epub 2017 Aug 30.

13.

A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens.

Baccelli I, Krosl J, Boucher G, Boivin I, Lavallée VP, Hébert J, Lemieux S, Marinier A, Sauvageau G.

Blood Cancer J. 2017 Feb 17;7(2):e529. doi: 10.1038/bcj.2017.10.

14.

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.

Wong PC, Seiffert D, Bird JE, Watson CA, Bostwick JS, Giancarli M, Allegretto N, Hua J, Harden D, Guay J, Callejo M, Miller MM, Lawrence RM, Banville J, Guy J, Maxwell BD, Priestley ES, Marinier A, Wexler RR, Bouvier M, Gordon DA, Schumacher WA, Yang J.

Sci Transl Med. 2017 Jan 4;9(371). pii: eaaf5294. doi: 10.1126/scitranslmed.aaf5294.

PMID:
28053157
15.

Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay.

Normandin K, Lavallée JF, Futter M, Beautrait A, Duchaine J, Guiral S, Marinier A, Archambault V.

Sci Rep. 2016 Nov 22;5:37581. doi: 10.1038/srep37581.

16.

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells.

Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hébert J, Sauvageau G, Kwok BH, Roux PP, Hoang T.

J Clin Invest. 2016 Dec 1;126(12):4569-4584. doi: 10.1172/JCI86489. Epub 2016 Oct 31.

17.

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors.

Lavallée VP, Krosl J, Lemieux S, Boucher G, Gendron P, Pabst C, Boivin I, Marinier A, Guidos CJ, Meloche S, Hébert J, Sauvageau G.

Blood. 2016 Jun 16;127(24):3054-61. doi: 10.1182/blood-2016-03-705053. Epub 2016 Mar 31.

PMID:
27034432
18.

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J, Sauvageau G.

Nat Genet. 2015 Sep;47(9):1030-7. doi: 10.1038/ng.3371. Epub 2015 Aug 3.

PMID:
26237430
19.

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.

Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M.

Nat Struct Mol Biol. 2015 Jan;22(1):37-43. doi: 10.1038/nsmb.2924. Epub 2014 Dec 1.

PMID:
25437913
20.

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.

Science. 2014 Sep 19;345(6203):1509-12. doi: 10.1126/science.1256337.

21.

Identification of small molecules that support human leukemia stem cell activity ex vivo.

Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G.

Nat Methods. 2014 Apr;11(4):436-42. doi: 10.1038/nmeth.2847. Epub 2014 Feb 23.

PMID:
24562423
22.

[Acute myeloid leukemia with t(8;21): unusual cytological presentation and immunophenotype].

Marinier A, Malfuson JV, Konopacki J, Foissaud V, Samson T.

Ann Biol Clin (Paris). 2014 Jan-Feb;72(1):120-3. doi: 10.1684/abc.2013.0922. French.

23.

E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.

Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F.

Nat Chem Biol. 2014 Feb;10(2):156-163. doi: 10.1038/nchembio.1412. Epub 2013 Dec 15.

24.

Identifying more epidemic clones during a hospital outbreak of multidrug-resistant Acinetobacter baumannii.

Domenech de Cellès M, Salomon J, Marinier A, Lawrence C, Gaillard JL, Herrmann JL, Guillemot D.

PLoS One. 2012;7(9):e45758. doi: 10.1371/journal.pone.0045758. Epub 2012 Sep 27.

25.

Novel tricyclic inhibitors of IkappaB kinase.

Kempson J, Spergel SH, Guo J, Quesnelle C, Gill P, Belanger D, Dyckman AJ, Li T, Watterson SH, Langevine CM, Das J, Moquin RV, Furch JA, Marinier A, Dodier M, Martel A, Nirschl D, Van Kirk K, Burke JR, Pattoli MA, Gillooly K, McIntyre KW, Chen L, Yang Z, Marathe PH, Wang-Iverson D, Dodd JH, McKinnon M, Barrish JC, Pitts WJ.

J Med Chem. 2009 Apr 9;52(7):1994-2005. doi: 10.1021/jm8015816.

PMID:
19267461
26.

Biaryl isoxazolinone antibacterial agents.

Quesnelle CA, Gill P, Roy S, Dodier M, Marinier A, Martel A, Snyder LB, D'Andrea SV, Bronson JJ, Frosco M, Beaulieu D, Warr GA, Denbleyker KL, Stickle TM, Yang H, Chaniewski SE, Ferraro CA, Taylor D, Russell JW, Santone KS, Clarke J, Drain RL, Knipe JO, Mosure K, Barrett JF.

Bioorg Med Chem Lett. 2005 Jun 2;15(11):2728-33.

PMID:
15869878
27.

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials.

Snyder LB, Meng Z, Mate R, D'Andrea SV, Marinier A, Quesnelle CA, Gill P, DenBleyker KL, Fung-Tomc JC, Frosco M, Martel A, Barrett JF, Bronson JJ.

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4735-9.

PMID:
15324898
28.

Rational design of RAR-selective ligands revealed by RARbeta crystal stucture.

Germain P, Kammerer S, Pérez E, Peluso-Iltis C, Tortolani D, Zusi FC, Starrett J, Lapointe P, Daris JP, Marinier A, de Lera AR, Rochel N, Gronemeyer H.

EMBO Rep. 2004 Sep;5(9):877-82.

29.

Identification of a broad-spectrum azasordarin with improved pharmacokinetic properties.

Serrano-Wu MH, Laurent DR, Carroll TM, Dodier M, Gao Q, Gill P, Quesnelle C, Marinier A, Mazzucco CE, Regueiro-Ren A, Stickle TM, Wu D, Yang H, Yang Z, Zheng M, Zoeckler ME, Vyas DM, Balasubramanian BN.

Bioorg Med Chem Lett. 2003 Apr 17;13(8):1419-23.

PMID:
12668003
30.

Sordaricin antifungal agents.

Quesnelle CA, Gill P, Dodier M, St Laurent D, Serrano-Wu M, Marinier A, Martel A, Mazzucco CE, Stickle TM, Barrett JF, Vyas DM, Balasubramanian BN.

Bioorg Med Chem Lett. 2003 Feb 10;13(3):519-24.

PMID:
12565963
31.

Synergistic cytotoxicity exhibited by combination treatment of selective retinoid ligands with taxol (Paclitaxel).

Vivat-Hannah V, You D, Rizzo C, Daris JP, Lapointe P, Zusi FC, Marinier A, Lorenzi MV, Gottardis MM.

Cancer Res. 2001 Dec 15;61(24):8703-11.

32.

Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates.

Marinier A, Martel A, Bachand C, Plamondon S, Turmel B, Daris JP, Banville J, Lapointe P, Ouellet C, Dextraze P, Menard M, Wright JJ, Alford J, Lee D, Stanley P, Nair X, Todderud G, Tramposch KM.

Bioorg Med Chem. 2001 Jun;9(6):1395-427.

PMID:
11408160
33.

Serine 232 and methionine 272 define the ligand binding pocket in retinoic acid receptor subtypes.

Ostrowski J, Roalsvig T, Hammer L, Marinier A, Starrett JE Jr, Yu KL, Reczek PR.

J Biol Chem. 1998 Feb 6;273(6):3490-5.

34.

Sulfated galactocerebrosides as potential antiinflammatory agents.

Marinier A, Martel A, Banville J, Bachand C, Remillard R, Lapointe P, Turmel B, Menard M, Harte WE Jr, Wright JJ, Todderud G, Tramposch KM, Bajorath J, Hollenbaugh D, Aruffo A.

J Med Chem. 1997 Sep 26;40(20):3234-47.

PMID:
9379443
35.

BMS-190394, a selectin inhibitor, prevents rat cutaneous inflammatory reactions.

Todderud G, Nair X, Lee D, Alford J, Davern L, Stanley P, Bachand C, Lapointe P, Marinier A, Martel A, Menard M, Wright JJ, Bajorath J, Hollenbaugh D, Aruffo A, Tramposch KM.

J Pharmacol Exp Ther. 1997 Sep;282(3):1298-304.

PMID:
9316838
36.

HIV-1 protease inhibitors: ketomethylene isosteres with unusually high affinity compared with hydroxyethylene isostere analogs.

Marinier A, Toth MV, Houseman K, Mueller R, Marshall GR.

Bioorg Med Chem. 1994 Sep;2(9):919-25.

PMID:
7712127

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