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Items: 1 to 50 of 174

1.

The Recovery of GABAergic Function in the Hippocampus CA1 Region After mTBI.

Figueiredo T, Harbert CL, Pidoplichko V, Almeida-Suhett CP, Rossetti K, Braga MFM, Marini AM.

Mol Neurobiol. 2019 Sep 13. doi: 10.1007/s12035-019-01753-z. [Epub ahead of print]

PMID:
31520315
2.

Discovery of Pyrido[3',2':5,6]thiopyrano[4,3-d]pyrimidine-Based Antiproliferative Multikinase Inhibitors.

Salerno S, Barresi E, García-Argáez AN, Taliani S, Simorini F, Amendola G, Tomassi S, Cosconati S, Novellino E, Da Settimo F, Marini AM, Dalla Via L.

ACS Med Chem Lett. 2019 Jan 17;10(4):457-462. doi: 10.1021/acsmedchemlett.8b00499. eCollection 2019 Apr 11.

PMID:
30996779
3.

Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations.

Kant S, Davuluri G, Alchirazi KA, Welch N, Heit C, Kumar A, Gangadhariah M, Kim A, McMullen MR, Willard B, Luse DS, Nagy LE, Vasiliou V, Marini AM, Weiner ID, Dasarathy S.

J Biol Chem. 2019 May 3;294(18):7231-7244. doi: 10.1074/jbc.RA118.005411. Epub 2019 Mar 14.

PMID:
30872403
4.

Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.

Salerno S, La Pietra V, Hyeraci M, Taliani S, Robello M, Barresi E, Milite C, Simorini F, García-Argáez AN, Marinelli L, Novellino E, Da Settimo F, Marini AM, Dalla Via L.

Eur J Med Chem. 2019 Mar 1;165:46-58. doi: 10.1016/j.ejmech.2019.01.015. Epub 2019 Jan 9.

PMID:
30660826
5.

Nitrogen isotope signature evidences ammonium deprotonation as a common transport mechanism for the AMT-Mep-Rh protein superfamily.

Ariz I, Boeckstaens M, Gouveia C, Martins AP, Sanz-Luque E, Fernández E, Soveral G, von Wirén N, Marini AM, Aparicio-Tejo PM, Cruz C.

Sci Adv. 2018 Sep 12;4(9):eaar3599. doi: 10.1126/sciadv.aar3599. eCollection 2018 Sep.

6.

Acute and long-term consequences of exposure to organophosphate nerve agents in humans.

Figueiredo TH, Apland JP, Braga MFM, Marini AM.

Epilepsia. 2018 Oct;59 Suppl 2:92-99. doi: 10.1111/epi.14500. Epub 2018 Aug 29. Review.

PMID:
30159887
7.

4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors.

Salerno S, Barresi E, Amendola G, Berrino E, Milite C, Marini AM, Da Settimo F, Novellino E, Supuran CT, Cosconati S, Taliani S.

J Med Chem. 2018 Jul 12;61(13):5765-5770. doi: 10.1021/acs.jmedchem.8b00670. Epub 2018 Jun 27.

PMID:
29912561
8.

Endoscopic versus surgical treatment for a rare form of gallstone ileus: Bouveret's syndrome. Two case reports and review of the literature.

Marini M, Panyor G, Rubertà F, Marini AM, Zefelippo A, Avesani EC.

Ann Ital Chir. 2018;89:162-167. Review.

PMID:
29848813
9.

New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors.

Salerno S, García-Argáez AN, Barresi E, Taliani S, Simorini F, La Motta C, Amendola G, Tomassi S, Cosconati S, Novellino E, Da Settimo F, Marini AM, Via LD.

Eur J Med Chem. 2018 Apr 25;150:446-456. doi: 10.1016/j.ejmech.2018.03.013. Epub 2018 Mar 7.

PMID:
29547832
10.

Correlation between individual inflammation genetic profile and platelet rich plasma efficacy in hair follicle regeneration: a pilot study reveals prognostic value of IL-1a polymorphism.

Rossano F, Di Martino S, Iodice L, Di Paolo M, Misso S, Tomeo R, Marini AM, Brugnone R, Marlino S, Santorelli A, Di Francia R.

Eur Rev Med Pharmacol Sci. 2017 Nov;21(22):5247-5257. doi: 10.26355/eurrev_201711_13848.

11.

From the Cover: Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration.

Pérez-Gómez A, Cabrera-García D, Warm D, Marini AM, Salas Puig J, Fernández-Sánchez MT, Novelli A.

Toxicol Sci. 2018 Jan 1;161(1):103-114. doi: 10.1093/toxsci/kfx201.

PMID:
29029261
12.

Alpha-Linolenic Acid Treatment Reduces the Contusion and Prevents the Development of Anxiety-Like Behavior Induced by a Mild Traumatic Brain Injury in Rats.

Figueiredo TH, Harbert CL, Pidoplichko V, Almeida-Suhett CP, Pan H, Rossetti K, Braga MFM, Marini AM.

Mol Neurobiol. 2018 Jan;55(1):187-200. doi: 10.1007/s12035-017-0732-y.

PMID:
28844093
13.

The ω-3 fatty acid α-linolenic acid extends Caenorhabditis elegans lifespan via NHR-49/PPARα and oxidation to oxylipins.

Qi W, Gutierrez GE, Gao X, Dixon H, McDonough JA, Marini AM, Fisher AL.

Aging Cell. 2017 Oct;16(5):1125-1135. doi: 10.1111/acel.12651. Epub 2017 Aug 3.

14.

The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock.

Arabi YM, Al-Dorzi HM, Alamry A, Hijazi R, Alsolamy S, Al Salamah M, Tamim HM, Al-Qahtani S, Al-Dawood A, Marini AM, Al Ehnidi FH, Mundekkadan S, Matroud A, Mohamed MS, Taher S.

Ann Intensive Care. 2017 Dec;7(1):57. doi: 10.1186/s13613-017-0280-7. Epub 2017 May 30.

15.

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling.

Merhi A, Delrée P, Marini AM.

Sci Rep. 2017 Mar 17;7:44602. doi: 10.1038/srep44602.

16.

1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.

Coviello V, Marchi B, Sartini S, Quattrini L, Marini AM, Simorini F, Taliani S, Salerno S, Orlandi P, Fioravanti A, Desidero TD, Vullo D, Da Settimo F, Supuran CT, Bocci G, La Motta C.

J Med Chem. 2016 Jul 14;59(13):6547-52. doi: 10.1021/acs.jmedchem.6b00616. Epub 2016 Jun 27.

PMID:
27305384
17.

The impact of implementing multifaceted interventions on the prevention of ventilator-associated pneumonia.

Khan R, Al-Dorzi HM, Al-Attas K, Ahmed FW, Marini AM, Mundekkadan S, Balkhy HH, Tannous J, Almesnad A, Mannion D, Tamim HM, Arabi YM.

Am J Infect Control. 2016 Mar 1;44(3):320-6. doi: 10.1016/j.ajic.2015.09.025.

PMID:
26940595
18.

Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.

Barresi E, Salerno S, Marini AM, Taliani S, La Motta C, Simorini F, Da Settimo F, Vullo D, Supuran CT.

Bioorg Med Chem. 2016 Feb 15;24(4):921-7. doi: 10.1016/j.bmc.2016.01.018. Epub 2016 Jan 11.

PMID:
26796953
19.

α-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced Neuropathology.

Piermartiri T, Pan H, Figueiredo TH, Marini AM.

Molecules. 2015 Nov 12;20(11):20355-80. doi: 10.3390/molecules201119698. Review.

20.

Yeast nitrogen catabolite repression is sustained by signals distinct from glutamine and glutamate reservoirs.

Fayyad-Kazan M, Feller A, Bodo E, Boeckstaens M, Marini AM, Dubois E, Georis I.

Mol Microbiol. 2016 Jan;99(2):360-79. doi: 10.1111/mmi.13236. Epub 2015 Nov 13.

21.

Repeated systemic administration of the nutraceutical alpha-linolenic acid exerts neuroprotective efficacy, an antidepressant effect and improves cognitive performance when given after soman exposure.

Pan H, Piermartiri TC, Chen J, McDonough J, Oppel C, Driwech W, Winter K, McFarland E, Black K, Figueiredo T, Grunberg N, Marini AM.

Neurotoxicology. 2015 Dec;51:38-50. doi: 10.1016/j.neuro.2015.09.006. Epub 2015 Sep 16.

PMID:
26386148
22.

Acute Response of the Hippocampal Transcriptome Following Mild Traumatic Brain Injury After Controlled Cortical Impact in the Rat.

Samal BB, Waites CK, Almeida-Suhett C, Li Z, Marini AM, Samal NR, Elkahloun A, Braga MF, Eiden LE.

J Mol Neurosci. 2015 Oct;57(2):282-303. doi: 10.1007/s12031-015-0626-2. Epub 2015 Aug 29.

PMID:
26319264
23.

Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2.

Salerno S, Marini AM, Fornaciari G, Simorini F, La Motta C, Taliani S, Sartini S, Da Settimo F, García-Argáez AN, Gia O, Cosconati S, Novellino E, D'Ocon P, Fioravanti A, Orlandi P, Bocci G, Dalla Via L.

Eur J Med Chem. 2015 Oct 20;103:29-43. doi: 10.1016/j.ejmech.2015.08.027. Epub 2015 Aug 14.

PMID:
26318056
24.

GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury.

Almeida-Suhett CP, Prager EM, Pidoplichko V, Figueiredo TH, Marini AM, Li Z, Eiden LE, Braga MF.

Exp Neurol. 2015 Nov;273:11-23. doi: 10.1016/j.expneurol.2015.07.028. Epub 2015 Jul 31.

PMID:
26238734
25.

Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides.

Barresi E, Bruno A, Taliani S, Cosconati S, Da Pozzo E, Salerno S, Simorini F, Daniele S, Giacomelli C, Marini AM, La Motta C, Marinelli L, Cosimelli B, Novellino E, Greco G, Da Settimo F, Martini C.

J Med Chem. 2015 Aug 13;58(15):6081-92. doi: 10.1021/acs.jmedchem.5b00689. Epub 2015 Jul 28.

PMID:
26177193
26.

Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32.

Boeckstaens M, Merhi A, Llinares E, Van Vooren P, Springael JY, Wintjens R, Marini AM.

PLoS Genet. 2015 Jul 14;11(7):e1005382. doi: 10.1371/journal.pgen.1005382. eCollection 2015 Jul.

27.

Wnt/β-Catenin Signaling Regulates the Expression of the Ammonium Permease Gene RHBG in Human Cancer Cells.

Merhi A, De Mees C, Abdo R, Victoria Alberola J, Marini AM.

PLoS One. 2015 Jun 1;10(6):e0128683. doi: 10.1371/journal.pone.0128683. eCollection 2015.

28.

Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in the Improvement in the Passive Avoidance Task After Soman Exposure.

Piermartiri TC, Pan H, Chen J, McDonough J, Grunberg N, Apland JP, Marini AM.

Neuromolecular Med. 2015 Sep;17(3):251-69. doi: 10.1007/s12017-015-8353-y. Epub 2015 Apr 29.

PMID:
25920465
29.

The General Amino Acid Permease FfGap1 of Fusarium fujikuroi Is Sorted to the Vacuole in a Nitrogen-Dependent, but Npr1 Kinase-Independent Manner.

Pfannmüller A, Wagner D, Sieber C, Schönig B, Boeckstaens M, Marini AM, Tudzynski B.

PLoS One. 2015 Apr 24;10(4):e0125487. doi: 10.1371/journal.pone.0125487. eCollection 2015.

30.

Alpha-linolenic acid: an omega-3 fatty acid with neuroprotective properties-ready for use in the stroke clinic?

Blondeau N, Lipsky RH, Bourourou M, Duncan MW, Gorelick PB, Marini AM.

Biomed Res Int. 2015;2015:519830. doi: 10.1155/2015/519830. Epub 2015 Feb 19. Review.

31.

Ammonia excretion in Caenorhabditis elegans: mechanism and evidence of ammonia transport of the Rhesus protein CeRhr-1.

Adlimoghaddam A, Boeckstaens M, Marini AM, Treberg JR, Brassinga AK, Weihrauch D.

J Exp Biol. 2015 Mar;218(Pt 5):675-83. doi: 10.1242/jeb.111856.

32.

Diagnostic accuracy of a screening electronic alert tool for severe sepsis and septic shock in the emergency department.

Alsolamy S, Al Salamah M, Al Thagafi M, Al-Dorzi HM, Marini AM, Aljerian N, Al-Enezi F, Al-Hunaidi F, Mahmoud AM, Alamry A, Arabi YM.

BMC Med Inform Decis Mak. 2014 Dec 5;14:105. doi: 10.1186/s12911-014-0105-7.

33.

Application of Failure Mode Effect Analysis to Improve the Care of Septic Patients Admitted Through the Emergency Department.

Alamry A, Al Owais SM, Marini AM, Al-Dorzi H, Alsolamy S, Arabi Y.

J Patient Saf. 2017 Jun;13(2):76-81. doi: 10.1097/PTS.0000000000000118.

PMID:
25119786
34.

Reduced GABAergic inhibition in the basolateral amygdala and the development of anxiety-like behaviors after mild traumatic brain injury.

Almeida-Suhett CP, Prager EM, Pidoplichko V, Figueiredo TH, Marini AM, Li Z, Eiden LE, Braga MF.

PLoS One. 2014 Jul 21;9(7):e102627. doi: 10.1371/journal.pone.0102627. eCollection 2014.

35.
36.

(-)-Phenserine attenuates soman-induced neuropathology.

Chen J, Pan H, Chen C, Wu W, Iskandar K, He J, Piermartiri T, Jacobowitz DM, Yu QS, McDonough JH, Greig NH, Marini AM.

PLoS One. 2014 Jun 23;9(6):e99818. doi: 10.1371/journal.pone.0099818. eCollection 2014.

37.

The TORC1 effector kinase Npr1 fine tunes the inherent activity of the Mep2 ammonium transport protein.

Boeckstaens M, Llinares E, Van Vooren P, Marini AM.

Nat Commun. 2014;5:3101. doi: 10.1038/ncomms4101.

PMID:
24476960
38.

Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies.

Sartini S, Coviello V, Bruno A, La Pietra V, Marinelli L, Simorini F, Taliani S, Salerno S, Marini AM, Fioravanti A, Orlandi P, Antonelli A, Da Settimo F, Novellino E, Bocci G, La Motta C.

J Med Chem. 2014 Feb 27;57(4):1225-35. doi: 10.1021/jm401358b. Epub 2014 Feb 5.

PMID:
24447248
39.

Pyogenic vertebral osteomyelitis complicating abdominal penetrating injury: case report and review of the literature.

Zefelippo A, Bertazzoni PM, Marini AM, De Rai P, Contessini-Avesani E.

World J Emerg Surg. 2013 Dec 27;8(1):56. doi: 10.1186/1749-7922-8-56.

40.

Temporal course of changes in gene expression suggests a cytokine-related mechanism for long-term hippocampal alteration after controlled cortical impact.

Almeida-Suhett CP, Li Z, Marini AM, Braga MF, Eiden LE.

J Neurotrauma. 2014 Apr 1;31(7):683-90. doi: 10.1089/neu.2013.3029. Epub 2014 Mar 3.

41.

Building capacity for quality and safety in critical care: A roundtable discussion from the second international patient safety conference in April 9-11, 2013, Riyadh, Saudi Arabia.

Arabi YM, Taher S, Berenholtz SM, Alamry A, Hijazi R, Alatassi A, Marini AM.

Ann Thorac Med. 2013 Oct;8(4):183-5. doi: 10.4103/1817-1737.118480.

42.

Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors.

Taliani S, Pugliesi I, Barresi E, Salerno S, Marchand C, Agama K, Simorini F, La Motta C, Marini AM, Di Leva FS, Marinelli L, Cosconati S, Novellino E, Pommier Y, Di Santo R, Da Settimo F.

J Med Chem. 2013 Sep 26;56(18):7458-62. doi: 10.1021/jm400932c. Epub 2013 Sep 16.

43.

SNPs altering ammonium transport activity of human Rhesus factors characterized by a yeast-based functional assay.

Deschuyteneer A, Boeckstaens M, De Mees C, Van Vooren P, Wintjens R, Marini AM.

PLoS One. 2013 Aug 13;8(8):e71092. doi: 10.1371/journal.pone.0071092. eCollection 2013.

44.

Neurotrophic and neuroprotective actions of (-)- and (+)-phenserine, candidate drugs for Alzheimer's disease.

Lilja AM, Luo Y, Yu QS, Röjdner J, Li Y, Marini AM, Marutle A, Nordberg A, Greig NH.

PLoS One. 2013;8(1):e54887. doi: 10.1371/journal.pone.0054887. Epub 2013 Jan 30.

45.

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

Nuti E, Santamaria S, Casalini F, Yamamoto K, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Marini AM, Salerno S, Taliani S, Da Settimo F, Nagase H, Rossello A.

Eur J Med Chem. 2013 Apr;62:379-94. doi: 10.1016/j.ejmech.2012.12.058. Epub 2013 Jan 11.

PMID:
23376997
46.

Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.

Sartini S, Cosconati S, Marinelli L, Barresi E, Di Maro S, Simorini F, Taliani S, Salerno S, Marini AM, Da Settimo F, Novellino E, La Motta C.

J Med Chem. 2012 Dec 13;55(23):10523-31. doi: 10.1021/jm301124s. Epub 2012 Nov 20.

PMID:
23134227
47.

Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.

Marini AM, Maresca A, Aggarwal M, Orlandini E, Nencetti S, Da Settimo F, Salerno S, Simorini F, La Motta C, Taliani S, Nuti E, Scozzafava A, McKenna R, Rossello A, Supuran CT.

J Med Chem. 2012 Nov 26;55(22):9619-29. doi: 10.1021/jm300878g. Epub 2012 Nov 8.

PMID:
23067387
48.

Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology.

Pan H, Hu XZ, Jacobowitz DM, Chen C, McDonough J, Van Shura K, Lyman M, Marini AM.

Neurotoxicology. 2012 Oct;33(5):1219-29. doi: 10.1016/j.neuro.2012.07.001. Epub 2012 Aug 3.

PMID:
22884490
49.

Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury.

Hu Z, Yu D, Almeida-Suhett C, Tu K, Marini AM, Eiden L, Braga MF, Zhu J, Li Z.

PLoS One. 2012;7(6):e39357. doi: 10.1371/journal.pone.0039357. Epub 2012 Jun 22.

50.

3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.

Taliani S, Pugliesi I, Barresi E, Simorini F, Salerno S, La Motta C, Marini AM, Cosimelli B, Cosconati S, Di Maro S, Marinelli L, Daniele S, Trincavelli ML, Greco G, Novellino E, Martini C, Da Settimo F.

J Med Chem. 2012 Feb 23;55(4):1490-9. doi: 10.1021/jm201177b. Epub 2012 Feb 7.

PMID:
22257095

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