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Items: 12


Target exposure and pharmacodynamics study of the indoleamine 2,3-dioxygenase-1 (IDO-1) inhibitor epacadostat in the CT26 mouse tumor model.

Poncelet L, Ait-Belkacem R, Marillier R, Gomes B, Stauber J.

J Pharm Biomed Anal. 2019 Jun 5;170:220-227. doi: 10.1016/j.jpba.2019.02.038. Epub 2019 Mar 22.


Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.

Gomes B, Driessens G, Bartlett D, Cai D, Cauwenberghs S, Crosignani S, Dalvie D, Denies S, Dillon CP, Fantin VR, Guo J, Letellier MC, Li W, Maegley K, Marillier R, Miller N, Pirson R, Rabolli V, Ray C, Streiner N, Torti VR, Tsaparikos K, Van den Eynde BJ, Wythes M, Yao LC, Zheng X, Tumang J, Kraus M.

Mol Cancer Ther. 2018 Dec;17(12):2530-2542. doi: 10.1158/1535-7163.MCT-17-1104. Epub 2018 Sep 19.


The TLR7 ligand R848 prevents mouse graft-versus-host disease and cooperates with anti-interleukin-27 antibody for maximal protection and regulatory T-cell upregulation.

Gaignage M, Marillier RG, Cochez PM, Dumoutier L, Uyttenhove C, Coutelier JP, Van Snick J.

Haematologica. 2019 Feb;104(2):392-402. doi: 10.3324/haematol.2018.195628. Epub 2018 Sep 13.


Mouse nidovirus LDV infection alleviates graft versus host disease and induces type I IFN-dependent inhibition of dendritic cells and allo-responsive T cells.

Gaignage M, Marillier RG, Uyttenhove C, Dauguet N, Saxena A, Ryffel B, Michiels T, Coutelier JP, Van Snick J.

Immun Inflamm Dis. 2017 Jun;5(2):200-213. doi: 10.1002/iid3.157. Epub 2017 Apr 4.


Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression.

Belle L, Agle K, Zhou V, Yin-Yuan C, Komorowski R, Eastwood D, Logan B, Sun J, Ghilardi N, Cua D, Williams CB, Gaignage M, Marillier R, van Snick J, Drobyski WR.

Blood. 2016 Oct 20;128(16):2068-2082. doi: 10.1182/blood-2016-02-698241. Epub 2016 Aug 3.


IL-27p28 is essential for parent-to-F1 acute graft-versus-host disease.

Marillier RG, Uyttenhove C, Goriely S, Marbaix E, Van Snick J.

Eur J Immunol. 2014 Jul;44(7):2064-73. doi: 10.1002/eji.201444491. Epub 2014 Apr 27.


Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection.

Uyttenhove C, Marillier RG, Tacchini-Cottier F, Charmoy M, Caspi RR, Damsker JM, Goriely S, Su D, Van Damme J, Struyf S, Opdenakker G, Van Snick J.

J Leukoc Biol. 2011 Jun;89(6):1001-7. doi: 10.1189/jlb.1210699. Epub 2011 Mar 8.


IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness.

Dewals BG, Marillier RG, Hoving JC, Leeto M, Schwegmann A, Brombacher F.

PLoS Negl Trop Dis. 2010 May 18;4(5):e689. doi: 10.1371/journal.pntd.0000689.


IL-4R{alpha}-responsive smooth muscle cells increase intestinal hypercontractility and contribute to resistance during acute Schistosomiasis.

Marillier RG, Brombacher TM, Dewals B, Leeto M, Barkhuizen M, Govender D, Kellaway L, Horsnell WG, Brombacher F.

Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G943-51. doi: 10.1152/ajpgi.00321.2009. Epub 2010 Apr 1.


IL-4Ralpha responsiveness of non-CD4 T cells contributes to resistance in schistosoma mansoni infection in pan-T cell-specific IL-4Ralpha-deficient mice.

Dewals B, Hoving JC, Leeto M, Marillier RG, Govender U, Cutler AJ, Horsnell WG, Brombacher F.

Am J Pathol. 2009 Aug;175(2):706-16. doi: 10.2353/ajpath.2009.090137. Epub 2009 Jul 23.


IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections.

Marillier RG, Michels C, Smith EM, Fick LC, Leeto M, Dewals B, Horsnell WG, Brombacher F.

BMC Immunol. 2008 Mar 28;9:11. doi: 10.1186/1471-2172-9-11.


TH1-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during murine schistosomiasis.

Leeto M, Herbert DR, Marillier R, Schwegmann A, Fick L, Brombacher F.

Am J Pathol. 2006 Nov;169(5):1701-12.

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