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Items: 29

1.

Reply to: Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease.

Rodríguez JA, Farré X, Muntané G, Marigorta UM, Hughes DA, Spataro N, Bosch E, Navarro A.

Nat Ecol Evol. 2019 Jul;3(7):994-995. doi: 10.1038/s41559-019-0926-y. Epub 2019 Jun 24. No abstract available.

PMID:
31235924
2.

Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study.

Hyams JS, Davis Thomas S, Gotman N, Haberman Y, Karns R, Schirmer M, Mo A, Mack DR, Boyle B, Griffiths AM, LeLeiko NS, Sauer CG, Keljo DJ, Markowitz J, Baker SS, Rosh J, Baldassano RN, Patel A, Pfefferkorn M, Otley A, Heyman M, Noe J, Oliva-Hemker M, Rufo PA, Strople J, Ziring D, Guthery SL, Sudel B, Benkov K, Wali P, Moulton D, Evans J, Kappelman MD, Marquis MA, Sylvester FA, Collins MH, Venkateswaran S, Dubinsky M, Tangpricha V, Spada KL, Saul B, Wang J, Serrano J, Hommel K, Marigorta UM, Gibson G, Xavier RJ, Kugathasan S, Walters T, Denson LA.

Lancet. 2019 Apr 27;393(10182):1708-1720. doi: 10.1016/S0140-6736(18)32592-3. Epub 2019 Mar 29.

PMID:
30935734
3.

Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation.

Somineni HK, Venkateswaran S, Kilaru V, Marigorta UM, Mo A, Okou DT, Kellermayer R, Mondal K, Cobb D, Walters TD, Griffiths A, Noe JD, Crandall WV, Rosh JR, Mack DR, Heyman MB, Baker SS, Stephens MC, Baldassano RN, Markowitz JF, Dubinsky MC, Cho J, Hyams JS, Denson LA, Gibson G, Cutler DJ, Conneely KN, Smith AK, Kugathasan S.

Gastroenterology. 2019 Jun;156(8):2254-2265.e3. doi: 10.1053/j.gastro.2019.01.270. Epub 2019 Feb 16.

PMID:
30779925
4.

Bowel Location Rather Than Disease Subtype Dominates Transcriptomic Heterogeneity in Pediatric IBD.

Venkateswaran S, Marigorta UM, Denson LA, Hyams JS, Gibson G, Kugathasan S.

Cell Mol Gastroenterol Hepatol. 2018 Aug 1;6(4):474-476.e3. doi: 10.1016/j.jcmgh.2018.07.001. eCollection 2018. No abstract available.

5.

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.

Jenks SA, Cashman KS, Zumaquero E, Marigorta UM, Patel AV, Wang X, Tomar D, Woodruff MC, Simon Z, Bugrovsky R, Blalock EL, Scharer CD, Tipton CM, Wei C, Lim SS, Petri M, Niewold TB, Anolik JH, Gibson G, Lee FE, Boss JM, Lund FE, Sanz I.

Immunity. 2018 Oct 16;49(4):725-739.e6. doi: 10.1016/j.immuni.2018.08.015. Epub 2018 Oct 9.

PMID:
30314758
6.

Pervasive Modulation of Obesity Risk by the Environment and Genomic Background.

Nagpal S, Gibson G, Marigorta UM.

Genes (Basel). 2018 Aug 14;9(8). pii: E411. doi: 10.3390/genes9080411.

7.

Disease-specific regulation of gene expression in a comparative analysis of juvenile idiopathic arthritis and inflammatory bowel disease.

Mo A, Marigorta UM, Arafat D, Chan LHK, Ponder L, Jang SR, Prince J, Kugathasan S, Prahalad S, Gibson G.

Genome Med. 2018 Jun 27;10(1):48. doi: 10.1186/s13073-018-0558-x.

8.

Replicability and Prediction: Lessons and Challenges from GWAS.

Marigorta UM, Rodríguez JA, Gibson G, Navarro A.

Trends Genet. 2018 Jul;34(7):504-517. doi: 10.1016/j.tig.2018.03.005. Epub 2018 Apr 30. Review.

9.

Correction: Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples.

Mandage R, Telford M, Rodríguez JA, Farré X, Laayouni H, Marigorta UM, Cundiff C, Heredia-Genestar JM, Navarro A, Santpere G.

PLoS One. 2018 Apr 30;13(4):e0196623. doi: 10.1371/journal.pone.0196623. eCollection 2018.

10.

Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.

Venkateswaran S, Prince J, Cutler DJ, Marigorta UM, Okou DT, Prahalad S, Mack D, Boyle B, Walters T, Griffiths A, Sauer CG, LeLeiko N, Keljo D, Markowitz J, Baker SS, Rosh J, Pfefferkorn M, Heyman MB, Patel A, Otley A, Baldassano R, Noe J, Rufo P, Oliva-Hemker M, Davis S, Zwick ME, Gibson G, Denson LA, Hyams J, Kugathasan S.

Inflamm Bowel Dis. 2018 Mar 19;24(4):829-838. doi: 10.1093/ibd/izx084.

11.

Antagonistic pleiotropy and mutation accumulation influence human senescence and disease.

Rodríguez JA, Marigorta UM, Hughes DA, Spataro N, Bosch E, Navarro A.

Nat Ecol Evol. 2017 Jan 30;1(3):55. doi: 10.1038/s41559-016-0055.

PMID:
28812720
12.

Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease.

Marigorta UM, Denson LA, Hyams JS, Mondal K, Prince J, Walters TD, Griffiths A, Noe JD, Crandall WV, Rosh JR, Mack DR, Kellermayer R, Heyman MB, Baker SS, Stephens MC, Baldassano RN, Markowitz JF, Kim MO, Dubinsky MC, Cho J, Aronow BJ, Kugathasan S, Gibson G.

Nat Genet. 2017 Oct;49(10):1517-1521. doi: 10.1038/ng.3936. Epub 2017 Aug 14.

13.

Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples.

Mandage R, Telford M, Rodríguez JA, Farré X, Layouni H, Marigorta UM, Cundiff C, Heredia-Genestar JM, Navarro A, Santpere G.

PLoS One. 2017 Jun 27;12(6):e0179446. doi: 10.1371/journal.pone.0179446. eCollection 2017. Erratum in: PLoS One. 2018 Apr 30;13(4):e0196623.

14.

Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression.

Zeng B, Lloyd-Jones LR, Holloway A, Marigorta UM, Metspalu A, Montgomery GW, Esko T, Brigham KL, Quyyumi AA, Idaghdour Y, Yang J, Visscher PM, Powell JE, Gibson G.

G3 (Bethesda). 2017 Aug 7;7(8):2533-2544. doi: 10.1534/g3.117.043752.

15.

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.

Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC.

Lancet. 2017 Apr 29;389(10080):1710-1718. doi: 10.1016/S0140-6736(17)30317-3. Epub 2017 Mar 2.

16.

Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies.

Mieth B, Kloft M, Rodríguez JA, Sonnenburg S, Vobruba R, Morcillo-Suárez C, Farré X, Marigorta UM, Fehr E, Dickhaus T, Blanchard G, Schunk D, Navarro A, Müller KR.

Sci Rep. 2016 Nov 28;6:36671. doi: 10.1038/srep36671.

17.

A Burden of Rare Variants Associated with Extremes of Gene Expression in Human Peripheral Blood.

Zhao J, Akinsanmi I, Arafat D, Cradick TJ, Lee CM, Banskota S, Marigorta UM, Bao G, Gibson G.

Am J Hum Genet. 2016 Feb 4;98(2):299-309. doi: 10.1016/j.ajhg.2015.12.023.

18.

PART of the WHOLE: A Case Study in Wellness-Oriented Personalized Medicine.

Gibson G, Marigorta UM, Ojagbeghru ER, Park S.

Yale J Biol Med. 2015 Nov 24;88(4):397-406. eCollection 2015 Dec.

19.

Expression quantitative trait locus analysis for translational medicine.

Gibson G, Powell JE, Marigorta UM.

Genome Med. 2015 Jun 24;7(1):60. doi: 10.1186/s13073-015-0186-7. eCollection 2015. Review.

20.

Integrating genomics into evolutionary medicine.

Rodríguez JA, Marigorta UM, Navarro A.

Curr Opin Genet Dev. 2014 Dec;29:97-102. doi: 10.1016/j.gde.2014.08.009. Epub 2014 Sep 16. Review.

PMID:
25218863
21.

A simulation study of gene-by-environment interactions in GWAS implies ample hidden effects.

Marigorta UM, Gibson G.

Front Genet. 2014 Jul 21;5:225. doi: 10.3389/fgene.2014.00225. eCollection 2014.

22.

Genomic analysis of the blood attributed to Louis XVI (1754-1793), king of France.

Olalde I, Sánchez-Quinto F, Datta D, Marigorta UM, Chiang CW, Rodríguez JA, Fernández-Callejo M, González I, Montfort M, Matas-Lalueza L, Civit S, Luiselli D, Charlier P, Pettener D, Ramírez O, Navarro A, Himmelbauer H, Marquès-Bonet T, Lalueza-Fox C.

Sci Rep. 2014 Apr 24;4:4666. doi: 10.1038/srep04666.

23.

Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European.

Olalde I, Allentoft ME, Sánchez-Quinto F, Santpere G, Chiang CW, DeGiorgio M, Prado-Martinez J, Rodríguez JA, Rasmussen S, Quilez J, Ramírez O, Marigorta UM, Fernández-Callejo M, Prada ME, Encinas JM, Nielsen R, Netea MG, Novembre J, Sturm RA, Sabeti P, Marquès-Bonet T, Navarro A, Willerslev E, Lalueza-Fox C.

Nature. 2014 Mar 13;507(7491):225-8. doi: 10.1038/nature12960. Epub 2014 Jan 26.

24.

High trans-ethnic replicability of GWAS results implies common causal variants.

Marigorta UM, Navarro A.

PLoS Genet. 2013 Jun;9(6):e1003566. doi: 10.1371/journal.pgen.1003566. Epub 2013 Jun 13.

25.

Implications of population history of European Romani on genetic susceptibility to disease.

Mendizabal I, Lao O, Marigorta UM, Kayser M, Comas D.

Hum Hered. 2013;76(3-4):194-200. doi: 10.1159/000360762. Epub 2014 May 21.

26.

Reconstructing the population history of European Romani from genome-wide data.

Mendizabal I, Lao O, Marigorta UM, Wollstein A, Gusmão L, Ferak V, Ioana M, Jordanova A, Kaneva R, Kouvatsi A, Kučinskas V, Makukh H, Metspalu A, Netea MG, de Pablo R, Pamjav H, Radojkovic D, Rolleston SJ, Sertic J, Macek M Jr, Comas D, Kayser M.

Curr Biol. 2012 Dec 18;22(24):2342-9. doi: 10.1016/j.cub.2012.10.039. Epub 2012 Dec 6.

27.

Adaptive evolution of loci covarying with the human African Pygmy phenotype.

Mendizabal I, Marigorta UM, Lao O, Comas D.

Hum Genet. 2012 Aug;131(8):1305-17. doi: 10.1007/s00439-012-1157-3. Epub 2012 Mar 11.

28.

Copy number variation analysis in the great apes reveals species-specific patterns of structural variation.

Gazave E, Darré F, Morcillo-Suarez C, Petit-Marty N, Carreño A, Marigorta UM, Ryder OA, Blancher A, Rocchi M, Bosch E, Baker C, Marquès-Bonet T, Eichler EE, Navarro A.

Genome Res. 2011 Oct;21(10):1626-39. doi: 10.1101/gr.117242.110. Epub 2011 Aug 8.

29.

Recent human evolution has shaped geographical differences in susceptibility to disease.

Marigorta UM, Lao O, Casals F, Calafell F, Morcillo-Suárez C, Faria R, Bosch E, Serra F, Bertranpetit J, Dopazo H, Navarro A.

BMC Genomics. 2011 Jan 24;12:55. doi: 10.1186/1471-2164-12-55.

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