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Items: 1 to 50 of 166

1.

MHC-restricted Ag85B-specific CD8+ T cells are enhanced by recombinant BCG prime and DNA boost immunization in mice.

Komine-Aizawa S, Jiang J, Mizuno S, Hayakawa S, Matsuo K, Boyd LF, Margulies DH, Honda M.

Eur J Immunol. 2019 May 28. doi: 10.1002/eji.201847988. [Epub ahead of print]

PMID:
31135967
2.

Structural aspects of chaperone-mediated peptide loading in the MHC-I antigen presentation pathway.

Natarajan K, Jiang J, Margulies DH.

Crit Rev Biochem Mol Biol. 2019 Apr;54(2):164-173. doi: 10.1080/10409238.2019.1610352. Epub 2019 May 14.

PMID:
31084439
3.

The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling.

Natarajan K, Jiang J, May NA, Mage MG, Boyd LF, McShan AC, Sgourakis NG, Bax A, Margulies DH.

Front Immunol. 2018 Jul 17;9:1657. doi: 10.3389/fimmu.2018.01657. eCollection 2018. Review.

4.

Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle.

McShan AC, Natarajan K, Kumirov VK, Flores-Solis D, Jiang J, Badstübner M, Toor JS, Bagshaw CR, Kovrigin EL, Margulies DH, Sgourakis NG.

Nat Chem Biol. 2018 Aug;14(8):811-820. doi: 10.1038/s41589-018-0096-2. Epub 2018 Jul 9.

5.

A transgenic mouse model for HLA-B*57:01-linked abacavir drug tolerance and reactivity.

Cardone M, Garcia K, Tilahun ME, Boyd LF, Gebreyohannes S, Yano M, Roderiquez G, Akue AD, Juengst L, Mattson E, Ananthula S, Natarajan K, Puig M, Margulies DH, Norcross MA.

J Clin Invest. 2018 Jul 2;128(7):2819-2832. doi: 10.1172/JCI99321. Epub 2018 May 21.

6.

How MHC molecules grab citrullinated peptides to foster rheumatoid arthritis.

Margulies DH.

J Biol Chem. 2018 Mar 2;293(9):3252-3253. doi: 10.1074/jbc.H118.001829.

7.

Effects of Cross-Presentation, Antigen Processing, and Peptide Binding in HIV Evasion of T Cell Immunity.

Frey BF, Jiang J, Sui Y, Boyd LF, Yu B, Tatsuno G, Billeskov R, Solaymani-Mohammadi S, Berman PW, Margulies DH, Berzofsky JA.

J Immunol. 2018 Mar 1;200(5):1853-1864. doi: 10.4049/jimmunol.1701523. Epub 2018 Jan 26.

8.

Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation.

Jiang J, Natarajan K, Boyd LF, Morozov GI, Mage MG, Margulies DH.

Science. 2017 Nov 24;358(6366):1064-1068. doi: 10.1126/science.aao5154. Epub 2017 Oct 12.

9.

An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role.

Natarajan K, McShan AC, Jiang J, Kumirov VK, Wang R, Zhao H, Schuck P, Tilahun ME, Boyd LF, Ying J, Bax A, Margulies DH, Sgourakis NG.

Nat Commun. 2017 May 16;8:15260. doi: 10.1038/ncomms15260.

10.

Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock.

Voss OH, Murakami Y, Pena MY, Lee HN, Tian L, Margulies DH, Street JM, Yuen PS, Qi CF, Krzewski K, Coligan JE.

Immunity. 2016 Jun 21;44(6):1365-78. doi: 10.1016/j.immuni.2016.05.005. Epub 2016 May 31.

11.

Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing.

Morozov GI, Zhao H, Mage MG, Boyd LF, Jiang J, Dolan MA, Venna R, Norcross MA, McMurtrey CP, Hildebrand W, Schuck P, Natarajan K, Margulies DH.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1006-15. doi: 10.1073/pnas.1519894113. Epub 2016 Feb 11.

12.

William E. Paul 1936-2015.

Shevach EM, Margulies DH.

Nat Immunol. 2015 Dec;16(12):1205. doi: 10.1038/ni.3316. No abstract available.

PMID:
26580498
13.

A Novel MHC-I Surface Targeted for Binding by the MCMV m06 Immunoevasin Revealed by Solution NMR.

Sgourakis NG, May NA, Boyd LF, Ying J, Bax A, Margulies DH.

J Biol Chem. 2015 Nov 27;290(48):28857-68. doi: 10.1074/jbc.M115.689661. Epub 2015 Oct 13.

14.

The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex.

Liu B, Chen W, Natarajan K, Li Z, Margulies DH, Zhu C.

Eur J Immunol. 2015 Jul;45(7):2099-110. doi: 10.1002/eji.201445358. Epub 2015 May 22.

15.

The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family.

Sgourakis NG, Natarajan K, Ying J, Vogeli B, Boyd LF, Margulies DH, Bax A.

Structure. 2014 Sep 2;22(9):1263-1273. doi: 10.1016/j.str.2014.05.018. Epub 2014 Aug 7.

16.

The in-betweeners: MAIT cells join the innate-like lymphocytes gang.

Margulies DH.

J Exp Med. 2014 Jul 28;211(8):1501-2. doi: 10.1084/jem.2118insight3. No abstract available.

17.

CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition.

Murakami Y, Tian L, Voss OH, Margulies DH, Krzewski K, Coligan JE.

Cell Death Differ. 2014 Nov;21(11):1746-57. doi: 10.1038/cdd.2014.86. Epub 2014 Jul 18.

18.

A structural and molecular dynamics approach to understanding the peptide-receptive transition state of MHC-I molecules.

Mage MG, Dolan MA, Wang R, Boyd LF, Revilleza MJ, Robinson H, Natarajan K, Myers NB, Hansen TH, Margulies DH.

Mol Immunol. 2013 Sep;55(2):123-5. doi: 10.1016/j.molimm.2012.10.021. Epub 2012 Nov 28. Review.

19.

Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasion.

Wang R, Natarajan K, Revilleza MJ, Boyd LF, Zhi L, Zhao H, Robinson H, Margulies DH.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):E3578-87. doi: 10.1073/pnas.1214088109. Epub 2012 Nov 19.

20.

The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics.

Mage MG, Dolan MA, Wang R, Boyd LF, Revilleza MJ, Robinson H, Natarajan K, Myers NB, Hansen TH, Margulies DH.

J Immunol. 2012 Aug 1;189(3):1391-9. doi: 10.4049/jimmunol.1200831. Epub 2012 Jun 29.

21.

Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity.

Norcross MA, Luo S, Lu L, Boyne MT, Gomarteli M, Rennels AD, Woodcock J, Margulies DH, McMurtrey C, Vernon S, Hildebrand WH, Buchli R.

AIDS. 2012 Jul 17;26(11):F21-9. doi: 10.1097/QAD.0b013e328355fe8f.

22.

Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.

Tilahun ME, Kwan A, Natarajan K, Quinn M, Tilahun AY, Xie C, Margulies DH, Osborne BA, Goldsby RA, Rajagopalan G.

PLoS One. 2011;6(11):e27203. doi: 10.1371/journal.pone.0027203. Epub 2011 Nov 15.

23.

How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance.

Revilleza MJ, Wang R, Mans J, Hong M, Natarajan K, Margulies DH.

J Biomed Biotechnol. 2011;2011:724607. doi: 10.1155/2011/724607. Epub 2011 Jun 30. Review.

24.

Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies.

Tilahun ME, Rajagopalan G, Shah-Mahoney N, Lawlor RG, Tilahun AY, Xie C, Natarajan K, Margulies DH, Ratner DI, Osborne BA, Goldsby RA.

Infect Immun. 2010 Jun;78(6):2801-11. doi: 10.1128/IAI.01121-09. Epub 2010 Mar 22.

25.

Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms.

Zhi L, Mans J, Paskow MJ, Brown PH, Schuck P, Jonjić S, Natarajan K, Margulies DH.

Biochemistry. 2010 Mar 23;49(11):2443-53. doi: 10.1021/bi902130j.

26.

Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.

Wang R, Natarajan K, Margulies DH.

J Immunol. 2009 Aug 15;183(4):2554-64. doi: 10.4049/jimmunol.0901276. Epub 2009 Jul 22.

27.

Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity.

Honda M, Wang R, Kong WP, Kanekiyo M, Akahata W, Xu L, Matsuo K, Natarajan K, Robinson H, Asher TE, Price DA, Douek DC, Margulies DH, Nabel GJ.

J Immunol. 2009 Aug 15;183(4):2425-34. doi: 10.4049/jimmunol.0900581. Epub 2009 Jul 20.

28.

Antigen-processing and presentation pathways select antigenic HIV peptides in the fight against viral evolution.

Margulies DH.

Nat Immunol. 2009 Jun;10(6):566-8. doi: 10.1038/ni0609-566. No abstract available.

PMID:
19448656
29.

A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens.

Tang X, Narayanan S, Peruzzi G, Apara A, Natarajan K, Margulies DH, Coligan JE, Borrego F.

J Immunol. 2009 May 1;182(9):5446-52. doi: 10.4049/jimmunol.0804052.

30.

Home schooling of NK cells.

Margulies DH.

Immunity. 2009 Mar 20;30(3):313-5. doi: 10.1016/j.immuni.2009.02.002.

31.

Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis.

Levin D, DiPaolo RJ, Brinster C, Revilleza MJ, Boyd LF, Teyton L, Natarajan K, Mage MG, Shevach EM, Margulies DH.

Eur J Immunol. 2008 Dec;38(12):3339-53. doi: 10.1002/eji.200838584.

32.

Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage.

Mans J, Zhi L, Revilleza MJ, Smith L, Redwood A, Natarajan K, Margulies DH.

Immunol Res. 2009;43(1-3):264-79. doi: 10.1007/s12026-008-8081-6.

33.

Estimation of low frequency antigen-presenting cells with a novel RELISPOT assay.

Dzutsev AK, Belyakov IM, Isakov DV, Gagnon SJ, Margulies DH, Berzofsky JA.

J Immunol Methods. 2008 Apr 20;333(1-2):71-8. doi: 10.1016/j.jim.2008.01.008. Epub 2008 Feb 8.

34.

The TLR3 signaling complex forms by cooperative receptor dimerization.

Leonard JN, Ghirlando R, Askins J, Bell JK, Margulies DH, Davies DR, Segal DM.

Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):258-63. doi: 10.1073/pnas.0710779105. Epub 2008 Jan 2.

35.

Role of alpha3 domain of class I MHC molecules in the activation of high- and low-avidity CD8+ CTLs.

Belyakov IM, Kozlowski S, Mage M, Ahlers JD, Boyd LF, Margulies DH, Berzofsky JA.

Int Immunol. 2007 Dec;19(12):1413-20. Epub 2007 Nov 1.

PMID:
17981793
36.

Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153.

Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, Robinson H, Simic H, Jonjic S, Tiemessen CT, Margulies DH.

J Biol Chem. 2007 Nov 30;282(48):35247-58. Epub 2007 Sep 26.

37.

Avidity of CD8 T cells sharpens immunodominance.

Dzutsev AH, Belyakov IM, Isakov DV, Margulies DH, Berzofsky JA.

Int Immunol. 2007 Apr;19(4):497-507. Epub 2007 Mar 21.

PMID:
17376783
38.

Crystal structure of the murine cytomegalovirus MHC-I homolog m144.

Natarajan K, Hicks A, Mans J, Robinson H, Guan R, Mariuzza RA, Margulies DH.

J Mol Biol. 2006 Apr 21;358(1):157-71. Epub 2006 Feb 9.

39.

Backbone and side chain resonance assignmentsof a TRAV14-3 mouse T cell receptor domain.

Hu JS, Plaksin D, Margulies DH.

J Biomol NMR. 2005 Mar;31(3):271-2. No abstract available.

PMID:
15803407
40.

Monoclonal antibodies: producing magic bullets by somatic cell hybridization.

Margulies DH.

J Immunol. 2005 Mar 1;174(5):2451-2. No abstract available.

41.

Resistance to viral infection by intraepithelial lymphocytes in HIV-1 P18-I10-specific T-cell receptor transgenic mice.

Kuribayashi H, Wakabayashi A, Shimizu M, Kaneko H, Norose Y, Nakagawa Y, Wang J, Kumagai Y, Margulies DH, Takahashi H.

Biochem Biophys Res Commun. 2004 Apr 2;316(2):356-63.

PMID:
15020225
42.

Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice.

Candon S, McHugh RS, Foucras G, Natarajan K, Shevach EM, Margulies DH.

J Immunol. 2004 Mar 1;172(5):2917-24.

43.
44.

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b).

Dam J, Guan R, Natarajan K, Dimasi N, Chlewicki LK, Kranz DM, Schuck P, Margulies DH, Mariuzza RA.

Nat Immunol. 2003 Dec;4(12):1213-22. Epub 2003 Nov 2.

PMID:
14595439
45.

CD28, costimulator or agonist receptor?

Margulies DH.

J Exp Med. 2003 Apr 21;197(8):949-53. No abstract available.

46.

A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen.

Lukashev DE, Caldwell CC, Chen P, Apasov SG, Margulies DH, Sitkovsky MV.

J Recept Signal Transduct Res. 2003 Feb;23(1):33-52.

PMID:
12680588
47.

Rapid induction of apoptosis in CD8+ HIV-1 envelope-specific murine CTLs by short exposure to antigenic peptide.

Takahashi M, Osono E, Nakagawa Y, Wang J, Berzofsky JA, Margulies DH, Takahashi H.

J Immunol. 2002 Dec 1;169(11):6588-93.

48.

Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family.

Dimasi N, Sawicki MW, Reineck LA, Li Y, Natarajan K, Margulies DH, Mariuzza RA.

J Mol Biol. 2002 Jul 12;320(3):573-85.

PMID:
12096910
49.

MHC class I recognition by Ly49 natural killer cell receptors.

Natarajan K, Dimasi N, Wang J, Margulies DH, Mariuzza RA.

Mol Immunol. 2002 May;38(14):1023-7. Review.

PMID:
11955594
50.

Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.

Natarajan K, Dimasi N, Wang J, Mariuzza RA, Margulies DH.

Annu Rev Immunol. 2002;20:853-85. Epub 2001 Oct 4. Review.

PMID:
11861620

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