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Items: 1 to 50 of 141

1.

Metal Ions Activate the Human Taste Receptor TAS2R7.

Wang Y, Zajac AL, Lei W, Christensen CM, Margolskee RF, Bouysset C, Golebiowski J, Zhao H, Fiorucci S, Jiang P.

Chem Senses. 2019 May 29;44(5):339-347. doi: 10.1093/chemse/bjz024.

2.

Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model.

Du YW, Liu Q, Luo XC, Zhao DX, Xue JB, Feng P, Margolskee RF, Wang H, Huang L.

J Vis Exp. 2018 Nov 9;(141). doi: 10.3791/58668.

3.

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine.

Lei W, Ren W, Ohmoto M, Urban JF Jr, Matsumoto I, Margolskee RF, Jiang P.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5552-5557. doi: 10.1073/pnas.1720758115. Epub 2018 May 7.

4.

Aggravated gut inflammation in mice lacking the taste signaling protein α-gustducin.

Feng P, Chai J, Yi H, Redding K, Margolskee RF, Huang L, Wang H.

Brain Behav Immun. 2018 Jul;71:23-27. doi: 10.1016/j.bbi.2018.04.010. Epub 2018 Apr 17.

PMID:
29678794
5.

Gli3 is a negative regulator of Tas1r3-expressing taste cells.

Qin Y, Sukumaran SK, Jyotaki M, Redding K, Jiang P, Margolskee RF.

PLoS Genet. 2018 Feb 7;14(2):e1007058. doi: 10.1371/journal.pgen.1007058. eCollection 2018 Feb.

6.

Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae.

Yoshida R, Takai S, Sanematsu K, Margolskee RF, Shigemura N, Ninomiya Y.

Neuroscience. 2018 Jan 15;369:29-39. doi: 10.1016/j.neuroscience.2017.10.047. Epub 2017 Nov 4.

7.

Bacterial d-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells.

Lee RJ, Hariri BM, McMahon DB, Chen B, Doghramji L, Adappa ND, Palmer JN, Kennedy DW, Jiang P, Margolskee RF, Cohen NA.

Sci Signal. 2017 Sep 5;10(495). pii: eaam7703. doi: 10.1126/scisignal.aam7703.

8.

Whole transcriptome profiling of taste bud cells.

Sukumaran SK, Lewandowski BC, Qin Y, Kotha R, Bachmanov AA, Margolskee RF.

Sci Rep. 2017 Aug 8;7(1):7595. doi: 10.1038/s41598-017-07746-z.

9.

Transcriptome analyses of taste organoids reveal multiple pathways involved in taste cell generation.

Ren W, Aihara E, Lei W, Gheewala N, Uchiyama H, Margolskee RF, Iwatsuki K, Jiang P.

Sci Rep. 2017 Jun 21;7(1):4004. doi: 10.1038/s41598-017-04099-5.

10.

Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides.

Sukumaran SK, Yee KK, Iwata S, Kotha R, Quezada-Calvillo R, Nichols BL, Mohan S, Pinto BM, Shigemura N, Ninomiya Y, Margolskee RF.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6035-40. doi: 10.1073/pnas.1520843113. Epub 2016 May 9.

11.

Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms.

Lewandowski BC, Sukumaran SK, Margolskee RF, Bachmanov AA.

J Neurosci. 2016 Feb 10;36(6):1942-53. doi: 10.1523/JNEUROSCI.2947-15.2016.

12.

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.

Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, Gallini CA, Redding K, Margolskee RF, Osborne LC, Artis D, Garrett WS.

Science. 2016 Mar 18;351(6279):1329-33. doi: 10.1126/science.aaf1648. Epub 2016 Feb 4.

13.

Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus).

Lei W, Ravoninjohary A, Li X, Margolskee RF, Reed DR, Beauchamp GK, Jiang P.

PLoS One. 2015 Oct 21;10(10):e0139670. doi: 10.1371/journal.pone.0139670. eCollection 2015.

14.

Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor.

Maillet EL, Cui M, Jiang P, Mezei M, Hecht E, Quijada J, Margolskee RF, Osman R, Max M.

Chem Senses. 2015 Oct;40(8):577-86. doi: 10.1093/chemse/bjv045.

15.

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice.

Glendinning JI, Stano S, Holter M, Azenkot T, Goldman O, Margolskee RF, Vasselli JR, Sclafani A.

Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R552-60. doi: 10.1152/ajpregu.00056.2015. Epub 2015 Jul 8.

16.

Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds.

Yoshida R, Noguchi K, Shigemura N, Jyotaki M, Takahashi I, Margolskee RF, Ninomiya Y.

Diabetes. 2015 Nov;64(11):3751-62. doi: 10.2337/db14-1462. Epub 2015 Jun 26.

17.

Glucagon-like peptide-1 is specifically involved in sweet taste transmission.

Takai S, Yasumatsu K, Inoue M, Iwata S, Yoshida R, Shigemura N, Yanagawa Y, Drucker DJ, Margolskee RF, Ninomiya Y.

FASEB J. 2015 Jun;29(6):2268-80. doi: 10.1096/fj.14-265355. Epub 2015 Feb 12.

18.

Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo.

Ren W, Lewandowski BC, Watson J, Aihara E, Iwatsuki K, Bachmanov AA, Margolskee RF, Jiang P.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16401-6. doi: 10.1073/pnas.1409064111. Epub 2014 Nov 3.

19.

Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons.

Lei YT, Thuault SJ, Launay P, Margolskee RF, Kandel ER, Siegelbaum SA.

Front Cell Neurosci. 2014 Sep 4;8:267. doi: 10.3389/fncel.2014.00267. eCollection 2014.

20.

Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells.

Parker MR, Feng D, Chamuris B, Margolskee RF.

Neurosci Lett. 2014 Jun 13;571:72-7. doi: 10.1016/j.neulet.2014.04.047. Epub 2014 May 6.

21.

The bamboo-eating giant panda (Ailuropoda melanoleuca) has a sweet tooth: behavioral and molecular responses to compounds that taste sweet to humans.

Jiang P, Josue-Almqvist J, Jin X, Li X, Brand JG, Margolskee RF, Reed DR, Beauchamp GK.

PLoS One. 2014 Mar 26;9(3):e93043. doi: 10.1371/journal.pone.0093043. eCollection 2014.

22.

Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency.

Mokadem M, Zechner JF, Margolskee RF, Drucker DJ, Aguirre V.

Mol Metab. 2013 Dec 11;3(2):191-201. doi: 10.1016/j.molmet.2013.11.010. eCollection 2014 Apr.

23.

Bitter and sweet taste receptors regulate human upper respiratory innate immunity.

Lee RJ, Kofonow JM, Rosen PL, Siebert AP, Chen B, Doghramji L, Xiong G, Adappa ND, Palmer JN, Kennedy DW, Kreindler JL, Margolskee RF, Cohen NA.

J Clin Invest. 2014 Mar;124(3):1393-405. doi: 10.1172/JCI72094. Epub 2014 Feb 17.

24.

Endocrine taste cells.

Kokrashvili Z, Yee KK, Ilegems E, Iwatsuki K, Li Y, Mosinger B, Margolskee RF.

Br J Nutr. 2014 Jun;111 Suppl 1:S23-9. doi: 10.1017/S0007114513002262. Epub 2014 Jan 2.

25.

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components.

Lee RJ, Chen B, Redding KM, Margolskee RF, Cohen NA.

Innate Immun. 2014 Aug;20(6):606-17. doi: 10.1177/1753425913503386. Epub 2013 Sep 17.

26.

Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility.

Mosinger B, Redding KM, Parker MR, Yevshayeva V, Yee KK, Dyomina K, Li Y, Margolskee RF.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12319-24. doi: 10.1073/pnas.1302827110. Epub 2013 Jul 1.

27.

Angiotensin II modulates salty and sweet taste sensitivities.

Shigemura N, Iwata S, Yasumatsu K, Ohkuri T, Horio N, Sanematsu K, Yoshida R, Margolskee RF, Ninomiya Y.

J Neurosci. 2013 Apr 10;33(15):6267-77. doi: 10.1523/JNEUROSCI.5599-12.2013.

28.

Impact of T1r3 and Trpm5 on carbohydrate preference and acceptance in C57BL/6 mice.

Zukerman S, Glendinning JI, Margolskee RF, Sclafani A.

Chem Senses. 2013 Jun;38(5):421-37. doi: 10.1093/chemse/bjt011. Epub 2013 Apr 1.

29.

Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue.

Yee KK, Li Y, Redding KM, Iwatsuki K, Margolskee RF, Jiang P.

Stem Cells. 2013 May;31(5):992-1000. doi: 10.1002/stem.1338.

30.

Gustducin couples fatty acid receptors to GLP-1 release in colon.

Li Y, Kokrashvili Z, Mosinger B, Margolskee RF.

Am J Physiol Endocrinol Metab. 2013 Mar 15;304(6):E651-60. doi: 10.1152/ajpendo.00471.2012. Epub 2013 Jan 22.

31.

The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice.

Glendinning JI, Gillman J, Zamer H, Margolskee RF, Sclafani A.

Physiol Behav. 2012 Aug 20;107(1):50-8. doi: 10.1016/j.physbeh.2012.05.023. Epub 2012 Jun 6.

33.

Major taste loss in carnivorous mammals.

Jiang P, Josue J, Li X, Glaser D, Li W, Brand JG, Margolskee RF, Reed DR, Beauchamp GK.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4956-61. doi: 10.1073/pnas.1118360109. Epub 2012 Mar 12.

34.

Umami taste in mice uses multiple receptors and transduction pathways.

Yasumatsu K, Ogiwara Y, Takai S, Yoshida R, Iwatsuki K, Torii K, Margolskee RF, Ninomiya Y.

J Physiol. 2012 Mar 1;590(5):1155-70. doi: 10.1113/jphysiol.2011.211920. Epub 2011 Dec 19.

35.

A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice.

Eddy MC, Eschle BK, Peterson D, Lauras N, Margolskee RF, Delay ER.

Chem Senses. 2012 Jun;37(5):391-401. doi: 10.1093/chemse/bjr093. Epub 2011 Oct 10.

36.

Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells.

Yee KK, Sukumaran SK, Kotha R, Gilbertson TA, Margolskee RF.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5431-6. doi: 10.1073/pnas.1100495108. Epub 2011 Mar 7.

37.

REEP2 enhances sweet receptor function by recruitment to lipid rafts.

Ilegems E, Iwatsuki K, Kokrashvili Z, Benard O, Ninomiya Y, Margolskee RF.

J Neurosci. 2010 Oct 13;30(41):13774-83. doi: 10.1523/JNEUROSCI.0091-10.2010.

38.

Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice.

Sclafani A, Glass DS, Margolskee RF, Glendinning JI.

Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1643-50. doi: 10.1152/ajpregu.00495.2010. Epub 2010 Oct 6.

39.

Gustation genetics: sweet gustducin!

Reed DR, Margolskee RF.

Chem Senses. 2010 Sep;35(7):549-50. doi: 10.1093/chemse/bjq059. Epub 2010 Jul 21.

40.

Action potential-enhanced ATP release from taste cells through hemichannels.

Murata Y, Yasuo T, Yoshida R, Obata K, Yanagawa Y, Margolskee RF, Ninomiya Y.

J Neurophysiol. 2010 Aug;104(2):896-901. doi: 10.1152/jn.00414.2010. Epub 2010 Jun 2.

41.

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice.

Colsoul B, Schraenen A, Lemaire K, Quintens R, Van Lommel L, Segal A, Owsianik G, Talavera K, Voets T, Margolskee RF, Kokrashvili Z, Gilon P, Nilius B, Schuit FC, Vennekens R.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5208-13. doi: 10.1073/pnas.0913107107. Epub 2010 Mar 1.

42.

Endocannabinoids selectively enhance sweet taste.

Yoshida R, Ohkuri T, Jyotaki M, Yasuo T, Horio N, Yasumatsu K, Sanematsu K, Shigemura N, Yamamoto T, Margolskee RF, Ninomiya Y.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):935-9. doi: 10.1073/pnas.0912048107. Epub 2009 Dec 22.

43.

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

Maillet EL, Margolskee RF, Mosinger B.

J Med Chem. 2009 Nov 12;52(21):6931-5. doi: 10.1021/jm900823s.

44.

Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice.

Zukerman S, Touzani K, Margolskee RF, Sclafani A.

Chem Senses. 2009 Oct;34(8):685-94. doi: 10.1093/chemse/bjp055. Epub 2009 Sep 7.

45.

T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1.

Kokrashvili Z, Mosinger B, Margolskee RF.

Ann N Y Acad Sci. 2009 Jul;1170:91-4. doi: 10.1111/j.1749-6632.2009.04485.x.

PMID:
19686115
46.

Discrimination of taste qualities among mouse fungiform taste bud cells.

Yoshida R, Miyauchi A, Yasuo T, Jyotaki M, Murata Y, Yasumatsu K, Shigemura N, Yanagawa Y, Obata K, Ueno H, Margolskee RF, Ninomiya Y.

J Physiol. 2009 Sep 15;587(Pt 18):4425-39. doi: 10.1113/jphysiol.2009.175075. Epub 2009 Jul 21.

47.

Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.

Kokrashvili Z, Mosinger B, Margolskee RF.

Am J Clin Nutr. 2009 Sep;90(3):822S-825S. doi: 10.3945/ajcn.2009.27462T. Epub 2009 Jul 1.

48.

Contribution of the T1r3 taste receptor to the response properties of central gustatory neurons.

Lemon CH, Margolskee RF.

J Neurophysiol. 2009 May;101(5):2459-71. doi: 10.1152/jn.90892.2008. Epub 2009 Mar 11.

49.

Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.

Kokrashvili Z, Rodriguez D, Yevshayeva V, Zhou H, Margolskee RF, Mosinger B.

Gastroenterology. 2009 Aug;137(2):598-606, 606.e1-2. doi: 10.1053/j.gastro.2009.02.070. Epub 2009 Mar 9.

50.

Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity.

Ohkuri T, Yasumatsu K, Horio N, Jyotaki M, Margolskee RF, Ninomiya Y.

Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R960-71. doi: 10.1152/ajpregu.91018.2008. Epub 2009 Feb 11.

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