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Items: 28


Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion.

Margolis EB, Karkhanis AN.

Neurochem Int. 2019 Jul 10:104504. doi: 10.1016/j.neuint.2019.104504. [Epub ahead of print] Review.


Relative contributions and mapping of ventral tegmental area dopamine and GABA neurons by projection target in the rat.

Breton JM, Charbit AR, Snyder BJ, Fong PTK, Dias EV, Himmels P, Lock H, Margolis EB.

J Comp Neurol. 2019 Apr 1;527(5):916-941. doi: 10.1002/cne.24572. Epub 2018 Dec 11.


Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties.

Saunders BT, Richard JM, Margolis EB, Janak PH.

Nat Neurosci. 2018 Aug;21(8):1072-1083. doi: 10.1038/s41593-018-0191-4. Epub 2018 Jul 23.


Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor.

Margolis EB, Fujita W, Devi LA, Fields HL.

Neuropharmacology. 2017 Sep 1;123:420-432. doi: 10.1016/j.neuropharm.2017.06.019. Epub 2017 Jun 21.


Ventral tegmental area: cellular heterogeneity, connectivity and behaviour.

Morales M, Margolis EB.

Nat Rev Neurosci. 2017 Feb;18(2):73-85. doi: 10.1038/nrn.2016.165. Epub 2017 Jan 5. Review.


Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area.

Avegno EM, Salling MC, Borgkvist A, Mrejeru A, Whitebirch AC, Margolis EB, Sulzer D, Harrison NL.

Neuropharmacology. 2016 Nov;110(Pt A):386-395. doi: 10.1016/j.neuropharm.2016.07.031. Epub 2016 Jul 27.


Mu Opioid Receptor Actions in the Lateral Habenula.

Margolis EB, Fields HL.

PLoS One. 2016 Jul 18;11(7):e0159097. doi: 10.1371/journal.pone.0159097. eCollection 2016.


Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA.

Sci Signal. 2016 Apr 26;9(425):ra43. doi: 10.1126/scisignal.aad0694.


Understanding opioid reward.

Fields HL, Margolis EB.

Trends Neurosci. 2015 Apr;38(4):217-25. doi: 10.1016/j.tins.2015.01.002. Epub 2015 Jan 29. Review.


Direct bidirectional μ-opioid control of midbrain dopamine neurons.

Margolis EB, Hjelmstad GO, Fujita W, Fields HL.

J Neurosci. 2014 Oct 29;34(44):14707-16. doi: 10.1523/JNEUROSCI.2144-14.2014.


Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.

Berthet A, Margolis EB, Zhang J, Hsieh I, Zhang J, Hnasko TS, Ahmad J, Edwards RH, Sesaki H, Huang EJ, Nakamura K.

J Neurosci. 2014 Oct 22;34(43):14304-17. doi: 10.1523/JNEUROSCI.0930-14.2014.


New insights into the specificity and plasticity of reward and aversion encoding in the mesolimbic system.

Volman SF, Lammel S, Margolis EB, Kim Y, Richard JM, Roitman MF, Lobo MK.

J Neurosci. 2013 Nov 6;33(45):17569-76. doi: 10.1523/JNEUROSCI.3250-13.2013. Review.


Intra-VTA deltorphin, but not DPDPE, induces place preference in ethanol-drinking rats: distinct DOR-1 and DOR-2 mechanisms control ethanol consumption and reward.

Mitchell JM, Margolis EB, Coker AR, Allen DC, Fields HL.

Alcohol Clin Exp Res. 2014 Jan;38(1):195-203. doi: 10.1111/acer.12246. Epub 2013 Aug 27.


Opioid modulation of ventral pallidal afferents to ventral tegmental area neurons.

Hjelmstad GO, Xia Y, Margolis EB, Fields HL.

J Neurosci. 2013 Apr 10;33(15):6454-9. doi: 10.1523/JNEUROSCI.0178-13.2013.


Identification of rat ventral tegmental area GABAergic neurons.

Margolis EB, Toy B, Himmels P, Morales M, Fields HL.

PLoS One. 2012;7(7):e42365. doi: 10.1371/journal.pone.0042365. Epub 2012 Jul 31.


Alcohol self-administration, anxiety, and cortisol levels predict changes in delta opioid receptor function in the ventral tegmental area.

Mitchell JM, Margolis EB, Coker AR, Fields HL.

Behav Neurosci. 2012 Aug;126(4):515-22. doi: 10.1037/a0029027. Epub 2012 Jun 18.


A novel opioid receptor-mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons.

Margolis EB, Mitchell JM, Hjelmstad GO, Fields HL.

J Physiol. 2011 Sep 1;589(17):4229-42. doi: 10.1113/jphysiol.2011.209023. Epub 2011 Jun 20.


Nucleus accumbens medium spiny neurons target non-dopaminergic neurons in the ventral tegmental area.

Xia Y, Driscoll JR, Wilbrecht L, Margolis EB, Fields HL, Hjelmstad GO.

J Neurosci. 2011 May 25;31(21):7811-6. doi: 10.1523/JNEUROSCI.1504-11.2011.


Reliability in the identification of midbrain dopamine neurons.

Margolis EB, Coker AR, Driscoll JR, Lemaître AI, Fields HL.

PLoS One. 2010 Dec 9;5(12):e15222. doi: 10.1371/journal.pone.0015222.


Substance P inhibits GABAB receptor signalling in the ventral tegmental area.

Xia YF, Margolis EB, Hjelmstad GO.

J Physiol. 2010 May 1;588(Pt 9):1541-9. doi: 10.1113/jphysiol.2010.188367. Epub 2010 Mar 15.


Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons.

Dobi A, Margolis EB, Wang HL, Harvey BK, Morales M.

J Neurosci. 2010 Jan 6;30(1):218-29. doi: 10.1523/JNEUROSCI.3884-09.2010.


Delta-opioid receptor expression in the ventral tegmental area protects against elevated alcohol consumption.

Margolis EB, Fields HL, Hjelmstad GO, Mitchell JM.

J Neurosci. 2008 Nov 26;28(48):12672-81. doi: 10.1523/JNEUROSCI.4569-08.2008.


Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition.

Margolis EB, Mitchell JM, Ishikawa J, Hjelmstad GO, Fields HL.

J Neurosci. 2008 Sep 3;28(36):8908-13. doi: 10.1523/JNEUROSCI.1526-08.2008.


Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement.

Fields HL, Hjelmstad GO, Margolis EB, Nicola SM.

Annu Rev Neurosci. 2007;30:289-316. Review.


The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?

Margolis EB, Lock H, Hjelmstad GO, Fields HL.

J Physiol. 2006 Dec 15;577(Pt 3):907-24. Epub 2006 Sep 7.


Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex.

Margolis EB, Lock H, Chefer VI, Shippenberg TS, Hjelmstad GO, Fields HL.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2938-42. Epub 2006 Feb 13.


Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons.

Margolis EB, Hjelmstad GO, Bonci A, Fields HL.

J Neurophysiol. 2005 Jun;93(6):3086-93. Epub 2004 Dec 22.


Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons.

Margolis EB, Hjelmstad GO, Bonci A, Fields HL.

J Neurosci. 2003 Nov 5;23(31):9981-6.

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