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Items: 30


Novel functions of inactive rhomboid proteins in immunity and disease.

Geesala R, Issuree PD, Maretzky T.

J Leukoc Biol. 2019 Oct;106(4):823-835. doi: 10.1002/JLB.3VMR0219-069R. Epub 2019 Aug 1. Review.


Loss of RHBDF2 results in an early-onset spontaneous murine colitis.

Geesala R, Schanz W, Biggs M, Dixit G, Skurski J, Gurung P, Meyerholz DK, Elliott D, Issuree PD, Maretzky T.

J Leukoc Biol. 2019 Apr;105(4):767-781. doi: 10.1002/JLB.4A0718-283RR. Epub 2019 Jan 29.


Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme.

Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME.

J Biol Chem. 2018 Feb 23;293(8):2725-2734. doi: 10.1074/jbc.RA117.000793. Epub 2018 Jan 9.


The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.

Urriola-Muñoz P, Li X, Maretzky T, McIlwain DR, Mak TW, Reyes JG, Blobel CP, Moreno RD.

J Cell Physiol. 2018 Mar;233(3):2247-2256. doi: 10.1002/jcp.26097. Epub 2017 Aug 25.


Characterization of the catalytic properties of the membrane-anchored metalloproteinase ADAM9 in cell-based assays.

Maretzky T, Swendeman S, Mogollon E, Weskamp G, Sahin U, Reiss K, Blobel CP.

Biochem J. 2017 Apr 13;474(9):1467-1479. doi: 10.1042/BCJ20170075.


Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.

Li X, Maretzky T, Perez-Aguilar JM, Monette S, Weskamp G, Le Gall S, Beutler B, Weinstein H, Blobel CP.

J Cell Sci. 2017 Mar 1;130(5):868-878. doi: 10.1242/jcs.196436. Epub 2017 Jan 19.


iRhom2 regulates CSF1R cell surface expression and non-steady state myelopoiesis in mice.

Qing X, Rogers L, Mortha A, Lavin Y, Redecha P, Issuree PD, Maretzky T, Merad M, McIlwain D, Mak TW, Overall CM, Blobel CP, Salmon JE.

Eur J Immunol. 2016 Dec;46(12):2737-2748. doi: 10.1002/eji.201646482. Epub 2016 Sep 28.


Phosphatidylserine exposure is required for ADAM17 sheddase function.

Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.

Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523.


Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA.

Sci Signal. 2015 Nov 3;8(401):ra109. doi: 10.1126/scisignal.aac5356.


iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling.

Li X, Maretzky T, Weskamp G, Monette S, Qing X, Issuree PD, Crawford HC, McIlwain DR, Mak TW, Salmon JE, Blobel CP.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6080-5. doi: 10.1073/pnas.1505649112. Epub 2015 Apr 27.


The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site.

Wong E, Maretzky T, Peleg Y, Blobel CP, Sagi I.

J Biol Chem. 2015 May 8;290(19):12135-46. doi: 10.1074/jbc.M114.624072. Epub 2015 Mar 20.


The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.

Maretzky T, Evers A, Le Gall S, Alabi RO, Speck N, Reiss K, Blobel CP.

J Biol Chem. 2015 Mar 20;290(12):7416-25. doi: 10.1074/jbc.M114.603753. Epub 2015 Jan 20.


Characterization of oxygen-induced retinopathy in mice carrying an inactivating point mutation in the catalytic site of ADAM15.

Maretzky T, Blobel CP, Guaiquil V.

Invest Ophthalmol Vis Sci. 2014 Sep 23;55(10):6774-82. doi: 10.1167/iovs.14-14472.


Phytochemicals perturb membranes and promiscuously alter protein function.

Ingólfsson HI, Thakur P, Herold KF, Hobart EA, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC Jr, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS.

ACS Chem Biol. 2014 Aug 15;9(8):1788-98. doi: 10.1021/cb500086e. Epub 2014 Jun 17.


iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding.

Maretzky T, McIlwain DR, Issuree PD, Li X, Malapeira J, Amin S, Lang PA, Mak TW, Blobel CP.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11433-8. doi: 10.1073/pnas.1302553110. Epub 2013 Jun 25.


ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.

Hall KC, Hill D, Otero M, Plumb DA, Froemel D, Dragomir CL, Maretzky T, Boskey A, Crawford HC, Selleri L, Goldring MB, Blobel CP.

Mol Cell Biol. 2013 Aug;33(16):3077-90. doi: 10.1128/MCB.00291-13. Epub 2013 Jun 3.


iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.

Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP.

J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25.


iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.

McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW.

Science. 2012 Jan 13;335(6065):229-32. doi: 10.1126/science.1214448.


Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.

Maretzky T, Evers A, Zhou W, Swendeman SL, Wong PM, Rafii S, Reiss K, Blobel CP.

Nat Commun. 2011;2:229. doi: 10.1038/ncomms1232.


ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site.

Le Gall SM, Maretzky T, Issuree PD, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP.

J Cell Sci. 2010 Nov 15;123(Pt 22):3913-22. doi: 10.1242/jcs.069997. Epub 2010 Oct 27.


A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.

Maretzky T, Zhou W, Huang XY, Blobel CP.

Oncogene. 2011 Feb 3;30(5):611-8. doi: 10.1038/onc.2010.443. Epub 2010 Sep 27.


Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.

Maretzky T, Le Gall SM, Worpenberg-Pietruk S, Eder J, Overall CM, Huang XY, Poghosyan Z, Edwards DR, Blobel CP.

Cancer Res. 2009 Jun 1;69(11):4573-6. doi: 10.1158/0008-5472.CAN-08-4766.


Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.

Maretzky T, Yang G, Ouerfelli O, Overall CM, Worpenberg S, Hassiepen U, Eder J, Blobel CP.

Biochem J. 2009 Apr 28;420(1):105-13. doi: 10.1042/BJ20082127.


ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.

Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel CP, Saftig P, Reiss K.

Circ Res. 2008 May 23;102(10):1192-201. doi: 10.1161/CIRCRESAHA.107.169805. Epub 2008 Apr 17.


ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.

Maretzky T, Scholz F, Köten B, Proksch E, Saftig P, Reiss K.

J Invest Dermatol. 2008 Jul;128(7):1737-46. doi: 10.1038/sj.jid.5701242. Epub 2008 Jan 17.


ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.

Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P.

Cell Death Differ. 2007 May;14(5):1040-9. Epub 2007 Feb 9.


Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion.

Reiss K, Maretzky T, Haas IG, Schulte M, Ludwig A, Frank M, Saftig P.

J Biol Chem. 2006 Aug 4;281(31):21735-44. Epub 2006 Jun 2.


L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.

Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K.

Mol Cell Biol. 2005 Oct;25(20):9040-53.


ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P.

Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9182-7. Epub 2005 Jun 15.


ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.

Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P.

EMBO J. 2005 Feb 23;24(4):742-52. Epub 2005 Feb 3. Erratum in: EMBO J. 2005 May 4;24(9):1762.

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