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Association Between Speed of Multimorbidity Accumulation in Old Age and Life Experiences: A Cohort Study.

Dekhtyar S, Vetrano DL, Marengoni A, Wang HX, Pan KY, Fratiglioni L, Calderón-Larrañaga A.

Am J Epidemiol. 2019 Apr 24. pii: kwz101. doi: 10.1093/aje/kwz101. [Epub ahead of print]


Walking Speed Drives the Prognosis of Older Adults with Cardiovascular and Neuropsychiatric Multimorbidity.

Vetrano DL, Rizzuto D, Calderón-Larrañaga A, Onder G, Welmer AK, Qiu C, Bernabei R, Marengoni A, Fratiglioni L.

Am J Med. 2019 May 27. pii: S0002-9343(19)30432-2. doi: 10.1016/j.amjmed.2019.05.005. [Epub ahead of print]


Patterns of Multimorbidity in a Population-Based Cohort of Older People: Sociodemographic, Lifestyle, and Functional Differences.

Marengoni A, Roso-Llorach A, Vetrano DL, Fernández S, Guisado-Clavero M, Violán C, Calderón-Larrañaga A.

J Gerontol A Biol Sci Med Sci. 2019 May 24. pii: glz137. doi: 10.1093/gerona/glz137. [Epub ahead of print]


Predicting Cognitive and Functional Trajectories in People With Late-Onset Dementia: 2 Population-Based Studies.

Haaksma ML, Rizzuto D, Leoutsakos JS, Marengoni A, Tan ECK, Olde Rikkert MGM, Fratiglioni L, Melis RJF, Calderón-Larrañaga A.

J Am Med Dir Assoc. 2019 May 17. pii: S1525-8610(19)30320-2. doi: 10.1016/j.jamda.2019.03.025. [Epub ahead of print]


Drug Prescription and Delirium in Older Inpatients: Results From the Nationwide Multicenter Italian Delirium Day 2015-2016.

Aloisi G, Marengoni A, Morandi A, Zucchelli A, Cherubini A, Mossello E, Bo M, Di Santo SG, Mazzone A, Trabucchi M, Cappa S, Fimognari FL, Incalzi RA, Gareri P, Perticone F, Campanini M, Montorsi M, Latronico N, Zambon A, Bellelli G; Italian Study Group on Delirium (ISGoD).

J Clin Psychiatry. 2019 Mar 12;80(2). pii: 18m12430. doi: 10.4088/JCP.18m12430.


Need for De-Prescribing in Hospital Elderly Patients Discharged with Limited Life Expectancy: The REPOSI Study.

Pasina L, Brignolo Ottolini B, Cortesi L, Tettamanti M, Franchi C, Marengoni A, Mannucci PM, Nobili A, The Reposi Investigators.

Med Princ Pract. 2019 Mar 20. doi: 10.1159/000499692. [Epub ahead of print]


EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research.

Seppala LJ, van der Velde N, Masud T, Blain H, Petrovic M, van der Cammen TJ, Szczerbińska K, Hartikainen S, Kenny RA, Ryg J, Eklund P, Topinková E, Mair A, Laflamme L, Thaler H, Bahat G, Gutiérrez-Valencia M, Caballero-Mora MA, Landi F, Emmelot-Vonk MH; EuGMS Task and Finish Group on  Fall-Risk-Increasing Drugs, Cherubini A, Baeyens JP, Correa-Pérez A, Gudmundsson A, Marengoni A, O'Mahony D, Parekh N, Pisa FE, Rajkumar C, Wehling M, Ziere G; EuGMS Special Interest Group on Pharmacology.

Drugs Aging. 2019 Apr;36(4):299-307. doi: 10.1007/s40266-018-0622-7.


Using an Integrated Clinical and Functional Assessment Tool to Describe the Use of Social and Medical Care in an Urban Community-Dwelling Swedish Older Population.

Santoni G, Meinow B, Wimo A, Marengoni A, Fratiglioni L, Calderón-Larrañaga A.

J Am Med Dir Assoc. 2019 Jan 17. pii: S1525-8610(18)30666-2. doi: 10.1016/j.jamda.2018.11.017. [Epub ahead of print]


Multimorbidity and patient-centred care in the 3D trial.

Marengoni A, Vetrano DL, Calderón-Larrañaga A, Onder G.

Lancet. 2019 Jan 12;393(10167):127-128. doi: 10.1016/S0140-6736(18)32528-5. No abstract available.


Hypertension and frailty: a systematic review and meta-analysis.

Vetrano DL, Palmer KM, Galluzzo L, Giampaoli S, Marengoni A, Bernabei R, Onder G; Joint Action ADVANTAGE WP4 group.

BMJ Open. 2018 Dec 28;8(12):e024406. doi: 10.1136/bmjopen-2018-024406.


Target Population for Clinical Trials on Multimorbidity: Is Disease Count Enough?

Marengoni A, Vetrano DL, Onder G.

J Am Med Dir Assoc. 2019 Feb;20(2):113-114. doi: 10.1016/j.jamda.2018.10.012. Epub 2018 Nov 28. No abstract available.


Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways.

Calderón-Larrañaga A, Vetrano DL, Ferrucci L, Mercer SW, Marengoni A, Onder G, Eriksdotter M, Fratiglioni L.

J Intern Med. 2019 Mar;285(3):255-271. doi: 10.1111/joim.12843. Epub 2018 Nov 22.


Atrial fibrillation, antithrombotic treatment, and cognitive aging: A population-based study.

Ding M, Fratiglioni L, Johnell K, Santoni G, Fastbom J, Ljungman P, Marengoni A, Qiu C.

Neurology. 2018 Nov 6;91(19):e1732-e1740. doi: 10.1212/WNL.0000000000006456. Epub 2018 Oct 10.


The Relationship between Anaemia and Frailty: A Systematic Review and Meta-Analysis of Observational Studies.

Palmer K, Vetrano DL, Marengoni A, Tummolo AM, Villani ER, Acampora N, Bernabei R, Onder G.

J Nutr Health Aging. 2018;22(8):965-974. doi: 10.1007/s12603-018-1049-x.


The Impact of Frailty and Comorbidity on Institutionalization and Mortality in Persons With Dementia: A Prospective Cohort Study.

Haaksma ML, Rizzuto D, Ramakers IHGB, Garcia-Ptacek S, Marengoni A, van der Flier WM, Verhey FRJ, Olde Rikkert MGM, Melis RJF.

J Am Med Dir Assoc. 2019 Feb;20(2):165-170.e2. doi: 10.1016/j.jamda.2018.06.020. Epub 2018 Aug 23.


Delirium, Dementia, and In-Hospital Mortality: The Results From the Italian Delirium Day 2016, A National Multicenter Study.

Morandi A, Di Santo SG, Zambon A, Mazzone A, Cherubini A, Mossello E, Bo M, Marengoni A, Bianchetti A, Cappa S, Fimognari F, Antonelli Incalzi R, Gareri P, Perticone F, Campanini M, Penco I, Montorsi M, Di Bari M, Trabucchi M, Bellelli G; Italian Study Group on Delirium (ISGoD).

J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):910-916. doi: 10.1093/gerona/gly154.


Frailty predicts short-term survival even in older adults without multimorbidity.

Zucchelli A, Vetrano DL, Marengoni A, Grande G, Romanelli G, Calderón-Larrañaga A, Fratiglioni L, Rizzuto D.

Eur J Intern Med. 2018 Oct;56:53-56. doi: 10.1016/j.ejim.2018.06.012. Epub 2018 Jun 24.


Frailty and multimorbidity: a systematic review and meta-analysis.

Vetrano DL, Palmer K, Marengoni A, Marzetti E, Lattanzio F, Roller-Wirnsberger R, Lopez Samaniego L, Rodríguez-Mañas L, Bernabei R, Onder G; Joint Action ADVANTAGE WP4 group.

J Gerontol A Biol Sci Med Sci. 2018 May 3. doi: 10.1093/gerona/gly110. [Epub ahead of print]


Accounting for frailty when treating chronic diseases.

Onder G, Vetrano DL, Marengoni A, Bell JS, Johnell K, Palmer K; Optimising Pharmacotherapy through Pharmacoepidemiology Network (OPPEN).

Eur J Intern Med. 2018 Oct;56:49-52. doi: 10.1016/j.ejim.2018.02.021. Epub 2018 Mar 9. Review.


Trajectories of functional decline in older adults with neuropsychiatric and cardiovascular multimorbidity: A Swedish cohort study.

Vetrano DL, Rizzuto D, Calderón-Larrañaga A, Onder G, Welmer AK, Bernabei R, Marengoni A, Fratiglioni L.

PLoS Med. 2018 Mar 6;15(3):e1002503. doi: 10.1371/journal.pmed.1002503. eCollection 2018 Mar.


The Relationship Between COPD and Frailty: A Systematic Review and Meta-Analysis of Observational Studies.

Marengoni A, Vetrano DL, Manes-Gravina E, Bernabei R, Onder G, Palmer K.

Chest. 2018 Jul;154(1):21-40. doi: 10.1016/j.chest.2018.02.014. Epub 2018 Mar 1.


Rapidly developing multimorbidity and disability in older adults: does social background matter?

Calderón-Larrañaga A, Santoni G, Wang HX, Welmer AK, Rizzuto D, Vetrano DL, Marengoni A, Fratiglioni L.

J Intern Med. 2018 May;283(5):489-499. doi: 10.1111/joim.12739. Epub 2018 Mar 12.



Onder G, Marengoni A.

JAMA. 2017 Nov 7;318(17):1728. doi: 10.1001/jama.2017.15764. No abstract available.


The Effect of a 2-Year Intervention Consisting of Diet, Physical Exercise, Cognitive Training, and Monitoring of Vascular Risk on Chronic Morbidity-the FINGER Randomized Controlled Trial.

Marengoni A, Rizzuto D, Fratiglioni L, Antikainen R, Laatikainen T, Lehtisalo J, Peltonen M, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Ngandu T.

J Am Med Dir Assoc. 2018 Apr;19(4):355-360.e1. doi: 10.1016/j.jamda.2017.09.020. Epub 2017 Nov 3.


Pattern of in-hospital changes in drug use in the older people from 2010 to 2016.

Franchi C, Ardoino I, Nobili A, Pasina L, Mannucci PM, Marengoni A, Perticone F; REPOSI investigators.

Pharmacoepidemiol Drug Saf. 2017 Dec;26(12):1534-1539. doi: 10.1002/pds.4330. Epub 2017 Oct 13.


Multimorbidity care model: Recommendations from the consensus meeting of the Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS).

Palmer K, Marengoni A, Forjaz MJ, Jureviciene E, Laatikainen T, Mammarella F, Muth C, Navickas R, Prados-Torres A, Rijken M, Rothe U, Souchet L, Valderas J, Vontetsianos T, Zaletel J, Onder G; Joint Action on Chronic Diseases and Promoting Healthy Ageing Across the Life Cycle (JA-CHRODIS).

Health Policy. 2018 Jan;122(1):4-11. doi: 10.1016/j.healthpol.2017.09.006. Epub 2017 Sep 14.


An International Perspective on Chronic Multimorbidity: Approaching the Elephant in the Room.

Vetrano DL, Calderón-Larrañaga A, Marengoni A, Onder G, Bauer JM, Cesari M, Ferrucci L, Fratiglioni L.

J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1350-1356. doi: 10.1093/gerona/glx178.


Reply to: Function but not Multimorbidity at the Cornerstone of Geriatric Medicine.

Rizzuto D, Melis RJF, Marengoni A.

J Am Geriatr Soc. 2017 Oct;65(10):2334-2335. doi: 10.1111/jgs.15028. Epub 2017 Aug 22. No abstract available.


Antipsychotic prescription and mortality in hospitalized older persons.

Chiesa D, Marengoni A, Nobili A, Tettamanti M, Pasina L, Franchi C, Djade CD, Corrao S, Salerno F, Marcucci M, Romanelli G, Mannucci PM; REPOSI Investigators.

Psychogeriatrics. 2017 Nov;17(6):397-405. doi: 10.1111/psyg.12263. Epub 2017 Jun 6.


Comorbidity and progression of late onset Alzheimer's disease: A systematic review.

Haaksma ML, Vilela LR, Marengoni A, Calderón-Larrañaga A, Leoutsakos JS, Olde Rikkert MGM, Melis RJF.

PLoS One. 2017 May 4;12(5):e0177044. doi: 10.1371/journal.pone.0177044. eCollection 2017. Review.


Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy: study protocol of a cluster randomized clinical trial (Multi-PAP project).

Prados-Torres A, Del Cura-González I, Prados-Torres D, López-Rodríguez JA, Leiva-Fernández F, Calderón-Larrañaga A, López-Verde F, Gimeno-Feliu LA, Escortell-Mayor E, Pico-Soler V, Sanz-Cuesta T, Bujalance-Zafra MJ, Morey-Montalvo M, Boxó-Cifuentes JR, Poblador-Plou B, Fernández-Arquero JM, González-Rubio F, Ramiro-González MD, Coscollar-Santaliestra C, Martín-Fernández J, Barnestein-Fonseca MP, Valderas-Martínez JM, Marengoni A, Muth C; Multi-PAP Group.

Implement Sci. 2017 Apr 27;12(1):54. doi: 10.1186/s13012-017-0584-x.


C-reactive protein, lipoprotein (a) and cystatin C levels increase with multimorbidity in older persons.

Garrafa E, Casnici N, Squazzoni F, Uberti D, Marengoni A.

Eur J Intern Med. 2017 Jul;42:e25-e26. doi: 10.1016/j.ejim.2017.04.010. Epub 2017 Apr 23. No abstract available.


Prevalence of older in-patients at risk of clopidogrel resistance according to the STIB score. Results from REPOSI registry.

Gallotta A, Marengoni A, Pasina L, Cortesi L, Nobili A.

Eur J Intern Med. 2017 Jun;41:e17-e18. doi: 10.1016/j.ejim.2017.03.024. Epub 2017 Apr 11. No abstract available.


Effect of Chronic Diseases and Multimorbidity on Survival and Functioning in Elderly Adults.

Rizzuto D, Melis RJF, Angleman S, Qiu C, Marengoni A.

J Am Geriatr Soc. 2017 May;65(5):1056-1060. doi: 10.1111/jgs.14868. Epub 2017 Mar 17.


Improving Public Awareness of Multimorbidity.

Marengoni A, Fratiglioni L, Onder G.

J Am Med Dir Assoc. 2017 May 1;18(5):372-373. doi: 10.1016/j.jamda.2017.01.010. Epub 2017 Feb 24. No abstract available.


Social networks and health status in the elderly: the 'ANZIANI IN-RETE' population-based study.

Bianchetti L, Squazzoni F, Casnici N, Bianchini D, Garrafa E, Archetti C, Romano V, Rozzini L, Melchiori M, Fiorentini C, Uberti D, Calza S, Marengoni A.

Aging Clin Exp Res. 2017 Dec;29(6):1173-1179. doi: 10.1007/s40520-017-0726-7. Epub 2017 Feb 16.


Adherence to Selective Serotonin and Serotonin-Norepinephrine Reuptake Inhibitor Prescriptions Affects Overall Medication Adherence in Older Persons: Evidence From the Italian Nationwide OsMed Health-DB Database.

Marengoni A, Onder G, Degli Esposti L, Russo P, Sangiorgi D, Buda S, Fini M, Marchionni N, Bonassi S, Mammarella F, Marrocco W, Pozzi G, Palmer K, Monaco A, Pecorelli S, Pani L; Geriatrics Steering Committee of the Italian Medicines Agency on behalf of the OsMed Health-DB Network.

J Clin Psychiatry. 2016 Dec;77(12):1712-1718. doi: 10.4088/JCP.15m10503.


VKORC1 and CYP2C9 polymorphisms related to adverse events in case-control cohort of anticoagulated patients.

Misasi S, Martini G, Paoletti O, Calza S, Scovoli G, Marengoni A, Testa S, Caimi L, Marchina E.

Medicine (Baltimore). 2016 Dec;95(52):e5451. doi: 10.1097/MD.0000000000005451.


Combining Gait Speed and Recall Memory to Predict Survival in Late Life: Population-Based Study.

Marengoni A, Bandinelli S, Maietti E, Guralnik J, Zuliani G, Ferrucci L, Volpato S.

J Am Geriatr Soc. 2017 Mar;65(3):614-618. doi: 10.1111/jgs.14705. Epub 2016 Dec 28.


Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization.

Calderón-Larrañaga A, Vetrano DL, Onder G, Gimeno-Feliu LA, Coscollar-Santaliestra C, Carfí A, Pisciotta MS, Angleman S, Melis RJF, Santoni G, Mangialasche F, Rizzuto D, Welmer AK, Bernabei R, Prados-Torres A, Marengoni A, Fratiglioni L.

J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1417-1423. doi: 10.1093/gerona/glw233.


Potentially Serious Drug-Drug Interactions in Older Patients Hospitalized for Acute Ischemic and Hemorrhagic Stroke.

Caratozzolo S, Gipponi S, Marengoni A, Pari E, Scalvini A, Pasina L, Magoni M, Padovani A.

Eur Neurol. 2016;76(3-4):161-166. Epub 2016 Sep 9.


Therapeutic Duplicates in a Cohort of Hospitalized Elderly Patients: Results from the REPOSI Study.

Pasina L, Astuto S, Cortesi L, Tettamanti M, Franchi C, Marengoni A, Mannucci PM, Nobili A; REPOSI Investigators.

Drugs Aging. 2016 Sep;33(9):647-54. doi: 10.1007/s40266-016-0395-9.


Clinical Severity, Age, and Sex Overcome Cardiometabolic Morbidities but Not Stroke as Predictors of Mortality in Elderly Inpatients: Data From the REgistro POliterapie Società Italiana di Medicina Interna Registry.

Corrao S, Marengoni A, Natoli G, Nobili A, Mannucci P, Perticone F.

J Am Geriatr Soc. 2016 Aug;64(8):1737-9. doi: 10.1111/jgs.14197. Epub 2016 Jul 26. No abstract available.


Strategies to Improve Medication Adherence in Older Persons: Consensus Statement from the Senior Italia Federanziani Advisory Board.

Marengoni A, Monaco A, Costa E, Cherubini A, Prados-Torres A, Muth C, Melis RJ, Pasina L, van der Cammen TJ, Palmer K, Pecorelli S, Onder G.

Drugs Aging. 2016 Sep;33(9):629-37. doi: 10.1007/s40266-016-0387-9.


Scaling up health knowledge at European level requires sharing integrated data: an approach for collection of database specification.

Menditto E, Bolufer De Gea A, Cahir C, Marengoni A, Riegler S, Fico G, Costa E, Monaco A, Pecorelli S, Pani L, Prados-Torres A.

Clinicoecon Outcomes Res. 2016 Jun 13;8:253-65. doi: 10.2147/CEOR.S97548. eCollection 2016.


Potentially Inappropriate Drug Prescribing and the "Never Change a Winning Team" Principle.

Onder G, Nobili A, Marengoni A.

J Gerontol A Biol Sci Med Sci. 2016 Nov;71(11):1531-1532. Epub 2016 Jun 23. No abstract available.


Frailty and Drug Use.

Palmer K, Marengoni A, Russo P, Mammarella F, Onder G.

J Frailty Aging. 2016;5(2):100-3. doi: 10.14283/jfa.2016.84. No abstract available.


Multimorbidity: Epidemiology and Models of Care.

Marengoni A, Melis RJ, Prados Torres A, Onder G.

Biomed Res Int. 2016;2016:7029027. doi: 10.1155/2016/7029027. Epub 2016 Mar 27. No abstract available.


Frailty: The pleasure and pain of geriatric medicine.

Onder G, Marengoni A.

Eur J Intern Med. 2016 Jun;31:1-2. doi: 10.1016/j.ejim.2016.03.018. Epub 2016 Apr 7. No abstract available.


Coexisting chronic conditions in the older population: Variation by health indicators.

Marengoni A, Angleman S, Meinow B, Santoni G, Mangialasche F, Rizzuto D, Fastbom J, Melis R, Parker M, Johnell K, Fratiglioni L.

Eur J Intern Med. 2016 Jun;31:29-34. doi: 10.1016/j.ejim.2016.02.014. Epub 2016 Mar 2.


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