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Items: 28


The knocking down of the oncoprotein Golgi phosphoprotein 3 in T98G cells of glioblastoma multiforme disrupts cell migration by affecting focal adhesion dynamics in a focal adhesion kinase-dependent manner.

Arriagada C, Luchsinger C, González AE, Schwenke T, Arriagada G, Folch H, Ehrenfeld P, Burgos PV, Mardones GA.

PLoS One. 2019 Feb 19;14(2):e0212321. doi: 10.1371/journal.pone.0212321. eCollection 2019.


KDEL receptor regulates secretion by lysosome relocation- and autophagy-dependent modulation of lipid-droplet turnover.

Tapia D, Jiménez T, Zamora C, Espinoza J, Rizzo R, González-Cárdenas A, Fuentes D, Hernández S, Cavieres VA, Soza A, Guzmán F, Arriagada G, Yuseff MI, Mardones GA, Burgos PV, Luini A, González A, Cancino J.

Nat Commun. 2019 Feb 13;10(1):735. doi: 10.1038/s41467-019-08501-w.


Galectin-8 induces endothelial hyperpermeability through the eNOS pathway involving S-nitrosylation-mediated adherens junction disassembly.

Zamorano P, Koning T, Oyanadel C, Mardones GA, Ehrenfeld P, Boric MP, González A, Soza A, Sánchez FA.

Carcinogenesis. 2019 Apr 29;40(2):313-323. doi: 10.1093/carcin/bgz002.


HIV/SIV-Nef: Pas de trois Choreographies to Evade Immunity.

daSilva LLP, Mardones GA.

Trends Microbiol. 2018 Nov;26(11):889-891. doi: 10.1016/j.tim.2018.09.003. Epub 2018 Oct 1.


Functional disruption of the Golgi apparatus protein ARF1 sensitizes MDA-MB-231 breast cancer cells to the antitumor drugs Actinomycin D and Vinblastine through ERK and AKT signaling.

Luchsinger C, Aguilar M, Burgos PV, Ehrenfeld P, Mardones GA.

PLoS One. 2018 Apr 3;13(4):e0195401. doi: 10.1371/journal.pone.0195401. eCollection 2018.


α-SNAP is expressed in mouse ovarian granulosa cells and plays a key role in folliculogenesis and female fertility.

Arcos A, Paola M, Gianetti D, Acuña D, Velásquez ZD, Miró MP, Toro G, Hinrichsen B, Muñoz RI, Lin Y, Mardones GA, Ehrenfeld P, Rivera FJ, Michaut MA, Batiz LF.

Sci Rep. 2017 Sep 18;7(1):11765. doi: 10.1038/s41598-017-12292-9.


Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

González AE, Muñoz VC, Cavieres VA, Bustamante HA, Cornejo VH, Januário YC, González I, Hetz C, daSilva LL, Rojas-Fernández A, Hay RT, Mardones GA, Burgos PV.

FASEB J. 2017 Jun;31(6):2446-2459. doi: 10.1096/fj.201600713R. Epub 2017 Mar 2.


CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the γ1 and γ2 subunits of the AP-1 complex in protein trafficking.

Tavares LA, da Silva EM, da Silva-Januário ME, Januário YC, de Cavalho JV, Czernisz ÉS, Mardones GA, daSilva LL.

J Cell Sci. 2017 Jan 15;130(2):429-443. doi: 10.1242/jcs.192104. Epub 2016 Dec 1.


Inhibition of the Hantavirus Fusion Process by Predicted Domain III and Stem Peptides from Glycoprotein Gc.

Barriga GP, Villalón-Letelier F, Márquez CL, Bignon EA, Acuña R, Ross BH, Monasterio O, Mardones GA, Vidal SE, Tischler ND.

PLoS Negl Trop Dis. 2016 Jul 14;10(7):e0004799. doi: 10.1371/journal.pntd.0004799. eCollection 2016 Jul.


Distinct Biochemical Pools of Golgi Phosphoprotein 3 in the Human Breast Cancer Cell Lines MCF7 and MDA-MB-231.

Tenorio MJ, Ross BH, Luchsinger C, Rivera-Dictter A, Arriagada C, Acuña D, Aguilar M, Cavieres V, Burgos PV, Ehrenfeld P, Mardones GA.

PLoS One. 2016 Apr 28;11(4):e0154719. doi: 10.1371/journal.pone.0154719. eCollection 2016.


Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy.

Cavieres VA, González A, Muñoz VC, Yefi CP, Bustamante HA, Barraza RR, Tapia-Rojas C, Otth C, Barrera MJ, González C, Mardones GA, Inestrosa NC, Burgos PV.

PLoS One. 2015 Aug 26;10(8):e0136313. doi: 10.1371/journal.pone.0136313. eCollection 2015.


Protein kinase A activity is necessary for fission and fusion of Golgi to endoplasmic reticulum retrograde tubules.

Tenorio MJ, Luchsinger C, Mardones GA.

PLoS One. 2015 Aug 10;10(8):e0135260. doi: 10.1371/journal.pone.0135260. eCollection 2015.


Co-assembly of viral envelope glycoproteins regulates their polarized sorting in neurons.

Mattera R, Farías GG, Mardones GA, Bonifacino JS.

PLoS Pathog. 2014 May 15;10(5):e1004107. doi: 10.1371/journal.ppat.1004107. eCollection 2014 May.


Structural and functional characterization of cargo-binding sites on the μ4-subunit of adaptor protein complex 4.

Ross BH, Lin Y, Corales EA, Burgos PV, Mardones GA.

PLoS One. 2014 Feb 3;9(2):e88147. doi: 10.1371/journal.pone.0088147. eCollection 2014.


Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells.

Bustamante HA, Rivera-Dictter A, Cavieres VA, Muñoz VC, González A, Lin Y, Mardones GA, Burgos PV.

PLoS One. 2013 Dec 20;8(12):e83096. doi: 10.1371/journal.pone.0083096. eCollection 2013.


Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex.

Mardones GA, Burgos PV, Lin Y, Kloer DP, Magadán JG, Hurley JH, Bonifacino JS.

J Biol Chem. 2013 Mar 29;288(13):9563-71. doi: 10.1074/jbc.M113.450775. Epub 2013 Feb 12.


Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.

Pérez-Victoria FJ, Schindler C, Magadán JG, Mardones GA, Delevoye C, Romao M, Raposo G, Bonifacino JS.

Mol Biol Cell. 2010 Oct 1;21(19):3386-95. doi: 10.1091/mbc.E10-05-0392. Epub 2010 Aug 4.


AGAP2 regulates retrograde transport between early endosomes and the TGN.

Shiba Y, Römer W, Mardones GA, Burgos PV, Lamaze C, Johannes L.

J Cell Sci. 2010 Jul 15;123(Pt 14):2381-90. doi: 10.1242/jcs.057778. Epub 2010 Jun 15.


Termination of autophagy and reformation of lysosomes regulated by mTOR.

Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ.

Nature. 2010 Jun 17;465(7300):942-6. doi: 10.1038/nature09076. Epub 2010 Jun 6.


Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.

Burgos PV, Mardones GA, Rojas AL, daSilva LL, Prabhu Y, Hurley JH, Bonifacino JS.

Dev Cell. 2010 Mar 16;18(3):425-36. doi: 10.1016/j.devcel.2010.01.015.


Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes.

Popoff V, Mardones GA, Bai SK, Chambon V, Tenza D, Burgos PV, Shi A, Benaroch P, Urbé S, Lamaze C, Grant BD, Raposo G, Johannes L.

Traffic. 2009 Dec;10(12):1868-80. doi: 10.1111/j.1600-0854.2009.00993.x. Epub 2009 Oct 5.


Coatomer-dependent protein delivery to lipid droplets.

Soni KG, Mardones GA, Sougrat R, Smirnova E, Jackson CL, Bonifacino JS.

J Cell Sci. 2009 Jun 1;122(Pt 11):1834-41. doi: 10.1242/jcs.045849.


Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.

Rojas R, van Vlijmen T, Mardones GA, Prabhu Y, Rojas AL, Mohammed S, Heck AJ, Raposo G, van der Sluijs P, Bonifacino JS.

J Cell Biol. 2008 Nov 3;183(3):513-26. doi: 10.1083/jcb.200804048.


Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.

Pérez-Victoria FJ, Mardones GA, Bonifacino JS.

Mol Biol Cell. 2008 Jun;19(6):2350-62. doi: 10.1091/mbc.E07-11-1189. Epub 2008 Mar 26.


The trans-Golgi network accessory protein p56 promotes long-range movement of GGA/clathrin-containing transport carriers and lysosomal enzyme sorting.

Mardones GA, Burgos PV, Brooks DA, Parkinson-Lawrence E, Mattera R, Bonifacino JS.

Mol Biol Cell. 2007 Sep;18(9):3486-501. Epub 2007 Jun 27.


The retromer complex and clathrin define an early endosomal retrograde exit site.

Popoff V, Mardones GA, Tenza D, Rojas R, Lamaze C, Bonifacino JS, Raposo G, Johannes L.

J Cell Sci. 2007 Jun 15;120(Pt 12):2022-31.


Cis-Golgi matrix proteins move directly to endoplasmic reticulum exit sites by association with tubules.

Mardones GA, Snyder CM, Howell KE.

Mol Biol Cell. 2006 Jan;17(1):525-38. Epub 2005 Oct 26.


GMx33 associates with the trans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi.

Snyder CM, Mardones GA, Ladinsky MS, Howell KE.

Mol Biol Cell. 2006 Jan;17(1):511-24. Epub 2005 Oct 19.

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