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Items: 1 to 50 of 87

1.

The Collaborative African Genomics Network (CAfGEN): Applying Genomic technologies to probe host factors important to the progression of HIV and HIV-tuberculosis infection in sub-Saharan Africa.

Mboowa G, Mwesigwa S, Katagirya E, Retshabile G, Mlotshwa BC, Williams L, Kekitiinwa A, Kateete D, Wampande E, Wayengera M, Kintu BN, Kisitu GP, Kyobe S, Brown CW, Hanchard NA, Mardon G, Joloba M, Anabwani G, Pettitt E, Tsimako-Johnstone M, Kasvosve I, Maplanka K, Mpoloka SW, Hlatshwayo M, Matshaba M.

AAS Open Res. 2018 Apr 18;1:3. doi: 10.12688/aasopenres.12832.1.

2.

Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development.

Yeung K, Wang F, Li Y, Wang K, Mardon G, Chen R.

Nucleic Acids Res. 2018 Dec 14;46(22):11743-11758. doi: 10.1093/nar/gky892.

3.

The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.

Yin W, Kim HT, Wang S, Gunawan F, Wang L, Kishimoto K, Zhong H, Roman D, Preussner J, Guenther S, Graef V, Buettner C, Grohmann B, Looso M, Morimoto M, Mardon G, Offermanns S, Stainier DYR.

Nat Commun. 2018 Jul 19;9(1):2815. doi: 10.1038/s41467-018-05043-5.

4.

Conditional loss of Kcnj13 in the retinal pigment epithelium causes photoreceptor degeneration.

Roman D, Zhong H, Yaklichkin S, Chen R, Mardon G.

Exp Eye Res. 2018 Nov;176:219-226. doi: 10.1016/j.exer.2018.07.014. Epub 2018 Jul 25.

5.

SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium.

Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R.

J Cell Biol. 2018 Aug 6;217(8):2851-2865. doi: 10.1083/jcb.201712117. Epub 2018 Jun 13.

6.

Whole-Exome Sequencing Reveals Uncaptured Variation and Distinct Ancestry in the Southern African Population of Botswana.

Retshabile G, Mlotshwa BC, Williams L, Mwesigwa S, Mboowa G, Huang Z, Rustagi N, Swaminathan S, Katagirya E, Kyobe S, Wayengera M, Kisitu GP, Kateete DP, Wampande EM, Maplanka K, Kasvosve I, Pettitt ED, Matshaba M, Nsangi B, Marape M, Tsimako-Johnstone M, Brown CW, Yu F, Kekitiinwa A, Joloba M, Mpoloka SW, Mardon G, Anabwani G, Hanchard NA; Collaborative African Genomics Network (CAfGEN) of the H3Africa Consortium.

Am J Hum Genet. 2018 May 3;102(5):731-743. doi: 10.1016/j.ajhg.2018.03.010. Epub 2018 Apr 26.

7.

NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype.

Eblimit A, Zaneveld SA, Liu W, Thomas K, Wang K, Li Y, Mardon G, Chen R.

Exp Eye Res. 2018 Aug;173:32-43. doi: 10.1016/j.exer.2018.04.010. Epub 2018 Apr 17.

8.

Corrigendum to "Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice" [Exp. Eye Res. 166 (2018) 120-130].

Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Moayedi Y, Mardon G, Chen R.

Exp Eye Res. 2018 Jun;171:119. doi: 10.1016/j.exer.2018.03.011. Epub 2018 Mar 24. No abstract available.

PMID:
29579643
9.

POU6f1 Mediates Neuropeptide-Dependent Plasticity in the Adult Brain.

McClard CK, Kochukov MY, Herman I, Liu Z, Eblimit A, Moayedi Y, Ortiz-Guzman J, Colchado D, Pekarek B, Panneerselvam S, Mardon G, Arenkiel BR.

J Neurosci. 2018 Feb 7;38(6):1443-1461. doi: 10.1523/JNEUROSCI.1641-17.2017. Epub 2018 Jan 5.

10.

Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice.

Eblimit A, Agrawal SA, Thomas K, Anastassov IA, Abulikemu T, Moayedi Y, Mardon G, Chen R.

Exp Eye Res. 2018 Jan;166:120-130. doi: 10.1016/j.exer.2017.10.015. Epub 2017 Oct 31. Erratum in: Exp Eye Res. 2018 Mar 23;171:119.

11.

The collaborative African genomics network training program: a trainee perspective on training the next generation of African scientists.

Mlotshwa BC, Mwesigwa S, Mboowa G, Williams L, Retshabile G, Kekitiinwa A, Wayengera M, Kyobe S, Brown CW, Hanchard NA, Mardon G, Joloba M, Anabwani G, Mpoloka SW.

Genet Med. 2017 Jul;19(7):826-833. doi: 10.1038/gim.2016.177. Epub 2017 Apr 6.

12.

Conditional knockout of retinal determination genes in differentiating cells in Drosophila.

Jin M, Eblimit A, Pulikkathara M, Corr S, Chen R, Mardon G.

FEBS J. 2016 Aug;283(15):2754-66. doi: 10.1111/febs.13772. Epub 2016 Jun 23.

13.

Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets.

Jin M, Aibar S, Ge Z, Chen R, Aerts S, Mardon G.

Dev Biol. 2016 Jul 1;415(1):157-167. doi: 10.1016/j.ydbio.2016.05.007. Epub 2016 May 10.

14.

Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster.

Iyer J, Wang Q, Le T, Pizzo L, Grönke S, Ambegaokar SS, Imai Y, Srivastava A, Troisí BL, Mardon G, Artero R, Jackson GR, Isaacs AM, Partridge L, Lu B, Kumar JP, Girirajan S.

G3 (Bethesda). 2016 May 3;6(5):1427-37. doi: 10.1534/g3.116.027060.

15.

Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development.

Jin M, Mardon G.

Sci Rep. 2016 Mar 16;6:23228. doi: 10.1038/srep23228.

16.

A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution.

Yang Z, Zhong H, Chen J, Zhang X, Zhang H, Luo X, Xu S, Chen H, Lu D, Han Y, Li J, Fu L, Qi X, Peng Y, Xiang K, Lin Q, Guo Y, Li M, Cao X, Zhang Y, Liao S, Peng Y, Zhang L, Guo X, Dong S, Liang F, Wang J, Willden A, Seang Aun H, Serey B, Sovannary T, Bunnath L, Samnom H, Mardon G, Li Q, Meng A, Shi H, Su B.

Mol Biol Evol. 2016 May;33(5):1177-87. doi: 10.1093/molbev/msw003. Epub 2016 Jan 6.

17.

Erratum: CRISPR-engineered mosaicism rapidly reveals that loss of Kcnj13 function in mice mimics human disease phenotypes.

Zhong H, Chen Y, Li Y, Chen R, Mardon G.

Sci Rep. 2015 Jul 15;5:9731. doi: 10.1038/srep09731. No abstract available.

18.

AAV8(Y733F)-mediated gene therapy in a Spata7 knockout mouse model of Leber congenital amaurosis and retinitis pigmentosa.

Zhong H, Eblimit A, Moayedi Y, Boye SL, Chiodo VA, Chen Y, Li Y, Nichols RM, Hauswirth WW, Chen R, Mardon G.

Gene Ther. 2015 Aug;22(8):619-27. doi: 10.1038/gt.2015.42. Epub 2015 May 12.

19.

The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module.

Chen K, Wu K, Jiao X, Wang L, Ju X, Wang M, Di Sante G, Xu S, Wang Q, Li K, Sun X, Xu C, Li Z, Casimiro MC, Ertel A, Addya S, McCue PA, Lisanti MP, Wang C, Davis RJ, Mardon G, Pestell RG.

Cancer Res. 2015 May 15;75(10):1992-2004. doi: 10.1158/0008-5472.CAN-14-0611. Epub 2015 Mar 13.

20.

CRISPR-engineered mosaicism rapidly reveals that loss of Kcnj13 function in mice mimics human disease phenotypes.

Zhong H, Chen Y, Li Y, Chen R, Mardon G.

Sci Rep. 2015 Feb 10;5:8366. doi: 10.1038/srep08366. Erratum in: Sci Rep. 2015;5:9731.

21.

Spata7 is a retinal ciliopathy gene critical for correct RPGRIP1 localization and protein trafficking in the retina.

Eblimit A, Nguyen TM, Chen Y, Esteve-Rudd J, Zhong H, Letteboer S, Van Reeuwijk J, Simons DL, Ding Q, Wu KM, Li Y, Van Beersum S, Moayedi Y, Xu H, Pickard P, Wang K, Gan L, Wu SM, Williams DS, Mardon G, Roepman R, Chen R.

Hum Mol Genet. 2015 Mar 15;24(6):1584-601. doi: 10.1093/hmg/ddu573. Epub 2014 Nov 14.

22.

Genome-wide DNA binding pattern of the homeodomain transcription factor Sine oculis (So) in the developing eye of Drosophila melanogaster.

Jusiak B, Wang F, Karandikar UC, Kwak SJ, Wang H, Chen R, Mardon G.

Genom Data. 2014 Dec 1;2:153-155.

23.

Drosophila eyes absent is required for normal cone and pigment cell development.

Karandikar UC, Jin M, Jusiak B, Kwak S, Chen R, Mardon G.

PLoS One. 2014 Jul 24;9(7):e102143. doi: 10.1371/journal.pone.0102143. eCollection 2014.

24.

Research capacity. Enabling the genomic revolution in Africa.

H3Africa Consortium, Rotimi C, Abayomi A, Abimiku A, Adabayeri VM, Adebamowo C, Adebiyi E, Ademola AD, Adeyemo A, Adu D, Affolabi D, Agongo G, Ajayi S, Akarolo-Anthony S, Akinyemi R, Akpalu A, Alberts M, Alonso Betancourt O, Alzohairy AM, Ameni G, Amodu O, Anabwani G, Andersen K, Arogundade F, Arulogun O, Asogun D, Bakare R, Balde N, Baniecki ML, Beiswanger C, Benkahla A, Bethke L, Boehnke M, Boima V, Brandful J, Brooks AI, Brosius FC, Brown C, Bucheton B, Burke DT, Burnett BG, Carrington-Lawrence S, Carstens N, Chisi J, Christoffels A, Cooper R, Cordell H, Crowther N, Croxton T, de Vries J, Derr L, Donkor P, Doumbia S, Duncanson A, Ekem I, El Sayed A, Engel ME, Enyaru JC, Everett D, Fadlelmola FM, Fakunle E, Fischbeck KH, Fischer A, Folarin O, Gamieldien J, Garry RF, Gaseitsiwe S, Gbadegesin R, Ghansah A, Giovanni M, Goesbeck P, Gomez-Olive FX, Grant DS, Grewal R, Guyer M, Hanchard NA, Happi CT, Hazelhurst S, Hennig BJ, Hertz- C, Fowler, Hide W, Hilderbrandt F, Hugo-Hamman C, Ibrahim ME, James R, Jaufeerally-Fakim Y, Jenkins C, Jentsch U, Jiang PP, Joloba M, Jongeneel V, Joubert F, Kader M, Kahn K, Kaleebu P, Kapiga SH, Kassim SK, Kasvosve I, Kayondo J, Keavney B, Kekitiinwa A, Khan SH, Kimmel P, King MC, Kleta R, Koffi M, Kopp J, Kretzler M, Kumuthini J, Kyobe S, Kyobutungi C, Lackland DT, Lacourciere KA, Landouré G, Lawlor R, Lehner T, Lesosky M, Levitt N, Littler K, Lombard Z, Loring JF, Lyantagaye S, Macleod A, Madden EB, Mahomva CR, Makani J, Mamven M, Marape M, Mardon G, Marshall P, Martin DP, Masiga D, Mason R, Mate-Kole M, Matovu E, Mayige M, Mayosi BM, Mbanya JC, McCurdy SA, McCarthy MI, McIlleron H, Mc'Ligeyo SO, Merle C, Mocumbi AO, Mondo C, Moran JV, Motala A, Moxey-Mims M, Mpoloka WS, Msefula CL, Mthiyane T, Mulder N, Mulugeta Gh, Mumba D, Musuku J, Nagdee M, Nash O, Ndiaye D, Nguyen AQ, Nicol M, Nkomazana O, Norris S, Nsangi B, Nyarko A, Nyirenda M, Obe E, Obiakor R, Oduro A, Ofori-Acquah SF, Ogah O, Ogendo S, Ohene-Frempong K, Ojo A, Olanrewaju T, Oli J, Osafo C, Ouwe Missi Oukem-Boyer O, Ovbiagele B, Owen A, Owolabi MO, Owolabi L, Owusu-Dabo E, Pare G, Parekh R, Patterton HG, Penno MB, Peterson J, Pieper R, Plange-Rhule J, Pollak M, Puzak J, Ramesar RS, Ramsay M, Rasooly R, Reddy S, Sabeti PC, Sagoe K, Salako T, Samassékou O, Sandhu MS, Sankoh O, Sarfo FS, Sarr M, Shaboodien G, Sidibe I, Simo G, Simuunza M, Smeeth L, Sobngwi E, Soodyall H, Sorgho H, Sow Bah O, Srinivasan S, Stein DJ, Susser ES, Swanepoel C, Tangwa G, Tareila A, Tastan Bishop O, Tayo B, Tiffin N, Tinto H, Tobin E, Tollman SM, Traoré M, Treadwell MJ, Troyer J, Tsimako-Johnstone M, Tukei V, Ulasi I, Ulenga N, van Rooyen B, Wachinou AP, Waddy SP, Wade A, Wayengera M, Whitworth J, Wideroff L, Winkler CA, Winnicki S, Wonkam A, Yewondwos M, sen T, Yozwiak N, Zar H.

Science. 2014 Jun 20;344(6190):1346-8. doi: 10.1126/science.1251546. No abstract available.

25.

Regulation of Drosophila eye development by the transcription factor Sine oculis.

Jusiak B, Karandikar UC, Kwak SJ, Wang F, Wang H, Chen R, Mardon G.

PLoS One. 2014 Feb 25;9(2):e89695. doi: 10.1371/journal.pone.0089695. eCollection 2014.

26.

The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.

Moayedi Y, Basch ML, Pacheco NL, Gao SS, Wang R, Harrison W, Xiao N, Oghalai JS, Overbeek PA, Mardon G, Groves AK.

PLoS Genet. 2014 Jan;10(1):e1004055. doi: 10.1371/journal.pgen.1004055. Epub 2014 Jan 2.

27.

Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation.

Atkins M, Jiang Y, Sansores-Garcia L, Jusiak B, Halder G, Mardon G.

PLoS Genet. 2013 Aug;9(8):e1003731. doi: 10.1371/journal.pgen.1003731. Epub 2013 Aug 29.

28.

optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila.

Li Y, Jiang Y, Chen Y, Karandikar U, Hoffman K, Chattopadhyay A, Mardon G, Chen R.

Dev Biol. 2013 Sep 1;381(1):50-61. doi: 10.1016/j.ydbio.2013.06.015. Epub 2013 Jun 20.

29.

Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation.

Haase Gilbert E, Kwak SJ, Chen R, Mardon G.

PLoS One. 2013;8(4):e60908. doi: 10.1371/journal.pone.0060908. Epub 2013 Apr 3.

30.

Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survival.

Jin M, Jusiak B, Bai Z, Mardon G.

PLoS One. 2013;8(3):e58818. doi: 10.1371/journal.pone.0058818. Epub 2013 Mar 12.

31.

MAPK target sites of eyes absent are not required for eye development or survival in Drosophila.

Jusiak B, Abulimiti A, Haelterman N, Chen R, Mardon G.

PLoS One. 2012;7(12):e50776. doi: 10.1371/journal.pone.0050776. Epub 2012 Dec 12.

32.

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration.

Koenekoop RK, Wang H, Majewski J, Wang X, Lopez I, Ren H, Chen Y, Li Y, Fishman GA, Genead M, Schwartzentruber J, Solanki N, Traboulsi EI, Cheng J, Logan CV, McKibbin M, Hayward BE, Parry DA, Johnson CA, Nageeb M; Finding of Rare Disease Genes (FORGE) Canada Consortium, Poulter JA, Mohamed MD, Jafri H, Rashid Y, Taylor GR, Keser V, Mardon G, Xu H, Inglehearn CF, Fu Q, Toomes C, Chen R.

Nat Genet. 2012 Sep;44(9):1035-9. doi: 10.1038/ng.2356. Epub 2012 Jul 29.

33.

Exome capture sequencing identifies a novel mutation in BBS4.

Wang H, Chen X, Dudinsky L, Patenia C, Chen Y, Li Y, Wei Y, Abboud EB, Al-Rajhi AA, Lewis RA, Lupski JR, Mardon G, Gibbs RA, Perkins BD, Chen R.

Mol Vis. 2011;17:3529-40. Epub 2011 Dec 30.

34.

Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A mutations in patients with Leber congenital amaurosis.

Wang X, Wang H, Cao M, Li Z, Chen X, Patenia C, Gore A, Abboud EB, Al-Rajhi AA, Lewis RA, Lupski JR, Mardon G, Zhang K, Muzny D, Gibbs RA, Chen R.

Hum Mutat. 2011 Dec;32(12):1450-9. doi: 10.1002/humu.21587. Epub 2011 Sep 23.

35.

The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development.

Anderson AE, Karandikar UC, Pepple KL, Chen Z, Bergmann A, Mardon G.

Development. 2011 May;138(10):1957-66. doi: 10.1242/dev.058461. Epub 2011 Apr 13.

36.

Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling.

Jiang Y, Scott KL, Kwak SJ, Chen R, Mardon G.

Oncogene. 2011 Jul 21;30(29):3248-60. doi: 10.1038/onc.2011.46. Epub 2011 Mar 14.

37.

Potential involvement of more than one locus in trait manifestation for individuals with Leber congenital amaurosis.

Wiszniewski W, Lewis RA, Stockton DW, Peng J, Mardon G, Chen R, Lupski JR.

Hum Genet. 2011 Mar;129(3):319-27. doi: 10.1007/s00439-010-0928-y. Epub 2010 Dec 14.

38.

The Dachshund gene in development and hormone-responsive tumorigenesis.

Popov VM, Wu K, Zhou J, Powell MJ, Mardon G, Wang C, Pestell RG.

Trends Endocrinol Metab. 2010 Jan;21(1):41-9. doi: 10.1016/j.tem.2009.08.002. Epub 2009 Nov 5. Review.

39.

Signaling in the third dimension: the peripodial epithelium in eye disc development.

Atkins M, Mardon G.

Dev Dyn. 2009 Sep;238(9):2139-48. doi: 10.1002/dvdy.22034. Review.

40.

Mutations in SPATA7 cause Leber congenital amaurosis and juvenile retinitis pigmentosa.

Wang H, den Hollander AI, Moayedi Y, Abulimiti A, Li Y, Collin RW, Hoyng CB, Lopez I, Abboud EB, Al-Rajhi AA, Bray M, Lewis RA, Lupski JR, Mardon G, Koenekoop RK, Chen R.

Am J Hum Genet. 2009 Mar;84(3):380-7. doi: 10.1016/j.ajhg.2009.02.005. Epub 2009 Mar 5. Erratum in: Am J Hum Genet. 2010 Feb;86(2):293. Abboud, Emad B [added]; Al-Rajhi, Ali A [added].

41.

Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate.

Pepple KL, Atkins M, Venken K, Wellnitz K, Harding M, Frankfort B, Mardon G.

Development. 2008 Dec;135(24):4071-9. doi: 10.1242/dev.028951. Epub 2008 Nov 12.

42.

Mutation survey of known LCA genes and loci in the Saudi Arabian population.

Li Y, Wang H, Peng J, Gibbs RA, Lewis RA, Lupski JR, Mardon G, Chen R.

Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1336-43. doi: 10.1167/iovs.08-2589. Epub 2008 Oct 20.

43.

Mouse Dach1 and Dach2 are redundantly required for Müllerian duct development.

Davis RJ, Harding M, Moayedi Y, Mardon G.

Genesis. 2008 Apr;46(4):205-13. doi: 10.1002/dvg.20385.

PMID:
18395837
44.

A genetic screen in Drosophila for genes interacting with senseless during neuronal development identifies the importin moleskin.

Pepple KL, Anderson AE, Frankfort BJ, Mardon G.

Genetics. 2007 Jan;175(1):125-41. Epub 2006 Nov 16.

45.

Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless.

Ostrin EJ, Li Y, Hoffman K, Liu J, Wang K, Zhang L, Mardon G, Chen R.

Genome Res. 2006 Apr;16(4):466-76. Epub 2006 Mar 13.

46.

Mouse Dach2 mutants do not exhibit gross defects in eye development or brain function.

Davis RJ, Pesah YI, Harding M, Paylor R, Mardon G.

Genesis. 2006 Feb;44(2):84-92.

PMID:
16470613
47.

Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction.

Purcell P, Oliver G, Mardon G, Donner AL, Maas RL.

Gene Expr Patterns. 2005 Dec;6(1):110-8. Epub 2005 Jul 18.

PMID:
16024294
48.

Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund.

Pappu KS, Ostrin EJ, Middlebrooks BW, Sili BT, Chen R, Atkins MR, Gibbs R, Mardon G.

Development. 2005 Jun;132(12):2895-905.

49.

Keeping an eye on the fly genome.

Chen R, Mardon G.

Dev Biol. 2005 Jun 15;282(2):285-93. Review.

50.

Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila.

Pesah Y, Burgess H, Middlebrooks B, Ronningen K, Prosser J, Tirunagaru V, Zysk J, Mardon G.

Genesis. 2005 Apr;41(4):154-9.

PMID:
15789427

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