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Items: 1 to 50 of 75

1.

Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity-A Study on Rare BMI-Discordant Monozygotic Twin Pairs.

Sahebekhtiari N, Saraswat M, Joenväärä S, Jokinen R, Lovric A, Kaye S, Mardinoglu A, Rissanen A, Kaprio J, Renkonen R, Pietiläinen KH.

Proteomics Clin Appl. 2019 Jan 27:e1800173. doi: 10.1002/prca.201800173. [Epub ahead of print]

PMID:
30688043
2.

Discovery of KIRREL as a biomarker for prognostic stratification of patients with thin melanoma.

Lundgren S, Fagerström-Vahman H, Zhang C, Ben-Dror L, Mardinoglu A, Uhlen M, Nodin B, Jirström K.

Biomark Res. 2019 Jan 14;7:1. doi: 10.1186/s40364-018-0153-8. eCollection 2019.

3.

LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.

Cadenas C, Vosbeck S, Edlund K, Grgas K, Madjar K, Hellwig B, Adawy A, Glotzbach A, Stewart JD, Lesjak MS, Franckenstein D, Claus M, Hayen H, Schriewer A, Gianmoena K, Thaler S, Schmidt M, Micke P, Pontén F, Mardinoglu A, Zhang C, Käfferlein HU, Watzl C, Frank S, Rahnenführer J, Marchan R, Hengstler JG.

Int J Cancer. 2019 Jan 17. doi: 10.1002/ijc.32138. [Epub ahead of print]

PMID:
30653260
4.

Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.

Liu Z, Zhang C, Lee S, Kim W, Klevstig M, Harzandi AM, Sikanic N, Arif M, Ståhlman M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.

Metab Eng. 2019 Mar;52:263-272. doi: 10.1016/j.ymben.2019.01.001. Epub 2019 Jan 4.

PMID:
30615941
5.

Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis.

Benfeitas R, Bidkhori G, Mukhopadhyay B, Klevstig M, Arif M, Zhang C, Lee S, Cinar R, Nielsen J, Uhlen M, Boren J, Kunos G, Mardinoglu A.

EBioMedicine. 2018 Dec 31. pii: S2352-3964(18)30635-2. doi: 10.1016/j.ebiom.2018.12.057. [Epub ahead of print]

6.

Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.

Bidkhori G, Benfeitas R, Klevstig M, Zhang C, Nielsen J, Uhlen M, Boren J, Mardinoglu A.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11874-E11883. doi: 10.1073/pnas.1807305115. Epub 2018 Nov 27.

PMID:
30482855
7.

Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice.

Håversen L, Sundelin JP, Mardinoglu A, Rutberg M, Ståhlman M, Wilhelmsson U, Hultén LM, Pekny M, Fogelstrand P, Bentzon JF, Levin M, Borén J.

Sci Rep. 2018 Nov 19;8(1):16973. doi: 10.1038/s41598-018-34659-2.

8.

A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine.

Turanli B, Karagoz K, Gulfidan G, Sinha R, Mardinoglu A, Arga KY.

Curr Pharm Des. 2018;24(32):3778-3790. doi: 10.2174/1381612824666181106095959.

PMID:
30398107
9.

Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome.

Liu Z, Liang S, Que S, Zhou L, Zheng S, Mardinoglu A.

Front Physiol. 2018 Sep 19;9:1238. doi: 10.3389/fphys.2018.01238. eCollection 2018.

10.

ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling.

Zhang C, Bidkhori G, Benfeitas R, Lee S, Arif M, Uhlén M, Mardinoglu A.

Front Physiol. 2018 Sep 28;9:1355. doi: 10.3389/fphys.2018.01355. eCollection 2018.

11.

Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.

Lovric A, Granér M, Bjornson E, Arif M, Benfeitas R, Nyman K, Ståhlman M, Pentikäinen MO, Lundbom J, Hakkarainen A, Sirén R, Nieminen MS, Lundbom N, Lauerma K, Taskinen MR, Mardinoglu A, Boren J.

Sci Rep. 2018 Sep 21;8(1):14200. doi: 10.1038/s41598-018-31865-w.

12.

Metabolic Network-Based Identification and Prioritization of Anticancer Targets Based on Expression Data in Hepatocellular Carcinoma.

Bidkhori G, Benfeitas R, Elmas E, Kararoudi MN, Arif M, Uhlen M, Nielsen J, Mardinoglu A.

Front Physiol. 2018 Jul 17;9:916. doi: 10.3389/fphys.2018.00916. eCollection 2018.

13.

Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling.

Rosario D, Benfeitas R, Bidkhori G, Zhang C, Uhlen M, Shoaie S, Mardinoglu A.

Front Physiol. 2018 Jun 25;9:775. doi: 10.3389/fphys.2018.00775. eCollection 2018.

14.

High Cell Density Perfusion Culture has a Maintained Exoproteome and Metabolome.

Zamani L, Lundqvist M, Zhang Y, Aberg M, Edfors F, Bidkhori G, Lindahl A, Mie A, Mardinoglu A, Field R, Turner R, Rockberg J, Chotteau V.

Biotechnol J. 2018 Oct;13(10):e1800036. doi: 10.1002/biot.201800036. Epub 2018 Jul 13.

PMID:
29957873
15.

Drug Repositioning for Effective Prostate Cancer Treatment.

Turanli B, Grøtli M, Boren J, Nielsen J, Uhlen M, Arga KY, Mardinoglu A.

Front Physiol. 2018 May 15;9:500. doi: 10.3389/fphys.2018.00500. eCollection 2018. Review.

16.

Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia.

Danielsson F, Fasterius E, Sullivan D, Hases L, Sanli K, Zhang C, Mardinoglu A, Al-Khalili C, Huss M, Uhlén M, Williams C, Lundberg E.

Oncotarget. 2018 Apr 13;9(28):19730-19744. doi: 10.18632/oncotarget.24808. eCollection 2018 Apr 13.

17.

Systems biology in hepatology: approaches and applications.

Mardinoglu A, Boren J, Smith U, Uhlen M, Nielsen J.

Nat Rev Gastroenterol Hepatol. 2018 Jun;15(6):365-377. doi: 10.1038/s41575-018-0007-8. Review.

PMID:
29686404
18.

Identification of Discriminating Metabolic Pathways and Metabolites in Human PBMCs Stimulated by Various Pathogenic Agents.

Zhang X, Mardinoglu A, Joosten LAB, Kuivenhoven JA, Li Y, Netea MG, Groen AK.

Front Physiol. 2018 Feb 27;9:139. doi: 10.3389/fphys.2018.00139. eCollection 2018.

19.

Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.

Huvila J, Laajala TD, Edqvist PH, Mardinoglu A, Talve L, Pontén F, Grénman S, Carpén O, Aittokallio T, Auranen A.

Gynecol Oncol. 2018 Apr;149(1):173-180. doi: 10.1016/j.ygyno.2018.02.016. Epub 2018 Mar 2.

PMID:
29486992
20.

Translational study reveals a two-faced role of RBM3 in pancreatic cancer and suggests its potential value as a biomarker for improved patient stratification.

Karnevi E, Dror LB, Mardinoglu A, Elebro J, Heby M, Olofsson SE, Nodin B, Eberhard J, Gallagher W, Uhlén M, Jirström K.

Oncotarget. 2017 Dec 15;9(5):6188-6200. doi: 10.18632/oncotarget.23486. eCollection 2018 Jan 19.

21.

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, Söderlund S, Matikainen N, Ståhlman M, Bergh PO, Adiels M, Piening BD, Granér M, Lundbom N, Williams KJ, Romeo S, Nielsen J, Snyder M, Uhlén M, Bergström G, Perkins R, Marschall HU, Bäckhed F, Taskinen MR, Borén J.

Cell Metab. 2018 Mar 6;27(3):559-571.e5. doi: 10.1016/j.cmet.2018.01.005. Epub 2018 Feb 15.

PMID:
29456073
22.

Broad Views of Non-alcoholic Fatty Liver Disease.

Mardinoglu A, Uhlen M, Borén J.

Cell Syst. 2018 Jan 24;6(1):7-9. doi: 10.1016/j.cels.2018.01.004.

23.

Integrative Personal Omics Profiles during Periods of Weight Gain and Loss.

Piening BD, Zhou W, Contrepois K, Röst H, Gu Urban GJ, Mishra T, Hanson BM, Bautista EJ, Leopold S, Yeh CY, Spakowicz D, Banerjee I, Chen C, Kukurba K, Perelman D, Craig C, Colbert E, Salins D, Rego S, Lee S, Zhang C, Wheeler J, Sailani MR, Liang L, Abbott C, Gerstein M, Mardinoglu A, Smith U, Rubin DL, Pitteri S, Sodergren E, McLaughlin TL, Weinstock GM, Snyder MP.

Cell Syst. 2018 Feb 28;6(2):157-170.e8. doi: 10.1016/j.cels.2017.12.013. Epub 2018 Jan 17.

PMID:
29361466
24.

Letter: dose-response analysis revealed closer relationship between obesity and perioperative outcomes in patients after liver transplantation.

Liu Z, Mardinoglu A, Que S.

Aliment Pharmacol Ther. 2018 Jan;47(2):310-312. doi: 10.1111/apt.14425. No abstract available.

PMID:
29265455
25.

Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.

Mardinoglu A, Gogg S, Lotta LA, Stančáková A, Nerstedt A, Boren J, Blüher M, Ferrannini E, Langenberg C, Wareham NJ, Laakso M, Smith U.

EBioMedicine. 2018 Jan;27:151-155. doi: 10.1016/j.ebiom.2017.12.008. Epub 2017 Dec 7.

26.

TCSBN: a database of tissue and cancer specific biological networks.

Lee S, Zhang C, Arif M, Liu Z, Benfeitas R, Bidkhori G, Deshmukh S, Al Shobky M, Lovric A, Boren J, Nielsen J, Uhlen M, Mardinoglu A.

Nucleic Acids Res. 2018 Jan 4;46(D1):D595-D600. doi: 10.1093/nar/gkx994.

27.

The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis.

Liu Z, Que S, Zhou L, Zheng S, Romeo S, Mardinoglu A, Valenti L.

Sci Rep. 2017 Aug 24;7(1):9273. doi: 10.1038/s41598-017-09548-9.

28.

Network analyses identify liver-specific targets for treating liver diseases.

Lee S, Zhang C, Liu Z, Klevstig M, Mukhopadhyay B, Bergentall M, Cinar R, Ståhlman M, Sikanic N, Park JK, Deshmukh S, Harzandi AM, Kuijpers T, Grøtli M, Elsässer SJ, Piening BD, Snyder M, Smith U, Nielsen J, Bäckhed F, Kunos G, Uhlen M, Boren J, Mardinoglu A.

Mol Syst Biol. 2017 Aug 21;13(8):938. doi: 10.15252/msb.20177703.

29.

A pathology atlas of the human cancer transcriptome.

Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.

Science. 2017 Aug 18;357(6352). pii: eaan2507. doi: 10.1126/science.aan2507.

PMID:
28818916
30.

Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease.

Mardinoglu A, Stančáková A, Lotta LA, Kuusisto J, Boren J, Blüher M, Wareham NJ, Ferrannini E, Groop PH, Laakso M, Langenberg C, Smith U.

Cell Metab. 2017 Aug 1;26(2):281-283. doi: 10.1016/j.cmet.2017.07.006.

31.

New Challenges to Study Heterogeneity in Cancer Redox Metabolism.

Benfeitas R, Uhlen M, Nielsen J, Mardinoglu A.

Front Cell Dev Biol. 2017 Jul 11;5:65. doi: 10.3389/fcell.2017.00065. eCollection 2017. Review.

32.

Improving the economics of NASH/NAFLD treatment through the use of systems biology.

Bosley J, Boren C, Lee S, Grøtli M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.

Drug Discov Today. 2017 Oct;22(10):1532-1538. doi: 10.1016/j.drudis.2017.07.005. Epub 2017 Jul 20. Review.

PMID:
28736156
33.

Rediscussion on linearity between fibrosis stages and mortality risk in nonalcoholic fatty liver disease patients.

Liu Z, Que S, Mardinoglu A.

Hepatology. 2017 Oct;66(4):1357-1358. doi: 10.1002/hep.29390. Epub 2017 Sep 4. No abstract available.

PMID:
28727167
34.

Predicting growth of the healthy infant using a genome scale metabolic model.

Nilsson A, Mardinoglu A, Nielsen J.

NPJ Syst Biol Appl. 2017 Jan 31;3:3. doi: 10.1038/s41540-017-0004-5. eCollection 2017.

35.

A subcellular map of the human proteome.

Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.

Science. 2017 May 26;356(6340). pii: eaal3321. doi: 10.1126/science.aal3321. Epub 2017 May 11.

PMID:
28495876
36.

AUP1 (Ancient Ubiquitous Protein 1): A Molecular Link Between Hepatic Lipid Mobilization and VLDL Secretion.

Mardinoglu A, Borén J.

Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):609-610. doi: 10.1161/ATVBAHA.117.309152. No abstract available.

PMID:
28330944
37.

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.

Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.

Mol Syst Biol. 2017 Mar 2;13(3):916. doi: 10.15252/msb.20167422.

38.

Editorial: The Impact of Systems Medicine on Human Health and Disease.

Mardinoglu A, Nielsen J.

Front Physiol. 2016 Nov 24;7:552. eCollection 2016. No abstract available.

39.

Adaptive Evolution of Phosphorus Metabolism in Prochlorococcus.

Casey JR, Mardinoglu A, Nielsen J, Karl DM.

mSystems. 2016 Nov 15;1(6). pii: e00065-16. eCollection 2016 Nov-Dec.

40.

Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.

Heinonen S, Muniandy M, Buzkova J, Mardinoglu A, Rodríguez A, Frühbeck G, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH.

Diabetologia. 2017 Jan;60(1):169-181. Epub 2016 Oct 12.

PMID:
27734103
41.

ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.

Chaudhari A, Håversen L, Mobini R, Andersson L, Ståhlman M, Lu E, Rutberg M, Fogelstrand P, Ekroos K, Mardinoglu A, Levin M, Perkins R, Borén J.

Biochim Biophys Acta. 2016 Nov;1861(11):1643-1651. doi: 10.1016/j.bbalip.2016.07.009. Epub 2016 Jul 27.

PMID:
27476102
42.

Investigating the Combinatory Effects of Biological Networks on Gene Co-expression.

Zhang C, Lee S, Mardinoglu A, Hua Q.

Front Physiol. 2016 May 2;7:160. doi: 10.3389/fphys.2016.00160. eCollection 2016.

43.

Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.

Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie MJ, Boren J, Mardinoglu A.

Cell Metab. 2016 Jul 12;24(1):172-84. doi: 10.1016/j.cmet.2016.05.026. Epub 2016 Jun 23.

44.

Liver: Phenotypic and genetic variance: a systems approach to the liver.

Mardinoglu A, Uhlén M.

Nat Rev Gastroenterol Hepatol. 2016 Aug;13(8):439-40. doi: 10.1038/nrgastro.2016.93. Epub 2016 Jun 22. No abstract available.

PMID:
27329803
45.

Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis.

Lee S, Mardinoglu A, Zhang C, Lee D, Nielsen J.

Nucleic Acids Res. 2016 Jul 8;44(12):5529-39. doi: 10.1093/nar/gkw462. Epub 2016 May 23.

46.

Transcriptomics resources of human tissues and organs.

Uhlén M, Hallström BM, Lindskog C, Mardinoglu A, Pontén F, Nielsen J.

Mol Syst Biol. 2016 Apr 4;12(4):862. doi: 10.15252/msb.20155865. Review.

47.

Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.

Elsemman IE, Mardinoglu A, Shoaie S, Soliman TH, Nielsen J.

Mol Biosyst. 2016 Apr 26;12(5):1496-506. doi: 10.1039/c5mb00827a.

PMID:
27040643
48.

Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes.

Väremo L, Scheele C, Broholm C, Mardinoglu A, Kampf C, Asplund A, Nookaew I, Uhlén M, Pedersen BK, Nielsen J.

Cell Rep. 2016 Feb 16;14(6):1567. doi: 10.1016/j.celrep.2016.01.054. Epub 2016 Feb 16. No abstract available.

49.

Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools.

Björnson E, Borén J, Mardinoglu A.

Front Physiol. 2016 Jan 26;7:2. doi: 10.3389/fphys.2016.00002. eCollection 2016. Review.

50.

Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes.

Mardinoglu A, Boren J, Smith U.

Cell Metab. 2016 Jan 12;23(1):10-2. doi: 10.1016/j.cmet.2015.12.012.

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