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GC-MS/MS quantification of benzyl salicylate on skin and hair: A novel chemical simulant for human decontamination studies.

James T, Collins S, Amlôt R, Marczylo T.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Oct 15;1129:121818. doi: 10.1016/j.jchromb.2019.121818. Epub 2019 Oct 16.


Diesel exhaust particle and dust mite induced airway inflammation is modified by cerium dioxide nanoparticles.

Meldrum K, Robertson S, Römer I, Marczylo T, Gant TW, Smith R, Tetley TD, Leonard MO.

Environ Toxicol Pharmacol. 2020 Jan;73:103273. doi: 10.1016/j.etap.2019.103273. Epub 2019 Oct 11.


Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats.

Charrua A, Matos R, Oliveira R, Marczylo T, Nagy I, Cruz F.

Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb;393(2):263-272. doi: 10.1007/s00210-019-01729-9. Epub 2019 Sep 15.


Identification of Novel Predictive Biomarkers for Endometrial Malignancies: N-Acylethanolamines.

Ayakannu T, Taylor AH, Marczylo TH, Maccarrone M, Konje JC.

Front Oncol. 2019 Jun 11;9:430. doi: 10.3389/fonc.2019.00430. eCollection 2019.


New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System.

Ayakannu T, Taylor AH, Marczylo TH, Konje JC.

Med Sci Monit Basic Res. 2019 Mar 7;25:76-87. doi: 10.12659/MSMBR.914019.


Optimisation and validation of a GC-MS/MS method for the analysis of methyl salicylate in hair and skin samples for use in human-volunteer decontamination studies.

James T, Collins S, Amlôt R, Marczylo T.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 1;1109:84-89. doi: 10.1016/j.jchromb.2019.01.030. Epub 2019 Jan 31.


Pulmonary toxicity of inhaled nano-sized cerium oxide aerosols in Sprague-Dawley rats.

Guo C, Robertson S, Weber RJM, Buckley A, Warren J, Hodgson A, Rappoport JZ, Ignatyev K, Meldrum K, Römer I, Macchiarulo S, Chipman JK, Marczylo T, Leonard MO, Gant TW, Viant MR, Smith R.

Nanotoxicology. 2019 Aug;13(6):733-750. doi: 10.1080/17435390.2018.1554751. Epub 2019 Feb 1.


Electronic cigarettes: adolescent health and wellbeing - Authors' reply.

Newton JN, Dockrell M, Marczylo T.

Lancet. 2018 Aug 11;392(10146):474. doi: 10.1016/S0140-6736(18)31180-2. Epub 2018 Aug 9. No abstract available.


Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation.

Meldrum K, Robertson SB, Römer I, Marczylo T, Dean LSN, Rogers A, Gant TW, Smith R, Tetley TD, Leonard MO.

Part Fibre Toxicol. 2018 May 23;15(1):24. doi: 10.1186/s12989-018-0261-5.


The small airway epithelium as a target for the adverse pulmonary effects of silver nanoparticle inhalation.

Guo C, Buckley A, Marczylo T, Seiffert J, Römer I, Warren J, Hodgson A, Chung KF, Gant TW, Smith R, Leonard MO.

Nanotoxicology. 2018 Aug;12(6):539-553. doi: 10.1080/17435390.2018.1465140. Epub 2018 May 11.


Making sense of the latest evidence on electronic cigarettes.

Newton JN, Dockrell M, Marczylo T.

Lancet. 2018 Feb 17;391(10121):639-642. doi: 10.1016/S0140-6736(18)30202-2. Epub 2018 Feb 6. No abstract available.


An evaluation of the fixed concentration procedure for assessment of acute inhalation toxicity.

Sewell F, Ragan I, Indans I, Marczylo T, Stallard N, Griffiths D, Holmes T, Smith P, Horgan G.

Regul Toxicol Pharmacol. 2018 Apr;94:22-32. doi: 10.1016/j.yrtph.2018.01.001. Epub 2018 Jan 6.


Chemical warfare agent simulants for human volunteer trials of emergency decontamination: A systematic review.

James T, Wyke S, Marczylo T, Collins S, Gaulton T, Foxall K, Amlôt R, Duarte-Davidson R.

J Appl Toxicol. 2018 Jan;38(1):113-121. doi: 10.1002/jat.3527. Epub 2017 Oct 9. Review.


Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles.

Buckley A, Warren J, Hodgson A, Marczylo T, Ignatyev K, Guo C, Smith R.

Part Fibre Toxicol. 2017 Feb 10;14(1):5. doi: 10.1186/s12989-017-0185-5.


A global initiative to refine acute inhalation studies through the use of 'evident toxicity' as an endpoint: Towards adoption of the fixed concentration procedure.

Sewell F, Ragan I, Marczylo T, Anderson B, Braun A, Casey W, Dennison N, Griffiths D, Guest R, Holmes T, van Huygevoort T, Indans I, Kenny T, Kojima H, Lee K, Prieto P, Smith P, Smedley J, Stokes WS, Wnorowski G, Horgan G.

Regul Toxicol Pharmacol. 2015 Dec;73(3):770-9. doi: 10.1016/j.yrtph.2015.10.018. Epub 2015 Oct 23.


Effect of anandamide on endometrial adenocarcinoma (Ishikawa) cell numbers: implications for endometrial cancer therapy.

Ayakannu T, Taylor A, Willets J, Marczylo T, Brown L, Davies Q, Moss E, Konje J.

Lancet. 2015 Feb 26;385 Suppl 1:S20. doi: 10.1016/S0140-6736(15)60335-X.


Relationship between seminal plasma levels of anandamide congeners palmitoylethanolamide and oleoylethanolamide and semen quality.

Amoako AA, Marczylo TH, Elson J, Taylor AH, Willets JM, Konje JC.

Fertil Steril. 2014 Nov;102(5):1260-7. doi: 10.1016/j.fertnstert.2014.07.767. Epub 2014 Sep 8.


The effect of mifepristone (RU486) on the endocannabinoid system in human plasma and first-trimester trophoblast of women undergoing termination of pregnancy.

Karasu T, Marczylo TH, Marczylo EL, Taylor AH, Oloto E, Konje JC.

J Clin Endocrinol Metab. 2014 Mar;99(3):871-80. doi: 10.1210/jc.2013-2922. Epub 2013 Jan 1.


The endocannabinoid system and sex steroid hormone-dependent cancers.

Ayakannu T, Taylor AH, Marczylo TH, Willets JM, Konje JC.

Int J Endocrinol. 2013;2013:259676. doi: 10.1155/2013/259676. Epub 2013 Nov 27. Review.


Plasma anandamide and related n-acylethanolamide levels are not elevated in pregnancies complicated by hyperemesis gravidarum.

Gebeh AK, Willets JM, Marczylo TH, Konje JC.

J Matern Fetal Neonatal Med. 2014 Jun;27(9):954-9. doi: 10.3109/14767058.2013.847413. Epub 2013 Oct 22.


Anandamide produced by Ca(2+)-insensitive enzymes induces excitation in primary sensory neurons.

Varga A, Jenes A, Marczylo TH, Sousa-Valente J, Chen J, Austin J, Selvarajah S, Piscitelli F, Andreou AP, Taylor AH, Kyle F, Yaqoob M, Brain S, White JP, Csernoch L, Di Marzo V, Buluwela L, Nagy I.

Pflugers Arch. 2014 Jul;466(7):1421-35. doi: 10.1007/s00424-013-1360-7. Epub 2013 Oct 10.


Anandamide levels fluctuate in the bovine oviduct during the oestrous cycle.

Gervasi MG, Marczylo TH, Lam PM, Rana S, Franchi AM, Konje JC, Perez-Martinez S.

PLoS One. 2013 Aug 16;8(8):e72521. doi: 10.1371/journal.pone.0072521. eCollection 2013.


Anandamide modulates human sperm motility: implications for men with asthenozoospermia and oligoasthenoteratozoospermia.

Amoako AA, Marczylo TH, Marczylo EL, Elson J, Willets JM, Taylor AH, Konje JC.

Hum Reprod. 2013 Aug;28(8):2058-66. doi: 10.1093/humrep/det232. Epub 2013 May 21.


Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity.

Gebeh AK, Willets JM, Bari M, Hirst RA, Marczylo TH, Taylor AH, Maccarrone M, Konje JC.

J Clin Endocrinol Metab. 2013 Mar;98(3):1226-34. doi: 10.1210/jc.2012-3390. Epub 2013 Jan 31.


Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine.

Barregard L, Møller P, Henriksen T, Mistry V, Koppen G, Rossner P Jr, Sram RJ, Weimann A, Poulsen HE, Nataf R, Andreoli R, Manini P, Marczylo T, Lam P, Evans MD, Kasai H, Kawai K, Li YS, Sakai K, Singh R, Teichert F, Farmer PB, Rozalski R, Gackowski D, Siomek A, Saez GT, Cerda C, Broberg K, Lindh C, Hossain MB, Haghdoost S, Hu CW, Chao MR, Wu KY, Orhan H, Senduran N, Smith RJ, Santella RM, Su Y, Cortez C, Yeh S, Olinski R, Loft S, Cooke MS.

Antioxid Redox Signal. 2013 Jun 20;18(18):2377-91. doi: 10.1089/ars.2012.4714. Epub 2013 Jan 31.


Impact of reference gene selection for type 2 cannabinoid receptor gene expression studies in human spermatozoa.

Amoako AA, Gebeh AK, Marczylo EL, Willets JM, Elson J, Marczylo TH, Konje JC.

Andrologia. 2013 Aug;45(4):278-84. doi: 10.1111/and.12006. Epub 2012 Aug 29.


Dietary intake of rosmarinic acid by Apc(Min) mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development.

Karmokar A, Marczylo TH, Cai H, Steward WP, Gescher AJ, Brown K.

Mol Nutr Food Res. 2012 May;56(5):775-83. doi: 10.1002/mnfr.201100617.


Characterisation of the endocannabinoid system in rat haemochorial placenta.

Fonseca BM, Correia-da-Silva G, Taylor AH, Lam PM, Marczylo TH, Konje JC, Teixeira NA.

Reprod Toxicol. 2012 Nov;34(3):347-56. doi: 10.1016/j.reprotox.2012.05.036. Epub 2012 May 18.


Rapid measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine in human biological matrices using ultra-high-performance liquid chromatography-tandem mass spectrometry.

Lam PM, Mistry V, Marczylo TH, Konje JC, Evans MD, Cooke MS.

Free Radic Biol Med. 2012 May 15;52(10):2057-63. doi: 10.1016/j.freeradbiomed.2012.03.004. Epub 2012 Apr 15.


Diagnostic accuracy of maternal serum macrophage inhibitory cytokine-1 and pregnancy-associated plasma protein-A at 6-10 weeks of gestation to predict miscarriage.

Tong S, Ngian GL, Onwude JL, Permezel M, Saglam B, Hay S, Konje JC, Marczylo TH, Fleming G, Walker SP, Lappas M.

Obstet Gynecol. 2012 May;119(5):1000-8. doi: 10.1097/AOG.0b013e3182518fd3.


Smoking induces differential miRNA expression in human spermatozoa: a potential transgenerational epigenetic concern?

Marczylo EL, Amoako AA, Konje JC, Gant TW, Marczylo TH.

Epigenetics. 2012 May;7(5):432-9. doi: 10.4161/epi.19794. Epub 2012 May 1.


Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium.

Brighton PJ, Marczylo TH, Rana S, Konje JC, Willets JM.

Br J Pharmacol. 2011 Nov;164(5):1479-94. doi: 10.1111/j.1476-5381.2011.01425.x.


Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells.

Esselen M, Fritz J, Hutter M, Teller N, Baechler S, Boettler U, Marczylo TH, Gescher AJ, Marko D.

Mol Nutr Food Res. 2011 May;55 Suppl 1:S143-53. doi: 10.1002/mnfr.201000315. Epub 2011 Jan 31.


The role of sex steroid hormones, cytokines and the endocannabinoid system in female fertility.

Karasu T, Marczylo TH, Maccarrone M, Konje JC.

Hum Reprod Update. 2011 May-Jun;17(3):347-61. doi: 10.1093/humupd/dmq058. Epub 2011 Jan 12. Review.


Quantitative analysis of anandamide and related acylethanolamides in human seminal plasma by ultra performance liquid chromatography tandem mass spectrometry.

Amoako AA, Marczylo TH, Lam PM, Willets JM, Derry A, Elson J, Konje JC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Dec 1;878(31):3231-7. doi: 10.1016/j.jchromb.2010.09.024. Epub 2010 Oct 1.


Simultaneous measurement of three N-acylethanolamides in human bio-matrices using ultra performance liquid chromatography-tandem mass spectrometry.

Lam PM, Marczylo TH, Konje JC.

Anal Bioanal Chem. 2010 Nov;398(5):2089-97. doi: 10.1007/s00216-010-4103-z. Epub 2010 Sep 12.


From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System.

Bambang KN, Karasu T, Gebeh A, Taylor AH, Marczylo TH, Lam P, Willets JM, Konje JC.

Pharmaceuticals (Basel). 2010 Sep 2;3(9):2910-2929. Review.


The endocannabinoid 2-arachidonoylglycerol (2-AG) and metabolizing enzymes during rat fetoplacental development: a role in uterine remodelling.

Fonseca BM, Correia-da-Silva G, Taylor AH, Lam PM, Marczylo TH, Bell SC, Konje JC, Teixeira NA.

Int J Biochem Cell Biol. 2010 Nov;42(11):1884-92. doi: 10.1016/j.biocel.2010.08.006. Epub 2010 Aug 19.


N-acylethanolamine levels and expression of their metabolizing enzymes during pregnancy.

Fonseca BM, Correia-da-Silva G, Taylor AH, Lam PM, Marczylo TH, Konje JC, Bell SC, Teixeira NA.

Endocrinology. 2010 Aug;151(8):3965-74. doi: 10.1210/en.2009-1424. Epub 2010 Jun 9.


The plasma levels of the endocannabinoid, anandamide, increase with the induction of labour.

Nallendran V, Lam PM, Marczylo TH, Bankart MJ, Taylor AH, Taylor DJ, Konje JC.

BJOG. 2010 Jun;117(7):863-9. doi: 10.1111/j.1471-0528.2010.02555.x. Epub 2010 Apr 20.


Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase.

Cai H, Marczylo TH, Teller N, Brown K, Steward WP, Marko D, Gescher AJ.

Eur J Cancer. 2010 Mar;46(4):811-7. doi: 10.1016/j.ejca.2009.12.017. Epub 2010 Jan 7.


Anandamide levels in human female reproductive tissues: solid-phase extraction and measurement by ultraperformance liquid chromatography tandem mass spectrometry.

Marczylo TH, Lam PM, Amoako AA, Konje JC.

Anal Biochem. 2010 May 15;400(2):155-62. doi: 10.1016/j.ab.2009.12.025. Epub 2009 Dec 22.


Pilot study of oral anthocyanins for colorectal cancer chemoprevention.

Thomasset S, Berry DP, Cai H, West K, Marczylo TH, Marsden D, Brown K, Dennison A, Garcea G, Miller A, Hemingway D, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2009 Jul;2(7):625-33. doi: 10.1158/1940-6207.CAPR-08-0201.


Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice.

Marczylo TH, Cooke D, Brown K, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2009 Nov;64(6):1261-8. doi: 10.1007/s00280-009-0996-7. Epub 2009 Apr 11.


Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes.

Teller N, Thiele W, Marczylo TH, Gescher AJ, Boettler U, Sleeman J, Marko D.

J Agric Food Chem. 2009 Apr 22;57(8):3094-101. doi: 10.1021/jf803094a.


Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method.

Marczylo TH, Steward WP, Gescher AJ.

J Agric Food Chem. 2009 Feb 11;57(3):797-803. doi: 10.1021/jf803038f.


Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.

Warrilow AG, Jackson CJ, Parker JE, Marczylo TH, Kelly DE, Lamb DC, Kelly SL.

Antimicrob Agents Chemother. 2009 Mar;53(3):1157-64. doi: 10.1128/AAC.01237-08. Epub 2008 Dec 15.


A solid-phase method for the extraction and measurement of anandamide from multiple human biomatrices.

Marczylo TH, Lam PM, Nallendran V, Taylor AH, Konje JC.

Anal Biochem. 2009 Jan 1;384(1):106-13. doi: 10.1016/j.ab.2008.08.040. Epub 2008 Sep 18.


Ultra performance liquid chromatography tandem mass spectrometry method for the measurement of anandamide in human plasma.

Lam PM, Marczylo TH, El-Talatini M, Finney M, Nallendran V, Taylor AH, Konje JC.

Anal Biochem. 2008 Sep 15;380(2):195-201. doi: 10.1016/j.ab.2008.05.033. Epub 2008 May 27.


Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts.

Kaur S, Greaves P, Cooke DN, Edwards R, Steward WP, Gescher AJ, Marczylo TH.

J Agric Food Chem. 2007 May 2;55(9):3378-85. Epub 2007 Apr 4.


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