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Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion.

Commander R, Wei C, Sharma A, Mouw JK, Burton LJ, Summerbell E, Mahboubi D, Peterson RJ, Konen J, Zhou W, Du Y, Fu H, Shanmugam M, Marcus AI.

Nat Commun. 2020 Mar 24;11(1):1533. doi: 10.1038/s41467-020-15219-7.


Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes.

Zoeller EL, Pedro B, Konen J, Dwivedi B, Rupji M, Sundararaman N, Wang L, Horton JR, Zhong C, Barwick BG, Cheng X, Martinez ED, Torres MP, Kowalski J, Marcus AI, Vertino PM.

J Cell Sci. 2019 Oct 9;132(19). pii: jcs231514. doi: 10.1242/jcs.231514.


Inhibition of IGF1R enhances 2-deoxyglucose in the treatment of non-small cell lung cancer.

Liu F, Liu Y, Liu X, Mao K, Zhong D, Marcus AI, Khuri FR, Sun SY, He Y, Zhou W.

Lung Cancer. 2018 Sep;123:36-43. doi: 10.1016/j.lungcan.2018.06.026. Epub 2018 Jun 23.


The complex ecosystem in non small cell lung cancer invasion.

Haney S, Konen J, Marcus AI, Bazhenov M.

PLoS Comput Biol. 2018 May 24;14(5):e1006131. doi: 10.1371/journal.pcbi.1006131. eCollection 2018 May.


TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics.

Hou Y, Konen J, Brat DJ, Marcus AI, Cooper LAD.

Sci Rep. 2018 May 8;8(1):7248. doi: 10.1038/s41598-018-25337-4.


Vimentin Is Required for Lung Adenocarcinoma Metastasis via Heterotypic Tumor Cell-Cancer-Associated Fibroblast Interactions during Collective Invasion.

Richardson AM, Havel LS, Koyen AE, Konen JM, Shupe J, Wiles WG 4th, Martin WD, Grossniklaus HE, Sica G, Gilbert-Ross M, Marcus AI.

Clin Cancer Res. 2018 Jan 15;24(2):420-432. doi: 10.1158/1078-0432.CCR-17-1776. Epub 2017 Dec 5.


Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion.

Konen J, Summerbell E, Dwivedi B, Galior K, Hou Y, Rusnak L, Chen A, Saltz J, Zhou W, Boise LH, Vertino P, Cooper L, Salaita K, Kowalski J, Marcus AI.

Nat Commun. 2017 May 12;8:15078. doi: 10.1038/ncomms15078.


Modulation of Bax and mTOR for Cancer Therapeutics.

Li R, Ding C, Zhang J, Xie M, Park D, Ding Y, Chen G, Zhang G, Gilbert-Ross M, Zhou W, Marcus AI, Sun SY, Chen ZG, Sica GL, Ramalingam SS, Magis AT, Fu H, Khuri FR, Curran WJ, Owonikoko TK, Shin DM, Zhou J, Deng X.

Cancer Res. 2017 Jun 1;77(11):3001-3012. doi: 10.1158/0008-5472.CAN-16-2356. Epub 2017 Apr 5.


Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma.

Gilbert-Ross M, Konen J, Koo J, Shupe J, Robinson BS, Wiles WG 4th, Huang C, Martin WD, Behera M, Smith GH, Hill CE, Rossi MR, Sica GL, Rupji M, Chen Z, Kowalski J, Kasinski AL, Ramalingam SS, Fu H, Khuri FR, Zhou W, Marcus AI.

JCI Insight. 2017 Mar 9;2(5):e90487. doi: 10.1172/jci.insight.90487.


Coordinated cell motility is regulated by a combination of LKB1 farnesylation and kinase activity.

Wilkinson S, Hou Y, Zoine JT, Saltz J, Zhang C, Chen Z, Cooper LA, Marcus AI.

Sci Rep. 2017 Jan 19;7:40929. doi: 10.1038/srep40929.


Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics.

Lee B, Konen J, Wilkinson S, Marcus AI, Jiang Y.

Sci Rep. 2017 Jan 3;7:39498. doi: 10.1038/srep39498.


A role for activated Cdc42 in glioblastoma multiforme invasion.

Okura H, Golbourn BJ, Shahzad U, Agnihotri S, Sabha N, Krieger JR, Figueiredo CA, Chalil A, Landon-Brace N, Riemenschneider A, Arai H, Smith CA, Xu S, Kaluz S, Marcus AI, Van Meir EG, Rutka JT.

Oncotarget. 2016 Aug 30;7(35):56958-56975. doi: 10.18632/oncotarget.10925.


LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.

Konen J, Wilkinson S, Lee B, Fu H, Zhou W, Jiang Y, Marcus AI.

Mol Biol Cell. 2016 Apr 1;27(7):1069-84. doi: 10.1091/mbc.E15-08-0569. Epub 2016 Feb 10.


Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveals a Mechanism for Regulation of Tumor Progression.

Coke CJ, Scarlett KA, Chetram MA, Jones KJ, Sandifer BJ, Davis AS, Marcus AI, Hinton CV.

J Biol Chem. 2016 May 6;291(19):9991-10005. doi: 10.1074/jbc.M115.712661. Epub 2016 Feb 3.


RhoA, a novel tumor suppressor or oncogene as a therapeutic target?

Gilbert-Ross M, Marcus AI, Zhou W.

Genes Dis. 2015 Mar;2(1):2-3. No abstract available.


Förster resonance energy transfer (FRET) microscopy for monitoring biomolecular interactions.

Mattheyses AL, Marcus AI.

Methods Mol Biol. 2015;1278:329-39. doi: 10.1007/978-1-4939-2425-7_20.


Re-expression of LKB1 in LKB1-mutant EKVX cells leads to resistance to paclitaxel through the up-regulation of MDR1 expression.

Mao K, Liu F, Liu X, Khuri FR, Marcus AI, Li M, Zhou W.

Lung Cancer. 2015 May;88(2):131-8. doi: 10.1016/j.lungcan.2015.02.017. Epub 2015 Mar 1.


LKB1 Tumor Suppressor: Therapeutic Opportunities Knock when LKB1 Is Inactivated.

Zhou W, Zhang J, Marcus AI.

Genes Dis. 2014 Sep 1;1(1):64-74.


Multiple myeloma in Nigeria: a multi-centre epidemiological and biomedical study.

Nnonyelum ON, Anazoeze MJ, Eunice NO, Emmanuel OO, Stella AT, Marcus AI, Taiwo BM, Olufela KO, Chinawaeze AJ, Orkuma JA, Dalhat GG, Otobo UI.

Pan Afr Med J. 2015 Nov 24;22:292. doi: 10.11604/pamj.2015.22.292.7774. eCollection 2015.


Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity.

Havel LS, Kline ER, Salgueiro AM, Marcus AI.

Oncogene. 2015 Apr 9;34(15):1979-90. doi: 10.1038/onc.2014.123. Epub 2014 May 26.


Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independently of catalytic function.

Brentnall M, Weir DB, Rongvaux A, Marcus AI, Boise LH.

J Cell Sci. 2014 May 15;127(Pt 10):2217-26. doi: 10.1242/jcs.135137. Epub 2014 Mar 7.


uPAR-targeted optical imaging contrasts as theranostic agents for tumor margin detection.

Yang L, Sajja HK, Cao Z, Qian W, Bender L, Marcus AI, Lipowska M, Wood WC, Wang YA.

Theranostics. 2013 Dec 17;4(1):106-18. doi: 10.7150/thno.7409. eCollection 2013.


Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin.

Antony ML, Lee J, Hahm ER, Kim SH, Marcus AI, Kumari V, Ji X, Yang Z, Vowell CL, Wipf P, Uechi GT, Yates NA, Romero G, Sarkar SN, Singh SV.

J Biol Chem. 2014 Jan 17;289(3):1852-65. doi: 10.1074/jbc.M113.496844. Epub 2013 Dec 2.


Withaferin A inhibits experimental epithelial-mesenchymal transition in MCF-10A cells and suppresses vimentin protein level in vivo in breast tumors.

Lee J, Hahm ER, Marcus AI, Singh SV.

Mol Carcinog. 2015 Jun;54(6):417-29. doi: 10.1002/mc.22110. Epub 2013 Nov 30.


Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition.

Yang Z, Garcia A, Xu S, Powell DR, Vertino PM, Singh S, Marcus AI.

PLoS One. 2013 Sep 12;8(9):e75069. doi: 10.1371/journal.pone.0075069. eCollection 2013.


Energizing the search to target LKB1-mutant tumors.

Marcus AI, Khuri FR.

Cancer Discov. 2013 Aug;3(8):843-5. doi: 10.1158/2159-8290.CD-13-0296.


Acetylated tubulin (AT) as a prognostic marker in squamous cell carcinoma of the head and neck.

Saba NF, Magliocca KR, Kim S, Muller S, Chen Z, Owonikoko TK, Sarlis NJ, Eggers C, Phelan V, Grist WJ, Chen AY, Ramalingam SS, Chen ZG, Beitler JJ, Shin DM, Khuri FR, Marcus AI.

Head Neck Pathol. 2014 Mar;8(1):66-72. doi: 10.1007/s12105-013-0476-6. Epub 2013 Jul 24.


Dysregulation of mTOR activity through LKB1 inactivation.

Zhou W, Marcus AI, Vertino PM.

Chin J Cancer. 2013 Aug;32(8):427-33. doi: 10.5732/cjc.013.10086. Epub 2013 May 14. Review.


LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.

Kline ER, Shupe J, Gilbert-Ross M, Zhou W, Marcus AI.

J Biol Chem. 2013 Jun 14;288(24):17663-74. doi: 10.1074/jbc.M112.444620. Epub 2013 May 1.


Integrating image analysis algorithms in a web interface for the quantification of microtubule dynamics.

Kong KY, Marcus AI, Giannakakou P, Wang MD.

Int J Comput Biol Drug Des. 2012;5(3-4):298-313. doi: 10.1504/IJCBDD.2012.049211. Epub 2012 Sep 24.


AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain.

Thaiparambil JT, Eggers CM, Marcus AI.

Mol Cell Biol. 2012 Aug;32(16):3203-17. doi: 10.1128/MCB.00418-12. Epub 2012 Jun 11.


STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells.

Eggers CM, Kline ER, Zhong D, Zhou W, Marcus AI.

J Biol Chem. 2012 May 25;287(22):18758-68. doi: 10.1074/jbc.M111.316422. Epub 2012 Apr 6.


Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.

Olivera A, Moore TW, Hu F, Brown AP, Sun A, Liotta DC, Snyder JP, Yoon Y, Shim H, Marcus AI, Miller AH, Pace TW.

Int Immunopharmacol. 2012 Feb;12(2):368-77. doi: 10.1016/j.intimp.2011.12.009. Epub 2011 Dec 22.


A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias.

Khoury HJ, Garcia-Manero G, Borthakur G, Kadia T, Foudray MC, Arellano M, Langston A, Bethelmie-Bryan B, Rush S, Litwiler K, Karan S, Simmons H, Marcus AI, Ptaszynski M, Kantarjian H.

Cancer. 2012 Jul 15;118(14):3556-64. doi: 10.1002/cncr.26664. Epub 2011 Dec 2.


A Web Interface for the Quantification of Microtubule Dynamics.

Kong KY, Marcus AI, Giaanakakou P, Wang MD.

IEEE Int Conf Bioinform Biomed Workshops. 2011 Nov;2011:209-214.


Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis.

Kline ER, Muller S, Pan L, Tighiouart M, Chen ZG, Marcus AI.

Head Neck. 2011 Oct;33(10):1501-12. doi: 10.1002/hed.21638. Epub 2010 Dec 9.


Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation.

Thaiparambil JT, Bender L, Ganesh T, Kline E, Patel P, Liu Y, Tighiouart M, Vertino PM, Harvey RD, Garcia A, Marcus AI.

Int J Cancer. 2011 Dec 1;129(11):2744-55. doi: 10.1002/ijc.25938. Epub 2011 May 2.


LKB1 regulated pathways in lung cancer invasion and metastasis.

Marcus AI, Zhou W.

J Thorac Oncol. 2010 Dec;5(12):1883-6. doi: 10.1097/JTO.0b013e3181fbc28a. Review.


Automatic tip selection for microtubule dynamics quantification.

Malavé MO, Zhao X, Kong KY, Marcus AI, Wang MD.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:3142-5. doi: 10.1109/IEMBS.2010.5627190.


Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes.

David E, Kaufman JL, Flowers CR, Schafer-Hales K, Torre C, Chen J, Marcus AI, Sun SY, Boise LH, Lonial S.

Blood. 2010 Dec 9;116(24):5285-8. doi: 10.1182/blood-2010-03-272393. Epub 2010 Sep 15.


p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells.

Kang S, Elf S, Lythgoe K, Hitosugi T, Taunton J, Zhou W, Xiong L, Wang D, Muller S, Fan S, Sun SY, Marcus AI, Gu TL, Polakiewicz RD, Chen ZG, Khuri FR, Shin DM, Chen J.

J Clin Invest. 2010 Apr;120(4):1165-77. doi: 10.1172/JCI40582. Epub 2010 Mar 15.


Biomolecule labeling and imaging with a new fluorenyl two-photon fluorescent probe.

Morales AR, Yanez CO, Schafer-Hales KJ, Marcus AI, Belfield KD.

Bioconjug Chem. 2009 Oct 21;20(10):1992-2000. doi: 10.1021/bc900302t. Epub 2009 Oct 2.


Excited state intramolecular proton transfer and photophysics of a new fluorenyl two-photon fluorescent probe.

Morales AR, Schafer-Hales KJ, Yanez CO, Bondar MV, Przhonska OV, Marcus AI, Belfield KD.

Chemphyschem. 2009 Aug 24;10(12):2073-81. doi: 10.1002/cphc.200900032.


Modulation of choroidal neovascularization by subretinal injection of retinal pigment epithelium and polystyrene microbeads.

Schmack I, Berglin L, Nie X, Wen J, Kang SJ, Marcus AI, Yang H, Lynn MJ, Kapp JA, Grossniklaus HE.

Mol Vis. 2009;15:146-61. Epub 2009 Jan 21.


Amine-reactive fluorene probes: synthesis, optical characterization, bioconjugation, and two-photon fluorescence imaging.

Morales AR, Schafer-Hales KJ, Marcus AI, Belfield KD.

Bioconjug Chem. 2008 Dec;19(12):2559-67. doi: 10.1021/bc800415t.


2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1/AMP-activated protein kinase signaling activation or glycolysis inhibition.

Zhong D, Liu X, Schafer-Hales K, Marcus AI, Khuri FR, Sun SY, Zhou W.

Mol Cancer Ther. 2008 Apr;7(4):809-17. doi: 10.1158/1535-7163.MCT-07-0559.


The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.

Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI.

Cancer Res. 2008 Feb 1;68(3):740-8. doi: 10.1158/0008-5472.CAN-07-2989.


Visualization of spindle behavior using confocal microscopy.

Marcus AI.

Methods Mol Med. 2007;137:125-37.


Automatic microtubule tracking for QD-based in vivo cell imaging and drug efficacy study.

Kong KY, Marcus AI, Hong JY, Giannakakou P, Wang MD.

Conf Proc IEEE Eng Med Biol Soc. 2006;2006:3321-4.


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