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Items: 1 to 50 of 146

1.

Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.

Culley KL, Lessard SG, Green JD, Quinn J, Chang J, Khilnani T, Wondimu EB, Dragomir CL, Marcu KB, Goldring MB, Otero M.

Sci Rep. 2019 Jun 20;9(1):8905. doi: 10.1038/s41598-019-45334-5.

2.

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy.

Singh P, Marcu KB, Goldring MB, Otero M.

Ann N Y Acad Sci. 2019 Apr;1442(1):17-34. doi: 10.1111/nyas.13930. Epub 2018 Jul 15. Review.

PMID:
30008181
3.

Roles of NF-κB Signaling in the Regulation of miRNAs Impacting on Inflammation in Cancer.

Markopoulos GS, Roupakia E, Tokamani M, Alabasi G, Sandaltzopoulos R, Marcu KB, Kolettas E.

Biomedicines. 2018 Mar 30;6(2). pii: E40. doi: 10.3390/biomedicines6020040. Review.

4.

A step-by-step microRNA guide to cancer development and metastasis.

Markopoulos GS, Roupakia E, Tokamani M, Chavdoula E, Hatziapostolou M, Polytarchou C, Marcu KB, Papavassiliou AG, Sandaltzopoulos R, Kolettas E.

Cell Oncol (Dordr). 2017 Aug;40(4):303-339. doi: 10.1007/s13402-017-0341-9. Epub 2017 Jul 26. Review.

PMID:
28748501
5.

RTA Occupancy of the Origin of Lytic Replication during Murine Gammaherpesvirus 68 Reactivation from B Cell Latency.

Santana AL, Oldenburg DG, Kirillov V, Malik L, Dong Q, Sinayev R, Marcu KB, White DW, Krug LT.

Pathogens. 2017 Feb 16;6(1). pii: E9. doi: 10.3390/pathogens6010009.

6.

Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation.

Olivotto E, Otero M, Marcu KB, Goldring MB.

RMD Open. 2015 Aug 15;1(Suppl 1):e000061. doi: 10.1136/rmdopen-2015-000061. eCollection 2015. Review.

7.

Cell migration to CXCL12 requires simultaneous IKKα and IKKβ-dependent NF-κB signaling.

Penzo M, Habiel DM, Ramadass M, Kew RR, Marcu KB.

Biochim Biophys Acta. 2014 Sep;1843(9):1796-1804. doi: 10.1016/j.bbamcr.2014.04.011. Epub 2014 Apr 18.

8.

IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation.

Olivotto E, Otero M, Astolfi A, Platano D, Facchini A, Pagani S, Flamigni F, Facchini A, Goldring MB, Borzì RM, Marcu KB.

PLoS One. 2013 Sep 2;8(9):e73024. doi: 10.1371/journal.pone.0073024. eCollection 2013.

9.

Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites.

Hashimoto K, Otero M, Imagawa K, de Andrés MC, Coico JM, Roach HI, Oreffo RO, Marcu KB, Goldring MB.

J Biol Chem. 2013 Apr 5;288(14):10061-72. doi: 10.1074/jbc.M112.421156. Epub 2013 Feb 15.

10.

IKKβ in myeloid cells controls the host response to lethal and sublethal Francisella tularensis LVS infection.

Samaniego S, Marcu KB.

PLoS One. 2013;8(1):e54124. doi: 10.1371/journal.pone.0054124. Epub 2013 Jan 22.

11.

The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage.

Sfikas A, Batsi C, Tselikou E, Vartholomatos G, Monokrousos N, Pappas P, Christoforidis S, Tzavaras T, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E.

Cell Signal. 2012 Nov;24(11):2007-23. doi: 10.1016/j.cellsig.2012.06.010. Epub 2012 Jun 29.

12.

The IKKα-dependent NF-κB p52/RelB noncanonical pathway is essential to sustain a CXCL12 autocrine loop in cells migrating in response to HMGB1.

Kew RR, Penzo M, Habiel DM, Marcu KB.

J Immunol. 2012 Mar 1;188(5):2380-6. doi: 10.4049/jimmunol.1102454. Epub 2012 Jan 27.

13.

Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis.

Goldring MB, Marcu KB.

Trends Mol Med. 2012 Feb;18(2):109-18. doi: 10.1016/j.molmed.2011.11.005. Epub 2011 Dec 17. Review.

14.

E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress.

Otero M, Plumb DA, Tsuchimochi K, Dragomir CL, Hashimoto K, Peng H, Olivotto E, Bevilacqua M, Tan L, Yang Z, Zhan Y, Oettgen P, Li Y, Marcu KB, Goldring MB.

J Biol Chem. 2012 Jan 27;287(5):3559-72. doi: 10.1074/jbc.M111.265744. Epub 2011 Dec 9.

15.

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages.

Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, Bliska JB.

PLoS Pathog. 2011 Apr;7(4):e1002026. doi: 10.1371/journal.ppat.1002026. Epub 2011 Apr 21.

16.

Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.

Goldring MB, Otero M, Plumb DA, Dragomir C, Favero M, El Hachem K, Hashimoto K, Roach HI, Olivotto E, Borzì RM, Marcu KB.

Eur Cell Mater. 2011 Feb 24;21:202-20.

17.

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype.

Storci G, Sansone P, Mari S, D'Uva G, Tavolari S, Guarnieri T, Taffurelli M, Ceccarelli C, Santini D, Chieco P, Marcu KB, Bonafè M.

J Cell Physiol. 2010 Nov;225(3):682-91. doi: 10.1002/jcp.22264.

18.

Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors.

Borzí RM, Olivotto E, Pagani S, Vitellozzi R, Neri S, Battistelli M, Falcieri E, Facchini A, Flamigni F, Penzo M, Platano D, Santi S, Facchini A, Marcu KB.

Arthritis Rheum. 2010 Aug;62(8):2370-81. doi: 10.1002/art.27512.

19.

Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected].

Penzo M, Molteni R, Suda T, Samaniego S, Raucci A, Habiel DM, Miller F, Jiang HP, Li J, Pardi R, Palumbo R, Olivotto E, Kew RR, Bianchi ME, Marcu KB.

J Immunol. 2010 Apr 15;184(8):4497-509. doi: 10.4049/jimmunol.0903131. Epub 2010 Mar 15. Erratum in: J Immunol. 2010 Jun 15;184(12):7314.

20.

NF-kappaB signaling: multiple angles to target OA.

Marcu KB, Otero M, Olivotto E, Borzi RM, Goldring MB.

Curr Drug Targets. 2010 May;11(5):599-613. Review.

21.

GADD45beta enhances Col10a1 transcription via the MTK1/MKK3/6/p38 axis and activation of C/EBPbeta-TAD4 in terminally differentiating chondrocytes.

Tsuchimochi K, Otero M, Dragomir CL, Plumb DA, Zerbini LF, Libermann TA, Marcu KB, Komiya S, Ijiri K, Goldring MB.

J Biol Chem. 2010 Mar 12;285(11):8395-407. doi: 10.1074/jbc.M109.038638. Epub 2010 Jan 4.

22.

Cartilage homeostasis in health and rheumatic diseases.

Goldring MB, Marcu KB.

Arthritis Res Ther. 2009;11(3):224. doi: 10.1186/ar2592. Epub 2009 May 19. Review.

23.

Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation.

Batsi C, Markopoulou S, Kontargiris E, Charalambous C, Thomas C, Christoforidis S, Kanavaros P, Constantinou AI, Marcu KB, Kolettas E.

Biochem Pharmacol. 2009 Jul 1;78(1):33-44. doi: 10.1016/j.bcp.2009.03.017. Epub 2009 Mar 27.

24.

Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response.

Batsi C, Markopoulou S, Vartholomatos G, Georgiou I, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E.

Mech Ageing Dev. 2009 Jul;130(7):409-19. doi: 10.1016/j.mad.2009.04.002. Epub 2009 May 3.

25.

Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanism.

Giovannini C, Gramantieri L, Chieco P, Minguzzi M, Lago F, Pianetti S, Ramazzotti E, Marcu KB, Bolondi L.

J Hepatol. 2009 May;50(5):969-79. doi: 10.1016/j.jhep.2008.12.032. Epub 2009 Mar 10.

PMID:
19304334
26.

Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1.

Penzo M, Massa PE, Olivotto E, Bianchi F, Borzi RM, Hanidu A, Li X, Li J, Marcu KB.

J Cell Physiol. 2009 Jan;218(1):215-27. doi: 10.1002/jcp.21596. Erratum in: J Cell Physiol. 2010 Aug;224(2):566.

27.

Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.

Olivotto E, Borzi RM, Vitellozzi R, Pagani S, Facchini A, Battistelli M, Penzo M, Li X, Flamigni F, Li J, Falcieri E, Facchini A, Marcu KB.

Arthritis Rheum. 2008 Jan;58(1):227-39. doi: 10.1002/art.23211. Erratum in: Arthritis Rheum. 2008 Mar;58(3):887.

28.

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland.

Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M, Ceccarelli C, Santini D, Paterini P, Marcu KB, Chieco P, Bonafè M.

J Clin Invest. 2007 Dec;117(12):3988-4002.

29.

Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-kappaB activation.

Palumbo R, Galvez BG, Pusterla T, De Marchis F, Cossu G, Marcu KB, Bianchi ME.

J Cell Biol. 2007 Oct 8;179(1):33-40.

30.

IkappaB kinase subunits alpha and gamma are required for activation of NF-kappaB and induction of apoptosis by mammalian reovirus.

Hansberger MW, Campbell JA, Danthi P, Arrate P, Pennington KN, Marcu KB, Ballard DW, Dermody TS.

J Virol. 2007 Feb;81(3):1360-71. Epub 2006 Nov 22.

31.

Authors reply to I.B. Rogozin and Y.I. Pavlov: 'The cytidine deaminase AID exhibits similar functional properties in yeast and mammals'.

Krause K, Marcu KB, Greeve J.

Mol Immunol. 2006 Apr;43(11):1924-6. Epub 2005 Dec 6. No abstract available.

PMID:
16337270
32.

The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system.

Krause K, Marcu KB, Greeve J.

Mol Immunol. 2006 Feb;43(4):295-307. Epub 2005 Jun 15.

33.
34.

Polyamine depletion inhibits NF-kappaB binding to DNA and interleukin-8 production in human chondrocytes stimulated by tumor necrosis factor-alpha.

Facchini A, Borzí RM, Marcu KB, Stefanelli C, Olivotto E, Goldring MB, Facchini A, Flamigni F.

J Cell Physiol. 2005 Sep;204(3):956-63.

35.

Gene expression profiling in conjunction with physiological rescues of IKKalpha-null cells with wild type or mutant IKKalpha reveals distinct classes of IKKalpha/NF-kappaB-dependent genes.

Massa PE, Li X, Hanidu A, Siamas J, Pariali M, Pareja J, Savitt AG, Catron KM, Li J, Marcu KB.

J Biol Chem. 2005 Apr 8;280(14):14057-69. Epub 2005 Feb 4.

36.

Chemokines in cartilage degradation.

Borzì RM, Mazzetti I, Marcu KB, Facchini A.

Clin Orthop Relat Res. 2004 Oct;(427 Suppl):S53-61. Review.

PMID:
15480075
37.

Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas.

Greeve J, Philipsen A, Krause K, Klapper W, Heidorn K, Castle BE, Janda J, Marcu KB, Parwaresch R.

Blood. 2003 May 1;101(9):3574-80. Epub 2003 Jan 2.

38.

IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

Li X, Massa PE, Hanidu A, Peet GW, Aro P, Savitt A, Mische S, Li J, Marcu KB.

J Biol Chem. 2002 Nov 22;277(47):45129-40. Epub 2002 Sep 6.

39.

Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition.

Li J, Peet GW, Balzarano D, Li X, Massa P, Barton RW, Marcu KB.

J Biol Chem. 2001 May 25;276(21):18579-90. Epub 2001 Feb 21.

40.
41.

Activation and regulation of the IkappaB kinase in human B cells by CD40 signaling.

Kosaka Y, Calderhead DM, Manning EM, Hambor JE, Black A, Geleziunas R, Marcu KB, Noelle RJ.

Eur J Immunol. 1999 Apr;29(4):1353-62.

42.

Recombinant IkappaB kinases alpha and beta are direct kinases of Ikappa Balpha.

Li J, Peet GW, Pullen SS, Schembri-King J, Warren TC, Marcu KB, Kehry MR, Barton R, Jakes S.

J Biol Chem. 1998 Nov 13;273(46):30736-41.

43.

Molecular determinants of NF-kappaB-inducing kinase action.

Lin X, Mu Y, Cunningham ET Jr, Marcu KB, Geleziunas R, Greene WC.

Mol Cell Biol. 1998 Oct;18(10):5899-907.

44.

Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.

Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC.

Mol Cell Biol. 1998 Sep;18(9):5157-65.

45.

Generation of switch hybrid DNA between Ig heavy chain-mu and downstream switch regions in B lymphocytes.

Müller JR, Giese T, Henry DL, Mushinski JF, Marcu KB.

J Immunol. 1998 Aug 1;161(3):1354-62.

46.

Efficient recombination of a switch substrate retrovector in CD40-activated B lymphocytes: implications for the control of CH gene switch recombination.

Ballantyne J, Henry DL, Muller JR, Briere F, Snapper CM, Kehry M, Marcu KB.

J Immunol. 1998 Aug 1;161(3):1336-47. Erratum in: J Immunol 1999 Mar 1;162(5):3103.

48.
50.

The immunoglobulin class switch: beyond "accessibility".

Snapper CM, Marcu KB, Zelazowski P.

Immunity. 1997 Mar;6(3):217-23. Review. No abstract available.

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