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Items: 21


Developmental differences in stress responding after repeated underwater trauma exposures in rats.

Altman DE, Simmons LP, Vuong CT, Taylor RM, Sousa JC, Marcsisin SR, Zottig VE, Moore NLT.

Stress. 2018 May;21(3):267-273. doi: 10.1080/10253890.2018.1439012. Epub 2018 Feb 16.


A Randomized Trial Evaluating the Prophylactic Activity of DSM265 Against Preerythrocytic Plasmodium falciparum Infection During Controlled Human Malarial Infection by Mosquito Bites and Direct Venous Inoculation.

Murphy SC, Duke ER, Shipman KJ, Jensen RL, Fong Y, Ferguson S, Janes HE, Gillespie K, Seilie AM, Hanron AE, Rinn L, Fishbaugher M, VonGoedert T, Fritzen E, Kappe SH, Chang M, Sousa JC, Marcsisin SR, Chalon S, Duparc S, Kerr N, Möhrle JJ, Andenmatten N, Rueckle T, Kublin JG.

J Infect Dis. 2018 Feb 14;217(5):693-702. doi: 10.1093/infdis/jix613. Erratum in: J Infect Dis. 2018 Jul 2;218(3):508.


Comparison of Anti-Xa Activity in Patients Receiving Apixaban or Rivaroxaban.

Bookstaver DA, Sparks K, Pybus BS, Davis DK, Marcsisin SR, Sousa JC.

Ann Pharmacother. 2018 Mar;52(3):251-256. doi: 10.1177/1060028017738262. Epub 2017 Oct 19.


Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.

Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S.

Structure. 2017 Jul 5;25(7):1089-1099.e3. doi: 10.1016/j.str.2017.05.020. Epub 2017 Jun 22.


Cytochrome P450 2D-mediated metabolism is not necessary for tafenoquine and primaquine to eradicate the erythrocytic stages of Plasmodium berghei.

Milner EE, Berman J, Caridha D, Dickson SP, Hickman M, Lee PJ, Marcsisin SR, Read LT, Roncal N, Vesely BA, Xie LH, Zhang J, Zhang P, Li Q.

Malar J. 2016 Dec 7;15(1):588.


Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate Dehydrogenase Deficiency: Implications for Use in Malaria Transmission-Blocking Programs.

Wickham KS, Baresel PC, Marcsisin SR, Sousa J, Vuong CT, Reichard GA, Campo B, Tekwani BL, Walker LA, Rochford R.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5906-13. doi: 10.1128/AAC.00600-16. Print 2016 Oct.


Pre-clinical evaluation of CYP 2D6 dependent drug-drug interactions between primaquine and SSRI/SNRI antidepressants.

Jin X, Potter B, Luong TL, Nelson J, Vuong C, Potter C, Xie L, Zhang J, Zhang P, Sousa J, Li Q, Pybus BS, Kreishman-Deitrick M, Hickman M, Smith PL, Paris R, Reichard G, Marcsisin SR.

Malar J. 2016 May 17;15(1):280. doi: 10.1186/s12936-016-1329-z.


Differential kinetic profiles and metabolism of primaquine enantiomers by human hepatocytes.

Fasinu PS, Avula B, Tekwani BL, Nanayakkara NP, Wang YH, Bandara Herath HM, McChesney JD, Reichard GA, Marcsisin SR, Elsohly MA, Khan SI, Khan IA, Walker LA.

Malar J. 2016 Apr 19;15:224. doi: 10.1186/s12936-016-1270-1.


Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art.

Marcsisin SR, Reichard G, Pybus BS.

Pharmacol Ther. 2016 May;161:1-10. doi: 10.1016/j.pharmthera.2016.03.011. Epub 2016 Mar 22. Review.


Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe.

Marcsisin SR, Liptak C, Marineau J, Bradner JE, Engen JR.

Anal Chem. 2015 Jun 16;87(12):6349-56. doi: 10.1021/acs.analchem.5b01220. Epub 2015 May 29.


Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics.

Vuong C, Xie LH, Potter BM, Zhang J, Zhang P, Duan D, Nolan CK, Sciotti RJ, Zottig VE, Nanayakkara NP, Tekwani BL, Walker LA, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Smith B, Marcsisin SR.

Antimicrob Agents Chemother. 2015 Jul;59(7):3864-9. doi: 10.1128/AAC.00343-15. Epub 2015 Apr 13.


Differential CYP 2D6 metabolism alters primaquine pharmacokinetics.

Potter BM, Xie LH, Vuong C, Zhang J, Zhang P, Duan D, Luong TL, Bandara Herath HM, Dhammika Nanayakkara NP, Tekwani BL, Walker LA, Nolan CK, Sciotti RJ, Zottig VE, Smith PL, Paris RM, Read LT, Li Q, Pybus BS, Sousa JC, Reichard GA, Marcsisin SR.

Antimicrob Agents Chemother. 2015 Apr;59(4):2380-7. doi: 10.1128/AAC.00015-15. Epub 2015 Feb 2.


Enantioselective metabolism of primaquine by human CYP2D6.

Fasinu PS, Tekwani BL, Nanayakkara NP, Avula B, Herath HM, Wang YH, Adelli VR, Elsohly MA, Khan SI, Khan IA, Pybus BS, Marcsisin SR, Reichard GA, McChesney JD, Walker LA.

Malar J. 2014 Dec 17;13:507. doi: 10.1186/1475-2875-13-507.


Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations.

Jin X, Luong TL, Reese N, Gaona H, Collazo-Velez V, Vuong C, Potter B, Sousa JC, Olmeda R, Li Q, Xie L, Zhang J, Zhang P, Reichard G, Melendez V, Marcsisin SR, Pybus BS.

J Pharmacol Toxicol Methods. 2014 Sep-Oct;70(2):188-94. doi: 10.1016/j.vascn.2014.08.002. Epub 2014 Aug 20.


Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds.

Marcsisin SR, Sousa JC, Reichard GA, Caridha D, Zeng Q, Roncal N, McNulty R, Careagabarja J, Sciotti RJ, Bennett JW, Zottig VE, Deye G, Li Q, Read L, Hickman M, Dhammika Nanayakkara NP, Walker LA, Smith B, Melendez V, Pybus BS.

Malar J. 2014 Jan 3;13:2. doi: 10.1186/1475-2875-13-2.


Ethosuximide and phenytoin dose-dependently attenuate acute nonconvulsive seizures after traumatic brain injury in rats.

Mountney A, Shear DA, Potter B, Marcsisin SR, Sousa J, Melendez V, Tortella FC, Lu XC.

J Neurotrauma. 2013 Dec 1;30(23):1973-82. doi: 10.1089/neu.2013.3001. Epub 2013 Oct 18.


CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever.

Marcsisin SR, Jin X, Bettger T, McCulley N, Sousa JC, Shanks GD, Tekwani BL, Sahu R, Reichard GA, Sciotti RJ, Melendez V, Pybus BS.

Malar J. 2013 Jun 21;12:214. doi: 10.1186/1475-2875-12-214.


The metabolism of primaquine to its active metabolite is dependent on CYP 2D6.

Pybus BS, Marcsisin SR, Jin X, Deye G, Sousa JC, Li Q, Caridha D, Zeng Q, Reichard GA, Ockenhouse C, Bennett J, Walker LA, Ohrt C, Melendez V.

Malar J. 2013 Jun 20;12:212. doi: 10.1186/1475-2875-12-212.


On the solution conformation and dynamics of the HIV-1 viral infectivity factor.

Marcsisin SR, Narute PS, Emert-Sedlak LA, Kloczewiak M, Smithgall TE, Engen JR.

J Mol Biol. 2011 Jul 29;410(5):1008-22. doi: 10.1016/j.jmb.2011.04.053.


Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif.

Marcsisin SR, Engen JR.

J Mol Biol. 2010 Oct 8;402(5):892-904. doi: 10.1016/j.jmb.2010.08.026. Epub 2010 Aug 20.


Hydrogen exchange mass spectrometry: what is it and what can it tell us?

Marcsisin SR, Engen JR.

Anal Bioanal Chem. 2010 Jun;397(3):967-72. doi: 10.1007/s00216-010-3556-4. Epub 2010 Mar 1. Review.

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