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A new strategy for vascular complications in young people with type 1 diabetes mellitus.

Marcovecchio ML, Dalton RN, Daneman D, Deanfield J, Jones TW, Neil HAW, Dunger DB; Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group.

Nat Rev Endocrinol. 2019 Jul;15(7):429-435. doi: 10.1038/s41574-019-0198-2. Review.


Elevated high-density lipoprotein in adolescents with Type 1 diabetes is associated with endothelial dysfunction in the presence of systemic inflammation.

Chiesa ST, Charakida M, McLoughlin E, Nguyen HC, Georgiopoulos G, Motran L, Elia Y, Marcovecchio ML, Dunger DB, Dalton RN, Daneman D, Sochett E, Mahmud FH, Deanfield JE.

Eur Heart J. 2019 Mar 12. pii: ehz114. doi: 10.1093/eurheartj/ehz114. [Epub ahead of print]


Role of THRB, ARG1, and ADRB2 Genetic Variants on Bronchodilators Response in Asthmatic Children.

Scaparrotta A, Franzago M, Marcovecchio ML, Di Pillo S, Chiarelli F, Mohn A, Stuppia L.

J Aerosol Med Pulm Drug Deliv. 2019 Jun;32(3):164-173. doi: 10.1089/jamp.2018.1493. Epub 2019 Mar 11.


ISPAD Clinical Practice Consensus Guidelines 2018: Microvascular and macrovascular complications in children and adolescents.

Donaghue KC, Marcovecchio ML, Wadwa RP, Chew EY, Wong TY, Calliari LE, Zabeen B, Salem MA, Craig ME.

Pediatr Diabetes. 2018 Oct;19 Suppl 27:262-274. doi: 10.1111/pedi.12742. No abstract available.


Renal and Cardiovascular Risk According to Tertiles of Urinary Albumin-to-Creatinine Ratio: The Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT).

Marcovecchio ML, Chiesa ST, Armitage J, Daneman D, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dalton RN, Deanfield J, Dunger DB; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group.

Diabetes Care. 2018 Sep;41(9):1963-1969. doi: 10.2337/dc18-1125. Epub 2018 Jul 19.


A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, McKeigue PM, Valo E, Forsblom C, Harjutsalo V; Finnish Diabetic Nephropathy Study (FinnDiane), Perna A, Rurali E, Marcovecchio ML, Igo RP Jr, Salem RM, Perico N, Lajer M, Käräjämäki A, Imamura M, Kubo M, Takahashi A, Sim X, Liu J, van Dam RM, Jiang G, Tam CHT, Luk AOY, Lee HM, Lim CKP, Szeto CC, So WY, Chan JCN; Hong Kong Diabetes Registry Theme-based Research Scheme Project Group, Ang SF, Dorajoo R, Wang L, Clara TSH, McKnight AJ, Duffy S; Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group, Pezzolesi MG; GENIE (GEnetics of Nephropathy an International Effort) Consortium, Marre M, Gyorgy B, Hadjadj S, Hiraki LT; Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, Ahluwalia TS, Almgren P, Schulz CA, Orho-Melander M, Linneberg A, Christensen C, Witte DR, Grarup N, Brandslund I, Melander O, Paterson AD, Tregouet D, Maxwell AP, Lim SC, Ma RCW, Tai ES, Maeda S, Lyssenko V, Tuomi T, Krolewski AS, Rich SS, Hirschhorn JN, Florez JC, Dunger D, Pedersen O, Hansen T, Rossing P, Remuzzi G; SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium, Brosnan MJ, Palmer CNA, Groop PH, Colhoun HM, Groop LC, McCarthy MI.

Diabetes. 2018 Jul;67(7):1414-1427. doi: 10.2337/db17-0914. Epub 2018 Apr 27.


Biomarkers of diabetic kidney disease.

Colhoun HM, Marcovecchio ML.

Diabetologia. 2018 May;61(5):996-1011. doi: 10.1007/s00125-018-4567-5. Epub 2018 Mar 8. Review.


ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes.

Dunger DB, Marcovecchio ML, Deanfield J.

N Engl J Med. 2018 Feb 8;378(6):580-581. doi: 10.1056/NEJMc1715763. No abstract available.


Usefulness of molecular diagnosis in egg allergic children.

Petrosino MI, Scaparrotta A, Marcovecchio ML, Panichi D, Rapino D, Attanasi M, Filippo PD, Pillo SD, Chiarelli F.

Arch Med Sci. 2018 Jan;14(1):132-137. doi: 10.5114/aoms.2016.58796. Epub 2016 Mar 23.


Cardiovascular autonomic dysfunction predicts increasing albumin excretion in type 1 diabetes.

Lu L, Marcovecchio ML, Dalton RN, Dunger D.

Pediatr Diabetes. 2018 May;19(3):464-469. doi: 10.1111/pedi.12614. Epub 2017 Nov 24.


90K immunostimulatory glycoprotein in children with juvenile idiopathic arthritis.

Cecamore C, Marsili M, Salvatore R, Troiani R, D'Egidio M, Tinari N, Pelliccia P, Chiarelli F, Marcovecchio ML, Breda L.

Mod Rheumatol. 2018 Jul;28(4):637-641. doi: 10.1080/14397595.2017.1397895. Epub 2017 Nov 20.


ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes.

Marcovecchio ML, Chiesa ST, Bond S, Daneman D, Dawson S, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dalton RN, Deanfield J, Dunger DB; AdDIT Study Group.

N Engl J Med. 2017 Nov 2;377(18):1733-1745. doi: 10.1056/NEJMoa1703518.


Pharmacotherapy options for pediatric diabetes.

Marcovecchio ML, Chiarelli F.

Curr Opin Pediatr. 2017 Aug;29(4):481-487. doi: 10.1097/MOP.0000000000000504. Review.


Clustering of cardio-metabolic risk factors in parents of adolescents with type 1 diabetes and microalbuminuria.

Marcovecchio ML, Tossavainen PH, Owen K, Fullah C, Benitez-Aguirre P, Masi S, Ong K, Nguyen H, Chiesa ST, Dalton RN, Deanfield J, Dunger DB.

Pediatr Diabetes. 2017 Dec;18(8):947-954. doi: 10.1111/pedi.12515. Epub 2017 Mar 8.


One-hour post-load plasma glucose levels associated with decreased insulin sensitivity and secretion and early makers of cardiometabolic risk.

Marcovecchio ML, Bagordo M, Marisi E, de Giorgis T, Chiavaroli V, Chiarelli F, Mohn A.

J Endocrinol Invest. 2017 Jul;40(7):771-778. doi: 10.1007/s40618-017-0638-6. Epub 2017 Mar 1.


Plasma from pre-pubertal obese children impairs insulin stimulated Nitric Oxide (NO) bioavailability in endothelial cells: Role of ER stress.

Di Pietro N, Marcovecchio ML, Di Silvestre S, de Giorgis T, Cordone VGP, Lanuti P, Chiarelli F, Bologna G, Mohn A, Pandolfi A.

Mol Cell Endocrinol. 2017 Mar 5;443:52-62. doi: 10.1016/j.mce.2017.01.001. Epub 2017 Jan 3.


Being born large for gestational age is associated with earlier pubertal take-off and longer growth duration: a longitudinal study.

Di Giovanni I, Marcovecchio ML, Chiavaroli V, de Giorgis T, Chiarelli F, Mohn A.

Acta Paediatr. 2017 Jan;106(1):61-66. doi: 10.1111/apa.13633. Epub 2016 Nov 14.


The Genetic Landscape of Renal Complications in Type 1 Diabetes.

Sandholm N, Van Zuydam N, Ahlqvist E, Juliusdottir T, Deshmukh HA, Rayner NW, Di Camillo B, Forsblom C, Fadista J, Ziemek D, Salem RM, Hiraki LT, Pezzolesi M, Trégouët D, Dahlström E, Valo E, Oskolkov N, Ladenvall C, Marcovecchio ML, Cooper J, Sambo F, Malovini A, Manfrini M, McKnight AJ, Lajer M, Harjutsalo V, Gordin D, Parkkonen M; The FinnDiane Study Group, Tuomilehto J, Lyssenko V, McKeigue PM, Rich SS, Brosnan MJ, Fauman E, Bellazzi R, Rossing P, Hadjadj S, Krolewski A, Paterson AD; The DCCT/EDIC Study Group, Florez JC, Hirschhorn JN, Maxwell AP; GENIE Consortium, Dunger D, Cobelli C, Colhoun HM, Groop L, McCarthy MI, Groop PH; SUMMIT Consortium.

J Am Soc Nephrol. 2017 Feb;28(2):557-574. doi: 10.1681/ASN.2016020231. Epub 2016 Sep 19.


Increased GLP-1 response to oral glucose in pre-pubertal obese children.

Giannini C, Pietropaoli N, Polidori N, Chiarelli F, Marcovecchio ML, Mohn A.

J Pediatr Endocrinol Metab. 2016 Aug 1;29(8):901-6. doi: 10.1515/jpem-2016-0050.


Erythema multiforme syndrome associated with acute acquired cytomegalovirus infection.

Petrosino MI, Attanasi M, Marcovecchio ML, Scaparrotta A, Di Pillo S, Rossi N, Chiarelli F.

Arch Med Sci. 2016 Jun 1;12(3):684-6. doi: 10.5114/aoms.2016.59943. Epub 2016 May 18. No abstract available.


Association between markers of endothelial dysfunction and early signs of renal dysfunction in pediatric obesity and type 1 diabetes.

Marcovecchio ML, de Giorgis T, Di Giovanni I, Chiavaroli V, Chiarelli F, Mohn A.

Pediatr Diabetes. 2017 Jun;18(4):283-289. doi: 10.1111/pedi.12391. Epub 2016 Jun 1.


Low AMY1 Gene Copy Number Is Associated with Increased Body Mass Index in Prepubertal Boys.

Marcovecchio ML, Florio R, Verginelli F, De Lellis L, Capelli C, Verzilli D, Chiarelli F, Mohn A, Cama A.

PLoS One. 2016 May 5;11(5):e0154961. doi: 10.1371/journal.pone.0154961. eCollection 2016.


Influence of inhaled corticosteroids on pubertal growth and final height in asthmatic children.

De Leonibus C, Attanasi M, Roze Z, Martin B, Marcovecchio ML, Di Pillo S, Chiarelli F, Mohn A.

Pediatr Allergy Immunol. 2016 Aug;27(5):499-506. doi: 10.1111/pai.12558. Epub 2016 May 6.


Longitudinal Assessment of Blood Pressure in School-Aged Children: A 3-Year Follow-Up Study.

Marcovecchio ML, Mohn A, Diddi G, Polidori N, Chiarelli F, Fuiano N.

Pediatr Cardiol. 2016 Feb;37(2):255-61. doi: 10.1007/s00246-015-1271-9. Epub 2015 Oct 6.


Increased left atrial size in obese children and its association with insulin resistance: a pilot study.

Marcovecchio ML, Gravina M, Gallina S, D'Adamo E, De Caterina R, Chiarelli F, Mohn A, Renda G.

Eur J Pediatr. 2016 Jan;175(1):121-30. doi: 10.1007/s00431-015-2608-3. Epub 2015 Aug 15.


Blood pressure from childhood to adolescence in obese youths in relation to insulin resistance and asymmetric dimethylarginine.

de Giorgis T, Marcovecchio ML, Giannini C, Chiavaroli V, Chiarelli F, Mohn A.

J Endocrinol Invest. 2016 Feb;39(2):169-76. doi: 10.1007/s40618-015-0351-2. Epub 2015 Jul 16.


Diabetes and epilepsy in children and adolescents.

Marcovecchio ML, Petrosino MI, Chiarelli F.

Curr Diab Rep. 2015 Apr;15(4):21. doi: 10.1007/s11892-015-0588-3. Review.


Airway hyper-responsiveness to mannitol provides a good evaluation of atopy in childhood asthma.

Attanasi M, Rapino D, Marcovecchio ML, Consilvio NP, Scaparrotta A, Cingolani A, Di Pillo S, Chiarelli F.

Acta Paediatr. 2015 Jul;104(7):718-23. doi: 10.1111/apa.12968. Epub 2015 Mar 31.


ISPAD Clinical Practice Consensus Guidelines 2014. Microvascular and macrovascular complications in children and adolescents.

Donaghue KC, Wadwa RP, Dimeglio LA, Wong TY, Chiarelli F, Marcovecchio ML, Salem M, Raza J, Hofman PL, Craig ME; International Society for Pediatric and Adolescent Diabetes.

Pediatr Diabetes. 2014 Sep;15 Suppl 20:257-69. doi: 10.1111/pedi.12180. No abstract available.


Circulating asymmetric dimethylarginine and lipid profile in pre-pubertal children with growth hormone deficiency: effect of 12-month growth hormone replacement therapy.

De Marco S, Marcovecchio ML, Caniglia D, De Leonibus C, Chiarelli F, Mohn A.

Growth Horm IGF Res. 2014 Oct;24(5):216-20. doi: 10.1016/j.ghir.2014.08.001. Epub 2014 Aug 14.


The effect of obesity and type 1 diabetes on renal function in children and adolescents.

Franchini S, Savino A, Marcovecchio ML, Tumini S, Chiarelli F, Mohn A.

Pediatr Diabetes. 2015 Sep;16(6):427-33. doi: 10.1111/pedi.12196. Epub 2014 Aug 11.


Progression of cardio-metabolic risk factors in subjects born small and large for gestational age.

Chiavaroli V, Marcovecchio ML, de Giorgis T, Diesse L, Chiarelli F, Mohn A.

PLoS One. 2014 Aug 12;9(8):e104278. doi: 10.1371/journal.pone.0104278. eCollection 2014.


Association between rs12970134 Near MC4R and adiposity indexes in a homogenous population of Caucasian schoolchildren.

Marcovecchio ML, Capanna R, D'Adamo E, Mammarella S, De Lellis L, Chiarelli F, Cama A, Mohn A.

Horm Res Paediatr. 2014;82(3):187-93. doi: 10.1159/000365103. Epub 2014 Aug 12.


Lifecourse: management of type 1 diabetes.

Hattersley AT, Marcovecchio ML, Chiarelli F, Silverstein J, Heller S, Damm P, Mathiesen ER, Zinman B, Sinclair A.

Lancet Diabetes Endocrinol. 2014 Mar;2(3):194-5. doi: 10.1016/S2213-8587(13)70179-7. Epub 2014 Jan 29. No abstract available.


Low circulating levels of IGF-1 in healthy adults are associated with reduced β-cell function, increased intramyocellular lipid, and enhanced fat utilization during fasting.

Thankamony A, Capalbo D, Marcovecchio ML, Sleigh A, Jørgensen SW, Hill NR, Mooslehner K, Yeo GS, Bluck L, Juul A, Vaag A, Dunger DB.

J Clin Endocrinol Metab. 2014 Jun;99(6):2198-207. doi: 10.1210/jc.2013-4542. Epub 2014 Mar 11.


Genome-wide association study of urinary albumin excretion rate in patients with type 1 diabetes.

Sandholm N, Forsblom C, Mäkinen VP, McKnight AJ, Osterholm AM, He B, Harjutsalo V, Lithovius R, Gordin D, Parkkonen M, Saraheimo M, Thorn LM, Tolonen N, Wadén J, Tuomilehto J, Lajer M, Ahlqvist E, Möllsten A, Marcovecchio ML, Cooper J, Dunger D, Paterson AD, Zerbini G, Groop L; SUMMIT Consortium, Tarnow L, Maxwell AP, Tryggvason K, Groop PH; FinnDiane Study Group.

Diabetologia. 2014 Jun;57(6):1143-53. doi: 10.1007/s00125-014-3202-3. Epub 2014 Mar 5.


Usefulness of nBos d 4, 5 and nBos d 8 Specific IgE Antibodies in Cow's Milk Allergic Children.

Cingolani A, Di Pillo S, Cerasa M, Rapino D, Consilvio NP, Attanasi M, Scaparrotta A, Marcovecchio ML, Mohn A, Chiarelli F.

Allergy Asthma Immunol Res. 2014 Mar;6(2):121-5. doi: 10.4168/aair.2014.6.2.121. Epub 2013 Nov 8.


An update on the pharmacotherapy options for pediatric diabetes.

Marcovecchio ML, Chiarelli F.

Expert Opin Biol Ther. 2014 Mar;14(3):355-64. doi: 10.1517/14712598.2014.874413. Epub 2014 Jan 6. Review.


Is asymmetric dimethylarginine associated with being born small and large for gestational age?

Chiavaroli V, Diesse L, de Giorgis T, Giannini C, Marcovecchio ML, Chiarelli F, Mohn A.

Antioxid Redox Signal. 2014 May 20;20(15):2317-22. doi: 10.1089/ars.2013.5787. Epub 2014 Mar 11. Review.


The contribution of glycemic control to impaired growth during puberty in young people with type 1 diabetes and microalbuminuria.

Marcovecchio ML, Heywood JJ, Dalton RN, Dunger DB.

Pediatr Diabetes. 2014 Jun;15(4):303-8. doi: 10.1111/pedi.12090. Epub 2013 Dec 9.


Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

Downes K, Marcovecchio ML, Clarke P, Cooper JD, Ferreira RC, Howson JM, Jolley J, Nutland S, Stevens HE, Walker NM, Wallace C, Dunger DB, Todd JA.

Diabetologia. 2014 Feb;57(2):366-72. doi: 10.1007/s00125-013-3113-8. Epub 2013 Nov 22.


Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): urinary screening and baseline biochemical and cardiovascular assessments.

Marcovecchio ML, Woodside J, Jones T, Daneman D, Neil A, Prevost T, Dalton RN, Deanfield J, Dunger DB; AdDIT Investigators.

Diabetes Care. 2014;37(3):805-13. doi: 10.2337/dc13-1634. Epub 2013 Nov 6.


Triglycerides-to-HDL ratio as a new marker of endothelial dysfunction in obese prepubertal children.

de Giorgis T, Marcovecchio ML, Di Giovanni I, Giannini C, Chiavaroli V, Chiarelli F, Mohn A.

Eur J Endocrinol. 2013 Dec 21;170(2):173-80. doi: 10.1530/EJE-13-0452. Print 2014 Feb.


Timing of puberty and physical growth in obese children: a longitudinal study in boys and girls.

De Leonibus C, Marcovecchio ML, Chiavaroli V, de Giorgis T, Chiarelli F, Mohn A.

Pediatr Obes. 2014 Aug;9(4):292-9. doi: 10.1111/j.2047-6310.2013.00176.x. Epub 2013 May 27.


Etanercept improves lipid profile and oxidative stress measures in patients with juvenile idiopathic arthritis.

De Sanctis S, Marcovecchio ML, Gaspari S, Del Torto M, Mohn A, Chiarelli F, Breda L.

J Rheumatol. 2013 Jun;40(6):943-8. doi: 10.3899/jrheum.121281. Epub 2013 Apr 1.


Rheumatic fever: a disease still to be kept in mind.

Breda L, Miulli E, Marzetti V, Chiarelli F, Marcovecchio ML.

Rheumatology (Oxford). 2013 May;52(5):953. doi: 10.1093/rheumatology/ket016. Epub 2013 Mar 1. No abstract available.


Obesity and growth during childhood and puberty.

Marcovecchio ML, Chiarelli F.

World Rev Nutr Diet. 2013;106:135-41. doi: 10.1159/000342545. Epub 2013 Feb 11. Review.


Update on statural growth and pubertal development in obese children.

De Leonibus C, Marcovecchio ML, Chiarelli F.

Pediatr Rep. 2012 Dec 6;4(4):e35. doi: 10.4081/pr.2012.e35.


Improved oxidative stress and cardio-metabolic status in obese prepubertal children with liver steatosis treated with lifestyle combined with Vitamin E.

D'Adamo E, Marcovecchio ML, Giannini C, de Giorgis T, Chiavaroli V, Chiarelli F, Mohn A.

Free Radic Res. 2013 Mar;47(3):146-53. doi: 10.3109/10715762.2012.755262. Epub 2013 Jan 9.


The effects of acute and chronic stress on diabetes control.

Marcovecchio ML, Chiarelli F.

Sci Signal. 2012 Oct 23;5(247):pt10. doi: 10.1126/scisignal.2003508. Review.


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