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Protective Immunity and New Vaccines for Lyme Disease.

Gomes-Solecki M, Arnaboldi PM, Backenson PB, Benach JL, Cooper CL, Dattwyler RJ, Diuk-Wasser M, Fikrig E, Hovius JW, Laegreid W, Lundberg U, Marconi RT, Marques AR, Molloy P, Narasimhan S, Pal U, Pedra JHF, Plotkin S, Rock DL, Rosa P, Telford SR, Tsao J, Yang XF, Schutzer SE.

Clin Infect Dis. 2019 Oct 17. pii: ciz872. doi: 10.1093/cid/ciz872. [Epub ahead of print]


The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity.

Caimano MJ, Groshong AM, Belperron A, Mao J, Hawley KL, Luthra A, Graham DE, Earnhart CG, Marconi RT, Bockenstedt LK, Blevins JS, Radolf JD.

Front Microbiol. 2019 Aug 21;10:1923. doi: 10.3389/fmicb.2019.01923. eCollection 2019.


Diversity of the Lyme Disease Spirochetes and its Influence on Immune Responses to Infection and Vaccination.

Izac JR, Marconi RT.

Vet Clin North Am Small Anim Pract. 2019 Jul;49(4):671-686. doi: 10.1016/j.cvsm.2019.02.007. Epub 2019 Apr 6. Review.


Analysis of the antigenic determinants of the OspC protein of the Lyme disease spirochetes: Evidence that the C10 motif is not immunodominant or required to elicit bactericidal antibody responses.

Izac JR, Camire AC, Earnhart CG, Embers ME, Funk RA, Breitschwerdt EB, Marconi RT.

Vaccine. 2019 Apr 17;37(17):2401-2407. doi: 10.1016/j.vaccine.2019.02.007. Epub 2019 Mar 25.


Outer Membrane Protein A Conservation among Orientia tsutsugamushi Isolates Suggests Its Potential as a Protective Antigen and Diagnostic Target.

Evans SM, Adcox HE, VieBrock L, Green RS, Luce-Fedrow A, Chattopadhyay S, Jiang J, Marconi RT, Paris D, Richards AL, Carlyon JA.

Trop Med Infect Dis. 2018 Jun 11;3(2). pii: E63. doi: 10.3390/tropicalmed3020063.


The Borrelia burgdorferi c-di-GMP Binding Receptors, PlzA and PlzB, Are Functionally Distinct.

Kostick-Dunn JL, Izac JR, Freedman JC, Szkotnicki LT, Oliver LD Jr, Marconi RT.

Front Cell Infect Microbiol. 2018 Jul 11;8:213. doi: 10.3389/fcimb.2018.00213. eCollection 2018.


The Treponema denticola PAS Domain-Containing Histidine Kinase Hpk2 Is a Heme Binding Sensor of Oxygen Levels.

Sarkar J, Miller DP, Oliver LD Jr.,, Marconi RT.

J Bacteriol. 2018 Aug 24;200(18). pii: e00116-18. doi: 10.1128/JB.00116-18. Print 2018 Sep 15.


Antimicrobial activity of amixicile against Treponema denticola and other oral spirochetes associated with periodontal disease.

Reed LA, O'Bier NS, Oliver LD Jr, Hoffman PS, Marconi RT.

J Periodontol. 2018 Dec;89(12):1467-1474. doi: 10.1002/JPER.17-0185. Epub 2018 Sep 5.


Erratum to: Gene Regulation, Two Component Regulatory Systems, and Adaptive Responses in Treponema Denticola.

Marconi RT.

Curr Top Microbiol Immunol. 2018;415:295. doi: 10.1007/82_2018_95. No abstract available.


Plasminogen binding and degradation by Treponema denticola: Identification of the plasminogen binding interface on the FhbB protein.

Tegels BK, Oliver LD Jr, Miller DP, Marconi RT.

Mol Oral Microbiol. 2018 Jun;33(3):249-256. doi: 10.1111/omi.12221. Epub 2018 Apr 23.


Gene Regulation, Two Component Regulatory Systems, and Adaptive Responses in Treponema Denticola.

Marconi RT.

Curr Top Microbiol Immunol. 2018;415:39-62. doi: 10.1007/82_2017_66. Review. Erratum in: Curr Top Microbiol Immunol. 2018 Jun 28;:.


Identification of a defined linear epitope in the OspA protein of the Lyme disease spirochetes that elicits bactericidal antibody responses: Implications for vaccine development.

Izac JR, Oliver LD Jr, Earnhart CG, Marconi RT.

Vaccine. 2017 May 31;35(24):3178-3185. doi: 10.1016/j.vaccine.2017.04.079. Epub 2017 May 4.


Orientia tsutsugamushi Ank9 is a multifunctional effector that utilizes a novel GRIP-like Golgi localization domain for Golgi-to-endoplasmic reticulum trafficking and interacts with host COPB2.

Beyer AR, Rodino KG, VieBrock L, Green RS, Tegels BK, Oliver LD Jr, Marconi RT, Carlyon JA.

Cell Microbiol. 2017 Jul;19(7). doi: 10.1111/cmi.12727. Epub 2017 Feb 3.


Anaplasma marginale Outer Membrane Protein A Is an Adhesin That Recognizes Sialylated and Fucosylated Glycans and Functionally Depends on an Essential Binding Domain.

Hebert KS, Seidman D, Oki AT, Izac J, Emani S, Oliver LD Jr.,, Miller DP, Tegels BK, Kannagi R, Marconi RT, Carlyon JA.

Infect Immun. 2017 Feb 23;85(3). pii: e00968-16. doi: 10.1128/IAI.00968-16. Print 2017 Mar.


Antibody profiling of canine IgG responses to the OspC protein of the Lyme disease spirochetes supports a multivalent approach in vaccine and diagnostic assay development.

Oliver LD Jr, Earnhart CG, Virginia-Rhodes D, Theisen M, Marconi RT.

Vet J. 2016 Dec;218:27-33. doi: 10.1016/j.tvjl.2016.11.001. Epub 2016 Nov 9.


Cyclic-di-GMP binding induces structural rearrangements in the PlzA and PlzC proteins of the Lyme disease and relapsing fever spirochetes: a possible switch mechanism for c-di-GMP-mediated effector functions.

Mallory KL, Miller DP, Oliver LD Jr, Freedman JC, Kostick-Dunn JL, Carlyon JA, Marion JD, Bell JK, Marconi RT.

Pathog Dis. 2016 Nov;74(8). pii: ftw105. Epub 2016 Oct 18.


The Treponema denticola FhbB Protein Is a Dominant Early Antigen That Elicits FhbB Variant-Specific Antibodies That Block Factor H Binding and Cleavage by Dentilisin.

Miller DP, Oliver LD Jr, Tegels BK, Reed LA, O'Bier NS, Kurniyati K, Faust LA, Lawson CK, Allard AM, Caimano MJ, Marconi RT.

Infect Immun. 2016 Jun 23;84(7):2051-2058. doi: 10.1128/IAI.01542-15. Print 2016 Jul.


Comparison of effectiveness of cefovecin, doxycycline, and amoxicillin for the treatment of experimentally induced early Lyme borreliosis in dogs.

Wagner B, Johnson J, Garcia-Tapia D, Honsberger N, King V, Strietzel C, Hardham JM, Heinz TJ, Marconi RT, Meeus PF.

BMC Vet Res. 2015 Jul 25;11:163. doi: 10.1186/s12917-015-0475-9.


Orientia tsutsugamushi Strain Ikeda Ankyrin Repeat-Containing Proteins Recruit SCF1 Ubiquitin Ligase Machinery via Poxvirus-Like F-Box Motifs.

Beyer AR, VieBrock L, Rodino KG, Miller DP, Tegels BK, Marconi RT, Carlyon JA.

J Bacteriol. 2015 Oct;197(19):3097-109. doi: 10.1128/JB.00276-15. Epub 2015 Jul 13.


Essential domains of Anaplasma phagocytophilum invasins utilized to infect mammalian host cells.

Seidman D, Hebert KS, Truchan HK, Miller DP, Tegels BK, Marconi RT, Carlyon JA.

PLoS Pathog. 2015 Feb 6;11(2):e1004669. doi: 10.1371/journal.ppat.1004669. eCollection 2015 Feb.


The Borrelia hermsii factor H binding protein FhbA is not required for infectivity in mice or for resistance to human complement in vitro.

Fine LM, Miller DP, Mallory KL, Tegels BK, Earnhart CG, Marconi RT.

Infect Immun. 2014 Aug;82(8):3324-32. doi: 10.1128/IAI.01892-14. Epub 2014 May 27.


Analysis of the complement sensitivity of oral treponemes and the potential influence of FH binding, FH cleavage and dentilisin activity on the pathogenesis of periodontal disease.

Miller DP, McDowell JV, Bell JK, Goetting-Minesky MP, Fenno JC, Marconi RT.

Mol Oral Microbiol. 2014 Oct;29(5):194-207. doi: 10.1111/omi.12054. Epub 2014 Jun 3.


Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells.

Seidman D, Ojogun N, Walker NJ, Mastronunzio J, Kahlon A, Hebert KS, Karandashova S, Miller DP, Tegels BK, Marconi RT, Fikrig E, Borjesson DL, Carlyon JA.

Cell Microbiol. 2014 Aug;16(8):1133-45. doi: 10.1111/cmi.12286. Epub 2014 Apr 3.


Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity.

Earnhart CG, Rhodes DV, Smith AA, Yang X, Tegels B, Carlyon JA, Pal U, Marconi RT.

Pathog Dis. 2014 Mar;70(2):176-84. doi: 10.1111/2049-632X.12119. Epub 2014 Feb 3.


Identification of Borrelia burgdorferi ospC genotypes in canine tissue following tick infestation: implications for Lyme disease vaccine and diagnostic assay design.

Rhodes DV, Earnhart CG, Mather TN, Meeus PF, Marconi RT.

Vet J. 2013 Nov;198(2):412-8. doi: 10.1016/j.tvjl.2013.07.019. Epub 2013 Aug 17.


Sequence divergence in the Treponema denticola FhbB protein and its impact on factor H binding.

Miller DP, McDowell JV, Rhodes DV, Allard A, Caimano M, Bell JK, Marconi RT.

Mol Oral Microbiol. 2013 Aug;28(4):316-30. doi: 10.1111/omi.12027. Epub 2013 Apr 22.


Structure of factor H-binding protein B (FhbB) of the periopathogen, Treponema denticola: insights into progression of periodontal disease.

Miller DP, Bell JK, McDowell JV, Conrad DH, Burgner JW, HĂ©roux A, Marconi RT.

J Biol Chem. 2012 Apr 13;287(16):12715-22. doi: 10.1074/jbc.M112.339721. Epub 2012 Feb 24.


Tick salivary proteins offer the lyme disease spirochetes an easy ride and another way to hide.

Marconi RT, McDowell JV.

Cell Host Microbe. 2011 Aug 18;10(2):95-6. doi: 10.1016/j.chom.2011.08.003.


Crystallization of the factor H-binding protein, FhbB, from the periopathogen Treponema denticola.

Miller DP, McDowell JV, Bell JK, Marconi RT.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jun 1;67(Pt 6):678-81. doi: 10.1107/S1744309111011298. Epub 2011 May 25.


The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes.

Kostick JL, Szkotnicki LT, Rogers EA, Bocci P, Raffaelli N, Marconi RT.

Mol Microbiol. 2011 Jul;81(1):219-31. doi: 10.1111/j.1365-2958.2011.07687.x. Epub 2011 Jun 5.


Disulfide-mediated oligomer formation in Borrelia burgdorferi outer surface protein C, a critical virulence factor and potential Lyme disease vaccine candidate.

Earnhart CG, Rhodes DV, Marconi RT.

Clin Vaccine Immunol. 2011 Jun;18(6):901-6. doi: 10.1128/CVI.05004-11. Epub 2011 Apr 27.


Molecular signaling mechanisms of the periopathogen, Treponema denticola.

Frederick JR, Sarkar J, McDowell JV, Marconi RT.

J Dent Res. 2011 Oct;90(10):1155-63. doi: 10.1177/0022034511402994. Epub 2011 Mar 29. Review.


Identification of the primary mechanism of complement evasion by the periodontal pathogen, Treponema denticola.

McDowell JV, Frederick J, Miller DP, Goetting-Minesky MP, Goodman H, Fenno JC, Marconi RT.

Mol Oral Microbiol. 2011 Apr;26(2):140-9. doi: 10.1111/j.2041-1014.2010.00598.x. Epub 2010 Dec 3.


The Hpk2-Rrp2 two-component regulatory system of Treponema denticola: a potential regulator of environmental and adaptive responses.

Sarkar J, Frederick J, Marconi RT.

Mol Oral Microbiol. 2010 Aug;25(4):241-51. doi: 10.1111/j.2041-1014.2010.00578.x.


Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment.

Earnhart CG, Leblanc DV, Alix KE, Desrosiers DC, Radolf JD, Marconi RT.

Mol Microbiol. 2010 Apr;76(2):393-408. doi: 10.1111/j.1365-2958.2010.07103.x. Epub 2010 Feb 28.


Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi.

Freedman JC, Rogers EA, Kostick JL, Zhang H, Iyer R, Schwartz I, Marconi RT.

FEMS Immunol Med Microbiol. 2010 Mar;58(2):285-94. doi: 10.1111/j.1574-695X.2009.00635.x. Epub 2009 Nov 23.


Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin.

Rogers EA, Abdunnur SV, McDowell JV, Marconi RT.

Infect Immun. 2009 Oct;77(10):4396-405. doi: 10.1128/IAI.00393-09. Epub 2009 Jul 20.


Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions.

Rogers EA, Terekhova D, Zhang HM, Hovis KM, Schwartz I, Marconi RT.

Mol Microbiol. 2009 Mar;71(6):1551-73. doi: 10.1111/j.1365-2958.2009.06621.x. Epub 2009 Jan 23.


Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola.

McDowell JV, Huang B, Fenno JC, Marconi RT.

Infect Immun. 2009 Apr;77(4):1417-25. doi: 10.1128/IAI.01544-08. Epub 2009 Feb 9.


Analysis of a growth-phase-regulated two-component regulatory system in the periodontal pathogen Treponema denticola.

Frederick JR, Rogers EA, Marconi RT.

J Bacteriol. 2008 Sep;190(18):6162-9. doi: 10.1128/JB.00046-08. Epub 2008 Jul 11.


Identification of an antiparallel coiled-coil/loop domain required for ligand binding by the Borrelia hermsii FhbA protein: additional evidence for the role of FhbA in the host-pathogen interaction.

Hovis KM, Freedman JC, Zhang H, Forbes JL, Marconi RT.

Infect Immun. 2008 May;76(5):2113-22. doi: 10.1128/IAI.01266-07. Epub 2008 Feb 25. Erratum in: Infect Immun. 2008 Jul;76(7):3358.


The Scl1 protein of M6-type group A Streptococcus binds the human complement regulatory protein, factor H, and inhibits the alternative pathway of complement.

Caswell CC, Han R, Hovis KM, Ciborowski P, Keene DR, Marconi RT, Lukomski S.

Mol Microbiol. 2008 Feb;67(3):584-96. Epub 2007 Dec 18.


An octavalent lyme disease vaccine induces antibodies that recognize all incorporated OspC type-specific sequences.

Earnhart CG, Marconi RT.

Hum Vaccin. 2007 Nov-Dec;3(6):281-9. Epub 2007 Jul 2.


OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine.

Earnhart CG, Marconi RT.

Clin Vaccine Immunol. 2007 May;14(5):628-34. Epub 2007 Mar 14.


Identification of the gene encoding the FhbB protein of Treponema denticola, a highly unique factor H-like protein 1 binding protein.

McDowell JV, Frederick J, Stamm L, Marconi RT.

Infect Immun. 2007 Feb;75(2):1050-4. Epub 2006 Nov 13.

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