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Items: 1 to 50 of 54

1.

Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.

Marro ML, Patterson AW, Lee L, Deng L, Reynolds A, Ren X, Axford L, Patnaik A, Hollis-Symynkywicz M, Casson N, Custeau D, Ames L, Loi S, Zhang L, Honda T, Blank J, Harrison TJ, Papillon JPN, Hamann LG, Marcinkeviciene J, Regard JB.

J Pharmacol Exp Ther. 2018 Oct;367(1):147-154. doi: 10.1124/jpet.118.248435. Epub 2018 Aug 3.

PMID:
30076263
2.

Cardiac size of high-volume resistance trained female athletes: shaping the body but not the heart.

Venckunas T, Simonavicius J, Marcinkeviciene JE.

Physiol Int. 2016 Mar;103(1):105-11. doi: 10.1556/036.103.2016.1.10.

PMID:
27030632
3.

Mechanism of inhibition for BMS-791325, a novel non-nucleoside inhibitor of hepatitis C virus NS5B polymerase.

Rigat KL, Lu H, Wang YK, Argyrou A, Fanslau C, Beno B, Wang Y, Marcinkeviciene J, Ding M, Gentles RG, Gao M, Abell LM, Roberts SB.

J Biol Chem. 2014 Nov 28;289(48):33456-68. doi: 10.1074/jbc.M114.613653. Epub 2014 Oct 9.

4.

Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.

Zhao G, Kwon C, Wang A, Robertson JG, Marcinkeviciene J, Parker RA, Kirby MS, Hamann LG.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1622-5. doi: 10.1016/j.bmcl.2013.01.104. Epub 2013 Jan 31.

PMID:
23416006
5.

Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor.

Wang A, Dorso C, Kopcho L, Locke G, Langish R, Harstad E, Shipkova P, Marcinkeviciene J, Hamann L, Kirby MS.

BMC Pharmacol. 2012 Apr 4;12:2. doi: 10.1186/1471-2210-12-2.

6.

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

Thompson LA, Shi J, Decicco CP, Tebben AJ, Olson RE, Boy KM, Guernon JM, Good AC, Liauw A, Zheng C, Copeland RA, Combs AP, Trainor GL, Camac DM, Muckelbauer JK, Lentz KA, Grace JE, Burton CR, Toyn JH, Barten DM, Marcinkeviciene J, Meredith JE, Albright CF, Macor JE.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6909-15. doi: 10.1016/j.bmcl.2011.06.116. Epub 2011 Jul 2.

PMID:
21974952
7.

Strongmen sport is associated with larger absolute heart size and impaired cardiac relaxation.

Venckunas T, Vasiliauskas D, Marcinkeviciene JE, Grizas V, Stasiulis A, Malkova D.

J Strength Cond Res. 2011 Oct;25(10):2919-25. doi: 10.1519/JSC.0b013e31820f50ef.

PMID:
21912280
8.

Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE).

Boy KM, Guernon JM, Shi J, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Marcinkeviciene J, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Lentz KA, Bronson JJ, Olson RE, Macor JE, Thompson LA 3rd.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6916-24. doi: 10.1016/j.bmcl.2011.06.109. Epub 2011 Jun 30.

PMID:
21782431
9.

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.

Marcin LR, Higgins MA, Zusi FC, Zhang Y, Dee MF, Parker MF, Muckelbauer JK, Camac DM, Morin PE, Ramamurthy V, Tebben AJ, Lentz KA, Grace JE, Marcinkeviciene JA, Kopcho LM, Burton CR, Barten DM, Toyn JH, Meredith JE, Albright CF, Bronson JJ, Macor JE, Thompson LA.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):537-41. doi: 10.1016/j.bmcl.2010.10.079.

PMID:
21078556
10.

Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.

Meng W, Brigance RP, Chao HJ, Fura A, Harrity T, Marcinkeviciene J, O'Connor SP, Tamura JK, Xie D, Zhang Y, Klei HE, Kish K, Weigelt CA, Turdi H, Wang A, Zahler R, Kirby MS, Hamann LG.

J Med Chem. 2010 Aug 12;53(15):5620-8. doi: 10.1021/jm100634a.

PMID:
20684603
11.

[Return to work after coronary artery bypass surgery].

Vasiliauskas D, Raugaliene R, Grizas V, Marcinkeviciene J, Jasiukeviciene L, Kubilius R, Barsys V.

Medicina (Kaunas). 2008;44(11):841-7. Lithuanian.

12.

[3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors.

Iben LG, Kopcho L, Marcinkeviciene J, Zheng C, Thompson LA, Albright CF, Toyn JH.

Eur J Pharmacol. 2008 Sep 28;593(1-3):10-5. doi: 10.1016/j.ejphar.2008.06.112. Epub 2008 Jul 11.

PMID:
18655784
13.

[Evaluation of a chronic fatigue in patients with moderate-to-severe chronic heart failure].

Jasiukeviciene L, Vasiliauskas D, Kavoliūniene A, Marcinkeviciene J, Grybauskiene R, Grizas V, Tumyniene V.

Medicina (Kaunas). 2008;44(5):366-72. Lithuanian.

14.

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

Meredith JE Jr, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF.

J Pharmacol Exp Ther. 2008 Aug;326(2):502-13. doi: 10.1124/jpet.108.138974. Epub 2008 May 22.

PMID:
18499745
15.

Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.

Locke GA, Cheng D, Witmer MR, Tamura JK, Haque T, Carney RF, Rendina AR, Marcinkeviciene J.

Arch Biochem Biophys. 2008 Jul 1;475(1):72-9. doi: 10.1016/j.abb.2008.04.011. Epub 2008 Apr 18.

PMID:
18455495
16.

Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation.

Metzler WJ, Yanchunas J, Weigelt C, Kish K, Klei HE, Xie D, Zhang Y, Corbett M, Tamura JK, He B, Hamann LG, Kirby MS, Marcinkeviciene J.

Protein Sci. 2008 Feb;17(2):240-50. doi: 10.1110/ps.073253208.

17.

Echocardiographic parameters in athletes of different sports.

Venckunas T, Lionikas A, Marcinkeviciene JE, Raugaliene R, Alekrinskis A, Stasiulis A.

J Sports Sci Med. 2008 Mar 1;7(1):151-6. eCollection 2008.

18.

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.

Simpkins LM, Bolton S, Pi Z, Sutton JC, Kwon C, Zhao G, Magnin DR, Augeri DJ, Gungor T, Rotella DP, Sun Z, Liu Y, Slusarchyk WS, Marcinkeviciene J, Robertson JG, Wang A, Robl JA, Atwal KS, Zahler RL, Parker RA, Kirby MS, Hamann LG.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6476-80. Epub 2007 Oct 1.

PMID:
17937986
19.

Exercise training after coronary angioplasty improves cardiorespiratory function.

Vasiliauskas D, Benetis R, Jasiukeviciene L, Grizas V, Marcinkeviciene J, Navickas R, Leimoniene L.

Scand Cardiovasc J. 2007 Jun;41(3):142-8.

PMID:
17487762
20.

A pre-steady state analysis of ligand binding to human glucokinase: evidence for a preexisting equilibrium.

Kim YB, Kalinowski SS, Marcinkeviciene J.

Biochemistry. 2007 Feb 6;46(5):1423-31.

PMID:
17260972
21.

[Left ventricular remodeling in ischemic heart disease patients with signs and symptoms of chronic heart failure: an impact of the long-term exercise training].

Vasiliauskas D, Kavoliūniene A, Jasiukeviciene L, Grizas V, Marcinkeviciene J, Raugaliene R, Leimoniene L, Tumyniene V.

Medicina (Kaunas). 2006;42(12):965-74. Lithuanian.

22.

Development of structural cardiac adaptation in basketball players.

Vasiliauskas D, Venckūnas T, Marcinkeviciene J, Bartkeviciene A.

Eur J Cardiovasc Prev Rehabil. 2006 Dec;13(6):985-9.

PMID:
17143132
23.

Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1.

Magnin DR, Taunk PC, Robertson JG, Wang A, Marcinkeviciene J, Kirby MS, Hamann LG.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1731-4. Epub 2005 Dec 20.

PMID:
16376077
24.

Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118).

Kim YB, Kopcho LM, Kirby MS, Hamann LG, Weigelt CA, Metzler WJ, Marcinkeviciene J.

Arch Biochem Biophys. 2006 Jan 1;445(1):9-18. Epub 2005 Dec 5.

PMID:
16364232
25.

[Relationship between the metabolic syndrome, endothelial function and intima-media thickness in asymptomatic middle-aged individuals].

Gustiene O, Slapikas R, Marcinkeviciene J, Petrauskiene I, Milasauskiene Z, Griskeviciūte R, Plepyte J, Zaliūnas R.

Medicina (Kaunas). 2005;41(10):825-36. Lithuanian.

26.

Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors.

Zhao G, Taunk PC, Magnin DR, Simpkins LM, Robl JA, Wang A, Robertson JG, Marcinkeviciene J, Sitkoff DF, Parker RA, Kirby MS, Hamann LG.

Bioorg Med Chem Lett. 2005 Sep 15;15(18):3992-5.

PMID:
16046120
27.

Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

Augeri DJ, Robl JA, Betebenner DA, Magnin DR, Khanna A, Robertson JG, Wang A, Simpkins LM, Taunk P, Huang Q, Han SP, Abboa-Offei B, Cap M, Xin L, Tao L, Tozzo E, Welzel GE, Egan DM, Marcinkeviciene J, Chang SY, Biller SA, Kirby MS, Parker RA, Hamann LG.

J Med Chem. 2005 Jul 28;48(15):5025-37.

PMID:
16033281
28.

Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach.

Kopcho LM, Kim YB, Wang A, Liu MA, Kirby MS, Marcinkeviciene J.

Arch Biochem Biophys. 2005 Apr 15;436(2):367-76.

PMID:
15797249
29.

Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.

Kopcho LM, Ma J, Marcinkeviciene J, Lai Z, Witmer MR, Cheng J, Yanchunas J, Tredup J, Corbett M, Calambur D, Wittekind M, Paruchuri M, Kothari D, Lee G, Ganguly S, Ramamurthy V, Morin PE, Camac DM, King RW, Lasut AL, Ross OH, Hillman MC, Fish B, Shen K, Dowling RL, Kim YB, Graciani NR, Collins D, Combs AP, George H, Thompson LA, Copeland RA.

Arch Biochem Biophys. 2003 Feb 15;410(2):307-16.

PMID:
12573291
30.

Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism.

Toulokhonova L, Metzler WJ, Witmer MR, Copeland RA, Marcinkeviciene J.

J Biol Chem. 2003 Feb 14;278(7):4582-9. Epub 2002 Nov 27.

31.

Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase.

Haque TS, Tadesse S, Marcinkeviciene J, Rogers MJ, Sizemore C, Kopcho LM, Amsler K, Ecret LD, Zhan DL, Hobbs F, Slee A, Trainor GL, Stern AM, Copeland RA, Combs AP.

J Med Chem. 2002 Oct 10;45(21):4669-78.

PMID:
12361393
32.

Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers.

Marcinkeviciene J, Kopcho LM, Yang T, Copeland RA, Glass BM, Combs AP, Falahatpisheh N, Thompson L.

J Biol Chem. 2002 Aug 9;277(32):28677-82. Epub 2002 May 23.

33.

Enoyl-ACP reductase (FabI) of Haemophilus influenzae: steady-state kinetic mechanism and inhibition by triclosan and hexachlorophene.

Marcinkeviciene J, Jiang W, Kopcho LM, Locke G, Luo Y, Copeland RA.

Arch Biochem Biophys. 2001 Jun 1;390(1):101-8. Erratum in: Arch Biochem Biophys 2001 Dec 15;396(2):249.

PMID:
11368521
34.

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide.

Marcinkeviciene J, Luo Y, Graciani NR, Combs AP, Copeland RA.

J Biol Chem. 2001 Jun 29;276(26):23790-4. Epub 2001 Apr 16.

35.

Characterization of recombinant, soluble beta-secretase from an insect cell expression system.

Mallender WD, Yager D, Onstead L, Nichols MR, Eckman C, Sambamurti K, Kopcho LM, Marcinkeviciene J, Copeland RA, Rosenberry TL.

Mol Pharmacol. 2001 Mar;59(3):619-26.

PMID:
11179458
36.

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis.

Copeland RA, Marcinkeviciene J, Haque TS, Kopcho LM, Jiang W, Wang K, Ecret LD, Sizemore C, Amsler KA, Foster L, Tadesse S, Combs AP, Stern AM, Trainor GL, Slee A, Rogers MJ, Hobbs F.

J Biol Chem. 2000 Oct 27;275(43):33373-8.

37.

Role of lys100 in human dihydroorotate dehydrogenase: mutagenesis studies and chemical rescue by external amines.

Jiang W, Locke G, Harpel MR, Copeland RA, Marcinkeviciene J.

Biochemistry. 2000 Jul 11;39(27):7990-7.

PMID:
10891080
38.

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones.

Marcinkeviciene J, Rogers MJ, Kopcho L, Jiang W, Wang K, Murphy DJ, Lippy J, Link S, Chung TD, Hobbs F, Haque T, Trainor GL, Slee A, Stern AM, Copeland RA.

Biochem Pharmacol. 2000 Aug 1;60(3):339-42.

PMID:
10856428
39.

A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism.

Marcinkeviciene J, Jiang W, Locke G, Kopcho LM, Rogers MJ, Copeland RA.

Arch Biochem Biophys. 2000 May 1;377(1):178-86.

PMID:
10775458
40.

Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism.

Marcinkeviciene J, Tinney LM, Wang KH, Rogers MJ, Copeland RA.

Biochemistry. 1999 Oct 5;38(40):13129-37.

PMID:
10529184
41.

Thioredoxin reductase-thioredoxin fusion enzyme from Mycobacterium leprae: comparison with the separately expressed thioredoxin reductase.

Wang PF, Marcinkeviciene J, Williams CH Jr, Blanchard JS.

Biochemistry. 1998 Nov 17;37(46):16378-89.

PMID:
9819230
42.

Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties.

Wilson T, de Lisle GW, Marcinkeviciene JA, Blanchard JS, Collins DM.

Microbiology. 1998 Oct;144 ( Pt 10):2687-95.

PMID:
9802010
43.
44.

NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis.

Miesel L, Weisbrod TR, Marcinkeviciene JA, Bittman R, Jacobs WR Jr.

J Bacteriol. 1998 May;180(9):2459-67.

45.

Catalytic properties of lipoamide dehydrogenase from Mycobacterium smegmatis.

Marcinkeviciene J, Blanchard JS.

Arch Biochem Biophys. 1997 Apr 15;340(2):168-76.

PMID:
9143318
46.
47.

Electrostimulated cardiomyoplasty: from experimental to clinical studies.

Dumcius A, Salcius K, Raliene L, Vaskelyte J, Giedraitis S, Sirvinskas E, Marcinkeviciene J, Skucas J.

Pacing Clin Electrophysiol. 1996 Aug;19(8):1205-10.

PMID:
8865218
48.

Purification and characterization of the Mycobacterium smegmatis catalase-peroxidase involved in isoniazid activation.

Marcinkeviciene JA, Magliozzo RS, Blanchard JS.

J Biol Chem. 1995 Sep 22;270(38):22290-5.

49.

Quinone reductase reaction catalyzed by Streptococcus faecalis NADH peroxidase.

Marcinkeviciene JA, Blanchard JS.

Biochemistry. 1995 May 23;34(20):6621-7.

PMID:
7756294
50.

Kinetics of glucose oxidase catalyzed electron transfer mediated by sulfur and selenium compounds.

Kulys J, Buch-Rasmussen T, Bechgaard K, Marcinkeviciene J, Christensen JB, Hansen HE.

FEBS Lett. 1993 Aug 23;329(1-2):205-9.

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