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Items: 35


GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis.

Biagioli M, Carino A, Fiorucci C, Marchianò S, Di Giorgio C, Roselli R, Magro M, Distrutti E, Bereshchenko O, Scarpelli P, Zampella A, Fiorucci S.

Cell Mol Gastroenterol Hepatol. 2019 Jun 18. pii: S2352-345X(19)30081-5. doi: 10.1016/j.jcmgh.2019.06.003. [Epub ahead of print]


Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation.

Carino A, Marchianò S, Biagioli M, Fiorucci C, Zampella A, Monti MC, Morretta E, Bordoni M, Di Giorgio C, Roselli R, Ricci P, Distrutti E, Fiorucci S.

Nutrients. 2019 May 21;11(5). pii: E1132. doi: 10.3390/nu11051132.


Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists.

Festa C, Finamore C, Marchianò S, Di Leva FS, Carino A, Monti MC, Del Gaudio F, Ceccacci S, Limongelli V, Zampella A, Fiorucci S, De Marino S.

ACS Med Chem Lett. 2019 Jan 10;10(4):504-510. doi: 10.1021/acsmedchemlett.8b00534. eCollection 2019 Apr 11.


Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury.

Sepe V, Marchianò S, Finamore C, Baronissi G, Di Leva FS, Carino A, Biagioli M, Fiorucci C, Cassiano C, Monti MC, Del Gaudio F, Novellino E, Limongelli V, Fiorucci S, Zampella A.

ACS Med Chem Lett. 2018 Dec 6;10(4):407-412. doi: 10.1021/acsmedchemlett.8b00423. eCollection 2019 Apr 11.


Lost in the fire.

Marchianò S, Murry CE.

Science. 2019 Apr 12;364(6436):123-124. doi: 10.1126/science.aax1006. No abstract available.


Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties.

Finamore C, Baronissi G, Marchianò S, Di Leva FS, Carino A, Monti MC, Limongelli V, Zampella A, Fiorucci S, Sepe V.

Molecules. 2019 Mar 16;24(6). pii: E1043. doi: 10.3390/molecules24061043.


Discovery of ((1,2,4-oxadiazol-5-yl)pyrrolidin-3-yl)ureidyl derivatives as selective non-steroidal agonists of the G-protein coupled bile acid receptor-1.

Di Leva FS, Festa C, Carino A, De Marino S, Marchianò S, Di Marino D, Finamore C, Monti MC, Zampella A, Fiorucci S, Limongelli V.

Sci Rep. 2019 Feb 21;9(1):2504. doi: 10.1038/s41598-019-38840-z.


Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties.

Biagioli M, Capobianco D, Carino A, Marchianò S, Fiorucci C, Ricci P, Distrutti E, Fiorucci S.

Nutrients. 2019 Feb 2;11(2). pii: E325. doi: 10.3390/nu11020325.


Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite.

Skledar DG, Carino A, Trontelj J, Troberg J, Distrutti E, Marchianò S, Tomašič T, Zega A, Finel M, Fiorucci S, Mašič LP.

Chemosphere. 2019 Jan;215:870-880. doi: 10.1016/j.chemosphere.2018.10.129. Epub 2018 Oct 18.


Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis.

Carino A, Marchianò S, Biagioli M, Bucci M, Vellecco V, Brancaleone V, Fiorucci C, Zampella A, Monti MC, Distrutti E, Fiorucci S.

FASEB J. 2019 Feb;33(2):2809-2822. doi: 10.1096/fj.201801373RR. Epub 2018 Oct 10.


Disruption of TFGβ-SMAD3 pathway by the nuclear receptor SHP mediates the antifibrotic activities of BAR704, a novel highly selective FXR ligand.

Carino A, Biagioli M, Marchianò S, Scarpelli P, Zampella A, Limongelli V, Fiorucci S.

Pharmacol Res. 2018 May;131:17-31. doi: 10.1016/j.phrs.2018.02.033. Epub 2018 Mar 9.


Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.

Biagioli M, Mencarelli A, Carino A, Cipriani S, Marchianò S, Fiorucci C, Donini A, Graziosi L, Baldelli F, Distrutti E, Costantino G, Fiorucci S.

Inflamm Bowel Dis. 2017 Dec 19;24(1):123-135. doi: 10.1093/ibd/izx031.


Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9.

Adorni MP, Ferri N, Marchianò S, Trimarco V, Rozza F, Izzo R, Bernini F, Zimetti F.

Ther Clin Risk Manag. 2017 Dec 11;13:1555-1562. doi: 10.2147/TCRM.S144121. eCollection 2017.


Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice.

Carino A, Cipriani S, Marchianò S, Biagioli M, Scarpelli P, Zampella A, Monti MC, Fiorucci S.

Sci Rep. 2017 Oct 20;7(1):13689. doi: 10.1038/s41598-017-13102-y.


Metabolic Variability of a Multispecies Probiotic Preparation Impacts on the Anti-inflammatory Activity.

Biagioli M, Laghi L, Carino A, Cipriani S, Distrutti E, Marchianò S, Parolin C, Scarpelli P, Vitali B, Fiorucci S.

Front Pharmacol. 2017 Jul 28;8:505. doi: 10.3389/fphar.2017.00505. eCollection 2017.


Nanotraps with biomimetic surface as decoys for chemokines.

Guryanov I, Cipriani S, Fiorucci S, Zashikhina N, Marchianò S, Scarpelli P, Korzhikov-Vlakh V, Popova E, Korzhikova-Vlakh E, Biondi B, Formaggio F, Tennikova T.

Nanomedicine. 2017 Nov;13(8):2575-2585. doi: 10.1016/j.nano.2017.07.006. Epub 2017 Jul 26.


The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis.

Biagioli M, Carino A, Cipriani S, Francisci D, Marchianò S, Scarpelli P, Sorcini D, Zampella A, Fiorucci S.

J Immunol. 2017 Jul 15;199(2):718-733. doi: 10.4049/jimmunol.1700183. Epub 2017 Jun 12.


Geranylgeraniol prevents the simvastatin-induced PCSK9 expression: Role of the small G protein Rac1.

Ferri N, Marchianò S, Lupo MG, Trenti A, Biondo G, Castaldello P, Corsini A.

Pharmacol Res. 2017 Aug;122:96-104. doi: 10.1016/j.phrs.2017.05.021. Epub 2017 May 26.


Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study.

Ruscica M, Ferri N, Fogacci F, Rosticci M, Botta M, Marchiano S, Magni P, D'Addato S, Giovannini M, Borghi C, Cicero AFG; Brisighella Heart Study Group.

J Am Heart Assoc. 2017 May 3;6(5). pii: e005764. doi: 10.1161/JAHA.117.005764.


Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases.

Festa C, De Marino S, Carino A, Sepe V, Marchianò S, Cipriani S, Di Leva FS, Limongelli V, Monti MC, Capolupo A, Distrutti E, Fiorucci S, Zampella A.

Front Pharmacol. 2017 Mar 30;8:162. doi: 10.3389/fphar.2017.00162. eCollection 2017.


A field-based disparity analysis of new 1,2,5-oxadiazole derivatives endowed with antiproliferative activity.

Porta F, Gelain A, Barlocco D, Ferri N, Marchianò S, Cappello V, Basile L, Guccione S, Meneghetti F, Villa S.

Chem Biol Drug Des. 2017 Nov;90(5):820-839. doi: 10.1111/cbdd.13003. Epub 2017 May 14.


An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties.

Porta F, Facchetti G, Ferri N, Gelain A, Meneghetti F, Villa S, Barlocco D, Masciocchi D, Asai A, Miyoshi N, Marchianò S, Kwon BM, Jin Y, Gandin V, Marzano C, Rimoldi I.

Eur J Med Chem. 2017 May 5;131:196-206. doi: 10.1016/j.ejmech.2017.03.017. Epub 2017 Mar 15.


In vitro anticancer activity evaluation of new cationic platinum(II) complexes based on imidazole moiety.

Rimoldi I, Facchetti G, Lucchini G, Castiglioni E, Marchianò S, Ferri N.

Bioorg Med Chem. 2017 Mar 15;25(6):1907-1913. doi: 10.1016/j.bmc.2017.02.010. Epub 2017 Feb 14.


Hyodeoxycholic acid derivatives as liver X receptor α and G-protein-coupled bile acid receptor agonists.

De Marino S, Carino A, Masullo D, Finamore C, Marchianò S, Cipriani S, Di Leva FS, Catalanotti B, Novellino E, Limongelli V, Fiorucci S, Zampella A.

Sci Rep. 2017 Feb 24;7:43290. doi: 10.1038/srep43290.


BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis.

Carino A, Cipriani S, Marchianò S, Biagioli M, Santorelli C, Donini A, Zampella A, Monti MC, Fiorucci S.

Sci Rep. 2017 Feb 16;7:42801. doi: 10.1038/srep42801.


Development of poly(lactide-co-glycolide) nanoparticles functionalized with a mitochondria penetrating peptide.

Selmin F, Magri G, Gennari CG, Marchianò S, Ferri N, Pellegrino S.

J Pept Sci. 2017 Feb;23(2):182-188. doi: 10.1002/psc.2952. Epub 2017 Jan 17.


PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement.

Ferri N, Marchianò S, Tibolla G, Baetta R, Dhyani A, Ruscica M, Uboldi P, Catapano AL, Corsini A.

Atherosclerosis. 2016 Oct;253:214-224. doi: 10.1016/j.atherosclerosis.2016.07.910. Epub 2016 Jul 22.


The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines.

Carino A, Graziosi L, D'Amore C, Cipriani S, Marchianò S, Marino E, Zampella A, Rende M, Mosci P, Distrutti E, Donini A, Fiorucci S.

Oncotarget. 2016 Sep 20;7(38):61021-61035. doi: 10.18632/oncotarget.10477.


Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands.

Finamore C, Festa C, Renga B, Sepe V, Carino A, Masullo D, Biagioli M, Marchianò S, Capolupo A, Monti MC, Fiorucci S, Zampella A.

Sci Rep. 2016 Jul 6;6:29320. doi: 10.1038/srep29320.


The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma.

Renga B, Francisci D, Carino A, Marchianò S, Cipriani S, Chiara Monti M, Del Sordo R, Schiaroli E, Distrutti E, Baldelli F, Fiorucci S.

Sci Rep. 2015 Oct 15;5:15403. doi: 10.1038/srep15403.


Influence of pinning effects on the electrochemical formation of silver patterns in agarose-containing sols and gels.

Pasquale MA, Saracco GP, Marchiano SL, Arvia AJ.

J Phys Chem B. 2005 Nov 3;109(43):20256-65.


The Risk Assessment Program and the Court of Penal Execution in the Province of Buenos Aires, Argentina.

Folino JO, Marengo CM, Marchiano SE, Ascazibar M.

Int J Offender Ther Comp Criminol. 2004 Feb;48(1):49-58.


[Suicide in convicts in Buenos Aires Province].

Folino JO, Marchiano S, Sanchez Wilde A.

Vertex. 2003 Dec-2004 Feb;14(54):286-91. Spanish.


Stability analysis of branched silver electrodeposits: solid phase growth under a marginally stable regime.

Pasquale MA, Marchiano SL, Schilardi PL, Salvarezza RC, Arvia AJ.

Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Apr;65(4 Pt 1):041608. Epub 2002 Apr 8.


Growth of three-dimensional silver fractal electrodeposits under damped free convection.

Carro P, Marchiano SL, Hernández Creus A, González S, Salvarezza RC, Arvia AJ.

Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1993 Oct;48(4):R2374-R2377. No abstract available.


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