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Items: 37


Nuphar Dimers: Crouching Sulfur, Hidden Reactivity.

Marcaurelle LA, Mulvihill MJ.

ACS Cent Sci. 2016 Jun 22;2(6):367-9. doi: 10.1021/acscentsci.6b00166. Epub 2016 Jun 14. No abstract available.


Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line.

Arai K, Buonamici S, Chan B, Corson L, Endo A, Gerard B, Hao MH, Karr C, Kira K, Lee L, Liu X, Lowe JT, Luo T, Marcaurelle LA, Mizui Y, Nevalainen M, O'Shea MW, Park ES, Perino SA, Prajapati S, Shan M, Smith PG, Tivitmahaisoon P, Wang JY, Warmuth M, Wu KM, Yu L, Zhang H, Zheng GZ, Keaney GF.

Org Lett. 2014 Nov 7;16(21):5560-3. doi: 10.1021/ol502556c. Epub 2014 Oct 26.


Synthesis of stereochemically and skeletally diverse fused ring systems from functionalized C-glycosides.

Gerard B, Lee MD 4th, Dandapani S, Duvall JR, Fitzgerald ME, Kesavan S, Lowe JT, Marié JC, Pandya BA, Suh BC, O'Shea MW, Dombrowski M, Hamann D, Lemercier B, Murillo T, Akella LB, Foley MA, Marcaurelle LA.

J Org Chem. 2013 Jun 7;78(11):5160-71. doi: 10.1021/jo4000916. Epub 2013 May 21.


An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries.

Mulrooney CA, Lahr DL, Quintin MJ, Youngsaye W, Moccia D, Asiedu JK, Mulligan EL, Akella LB, Marcaurelle LA, Montgomery P, Bittker JA, Clemons PA, Brudz S, Dandapani S, Duvall JR, Tolliday NJ, De Souza A.

J Comput Aided Mol Des. 2013 May;27(5):455-68. doi: 10.1007/s10822-013-9641-y. Epub 2013 Apr 13.


Translational synthetic chemistry.

Kesavan S, Marcaurelle LA.

Nat Chem Biol. 2013 Apr;9(4):210-3. doi: 10.1038/nchembio.1207. No abstract available.


Application of a catalytic asymmetric Povarov reaction using chiral ureas to the synthesis of a tetrahydroquinoline library.

Gerard B, O'Shea MW, Donckele E, Kesavan S, Akella LB, Xu H, Jacobsen EN, Marcaurelle LA.

ACS Comb Sci. 2012 Nov 12;14(11):621-30. doi: 10.1021/co300098v. Epub 2012 Oct 22. Erratum in: ACS Comb Sci. 2014 Jan 13;16(1):46.


Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

Lowe JT, Lee MD 4th, Akella LB, Davoine E, Donckele EJ, Durak L, Duvall JR, Gerard B, Holson EB, Joliton A, Kesavan S, Lemercier BC, Liu H, Marié JC, Mulrooney CA, Muncipinto G, Welzel-O'Shea M, Panko LM, Rowley A, Suh BC, Thomas M, Wagner FF, Wei J, Foley MA, Marcaurelle LA.

J Org Chem. 2012 Sep 7;77(17):7187-211. doi: 10.1021/jo300974j. Epub 2012 Aug 10.


Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

Heidebrecht RW Jr, Mulrooney C, Austin CP, Barker RH Jr, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, Hinkson P, Kramer M, Lukens AK, Masi D, Marcaurelle LA, Su XZ, Thomas CJ, Weïwer M, Wiegand RC, Wirth D, Xia M, Yuan J, Zhao J, Palmer M, Munoz B, Schreiber S.

ACS Med Chem Lett. 2012 Feb 9;3(2):112-117. Epub 2011 Dec 22.


Build/couple/pair strategy for the synthesis of stereochemically diverse macrolactams via head-to-tail cyclization.

Fitzgerald ME, Mulrooney CA, Duvall JR, Wei J, Suh BC, Akella LB, Vrcic A, Marcaurelle LA.

ACS Comb Sci. 2012 Feb 13;14(2):89-96. doi: 10.1021/co200161z. Epub 2012 Jan 17.


Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells.

Faloon PW, Chou DHC, Forbeck EM, Walpita D, Morgan B, Buhrlage S, Ting A, Perez J, MacPherson LJ, Duvall JR, Dandapani S, Marcaurelle LA, Munoz B, Palmer M, Foley M, Wagner B, Schreiber SL.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Oct 29 [updated 2011 May 26].


Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis.

Chou DH, Duvall JR, Gerard B, Liu H, Pandya BA, Suh BC, Forbeck EM, Faloon P, Wagner BK, Marcaurelle LA.

ACS Med Chem Lett. 2011 Sep 8;2(9):698-702.


Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.

Dandapani S, Lowe JT, Comer E, Marcaurelle LA.

J Org Chem. 2011 Oct 7;76(19):8042-8. doi: 10.1021/jo2011957. Epub 2011 Aug 29.


Practical asymmetric synthesis of β-hydroxy γ-amino acids via complimentary aldol reactions.

Pandya BA, Dandapani S, Duvall JR, Rowley A, Mulrooney CA, Ryba T, Dombrowski M, Harton M, Young DW, Marcaurelle LA.

Tetrahedron. 2011 Aug 26;67(34):6131-6137.


Application of a sparse matrix design strategy to the synthesis of dos libraries.

Akella LB, Marcaurelle LA.

ACS Comb Sci. 2011 Jul 11;13(4):357-64. doi: 10.1021/co200020j. Epub 2011 Apr 28.


Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification.

Gerard B, Duvall JR, Lowe JT, Murillo T, Wei J, Akella LB, Marcaurelle LA.

ACS Comb Sci. 2011 Jul 11;13(4):365-74. doi: 10.1021/co2000218. Epub 2011 Apr 28.


Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.

Comer E, Liu H, Joliton A, Clabaut A, Johnson C, Akella LB, Marcaurelle LA.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6751-6. doi: 10.1073/pnas.1015255108. Epub 2011 Mar 7.


Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold.

Gerard B, Marié JC, Pandya BA, Lee MD 4th, Liu H, Marcaurelle LA.

J Org Chem. 2011 Mar 18;76(6):1898-901. doi: 10.1021/jo1022926. Epub 2011 Feb 22.


Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.

Dandapani S, Marcaurelle LA.

Nat Chem Biol. 2010 Dec;6(12):861-3. doi: 10.1038/nchembio.479.


An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Marcaurelle LA, Comer E, Dandapani S, Duvall JR, Gerard B, Kesavan S, Lee MD 4th, Liu H, Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A, Ryba TD, Suh BC, Wei J, Young DW, Akella LB, Ross NT, Zhang YL, Fass DM, Reis SA, Zhao WN, Haggarty SJ, Palmer M, Foley MA.

J Am Chem Soc. 2010 Dec 1;132(47):16962-76. doi: 10.1021/ja105119r. Epub 2010 Nov 10.


The evolving role of molecular diversity in drug discovery.

Marcaurelle LA, Foley MA.

Curr Opin Chem Biol. 2010 Jun;14(3):285-8. doi: 10.1016/j.cbpa.2010.05.001. Epub 2010 May 14. No abstract available.


Current strategies for diversity-oriented synthesis.

Dandapani S, Marcaurelle LA.

Curr Opin Chem Biol. 2010 Jun;14(3):362-70. doi: 10.1016/j.cbpa.2010.03.018. Epub 2010 Apr 19. Review.


Small-Molecule Library Synthesis on Silicon-Functionalized SynPhase Lanterns.

Duvall JR, Vrcic A, Marcaurelle LA.

Curr Protoc Chem Biol. 2010;2(3):135-151. Epub 2010 Jul 1.


Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings.

Kelly AR, Wei J, Kesavan S, Marié JC, Windmon N, Young DW, Marcaurelle LA.

Org Lett. 2009 Jun 4;11(11):2257-60. doi: 10.1021/ol900562u.


Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.

Marcaurelle LA, Johannes C, Yohannes D, Tillotson BP, Mann D.

Bioorg Med Chem Lett. 2009 May 1;19(9):2500-3. doi: 10.1016/j.bmcl.2009.03.037. Epub 2009 Mar 17.


Identifying the proteins to which small-molecule probes and drugs bind in cells.

Ong SE, Schenone M, Margolin AA, Li X, Do K, Doud MK, Mani DR, Kuai L, Wang X, Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub TR, Gould RJ, Schreiber SL, Carr SA.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4617-22. doi: 10.1073/pnas.0900191106. Epub 2009 Mar 2.


Large scale preparation of silicon-functionalized SynPhase Polystyrene lanterns for solid-phase synthesis.

Ryba TD, Depew KM, Marcaurelle LA.

J Comb Chem. 2009 Jan-Feb;11(1):110-6. doi: 10.1021/cc8000986.


Application of natural product-inspired diversity-oriented synthesis to drug discovery.

Marcaurelle LA, Johannes CW.

Prog Drug Res. 2008;66:187, 189-216. Review.


Synthesis of thioether-linked analogues of the 2,3-sialyl-TF and MECA-79 antigens: mucin-type glycopeptides associated with cancer and inflammation.

Marcaurelle LA, Pratt MR, Bertozzi CR.

Chembiochem. 2003 Mar 3;4(2-3):224-8. No abstract available.


Linear synthesis of the tumor-associated carbohydrate antigens Globo-H, SSEA-3, and Gb3.

Bosse F, Marcaurelle LA, Seeberger PH.

J Org Chem. 2002 Sep 20;67(19):6659-70.


Recent advances in the chemical synthesis of mucin-like glycoproteins.

Marcaurelle LA, Bertozzi CR.

Glycobiology. 2002 Jun;12(6):69R-77R. Review.


Homogeneous glycopeptides and glycoproteins for biological investigation.

Grogan MJ, Pratt MR, Marcaurelle LA, Bertozzi CR.

Annu Rev Biochem. 2002;71:593-634. Epub 2001 Nov 9. Review.


Combinatorial carbohydrate chemistry.

Marcaurelle LA, Seeberger PH.

Curr Opin Chem Biol. 2002 Jun;6(3):289-96. Review.


Synthesis of oxime-linked mucin mimics containing the tumor-related T(N) and sialyl T(N) antigens.

Marcaurelle LA, Shin Y, Goon S, Bertozzi CR.

Org Lett. 2001 Nov 15;3(23):3691-4.


Aminooxy-, Hydrazide-, and Thiosemicarbazide-Functionalized Saccharides: Versatile Reagents for Glycoconjugate Synthesis.

Rodriguez EC, Marcaurelle LA, Bertozzi CR.

J Org Chem. 1998 Oct 16;63(21):7134-7135. No abstract available.


Chemoselective elaboration of O-linked glycopeptide mimetics by alkylation of 3-thioGalNAc.

Marcaurelle LA, Bertozzi CR.

J Am Chem Soc. 2001 Feb 28;123(8):1587-95.


Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain.

Marcaurelle LA, Mizoue LS, Wilken J, Oldham L, Kent SB, Handel TM, Bertozzi CR.

Chemistry. 2001 Mar 2;7(5):1129-32.


A short synthesis of bicyclic dipeptides corresponding to Xxx-L-Pro Xxx-D-Pro having constrained trans-proline amides.

Curran TP, Marcaurelle LA, O'Sullivan KM.

Org Lett. 1999 Oct 21;1(8):1225-8.


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