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Items: 1 to 50 of 272

1.

Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters.

Romano M, Fusco G, Choudhury HG, Mehmood S, Robinson CV, Zirah S, Hegemann JD, Lescop E, Marahiel MA, Rebuffat S, De Simone A, Beis K.

ACS Chem Biol. 2018 Jun 15;13(6):1598-1609. doi: 10.1021/acschembio.8b00226. Epub 2018 May 18.

2.

Enterobacter bugandensis: a novel enterobacterial species associated with severe clinical infection.

Pati NB, Doijad SP, Schultze T, Mannala GK, Yao Y, Jaiswal S, Ryan D, Suar M, Gwozdzinski K, Bunk B, Mraheil MA, Marahiel MA, Hegemann JD, Spröer C, Goesmann A, Falgenhauer L, Hain T, Imirzalioglu C, Mshana SE, Overmann J, Chakraborty T.

Sci Rep. 2018 Mar 29;8(1):5392. doi: 10.1038/s41598-018-23069-z.

3.

General rules of fragmentation evidencing lasso structures in CID and ETD.

Jeanne Dit Fouque K, Lavanant H, Zirah S, Hegemann JD, Fage CD, Marahiel MA, Rebuffat S, Afonso C.

Analyst. 2018 Feb 26;143(5):1157-1170. doi: 10.1039/c7an02052j.

PMID:
29404537
4.

Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis.

Bloudoff K, Fage CD, Marahiel MA, Schmeing TM.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):95-100. doi: 10.1073/pnas.1614191114. Epub 2016 Dec 19.

5.

Signatures of Mechanically Interlocked Topology of Lasso Peptides by Ion Mobility-Mass Spectrometry: Lessons from a Collection of Representatives.

Fouque KJD, Lavanant H, Zirah S, Hegemann JD, Zimmermann M, Marahiel MA, Rebuffat S, Afonso C.

J Am Soc Mass Spectrom. 2017 Feb;28(2):315-322. doi: 10.1007/s13361-016-1524-8. Epub 2016 Nov 3.

PMID:
27812920
6.

The B1 Protein Guides the Biosynthesis of a Lasso Peptide.

Zhu S, Fage CD, Hegemann JD, Mielcarek A, Yan D, Linne U, Marahiel MA.

Sci Rep. 2016 Oct 18;6:35604. doi: 10.1038/srep35604.

7.

Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase.

Fage CD, Hegemann JD, Nebel AJ, Steinbach RM, Zhu S, Linne U, Harms K, Bange G, Marahiel MA.

Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12717-21. doi: 10.1002/anie.201605232. Epub 2016 Sep 9.

PMID:
27611791
8.

Dual substrate-controlled kinase activity leads to polyphosphorylated lasso peptides.

Zhu S, Fage CD, Hegemann JD, Yan D, Marahiel MA.

FEBS Lett. 2016 Oct;590(19):3323-3334. doi: 10.1002/1873-3468.12386. Epub 2016 Sep 18.

9.

Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU.

Blauenburg B, Mielcarek A, Altegoer F, Fage CD, Linne U, Bange G, Marahiel MA.

PLoS One. 2016 Jul 6;11(7):e0158749. doi: 10.1371/journal.pone.0158749. eCollection 2016.

10.

Insights into the Unique Phosphorylation of the Lasso Peptide Paeninodin.

Zhu S, Hegemann JD, Fage CD, Zimmermann M, Xie X, Linne U, Marahiel MA.

J Biol Chem. 2016 Jun 24;291(26):13662-78. doi: 10.1074/jbc.M116.722108. Epub 2016 May 5.

11.

The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.

Hegemann JD, Fage CD, Zhu S, Harms K, Di Leva FS, Novellino E, Marinelli L, Marahiel MA.

Mol Biosyst. 2016 Apr;12(4):1106-9. doi: 10.1039/c6mb00081a. Epub 2016 Feb 11.

PMID:
26863937
12.

Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation.

Beck P, Cui H, Hegemann JD, Marahiel MA, Krüger A, Groll M.

ChemMedChem. 2015 Dec;10(12):1969-73. doi: 10.1002/cmdc.201500449. Epub 2015 Oct 16.

PMID:
26471124
13.

Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.

Steinchen W, Schuhmacher JS, Altegoer F, Fage CD, Srinivasan V, Linne U, Marahiel MA, Bange G.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13348-53. doi: 10.1073/pnas.1505271112. Epub 2015 Oct 12.

14.

A structural model for multimodular NRPS assembly lines.

Marahiel MA.

Nat Prod Rep. 2016 Feb;33(2):136-40. doi: 10.1039/c5np00082c. Review.

PMID:
26429504
15.

Rational and combinatorial tailoring of bioactive cyclic dipeptides.

Giessen TW, Marahiel MA.

Front Microbiol. 2015 Jul 30;6:785. doi: 10.3389/fmicb.2015.00785. eCollection 2015. Review.

16.

Lasso peptides: an intriguing class of bacterial natural products.

Hegemann JD, Zimmermann M, Xie X, Marahiel MA.

Acc Chem Res. 2015 Jul 21;48(7):1909-19. doi: 10.1021/acs.accounts.5b00156. Epub 2015 Jun 16. Review.

PMID:
26079760
17.

The PqqD homologous domain of the radical SAM enzyme ThnB is required for thioether bond formation during thurincin H maturation.

Wieckowski BM, Hegemann JD, Mielcarek A, Boss L, Burghaus O, Marahiel MA.

FEBS Lett. 2015 Jul 8;589(15):1802-6. doi: 10.1016/j.febslet.2015.05.032. Epub 2015 May 27.

18.

Molecular insights into frataxin-mediated iron supply for heme biosynthesis in Bacillus subtilis.

Mielcarek A, Blauenburg B, Miethke M, Marahiel MA.

PLoS One. 2015 Mar 31;10(3):e0122538. doi: 10.1371/journal.pone.0122538. eCollection 2015.

19.

A synthetic adenylation-domain-based tRNA-aminoacylation catalyst.

Giessen TW, Altegoer F, Nebel AJ, Steinbach RM, Bange G, Marahiel MA.

Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2492-6. doi: 10.1002/anie.201410047. Epub 2015 Jan 12.

PMID:
25583137
20.

Ion mobility-mass spectrometry of lasso peptides: signature of a rotaxane topology.

Jeanne Dit Fouque K, Afonso C, Zirah S, Hegemann JD, Zimmermann M, Marahiel MA, Rebuffat S, Lavanant H.

Anal Chem. 2015 Jan 20;87(2):1166-72. doi: 10.1021/ac503772n. Epub 2014 Dec 31.

PMID:
25495527
21.

The tRNA-dependent biosynthesis of modified cyclic dipeptides.

Giessen TW, Marahiel MA.

Int J Mol Sci. 2014 Aug 21;15(8):14610-31. doi: 10.3390/ijms150814610. Review.

22.

Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides.

Hegemann JD, De Simone M, Zimmermann M, Knappe TA, Xie X, Di Leva FS, Marinelli L, Novellino E, Zahler S, Kessler H, Marahiel MA.

J Med Chem. 2014 Jul 10;57(13):5829-34. doi: 10.1021/jm5004478. Epub 2014 Jun 27.

PMID:
24949551
23.

Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification.

Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V.

Chem Biol. 2014 Apr 24;21(4):552-562. doi: 10.1016/j.chembiol.2014.02.014. Epub 2014 Apr 3.

24.

Xanthomonins I-III: a new class of lasso peptides with a seven-residue macrolactam ring.

Hegemann JD, Zimmermann M, Zhu S, Steuber H, Harms K, Xie X, Marahiel MA.

Angew Chem Int Ed Engl. 2014 Feb 17;53(8):2230-4. doi: 10.1002/anie.201309267. Epub 2014 Jan 20.

PMID:
24446383
25.

Structural characterization of the heterobactin siderophores from Rhodococcus erythropolis PR4 and elucidation of their biosynthetic machinery.

Bosello M, Zeyadi M, Kraas FI, Linne U, Xie X, Marahiel MA.

J Nat Prod. 2013 Dec 27;76(12):2282-90. doi: 10.1021/np4006579. Epub 2013 Nov 26.

PMID:
24274668
26.

Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry.

Hegemann JD, Zimmermann M, Zhu S, Klug D, Marahiel MA.

Biopolymers. 2013 Sep;100(5):527-42. doi: 10.1002/bip.22326.

PMID:
23897438
27.

Radical S-adenosylmethionine enzyme catalyzed thioether bond formation in sactipeptide biosynthesis.

Flühe L, Marahiel MA.

Curr Opin Chem Biol. 2013 Aug;17(4):605-12. doi: 10.1016/j.cbpa.2013.06.031. Epub 2013 Jul 24. Review.

PMID:
23891473
28.

Insights into the generation of structural diversity in a tRNA-dependent pathway for highly modified bioactive cyclic dipeptides.

Giessen TW, von Tesmar AM, Marahiel MA.

Chem Biol. 2013 Jun 20;20(6):828-38. doi: 10.1016/j.chembiol.2013.04.017.

29.

The Bacillus subtilis EfeUOB transporter is essential for high-affinity acquisition of ferrous and ferric iron.

Miethke M, Monteferrante CG, Marahiel MA, van Dijl JM.

Biochim Biophys Acta. 2013 Oct;1833(10):2267-78. doi: 10.1016/j.bbamcr.2013.05.027. Epub 2013 Jun 10.

30.

A tRNA-dependent two-enzyme pathway for the generation of singly and doubly methylated ditryptophan 2,5-diketopiperazines.

Giessen TW, von Tesmar AM, Marahiel MA.

Biochemistry. 2013 Jun 18;52(24):4274-83. doi: 10.1021/bi4004827. Epub 2013 Jun 7.

PMID:
23705796
31.

The astexin-1 lasso peptides: biosynthesis, stability, and structural studies.

Zimmermann M, Hegemann JD, Xie X, Marahiel MA.

Chem Biol. 2013 Apr 18;20(4):558-69. doi: 10.1016/j.chembiol.2013.03.013.

32.

Two [4Fe-4S] clusters containing radical SAM enzyme SkfB catalyze thioether bond formation during the maturation of the sporulation killing factor.

Flühe L, Burghaus O, Wieckowski BM, Giessen TW, Linne U, Marahiel MA.

J Am Chem Soc. 2013 Jan 23;135(3):959-62. doi: 10.1021/ja310542g. Epub 2013 Jan 9.

PMID:
23282011
33.

Uptake of xenosiderophores in Bacillus subtilis occurs with high affinity and enhances the folding stabilities of substrate binding proteins.

Miethke M, Kraushaar T, Marahiel MA.

FEBS Lett. 2013 Jan 16;587(2):206-13. doi: 10.1016/j.febslet.2012.11.027. Epub 2012 Dec 5.

34.

Caulosegnins I-III: a highly diverse group of lasso peptides derived from a single biosynthetic gene cluster.

Hegemann JD, Zimmermann M, Xie X, Marahiel MA.

J Am Chem Soc. 2013 Jan 9;135(1):210-22. doi: 10.1021/ja308173b. Epub 2012 Dec 24.

PMID:
23214991
35.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.

36.

Isolation, structure elucidation, and biosynthesis of an unusual hydroxamic acid ester-containing siderophore from Actinosynnema mirum.

Giessen TW, Franke KB, Knappe TA, Kraas FI, Bosello M, Xie X, Linne U, Marahiel MA.

J Nat Prod. 2012 May 25;75(5):905-14. doi: 10.1021/np300046k. Epub 2012 May 11.

PMID:
22578145
37.

Determination of peptide topology through time-resolved double-resonance under electron capture dissociation conditions.

Pérot-Taillandier M, Zirah S, Rebuffat S, Linne U, Marahiel MA, Cole RB, Tabet JC, Afonso C.

Anal Chem. 2012 Jun 5;84(11):4957-64. doi: 10.1021/ac300607y. Epub 2012 May 11.

PMID:
22571326
38.

Dissecting the maturation steps of the lasso peptide microcin J25 in vitro.

Yan KP, Li Y, Zirah S, Goulard C, Knappe TA, Marahiel MA, Rebuffat S.

Chembiochem. 2012 May 7;13(7):1046-52. doi: 10.1002/cbic.201200016. Epub 2012 Apr 5.

PMID:
22488892
39.

An enzymatic pathway for the biosynthesis of the formylhydroxyornithine required for rhodochelin iron coordination.

Bosello M, Mielcarek A, Giessen TW, Marahiel MA.

Biochemistry. 2012 Apr 10;51(14):3059-66. doi: 10.1021/bi201837f. Epub 2012 Mar 30.

PMID:
22439765
40.

The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A.

Flühe L, Knappe TA, Gattner MJ, Schäfer A, Burghaus O, Linne U, Marahiel MA.

Nat Chem Biol. 2012 Feb 26;8(4):350-7. doi: 10.1038/nchembio.798. Erratum in: Nat Chem Biol. 2012 Aug;8(8):737.

PMID:
22366720
41.

NMR as an effective tool for the structure determination of lasso peptides.

Xie X, Marahiel MA.

Chembiochem. 2012 Mar 19;13(5):621-5. doi: 10.1002/cbic.201100754. Epub 2012 Jan 25. Review. No abstract available.

PMID:
22278977
42.

Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity.

Giessen TW, Marahiel MA.

FEBS Lett. 2012 Jul 16;586(15):2065-75. doi: 10.1016/j.febslet.2012.01.017. Epub 2012 Jan 21. Review.

43.

Exploring the mechanism of lipid transfer during biosynthesis of the acidic lipopeptide antibiotic CDA.

Kraas FI, Giessen TW, Marahiel MA.

FEBS Lett. 2012 Feb 3;586(3):283-8. doi: 10.1016/j.febslet.2012.01.003. Epub 2012 Jan 10.

44.

The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli.

Miethke M, Hou J, Marahiel MA.

Biochemistry. 2011 Dec 20;50(50):10951-64. doi: 10.1021/bi201517h. Epub 2011 Nov 18.

PMID:
22098718
45.

Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.

Knappe TA, Manzenrieder F, Mas-Moruno C, Linne U, Sasse F, Kessler H, Xie X, Marahiel MA.

Angew Chem Int Ed Engl. 2011 Sep 5;50(37):8714-7. doi: 10.1002/anie.201102190. Epub 2011 Aug 2. No abstract available.

PMID:
21812076
46.

The siderophore binding protein FeuA shows limited promiscuity toward exogenous triscatecholates.

Peuckert F, Ramos-Vega AL, Miethke M, Schwörer CJ, Albrecht AG, Oberthür M, Marahiel MA.

Chem Biol. 2011 Jul 29;18(7):907-19. doi: 10.1016/j.chembiol.2011.05.006.

47.

The frataxin homologue Fra plays a key role in intracellular iron channeling in Bacillus subtilis.

Albrecht AG, Landmann H, Nette D, Burghaus O, Peuckert F, Seubert A, Miethke M, Marahiel MA.

Chembiochem. 2011 Sep 5;12(13):2052-61. doi: 10.1002/cbic.201100190. Epub 2011 Jul 8.

PMID:
21744456
48.

Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin.

Robbel L, Helmetag V, Knappe TA, Marahiel MA.

Biochemistry. 2011 Jul 12;50(27):6073-80. doi: 10.1021/bi200699x. Epub 2011 Jun 15.

PMID:
21650455
49.

A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin.

Giessen TW, Kraas FI, Marahiel MA.

Biochemistry. 2011 Jun 28;50(25):5680-92. doi: 10.1021/bi2006114. Epub 2011 Jun 3.

PMID:
21612226
50.

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