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Items: 1 to 50 of 81

1.

Parstatin suppresses ocular neovascularization and inflammation.

Huang H, Vasilakis P, Zhong X, Shen JK, Geronatsiou K, Papadaki H, Maragoudakis ME, Gartaganis SP, Vinores SA, Tsopanoglou NE.

Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5825-32. doi: 10.1167/iovs.10-5576. Epub 2010 Jun 10.

2.

Thrombin's central role in angiogenesis and pathophysiological processes.

Tsopanoglou NE, Maragoudakis ME.

Eur Cytokine Netw. 2009 Dec;20(4):171-9. doi: 10.1684/ecn.2009.0166. Review.

3.

Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis.

Zania P, Gourni D, Aplin AC, Nicosia RF, Flordellis CS, Maragoudakis ME, Tsopanoglou NE.

J Pharmacol Exp Ther. 2009 Feb;328(2):378-89. doi: 10.1124/jpet.108.145664. Epub 2008 Nov 6.

PMID:
18988770
4.

Thrombin mediates mitogenesis and survival of human endothelial cells through distinct mechanisms.

Zania P, Papaconstantinou M, Flordellis CS, Maragoudakis ME, Tsopanoglou NE.

Am J Physiol Cell Physiol. 2008 May;294(5):C1215-26. doi: 10.1152/ajpcell.00452.2007. Epub 2008 Mar 26.

5.

Inhibition of angiogenesis by small-molecule antagonists of protease-activated receptor-1.

Tsopanoglou NE, Maragoudakis ME.

Semin Thromb Hemost. 2007 Oct;33(7):680-7. Review.

PMID:
18000795
6.

Methylene blue inhibits angiogenesis in chick chorioallontoic membrane through a nitric oxide-independent mechanism.

Zacharakis N, Tone P, Flordellis CS, Maragoudakis ME, Tsopanoglou NE.

J Cell Mol Med. 2006 Apr-Jun;10(2):493-8.

7.

Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis.

Zania P, Kritikou S, Flordellis CS, Maragoudakis ME, Tsopanoglou NE.

J Pharmacol Exp Ther. 2006 Jul;318(1):246-54. Epub 2006 Apr 4.

PMID:
16595737
8.

Thrombin functions through its RGD sequence in a non-canonical conformation.

Papaconstantinou ME, Carrell CJ, Pineda AO, Bobofchak KM, Mathews FS, Flordellis CS, Maragoudakis ME, Tsopanoglou NE, Di Cera E.

J Biol Chem. 2005 Aug 19;280(33):29393-6. Epub 2005 Jul 5.

9.

On the mode of action of thrombin-induced angiogenesis: thrombin peptide, TP508, mediates effects in endothelial cells via alphavbeta3 integrin.

Tsopanoglou NE, Papaconstantinou ME, Flordellis CS, Maragoudakis ME.

Thromb Haemost. 2004 Oct;92(4):846-57.

PMID:
15467917
10.

Role of thrombin in angiogenesis: a rebuttal.

Maragoudakis ME, Tsopanoglou NE.

J Thromb Haemost. 2004 May;2(5):841-2; discussion 843. No abstract available.

11.

Role of thrombin in angiogenesis and tumor progression.

Tsopanoglou NE, Maragoudakis ME.

Semin Thromb Hemost. 2004 Feb;30(1):63-9. Review.

PMID:
15034798
12.

The vascular architecture of the chick chorioallantoic membrane: sequential quantitative evaluation using corrosion casting.

Dimitropoulou C, Malkusch W, Fait E, Maragoudakis ME, Konerding MA.

Angiogenesis. 1998;2(3):255-63.

PMID:
14517465
13.
14.

Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase.

Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD.

Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H669-78. Epub 2003 Apr 3.

15.

On the mechanism of thrombin-induced angiogenesis: involvement of alphavbeta3-integrin.

Tsopanoglou NE, Andriopoulou P, Maragoudakis ME.

Am J Physiol Cell Physiol. 2002 Nov;283(5):C1501-10.

16.

Mechanism of thrombin-induced angiogenesis.

Maragoudakis ME, Tsopanoglou NE, Andriopoulou P.

Biochem Soc Trans. 2002 Apr;30(2):173-7. Review.

PMID:
12023846
17.

Effects of thrombin and of the phospholipase C inhibitor, D609, on the vascularity of the chick chorioallantoic membrane.

Dimitropoulou C, Maragoudakis ME, Konerding MA.

Gen Pharmacol. 2000 Nov;35(5):241-7.

PMID:
11888679
18.

Angiogenesis in health and disease.

Maragoudakis ME.

Gen Pharmacol. 2000 Nov;35(5):225-6. No abstract available.

PMID:
11888676
19.

Regulation of extracellular matrix remodeling and MMP-2 activation in cultured rat adrenal medullary endothelial cells.

Papadimitriou E, Waters CR, Manolopoulos VG, Unsworth BR, Maragoudakis ME, Lelkes PI.

Endothelium. 2001;8(4):243-53.

PMID:
11824476
20.

Modulation of angiogenesis and progelatinase a by thrombin receptor mimetics and antagonists.

Maragoudakis ME, Kraniti N, Giannopoulou E, Alexopoulos K, Matsoukas J.

Endothelium. 2001;8(3):195-205.

PMID:
11824472
21.

Regulation of extracellular matrix remodeling and MMP-2 activation in cultured rat adrenal medullary endothelial cells.

Papadimitriou E, Waters CR, Manolopoulos VG, Unsworth BR, Maragoudakis ME, Lelkes PL.

Endothelium. 2001;8(3):181-94.

PMID:
11824471
22.

Effects of thrombin/thrombosis in angiogenesis and tumour progression.

Maragoudakis ME, Tsopanoglou NE, Andriopoulou P, Maragoudakis MM.

Matrix Biol. 2000 Aug;19(4):345-51. Review.

PMID:
10963995
23.

On the mechanism(s) of thrombin induced angiogenesis.

Maragoudakis ME, Tsopanoglou NE.

Adv Exp Med Biol. 2000;476:47-55.

PMID:
10949654
24.

Nitric oxide synthase expression, enzyme activity and NO production during angiogenesis in the chick chorioallantoic membrane.

Pipili-Synetos E, Kritikou S, Papadimitriou E, Athanassiadou A, Flordellis C, Maragoudakis ME.

Br J Pharmacol. 2000 Jan;129(1):207-13.

26.

Evidence that platelets promote tube formation by endothelial cells on matrigel.

Pipili-Synetos E, Papadimitriou E, Maragoudakis ME.

Br J Pharmacol. 1998 Nov;125(6):1252-7.

27.

Involvement of nitric oxide in the inhibition of angiogenesis by interleukin-2.

Sakkoula E, Pipili-Synetos E, Maragoudakis ME.

Br J Pharmacol. 1997 Nov;122(5):793-5.

28.

Thrombin promotes endothelial cell alignment in Matrigel in vitro and angiogenesis in vivo.

Haralabopoulos GC, Grant DS, Kleinman HK, Maragoudakis ME.

Am J Physiol. 1997 Jul;273(1 Pt 1):C239-45.

PMID:
9252462
29.

Thrombin modulates vectorial secretion of extracellular matrix proteins in cultured endothelial cells.

Papadimitriou E, Manolopoulos VG, Hayman GT, Maragoudakis ME, Unsworth BR, Fenton JW 2nd, Lelkes PI.

Am J Physiol. 1997 Apr;272(4 Pt 1):C1112-22.

PMID:
9142835
30.

Assessment of angiogenesis in human cervical lesions.

Ravazoula P, Zolota V, Hatjicondi O, Sakellaropoulos G, Kourounis G, Maragoudakis ME.

Anticancer Res. 1996 Nov-Dec;16(6B):3861-4.

PMID:
9042271
31.

Validation of collagenous protein synthesis as an index for angiogenesis with the use of morphological methods.

Maragoudakis ME, Haralabopoulos GC, Tsopanoglou NE, Pipili-Synetos E.

Microvasc Res. 1995 Sep;50(2):215-22.

PMID:
8538501
32.

Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate.

Pipili-Synetos E, Papageorgiou A, Sakkoula E, Sotiropoulou G, Fotsis T, Karakiulakis G, Maragoudakis ME.

Br J Pharmacol. 1995 Sep;116(2):1829-34.

33.

Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo.

Haralabopoulos GC, Grant DS, Kleinman HK, Lelkes PI, Papaioannou SP, Maragoudakis ME.

Lab Invest. 1994 Oct;71(4):575-82.

PMID:
7526036
34.

Inhibition of angiogenesis by anthracyclines and titanocene dichloride.

Maragoudakis ME, Peristeris P, Missirlis E, Aletras A, Andriopoulou P, Haralabopoulos G.

Ann N Y Acad Sci. 1994 Sep 6;732:280-93.

PMID:
7526759
35.

Opposing effects on modulation of angiogenesis by protein kinase C and cAMP-mediated pathways.

Tsopanoglou NE, Haralabopoulos GC, Maragoudakis ME.

J Vasc Res. 1994 Jul-Aug;31(4):195-204.

PMID:
7517701
36.

Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction.

Tsopanoglou NE, Pipili-Synetos E, Maragoudakis ME.

Eur J Pharmacol. 1994 Jun 2;258(1-2):151-4.

PMID:
7523148
37.

Evidence that nitric oxide is an endogenous antiangiogenic mediator.

Pipili-Synetos E, Sakkoula E, Haralabopoulos G, Andriopoulou P, Peristeris P, Maragoudakis ME.

Br J Pharmacol. 1994 Mar;111(3):894-902.

38.

Suppression of angiogenesis by the antitumor agent titanocene dichloride.

Bastaki M, Missirlis E, Klouras N, Karakiulakis G, Maragoudakis ME.

Eur J Pharmacol. 1994 Jan 14;251(2-3):263-9.

PMID:
7512041
39.

Protein kinase C involvement in the regulation of angiogenesis.

Tsopanoglou NE, Pipili-Synetos E, Maragoudakis ME.

J Vasc Res. 1993 Jul-Aug;30(4):202-8.

PMID:
7689346
40.
41.

Thrombin promotes angiogenesis by a mechanism independent of fibrin formation.

Tsopanoglou NE, Pipili-Synetos E, Maragoudakis ME.

Am J Physiol. 1993 May;264(5 Pt 1):C1302-7.

PMID:
7684562
42.

Nitric oxide is involved in the regulation of angiogenesis.

Pipili-Synetos E, Sakkoula E, Maragoudakis ME.

Br J Pharmacol. 1993 Apr;108(4):855-7.

43.

Basement membrane biosynthesis as a target for developing inhibitors of angiogenesis with anti-tumor properties.

Maragoudakis ME, Missirlis E, Karakiulakis GD, Sarmonica M, Bastakis M, Tsopanoglou N.

Kidney Int. 1993 Jan;43(1):147-50.

44.

Effect of divalent metal ions on collagenase from Clostridium histolyticum.

Karakiulakis G, Papadimitriu E, Missirlis E, Maragoudakis ME.

Biochem Int. 1991 Jun;24(3):397-404.

PMID:
1663343
45.

Role of endothelium on alpha-adrenoceptor responsiveness and prostacyclin release from the mesenteric arterial bed of the rat.

Pipili-Synetos E, Sideri E, Maragoudakis ME.

J Auton Pharmacol. 1991 Jun;11(3):129-37.

PMID:
1649193
46.

Endothelium removal does not abolish angiotensin converting enzyme activity from the mesenteric arterial bed of the rat.

Pipili-Synetos E, Sideri E, Catravas JD, Maragoudakis ME.

Biochem Pharmacol. 1990 Sep 1;40(5):1149-51. No abstract available.

PMID:
2167680
47.

Basement membrane collagen-degrading activity from a malignant tumor is inhibited by anthracycline antibiotics.

Karakiulakis G, Missirlis E, Maragoudakis ME.

Biochim Biophys Acta. 1990 Aug 17;1035(2):218-22.

PMID:
2168213
48.

Antitumor effect of GPA1734 in rat Walker 256 carcinoma.

Missirlis E, Karakiulakis G, Maragoudakis ME.

Invest New Drugs. 1990 May;8(2):145-7.

PMID:
2384301
49.

Basement membrane biosynthesis as a target to tumor therapy.

Maragoudakis ME, Missirlis E, Sarmonika M, Panoutsacopoulou M, Karakiulakis G.

J Pharmacol Exp Ther. 1990 Feb;252(2):753-7.

PMID:
1690295
50.

Angiogenesis is associated with collagenous protein synthesis and degradation in the chick chorioallantoic membrane.

Missirlis E, Karakiulakis G, Maragoudakis ME.

Tissue Cell. 1990;22(4):419-26.

PMID:
1701927

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