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Cellular RNA surveillance in health and disease.

Wolin SL, Maquat LE.

Science. 2019 Nov 15;366(6467):822-827. doi: 10.1126/science.aax2957. Epub 2019 Nov 14. Review.


Publisher Correction: Quality and quantity control of gene expression by nonsense-mediated mRNA decay.

Kurosaki T, Popp MW, Maquat LE.

Nat Rev Mol Cell Biol. 2019 Jun;20(6):384. doi: 10.1038/s41580-019-0138-y.


Quality and quantity control of gene expression by nonsense-mediated mRNA decay.

Kurosaki T, Popp MW, Maquat LE.

Nat Rev Mol Cell Biol. 2019 Jul;20(7):406-420. doi: 10.1038/s41580-019-0126-2. Review. Erratum in: Nat Rev Mol Cell Biol. 2019 Apr 26;:.


UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond.

Kim YK, Maquat LE.

RNA. 2019 Apr;25(4):407-422. doi: 10.1261/rna.070136.118. Epub 2019 Jan 17. Review.


Defining nonsense-mediated mRNA decay intermediates in human cells.

Kurosaki T, Myers JR, Maquat LE.

Methods. 2019 Feb 15;155:68-76. doi: 10.1016/j.ymeth.2018.12.005. Epub 2018 Dec 19. Review.


Publisher Correction: NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides.

Kurosaki T, Miyoshi K, Myers JR, Maquat LE.

Nat Struct Mol Biol. 2018 Nov;25(11):1059. doi: 10.1038/s41594-018-0153-2.


NMD-degradome sequencing reveals ribosome-bound intermediates with 3'-end non-templated nucleotides.

Kurosaki T, Miyoshi K, Myers JR, Maquat LE.

Nat Struct Mol Biol. 2018 Oct;25(10):940-950. doi: 10.1038/s41594-018-0132-7. Epub 2018 Oct 1. Erratum in: Nat Struct Mol Biol. 2018 Nov;25(11):1059.


Evaluating the susceptibility of AGO2-loaded microRNAs to degradation by nucleases in vitro.

Elbarbary RA, Maquat LE.

Methods. 2019 Jan 1;152:18-22. doi: 10.1016/j.ymeth.2018.05.010. Epub 2018 May 17.


Introduction-RNA: From Single Molecules to Medicine.

Walter NG, Maquat LE.

Chem Rev. 2018 Apr 25;118(8):4117-4119. doi: 10.1021/acs.chemrev.8b00095. No abstract available.


Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression.

Cho H, Rambout X, Gleghorn ML, Nguyen PQT, Phipps CR, Miyoshi K, Myers JR, Kataoka N, Fasan R, Maquat LE.

Genes Dev. 2018 Apr 1;32(7-8):555-567. doi: 10.1101/gad.309773.117. Epub 2018 Apr 13.


Molecular autopsy provides evidence for widespread ribosome-phased mRNA fragmentation.

Kurosaki T, Maquat LE.

Nat Struct Mol Biol. 2018 Apr;25(4):299-301. doi: 10.1038/s41594-018-0048-2. No abstract available.


Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay.

Lucas BA, Lavi E, Shiue L, Cho H, Katzman S, Miyoshi K, Siomi MC, Carmel L, Ares M Jr, Maquat LE.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):968-973. doi: 10.1073/pnas.1715531115. Epub 2018 Jan 16.


Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing.

Rambout X, Dequiedt F, Maquat LE.

Chem Rev. 2018 Apr 25;118(8):4339-4364. doi: 10.1021/acs.chemrev.7b00470. Epub 2017 Dec 18. Review.


Identifying Cellular Nonsense-Mediated mRNA Decay (NMD) Targets: Immunoprecipitation of Phosphorylated UPF1 Followed by RNA Sequencing (p-UPF1 RIP-Seq).

Kurosaki T, Hoque M, Maquat LE.

Methods Mol Biol. 2018;1720:175-186. doi: 10.1007/978-1-4939-7540-2_13.


Nonsense-mediated mRNA Decay and Cancer.

Popp MW, Maquat LE.

Curr Opin Genet Dev. 2018 Feb;48:44-50. doi: 10.1016/j.gde.2017.10.007. Epub 2017 Nov 7. Review.


UPF1 helicase promotes TSN-mediated miRNA decay.

Elbarbary RA, Miyoshi K, Hedaya O, Myers JR, Maquat LE.

Genes Dev. 2017 Jul 15;31(14):1483-1493. doi: 10.1101/gad.303537.117. Epub 2017 Aug 21.


Distinct mechanisms obviate the potentially toxic effects of inverted-repeat Alu elements on cellular RNA metabolism.

Elbarbary RA, Maquat LE.

Nat Struct Mol Biol. 2017 Jun 6;24(6):496-498. doi: 10.1038/nsmb.3416. No abstract available.


Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.

Elbarbary RA, Miyoshi K, Myers JR, Du P, Ashton JM, Tian B, Maquat LE.

Science. 2017 May 26;356(6340):859-862. doi: 10.1126/science.aai9372.


Crystal structure of a poly(rA) staggered zipper at acidic pH: evidence that adenine N1 protonation mediates parallel double helix formation.

Gleghorn ML, Zhao J, Turner DH, Maquat LE.

Nucleic Acids Res. 2016 Sep 30;44(17):8417-24. doi: 10.1093/nar/gkw526. Epub 2016 Jun 10.


Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine.

Popp MW, Maquat LE.

Cell. 2016 Jun 2;165(6):1319-1322. doi: 10.1016/j.cell.2016.05.053. Review.


Coupling pre-mRNA splicing and 3' end formation to mRNA export: alternative ways to punch the nuclear export clock.

Elbarbary RA, Maquat LE.

Genes Dev. 2016 Mar 1;30(5):487-8. doi: 10.1101/gad.278937.116.


Retrotransposons as regulators of gene expression.

Elbarbary RA, Lucas BA, Maquat LE.

Science. 2016 Feb 12;351(6274):aac7247. doi: 10.1126/science.aac7247. Epub 2016 Feb 11. Review.


Eukaryotic antisense ahead of its time.

Maquat LE.

Nat Rev Mol Cell Biol. 2016 Apr;17(4):204. doi: 10.1038/nrm.2016.1. Epub 2016 Feb 24. No abstract available.


Nonsense-mediated mRNA decay in humans at a glance.

Kurosaki T, Maquat LE.

J Cell Sci. 2016 Feb 1;129(3):461-7. doi: 10.1242/jcs.181008. Epub 2016 Jan 19. Review.


CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention.

Elbarbary RA, Maquat LE.

Genes Dev. 2015 Apr 1;29(7):687-9. doi: 10.1101/gad.261438.115.


Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.

Popp MW, Maquat LE.

Nat Commun. 2015 Mar 26;6:6632. doi: 10.1038/ncomms7632.


RNA. A TRICK'n way to see the pioneer round of translation.

Popp MW, Maquat LE.

Science. 2015 Mar 20;347(6228):1316-7. doi: 10.1126/science.aaa9484. No abstract available.


The amazing web of post-transcriptional gene control: the sum of small changes can make for significant consequences.

Maquat LE.

RNA. 2015 Apr;21(4):488-9. doi: 10.1261/rna.049718.115. No abstract available.


Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.

Jackson KL, Dayton RD, Orchard EA, Ju S, Ringe D, Petsko GA, Maquat LE, Klein RL.

Gene Ther. 2015 Jan;22(1):20-8. doi: 10.1038/gt.2014.101. Epub 2014 Nov 6.


Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells.

Gong C, Maquat LE.

Methods Mol Biol. 2015;1206:81-6. doi: 10.1007/978-1-4939-1369-5_7.


A post-translational regulatory switch on UPF1 controls targeted mRNA degradation.

Kurosaki T, Li W, Hoque M, Popp MW, Ermolenko DN, Tian B, Maquat LE.

Genes Dev. 2014 Sep 1;28(17):1900-16. doi: 10.1101/gad.245506.114.


'Black sheep' that don't leave the double-stranded RNA-binding domain fold.

Gleghorn ML, Maquat LE.

Trends Biochem Sci. 2014 Jul;39(7):328-40. doi: 10.1016/j.tibs.2014.05.003. Epub 2014 Jun 19. Review.


Defective secretory-protein mRNAs take the RAPP.

Popp MW, Maquat LE.

Trends Biochem Sci. 2014 Apr;39(4):154-6. doi: 10.1016/j.tibs.2014.02.001. Epub 2014 Mar 3.


The dharma of nonsense-mediated mRNA decay in mammalian cells.

Popp MW, Maquat LE.

Mol Cells. 2014 Jan;37(1):1-8. doi: 10.14348/molcells.2014.2193. Epub 2014 Jan 27. Review.


Dodging two bullets with one dsRNA-binding protein.

Elbarbary RA, Maquat LE.

Cell Cycle. 2014;13(3):345-6. doi: 10.4161/cc.27512. Epub 2013 Dec 13. No abstract available.


Organizing principles of mammalian nonsense-mediated mRNA decay.

Popp MW, Maquat LE.

Annu Rev Genet. 2013;47:139-65. doi: 10.1146/annurev-genet-111212-133424. Review.


mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay.

Gong C, Tang Y, Maquat LE.

Nat Struct Mol Biol. 2013 Oct;20(10):1214-20. doi: 10.1038/nsmb.2664. Epub 2013 Sep 22.


STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown.

Elbarbary RA, Li W, Tian B, Maquat LE.

Genes Dev. 2013 Jul 1;27(13):1495-510. doi: 10.1101/gad.220962.113.


New gene expression pipelines gush lncRNAs.

Wang J, Lucas BA, Maquat LE.

Genome Biol. 2013 May 24;14(5):117. doi: 10.1186/gb-2013-14-5-117.


Staufen-mediated mRNA decay.

Park E, Maquat LE.

Wiley Interdiscip Rev RNA. 2013 Jul-Aug;4(4):423-35. doi: 10.1002/wrna.1168. Epub 2013 May 16. Review.


Control of myogenesis by rodent SINE-containing lncRNAs.

Wang J, Gong C, Maquat LE.

Genes Dev. 2013 Apr 1;27(7):793-804. doi: 10.1101/gad.212639.112. Epub 2013 Apr 4.


Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay.

Gleghorn ML, Gong C, Kielkopf CL, Maquat LE.

Nat Struct Mol Biol. 2013 Apr;20(4):515-24. doi: 10.1038/nsmb.2528. Epub 2013 Mar 24.


Temporal and spatial characterization of nonsense-mediated mRNA decay.

Trcek T, Sato H, Singer RH, Maquat LE.

Genes Dev. 2013 Mar 1;27(5):541-51. doi: 10.1101/gad.209635.112. Epub 2013 Feb 21.


Rules that govern UPF1 binding to mRNA 3' UTRs.

Kurosaki T, Maquat LE.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3357-62. doi: 10.1073/pnas.1219908110. Epub 2013 Feb 12.


Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity.

Park E, Gleghorn ML, Maquat LE.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):405-12. doi: 10.1073/pnas.1213508110. Epub 2012 Dec 20.


Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes.

Gong C, Popp MW, Maquat LE.

Methods. 2012 Oct;58(2):88-93. doi: 10.1016/j.ymeth.2012.06.020. Epub 2012 Jul 10.


Regulation of cytoplasmic mRNA decay.

Schoenberg DR, Maquat LE.

Nat Rev Genet. 2012 Mar 6;13(4):246-59. doi: 10.1038/nrg3160. Review. Erratum in: Nat Rev Genet. 2012 Jun;13(6):448.


Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question.

Hwang J, Maquat LE.

Curr Opin Genet Dev. 2011 Aug;21(4):422-30. doi: 10.1016/j.gde.2011.03.008. Review.


A yeast model of FUS/TLS-dependent cytotoxicity.

Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH Jr, Lindquist S, Ringe D, Petsko GA.

PLoS Biol. 2011 Apr;9(4):e1001052. doi: 10.1371/journal.pbio.1001052. Epub 2011 Apr 26.


"Alu"strious long ncRNAs and their role in shortening mRNA half-lives.

Gong C, Maquat LE.

Cell Cycle. 2011 Jun 15;10(12):1882-3. Epub 2011 Jun 15. No abstract available.

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