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Items: 1 to 50 of 143

1.

Long-term follow-up of antibody titers against measles, mumps, and rubella in recipients of allogenic hematopoietic cell transplantations.

Bögeholz J, Russkamp NF, Wilk CM, Gourri E, Haralambieva E, Schanz U, Mueller NJ, Manz MG, Müller AMS.

Biol Blood Marrow Transplant. 2019 Nov 1. pii: S1083-8791(19)30709-8. doi: 10.1016/j.bbmt.2019.10.027. [Epub ahead of print]

PMID:
31682977
2.

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection.

Caiado F, Maia-Silva D, Jardim C, Schmolka N, Carvalho T, Reforço C, Faria R, Kolundzija B, Simões AE, Baubec T, Vakoc CR, da Silva MG, Manz MG, Schumacher TN, Norell H, Silva-Santos B.

Nat Commun. 2019 Nov 1;10(1):4986. doi: 10.1038/s41467-019-12983-z.

3.

Pharmacological DNA demethylation restores SMAD1 expression and tumor suppressive signaling in diffuse large B-cell lymphoma.

Stelling A, Wu CT, Bertram K, Hashwah H, Theocharides APA, Manz MG, Tzankov A, Müller A.

Blood Adv. 2019 Oct 22;3(20):3020-3032. doi: 10.1182/bloodadvances.2019000210.

4.

The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma.

Hashwah H, Bertram K, Stirm K, Stelling A, Wu CT, Kasser S, Manz MG, Theocharides AP, Tzankov A, Müller A.

EMBO Mol Med. 2019 Oct;11(10):e10576. doi: 10.15252/emmm.201910576. Epub 2019 Sep 12.

5.

Daratumumab for relapsed or refractory AL amyloidosis with high plasma cell burden.

Schwotzer R, Manz MG, Pederiva S, Waibel C, Caspar C, Lerch E, Flammer AJ, Brouwers S, Seeger H, Heimgartner R, Fehr T, Rossi D, Bianchi E, Stüssi G, Ghilardi G, Gerber B.

Hematol Oncol. 2019 Sep 5. doi: 10.1002/hon.2677. [Epub ahead of print]

PMID:
31486522
6.

Impact of a Patient Blood Management monitoring and feedback programme on allogeneic blood transfusions and related costs.

Kaserer A, Rössler J, Braun J, Farokhzad F, Pape HC, Dutkowski P, Plass A, Horisberger T, Volbracht J, Manz MG, Spahn DR.

Anaesthesia. 2019 Dec;74(12):1534-1541. doi: 10.1111/anae.14816. Epub 2019 Aug 25.

PMID:
31448406
7.

Fate Distribution and Regulatory Role of Human Mesenchymal Stromal Cells in Engineered Hematopoietic Bone Organs.

Bourgine PE, Fritsch K, Pigeot S, Takizawa H, Kunz L, Kokkaliaris KD, Coutu DL, Manz MG, Martin I, Schroeder T.

iScience. 2019 Sep 27;19:504-513. doi: 10.1016/j.isci.2019.08.006. Epub 2019 Aug 7.

8.

Development of a novel fully-human anti-CD123 antibody to target acute myeloid leukemia.

Hutmacher C, Volta L, Rinaldi F, Murer P, Myburgh R, Manz MG, Neri D.

Leuk Res. 2019 Sep;84:106178. doi: 10.1016/j.leukres.2019.106178. Epub 2019 Jun 27.

PMID:
31326578
9.

Selective CD117+ HSC exchange therapy.

Manz MG, Russkamp NF.

Blood. 2019 May 9;133(19):2007-2009. doi: 10.1182/blood-2019-03-900894. No abstract available.

PMID:
31072963
10.

Sensitive Quantitative Proteomics of Human Hematopoietic Stem and Progenitor Cells by Data-independent Acquisition Mass Spectrometry.

Amon S, Meier-Abt F, Gillet LC, Dimitrieva S, Theocharides APA, Manz MG, Aebersold R.

Mol Cell Proteomics. 2019 Jul;18(7):1454-1467. doi: 10.1074/mcp.TIR119.001431. Epub 2019 Apr 11.

11.

Erratum to "Engineered humanized bone organs maintain human hematopoiesis in vivo": [Experimental Hematology 61 (2018) 45-51].

Fritsch K, Pigeot S, Feng X, Bourgine PE, Schroeder T, Martin I, Manz MG, Takizawa H.

Exp Hematol. 2019 Apr;72:72. doi: 10.1016/j.exphem.2019.01.007. Epub 2019 Jan 26. No abstract available.

PMID:
30689970
12.

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.

Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S.

Nat Commun. 2019 Jan 21;10(1):366. doi: 10.1038/s41467-018-08166-x.

13.

CD34+CD38- leukemic stem cell frequency to predict outcome in acute myeloid leukemia.

Zeijlemaker W, Grob T, Meijer R, Hanekamp D, Kelder A, Carbaat-Ham JC, Oussoren-Brockhoff YJM, Snel AN, Veldhuizen D, Scholten WJ, Maertens J, Breems DA, Pabst T, Manz MG, van der Velden VHJ, Slomp J, Preijers F, Cloos J, van de Loosdrecht AA, Löwenberg B, Valk PJM, Jongen-Lavrencic M, Ossenkoppele GJ, Schuurhuis GJ.

Leukemia. 2019 May;33(5):1102-1112. doi: 10.1038/s41375-018-0326-3. Epub 2018 Dec 12.

PMID:
30542144
14.

Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells.

Tugues S, Amorim A, Spath S, Martin-Blondel G, Schreiner B, De Feo D, Lutz M, Guscetti F, Apostolova P, Haftmann C, Hasselblatt P, Núñez NG, Hottiger MO, van den Broek M, Manz MG, Zeiser R, Becher B.

Sci Transl Med. 2018 Nov 28;10(469). pii: eaat8410. doi: 10.1126/scitranslmed.aat8410.

PMID:
30487251
15.

The sympathomimetic agonist mirabegron did not lower JAK2-V617F allele burden, but restored nestin-positive cells and reduced reticulin fibrosis in patients with myeloproliferative neoplasms: results of phase II study SAKK 33/14.

Drexler B, Passweg JR, Tzankov A, Bigler M, Theocharides AP, Cantoni N, Keller P, Stussi G, Ruefer A, Benz R, Favre G, Lundberg P, Nienhold R, Fuhrer A, Biaggi C, Manz MG, Bargetzi M, Mendez-Ferrer S, Skoda RC; Swiss Group for Clinical Cancer Research (SAKK).

Haematologica. 2019 Apr;104(4):710-716. doi: 10.3324/haematol.2018.200014. Epub 2018 Nov 8.

16.

Efficacy of selective digestive decontamination in patients with multiple myeloma undergoing high-dose chemotherapy and autologous stem cell transplantation.

Mürner CM, Stenner-Liewen F, Seifert B, Mueller NJ, Schmidt A, Renner C, Schanz U, Knuth A, Manz MG, Scharl M, Gerber B, Samaras P.

Leuk Lymphoma. 2019 Mar;60(3):685-695. doi: 10.1080/10428194.2018.1496332. Epub 2018 Aug 21.

PMID:
30126310
17.

Finally: development of humanized lymph nodes.

Theocharides APA, Manz MG.

Nat Methods. 2018 Aug;15(8):580-582. doi: 10.1038/s41592-018-0080-5. No abstract available.

PMID:
30065374
18.

A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies.

De Luca R, Kachel P, Kropivsek K, Snijder B, Manz MG, Neri D.

Protein Eng Des Sel. 2018 May 1;31(5):173-179. doi: 10.1093/protein/gzy015.

19.

Quantitative spatial analysis of haematopoiesis-regulating stromal cells in the bone marrow microenvironment by 3D microscopy.

Gomariz A, Helbling PM, Isringhausen S, Suessbier U, Becker A, Boss A, Nagasawa T, Paul G, Goksel O, Székely G, Stoma S, Nørrelykke SF, Manz MG, Nombela-Arrieta C.

Nat Commun. 2018 Jun 28;9(1):2532. doi: 10.1038/s41467-018-04770-z.

20.

Allogeneic hematopoietic cell transplantation in patients with GATA2 deficiency-a case report and comprehensive review of the literature.

Simonis A, Fux M, Nair G, Mueller NJ, Haralambieva E, Pabst T, Pachlopnik Schmid J, Schmidt A, Schanz U, Manz MG, Müller AMS.

Ann Hematol. 2018 Oct;97(10):1961-1973. doi: 10.1007/s00277-018-3388-4. Epub 2018 Jun 13. Review.

PMID:
29947977
21.

Plasmacytoid dendritic cells: origin matters.

Manz MG.

Nat Immunol. 2018 Jul;19(7):652-654. doi: 10.1038/s41590-018-0143-x. No abstract available.

PMID:
29925994
22.

CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions.

McClain KL, Picarsic J, Chakraborty R, Zinn D, Lin H, Abhyankar H, Scull B, Shih A, Lim KPH, Eckstein O, Lubega J, Peters TL, Olea W, Burke T, Ahmed N, Hicks MJ, Tran B, Jones J, Dauser R, Jeng M, Baiocchi R, Schiff D, Goldman S, Heym KM, Wilson H, Carcamo B, Kumar A, Rodriguez-Galindo C, Whipple NS, Campbell P, Murdoch G, Kofler J, Heales S, Malone M, Woltjer R, Quinn JF, Orchard P, Kruer MC, Jaffe R, Manz MG, Lira SA, Parsons DW, Merad M, Man TK, Allen CE.

Cancer. 2018 Jun 15;124(12):2607-2620. doi: 10.1002/cncr.31348. Epub 2018 Apr 6.

23.

The tumor suppressive TGF-β/SMAD1/S1PR2 signaling axis is recurrently inactivated in diffuse large B-cell lymphoma.

Stelling A, Hashwah H, Bertram K, Manz MG, Tzankov A, Müller A.

Blood. 2018 May 17;131(20):2235-2246. doi: 10.1182/blood-2017-10-810630. Epub 2018 Apr 3.

PMID:
29615404
24.

Molecular Minimal Residual Disease in Acute Myeloid Leukemia.

Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM.

N Engl J Med. 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863.

25.

Continuously infused amphotericin B deoxycholate for primary treatment of invasive fungal disease in acute myeloid leukaemia.

Rothenbühler C, Held U, Manz MG, Schanz U, Gerber B.

Hematol Oncol. 2018 Apr;36(2):471-480. doi: 10.1002/hon.2500. Epub 2018 Feb 12.

PMID:
29431860
26.

Engineered humanized bone organs maintain human hematopoiesis in vivo.

Fritsch K, Pigeot S, Feng X, Bourgine PE, Schroeder T, Martin I, Manz MG, Takizawa H.

Exp Hematol. 2018 May;61:45-51.e5. doi: 10.1016/j.exphem.2018.01.004. Epub 2018 Feb 9. Erratum in: Exp Hematol. 2019 Apr;72:72.

PMID:
29410245
27.

Quantification and three-dimensional microanatomical organization of the bone marrow.

Nombela-Arrieta C, Manz MG.

Blood Adv. 2017 Feb 14;1(6):407-416. doi: 10.1182/bloodadvances.2016003194. eCollection 2017 Feb 14. Review.

28.

NLRP3 Controls the Development of Gastrointestinal CD11b+ Dendritic Cells in the Steady State and during Chronic Bacterial Infection.

Arnold IC, Zhang X, Urban S, Artola-Borán M, Manz MG, Ottemann KM, Müller A.

Cell Rep. 2017 Dec 26;21(13):3860-3872. doi: 10.1016/j.celrep.2017.12.015.

29.

Mobilization of Hematopoietic Progenitor Cells with Standard- or Reduced-Dose Filgrastim after Vinorelbine in Multiple Myeloma Patients: A Randomized Prospective Single-Center Phase II Study.

Samaras P, Rütti MF, Seifert B, Bachmann H, Schanz U, Eisenring M, Renner C, Susanne Müller AM, Schmidt A, Mischo A, Fuchs I, Bargetzi M, Manz MG, Stupp R, Petrausch U, Stenner-Liewen F.

Biol Blood Marrow Transplant. 2018 Apr;24(4):694-699. doi: 10.1016/j.bbmt.2017.12.775. Epub 2017 Dec 12.

30.

Improvement of relative survival in elderly patients with acute myeloid leukaemia emerging from population-based cancer registries in Switzerland between 2001 and 2013.

Schnegg-Kaufmann A, Feller A, Baldomero H, Rovo A, Manz MG, Gregor M, Efthymiou A, Bargetzi M, Hess U, Spertini O, Chalandon Y, Passweg JR, Stussi G, Arndt V, Bonadies N; NICER Working Group.

Cancer Epidemiol. 2018 Feb;52:55-62. doi: 10.1016/j.canep.2017.11.008. Epub 2017 Dec 7.

PMID:
29223104
31.

Corrigendum: Development and function of human innate immune cells in a humanized mouse model.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Nat Biotechnol. 2017 Dec 8;35(12):1211. doi: 10.1038/nbt1217-1211c. No abstract available.

PMID:
29220023
32.

R-hyper-CVAD versus R-CHOP/cytarabine with high-dose therapy and autologous haematopoietic stem cell support in fit patients with mantle cell lymphoma: 20 years of single-center experience.

Widmer F, Balabanov S, Soldini D, Samaras P, Gerber B, Manz MG, Goede JS.

Ann Hematol. 2018 Feb;97(2):277-287. doi: 10.1007/s00277-017-3180-x. Epub 2017 Nov 16.

PMID:
29147847
33.

Humanised mouse models for haematopoiesis and infectious diseases.

Lysenko V, McHugh D, Behrmann L, Rochat MA, Wilk CM, Kovtonyuk L, Bourquin JP, Münz C, Manz MG, Speck R, Theocharides A.

Swiss Med Wkly. 2017 Oct 22;147:w14516. doi: 10.4414/smw.2017.14516. eCollection 2017. Review.

34.

Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments.

Ashcroft P, Manz MG, Bonhoeffer S.

PLoS Comput Biol. 2017 Oct 9;13(10):e1005803. doi: 10.1371/journal.pcbi.1005803. eCollection 2017 Oct.

35.

NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.

Singer J, Ruscheweyh HJ, Hofmann AL, Thurnherr T, Singer F, Toussaint NC, Ng CKY, Piscuoglio S, Beisel C, Christofori G, Dummer R, Hall MN, Krek W, Levesque MP, Manz MG, Moch H, Papassotiropoulos A, Stekhoven DJ, Wild P, Wüst T, Rinn B, Beerenwinkel N.

Bioinformatics. 2018 Jan 1;34(1):107-108. doi: 10.1093/bioinformatics/btx540.

36.

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth.

Hashwah H, Schmid CA, Kasser S, Bertram K, Stelling A, Manz MG, Müller A.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9701-9706. doi: 10.1073/pnas.1619555114. Epub 2017 Aug 22.

37.

Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness.

Takizawa H, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz Á, Nombela-Arrieta C, Manz MG.

Cell Stem Cell. 2017 Aug 3;21(2):225-240.e5. doi: 10.1016/j.stem.2017.06.013. Epub 2017 Jul 20.

38.

Acute central nervous system complications and ammonium levels in adult patients with acute lymphoblastic leukemia receiving l-asparaginase.

Strickler N, Balabanov S, Casauro K, Schanz U, Manz MG, Gerber B.

Leuk Lymphoma. 2018 Apr;59(4):855-862. doi: 10.1080/10428194.2017.1352090. Epub 2017 Jul 21.

PMID:
28728499
39.

Impact of inflammation on early hematopoiesis and the microenvironment.

Takizawa H, Manz MG.

Int J Hematol. 2017 Jul;106(1):27-33. doi: 10.1007/s12185-017-2266-5. Epub 2017 May 30. Review.

PMID:
28560577
40.

Response to Tyrosine Kinase Inhibitors in Myeloproliferative Neoplasia with 8p11 Translocation and CEP110-FGFR1 Rearrangement.

Wehrli M, Oppliger Leibundgut E, Gattiker HH, Manz MG, Müller AM, Goede JS.

Oncologist. 2017 Apr;22(4):480-483. doi: 10.1634/theoncologist.2016-0354. Epub 2017 Feb 27.

41.

Regulation of Inflammation- and Infection-Driven Hematopoiesis.

Boettcher S, Manz MG.

Trends Immunol. 2017 May;38(5):345-357. doi: 10.1016/j.it.2017.01.004. Epub 2017 Feb 16. Review.

PMID:
28216309
42.

sIL2R ratio as early marker for response in hairy cell leukemia and the prognostic relevance of IL28B genotype to interferon-α therapy.

Jud S, Goede JS, Senn O, Spanaus K, Manz MG, Benz R.

Ann Hematol. 2017 May;96(5):757-763. doi: 10.1007/s00277-017-2943-8. Epub 2017 Feb 18.

43.

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production.

Yu H, Borsotti C, Schickel JN, Zhu S, Strowig T, Eynon EE, Frleta D, Gurer C, Murphy AJ, Yancopoulos GD, Meffre E, Manz MG, Flavell RA.

Blood. 2017 Feb 23;129(8):959-969. doi: 10.1182/blood-2016-04-709584. Epub 2017 Jan 11.

44.

Therapeutic value of clofarabine in younger and middle-aged (18-65 years) adults with newly diagnosed AML.

Löwenberg B, Pabst T, Maertens J, van Norden Y, Biemond BJ, Schouten HC, Spertini O, Vellenga E, Graux C, Havelange V, de Greef GE, de Weerdt O, Legdeur MJ, Kuball J, Kooy MV, Gjertsen BT, Jongen-Lavrencic M, van de Loosdrecht AA, van Lammeren-Venema D, Hodossy B, Breems DA, Chalandon Y, Passweg J, Valk PJ, Manz MG, Ossenkoppele GJ; Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON) and Swiss Group for Clinical Cancer Research (SAKK).

Blood. 2017 Mar 23;129(12):1636-1645. doi: 10.1182/blood-2016-10-740613. Epub 2017 Jan 3.

PMID:
28049642
45.

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment.

Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H.

Front Immunol. 2016 Nov 14;7:502. eCollection 2016. Review.

46.

Marginal Zone Lymphoma Complicated by Protein Losing Enteropathy.

Stanek N, Bauerfeind P, Herzog G, Heinrich H, Sauter M, Lenggenhager D, Reiner C, Manz MG, Goede JS, Misselwitz B.

Case Rep Hematol. 2016;2016:9351408. Epub 2016 Nov 9.

47.

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia.

Rauch PJ, Ellegast JM, Widmer CC, Fritsch K, Goede JS, Valk PJ, Löwenberg B, Takizawa H, Manz MG.

Blood. 2016 Nov 3;128(18):2253-2257. Epub 2016 Aug 29.

PMID:
27574191
48.

Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice.

Das R, Strowig T, Verma R, Koduru S, Hafemann A, Hopf S, Kocoglu MH, Borsotti C, Zhang L, Branagan A, Eynon E, Manz MG, Flavell RA, Dhodapkar MV.

Nat Med. 2016 Nov;22(11):1351-1357. doi: 10.1038/nm.4202. Epub 2016 Oct 10.

49.

inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice.

Ellegast JM, Rauch PJ, Kovtonyuk LV, Müller R, Wagner U, Saito Y, Wildner-Verhey van Wijk N, Fritz C, Rafiei A, Lysenko V, Dudkiewicz E, Theocharides AP, Soldini D, Goede JS, Flavell RA, Manz MG.

Blood. 2016 Oct 27;128(17):2130-2134. Epub 2016 Aug 31.

50.

Cladribine, cytarabine and idarubicin (CLA-Ida) salvage chemotherapy in relapsed acute myeloid leukemia (AML).

Fridle C, Medinger M, Wilk MC, Seipel K, Passweg J, Manz MG, Pabst T.

Leuk Lymphoma. 2017 May;58(5):1068-1075. doi: 10.1080/10428194.2016.1235274. Epub 2016 Oct 13.

PMID:
27735213

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