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Items: 11

1.

In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner.

Manville RW, Abbott GW.

Commun Biol. 2019 Nov 1;2(1):401. doi: 10.1038/s42003-019-0648-3.

PMID:
31925247
2.

M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate.

Manville RW, Papanikolaou M, Abbott GW.

J Pharmacol Exp Ther. 2020 Feb;372(2):148-156. doi: 10.1124/jpet.119.263350. Epub 2019 Nov 22.

PMID:
31757819
3.

In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner.

Manville RW, Abbott GW.

Commun Biol. 2019 Nov 1;2:401. doi: 10.1038/s42003-019-0648-3. eCollection 2019.

4.

KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines.

Manville RW, van der Horst J, Redford KE, Katz BB, Jepps TA, Abbott GW.

Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21236-21245. doi: 10.1073/pnas.1907511116. Epub 2019 Sep 30.

PMID:
31570602
5.

Cilantro leaf harbors a potent potassium channel-activating anticonvulsant.

Manville RW, Abbott GW.

FASEB J. 2019 Oct;33(10):11349-11363. doi: 10.1096/fj.201900485R. Epub 2019 Jul 16.

PMID:
31311306
6.

Teamwork: Ion channels and transporters join forces in the brain.

Manville RW, Abbott GW.

Neuropharmacology. 2019 Dec 15;161:107601. doi: 10.1016/j.neuropharm.2019.04.007. Epub 2019 Apr 5.

PMID:
30959022
7.

Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation.

De Silva AM, Manville RW, Abbott GW.

Sci Adv. 2018 Nov 14;4(11):eaav0824. doi: 10.1126/sciadv.aav0824. eCollection 2018 Nov.

8.

Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.

Manville RW, Abbott GW.

Nat Commun. 2018 Sep 21;9(1):3845. doi: 10.1038/s41467-018-06339-2.

9.

Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels.

Manville RW, Abbott GW.

Mol Pharmacol. 2018 Oct;94(4):1155-1163. doi: 10.1124/mol.118.112953. Epub 2018 Jul 18.

10.

Direct neurotransmitter activation of voltage-gated potassium channels.

Manville RW, Papanikolaou M, Abbott GW.

Nat Commun. 2018 May 10;9(1):1847. doi: 10.1038/s41467-018-04266-w.

11.

SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.

Manville RW, Neverisky DL, Abbott GW.

Biophys J. 2017 Aug 8;113(3):613-626. doi: 10.1016/j.bpj.2017.06.055.

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