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Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines.

Pontecorvi P, Banki MA, Zampieri C, Zalfa C, Azmoon P, Kounnas MZ, Marchese C, Gonias SL, Mantuano E.

J Neuroinflammation. 2019 Dec 6;16(1):257. doi: 10.1186/s12974-019-1657-3.


Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages.

Das L, Azmoon P, Banki MA, Mantuano E, Gonias SL.

PLoS One. 2019 Nov 7;14(11):e0224738. doi: 10.1371/journal.pone.0224738. eCollection 2019.


A multimolecular signaling complex including PrPC and LRP1 is strictly dependent on lipid rafts and is essential for the function of tissue plasminogen activator.

Mattei V, Manganelli V, Martellucci S, Capozzi A, Mantuano E, Longo A, Ferri A, Garofalo T, Sorice M, Misasi R.

J Neurochem. 2019 Oct 11. doi: 10.1111/jnc.14891. [Epub ahead of print]


Novel missense mutation in the ATP1A2 gene associated with atypical sporapedic hemiplegic migraine.

Rispoli MG, Di Stefano V, Mantuano E, De Angelis MV.

BMJ Case Rep. 2019 Oct 5;12(10). pii: e231129. doi: 10.1136/bcr-2019-231129.


Different responses of PC12 cells to different pro-nerve growth factor protein variants.

Soligo M, Albini M, Bertoli FL, Marzano V, Protto V, Bracci-Laudiero L, Minnone G, De Benedetti F, Chiaretti A, Mantuano E, Manni L.

Neurochem Int. 2019 Oct;129:104498. doi: 10.1016/j.neuint.2019.104498. Epub 2019 Jul 3.


Can leukocyte telomere shortening be a possible biomarker to track Huntington's disease progression?

Mantuano E, Peconi M, Scarabino D.

Neural Regen Res. 2019 Oct;14(10):1709-1710. doi: 10.4103/1673-5374.257522. No abstract available.


Characterization of human frataxin missense variants in cancer tissues.

Petrosino M, Pasquo A, Novak L, Toto A, Gianni S, Mantuano E, Veneziano L, Minicozzi V, Pastore A, Puglisi R, Capriotti E, Chiaraluce R, Consalvi V.

Hum Mutat. 2019 Sep;40(9):1400-1413. doi: 10.1002/humu.23789. Epub 2019 Jun 18.


Corrigendum to "Restless legs syndrome in NKX2-1-related chorea: An expansion of the disease spectrum" [Brain Dev. 41 (2019) 250-256].

Iodice A, Carecchio M, Zorzi G, Garavaglia B, Spagnoli C, Salerno GG, Frattini D, Mencacci NE, Invernizzi F, Veneziano L, Mantuano E, Angriman M, Fusco C.

Brain Dev. 2019 Aug;41(7):643. doi: 10.1016/j.braindev.2019.04.011. Epub 2019 Apr 30. No abstract available.


Tissue-type plasminogen activator neutralizes LPS but not protease-activated receptor-mediated inflammatory responses to plasmin.

Zalfa C, Azmoon P, Mantuano E, Gonias SL.

J Leukoc Biol. 2019 Apr;105(4):729-740. doi: 10.1002/JLB.3A0818-329RRR. Epub 2019 Jan 28.


Leukocyte telomere shortening in Huntington's disease.

Scarabino D, Veneziano L, Peconi M, Frontali M, Mantuano E, Corbo RM.

J Neurol Sci. 2019 Jan 15;396:25-29. doi: 10.1016/j.jns.2018.10.024. Epub 2018 Oct 28.


Restless Legs Syndrome in NKX2-1-related chorea: An expansion of the disease spectrum.

Iodice A, Carecchio M, Zorzi G, Garavaglia B, Spagnoli C, Salerno GG, Frattini D, Mencacci NE, Invernizzi F, Veneziano L, Mantuano E, Angriman M, Fusco C.

Brain Dev. 2019 Mar;41(3):250-256. doi: 10.1016/j.braindev.2018.10.001. Epub 2018 Oct 21. Erratum in: Brain Dev. 2019 Aug;41(7):643.


PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology.

Gonias SL, Banki MA, Gilder AS, Azmoon P, Campana WM, Mantuano E.

J Cell Sci. 2018 Jul 26;131(14). pii: jcs217083. doi: 10.1242/jcs.217083.


The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres.

Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, Klemke RL, Mantuano E, Gonias SL.

Sci Rep. 2018 Feb 14;8(1):2982. doi: 10.1038/s41598-018-21358-1.


Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival.

Gonias SL, Karimi-Mostowfi N, Murray SS, Mantuano E, Gilder AS.

PLoS One. 2017 Oct 31;12(10):e0186649. doi: 10.1371/journal.pone.0186649. eCollection 2017.


Tissue-type plasminogen activator regulates macrophage activation and innate immunity.

Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL.

Blood. 2017 Sep 14;130(11):1364-1374. doi: 10.1182/blood-2017-04-780205. Epub 2017 Jul 6.


A channelopathy mutation in the voltage-sensor discloses contributions of a conserved phenylalanine to gating properties of Kv1.1 channels and ataxia.

Hasan S, Bove C, Silvestri G, Mantuano E, Modoni A, Veneziano L, Macchioni L, Hunter T, Hunter G, Pessia M, D'Adamo MC.

Sci Rep. 2017 Jul 4;7(1):4583. doi: 10.1038/s41598-017-03041-z.


Ionotropic glutamate receptors activate cell signaling in response to glutamate in Schwann cells.

Campana WM, Mantuano E, Azmoon P, Henry K, Banki MA, Kim JH, Pizzo DP, Gonias SL.

FASEB J. 2017 Apr;31(4):1744-1755. doi: 10.1096/fj.201601121R. Epub 2017 Jan 10.


Evidence that LDL receptor-related protein 1 acts as an early injury detection receptor and activates c-Jun in Schwann cells.

Flütsch A, Henry K, Mantuano E, Lam MS, Shibayama M, Takahashi K, Gonias SL, Campana WM.

Neuroreport. 2016 Dec 14;27(18):1305-1311.


The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains.

Laudati E, Gilder AS, Lam MS, Misasi R, Sorice M, Gonias SL, Mantuano E.

Mol Cell Neurosci. 2016 Oct;76:42-51. doi: 10.1016/j.mcn.2016.08.006. Epub 2016 Aug 23.


LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response.

Mantuano E, Brifault C, Lam MS, Azmoon P, Gilder AS, Gonias SL.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1369-74. doi: 10.1073/pnas.1515480113. Epub 2016 Jan 19.


Functional characterization of two novel mutations in TTF-1/NKX2.1 homeodomain in patients with benign hereditary chorea.

Provenzano C, Zamboni M, Veneziano L, Mantuano E, Garavaglia B, Zorzi G, Pagonabarraga J, Giunti P, Civitareale D.

J Neurol Sci. 2016 Jan 15;360:78-83. doi: 10.1016/j.jns.2015.11.050. Epub 2015 Nov 27.


The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration.

Mantuano E, Lam MS, Shibayama M, Campana WM, Gonias SL.

J Cell Sci. 2015 Sep 15;128(18):3478-88. doi: 10.1242/jcs.173765. Epub 2015 Aug 13.


Molecular mechanism of Spinocerebellar Ataxia type 6: glutamine repeat disorder, channelopathy and transcriptional dysregulation. The multifaceted aspects of a single mutation.

Giunti P, Mantuano E, Frontali M, Veneziano L.

Front Cell Neurosci. 2015 Feb 16;9:36. doi: 10.3389/fncel.2015.00036. eCollection 2015. Review.


A novel de novo mutation of the TITF1/NKX2-1 gene causing ataxia, benign hereditary chorea, hypothyroidism and a pituitary mass in a UK family and review of the literature.

Veneziano L, Parkinson MH, Mantuano E, Frontali M, Bhatia KP, Giunti P.

Cerebellum. 2014 Oct;13(5):588-95. doi: 10.1007/s12311-014-0570-7. Review.


Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: interaction with GABAergic transmission in amygdala and brainstem.

Avolio E, Mahata SK, Mantuano E, Mele M, Alò R, Facciolo RM, Talani G, Canonaco M.

Neuroscience. 2014 Jun 13;270:48-57. doi: 10.1016/j.neuroscience.2014.04.001. Epub 2014 Apr 13.


A shared haplotype for dentatorubropallidoluysian atrophy (DRPLA) in Italian families testifies of the recent introduction of the mutation.

Veneziano L, Mantuano E, Catalli C, Gellera C, Durr A, Romano S, Spadaro M, Frontali M, Novelletto A.

J Hum Genet. 2014 Mar;59(3):153-7. doi: 10.1038/jhg.2013.137. Epub 2014 Jan 9.


Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion.

Gupta S, Hau AM, Beach JR, Harwalker J, Mantuano E, Gonias SL, Egelhoff TT, Hansel DE.

PLoS One. 2013 Nov 27;8(11):e81081. doi: 10.1371/journal.pone.0081081. eCollection 2013.


LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.

Mantuano E, Lam MS, Gonias SL.

J Biol Chem. 2013 Nov 22;288(47):34009-18. doi: 10.1074/jbc.M113.509133. Epub 2013 Oct 15.


Low-density lipoprotein receptor related protein-1 (LRP1)-dependent cell signaling promotes neurotrophic activity in embryonic sensory neurons.

Yamauchi K, Yamauchi T, Mantuano E, Murakami K, Henry K, Takahashi K, Campana WM.

PLoS One. 2013 Sep 23;8(9):e75497. doi: 10.1371/journal.pone.0075497. eCollection 2013.


Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain.

Orita S, Henry K, Mantuano E, Yamauchi K, De Corato A, Ishikawa T, Feltri ML, Wrabetz L, Gaultier A, Pollack M, Ellisman M, Takahashi K, Gonias SL, Campana WM.

J Neurosci. 2013 Mar 27;33(13):5590-602. doi: 10.1523/JNEUROSCI.3342-12.2013.


LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin.

Stiles TL, Dickendesher TL, Gaultier A, Fernandez-Castaneda A, Mantuano E, Giger RJ, Gonias SL.

J Cell Sci. 2013 Jan 1;126(Pt 1):209-20. doi: 10.1242/jcs.113191. Epub 2012 Nov 6.


A new 4-phenyl-1,8-naphthyridine derivative affects carcinoma cell proliferation by impairing cell cycle progression and inducing apoptosis.

Capozzi A, Mantuano E, Matarrese P, Saccomanni G, Manera C, Mattei V, Gambardella L, Malorni W, Sorice M, Misasi R.

Anticancer Agents Med Chem. 2012 Jul;12(6):653-62.


The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury.

Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin JH, Gonias SL, Campana WM.

J Neurosci. 2011 Sep 21;31(38):13376-85. doi: 10.1523/JNEUROSCI.2850-11.2011.


Dramatically different levels of Cacna1a gene expression between pre-weaning wild type and leaner mice.

Veneziano L, Albertosi S, Pesci D, Mantuano E, Frontali M, Jodice C.

J Neurol Sci. 2011 Jun 15;305(1-2):71-4. doi: 10.1016/j.jns.2011.03.010. Epub 2011 Mar 26.


Anaemia and resistance to erythropoiesis-stimulating agents as prognostic factors in haemodialysis patients: results from the RISCAVID study.

Panichi V, Rosati A, Bigazzi R, Paoletti S, Mantuano E, Beati S, Marchetti V, Bernabini G, Grazi G, Rizza GM, Migliori M, Giusti R, Lippi A, Casani A, Barsotti G, Tetta C; RISCAVID Study Group.

Nephrol Dial Transplant. 2011 Aug;26(8):2641-8. doi: 10.1093/ndt/gfq802. Epub 2011 Feb 16.


Impact of calcium, phosphate, PTH abnormalities and management on mortality in hemodialysis: results from the RISCAVID study.

Panichi V, Bigazzi R, Paoletti S, Mantuano E, Beati S, Marchetti V, Bernabini G, Grazi G, Giust R, Rosati A, Migliori M, Pasquariello A, Panicucci E, Barsotti G, Bellasi A; RISCAVID Study Group.

J Nephrol. 2010 Sep-Oct;23(5):556-62.


Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration.

Mantuano E, Jo M, Gonias SL, Campana WM.

J Biol Chem. 2010 May 7;285(19):14259-66. doi: 10.1074/jbc.M109.085126. Epub 2010 Mar 2.


Identification of novel and recurrent CACNA1A gene mutations in fifteen patients with episodic ataxia type 2.

Mantuano E, Romano S, Veneziano L, Gellera C, Castellotti B, Caimi S, Testa D, Estienne M, Zorzi G, Bugiani M, Rajabally YA, Barcina MJ, Servidei S, Panico A, Frontali M, Mariotti C.

J Neurol Sci. 2010 Apr 15;291(1-2):30-6. doi: 10.1016/j.jns.2010.01.010. Epub 2010 Feb 2.


Erythropoietin promotes Schwann cell migration and assembly of the provisional extracellular matrix by recruiting beta1 integrin to the cell surface.

Inoue G, Gaultier A, Li X, Mantuano E, Richardson G, Takahashi K, Campana WM.

Glia. 2010 Mar;58(4):399-409. doi: 10.1002/glia.20931.


Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway.

Shi Y, Mantuano E, Inoue G, Campana WM, Gonias SL.

Sci Signal. 2009 Apr 28;2(68):ra18. doi: 10.1126/scisignal.2000188.


The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein.

Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias SL, Campana WM.

J Neurosci. 2008 Nov 5;28(45):11571-82. doi: 10.1523/JNEUROSCI.3053-08.2008.


Newly characterised 5' and 3' regions of CACNA1A gene harbour mutations associated with Familial Hemiplegic Migraine and Episodic Ataxia.

Veneziano L, Guida S, Mantuano E, Bernard P, Tarantino P, Boccone L, Hisama FM, Carrera P, Jodice C, Frontali M.

J Neurol Sci. 2009 Jan 15;276(1-2):31-7. doi: 10.1016/j.jns.2008.08.030. Epub 2008 Oct 30.


Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice.

Gallo D, Zannoni GF, De Stefano I, Mosca M, Ferlini C, Mantuano E, Scambia G.

J Nutr. 2008 Jul;138(7):1360-4.


17beta-Estradiol and soy phytochemicals selectively induce a type 2 polarization in mesenteric lymph nodes of ovariectomized rats.

Gallo D, Battaglia A, Mantuano E, Travaglia D, De Stefano I, Buzzonetti A, Scambia G.

Menopause. 2008 Jul-Aug;15(4 Pt 1):718-25. doi: 10.1097/gme.0b013e318167b92a.


Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling.

Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL.

J Biol Chem. 2008 Jul 18;283(29):19904-11. doi: 10.1074/jbc.M801762200. Epub 2008 May 22.


Comparative effects of 17beta-estradiol and phytoestrogens in the regulation of endometrial functions in the rodent uterus.

Gallo D, Zannoni GF, Fabrizi M, De Stefano I, Mantuano E, Scambia G.

J Endocrinol Invest. 2008 Jan;31(1):48-56.


Effect of simvastatin on plasma asymmetric dimethylarginine concentration in patients with chronic kidney disease.

Panichi V, Mantuano E, Paoletti S, Santi S, Manca Rizza G, Cutrupi S, Pizzini P, Spoto B, Tripepi G, Zoccali C.

J Nephrol. 2008 Jan-Feb;21(1):38-44.


Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer.

Gallo D, Mantuano E, Fabrizi M, Ferlini C, Mozzetti S, De Stefano I, Scambia G.

Endocr Relat Cancer. 2007 Jun;14(2):317-24.


Early onset progressive ataxia associated with the first CACNA1A mutation identified within the I-II loop.

Mantuano E, Veneziano L.

J Neurol Sci. 2007 Dec 15;263(1-2):226; author reply 226-7. Epub 2007 Jun 22. No abstract available.


The Pisa experience of renal biopsies, 1977-2005.

Panichi V, Pasquariello A, Innocenti M, Meola M, Mantuano E, Beati S, Paoletti S, Consani C, Puccini R, Casarosa L, Gattai V, Filippi C, Moriconi L, Barsotti G, Rindi P, Palla R.

J Nephrol. 2007 May-Jun;20(3):329-35.


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