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An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation.

Rong Y, Torres-Velez FJ, Ehrbar D, Doering J, Song R, Mantis NJ.

Hum Vaccin Immunother. 2019 Oct 29:1-15. doi: 10.1080/21645515.2019.1664243. [Epub ahead of print]


TNF Family Cytokines Induce Distinct Cell Death Modalities in the A549 Human Lung Epithelial Cell Line when Administered in Combination with Ricin Toxin.

Hodges AL, Kempen CG, McCaig WD, Parker CA, Mantis NJ, LaRocca TJ.

Toxins (Basel). 2019 Aug 1;11(8). pii: E450. doi: 10.3390/toxins11080450.


Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin-Ab complexes.

Mooney B, Torres-Velez FJ, Doering J, Ehrbar DJ, Mantis NJ.

J Leukoc Biol. 2019 Nov;106(5):1161-1176. doi: 10.1002/JLB.4A0419-123R. Epub 2019 Jul 16.


A Collection of Single-Domain Antibodies that Crowd Ricin Toxin's Active Site.

Angalakurthi SK, Vance DJ, Rong Y, Nguyen CMT, Rudolph MJ, Volkin D, Middaugh CR, Weis DD, Mantis NJ.

Antibodies (Basel). 2018 Dec;7(4). pii: 45. doi: 10.3390/antib7040045. Epub 2018 Dec 17.


Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies.

Van Slyke G, Angalakurthi SK, Toth RT 4th, Vance DJ, Rong Y, Ehrbar D, Shi Y, Middaugh CR, Volkin DB, Weis DD, Mantis NJ.

Immunohorizons. 2018 Sep;2(8):262-273. doi: 10.4049/immunohorizons.1800042.


Rescue of rhesus macaques from the lethality of aerosolized ricin toxin.

Roy CJ, Ehrbar DJ, Bohorova N, Bohorov O, Kim D, Pauly M, Whaley K, Rong Y, Torres-Velez FJ, Vitetta ES, Didier PJ, Doyle-Meyers L, Zeitlin L, Mantis NJ.

JCI Insight. 2019 Jan 10;4(1). pii: 124771. doi: 10.1172/jci.insight.124771. [Epub ahead of print]


Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.

Rudolph MJ, Vance DJ, Kelow S, Angalakurthi SK, Nguyen S, Davis SA, Rong Y, Middaugh CR, Weis DD, Dunbrack R Jr, Karanicolas J, Mantis NJ.

Protein Eng Des Sel. 2018 Jul 1;31(7-8):277-287. doi: 10.1093/protein/gzy022.


TRAIL (CD253) Sensitizes Human Airway Epithelial Cells to Toxin-Induced Cell Death.

Rong Y, Westfall J, Ehrbar D, LaRocca T, Mantis NJ.

mSphere. 2018 Sep 26;3(5). pii: e00399-18. doi: 10.1128/mSphere.00399-18.


Thermal stability and epitope integrity of a lyophilized ricin toxin subunit vaccine.

Westfall J, Yates JL, Van Slyke G, Ehrbar D, Measey T, Straube R, Donini O, Mantis NJ.

Vaccine. 2018 Sep 25;36(40):5967-5976. doi: 10.1016/j.vaccine.2018.08.059. Epub 2018 Aug 29.


Biomedical Applications of Lumazine Synthase.

Wei Y, Kumar P, Wahome N, Mantis NJ, Middaugh CR.

J Pharm Sci. 2018 Sep;107(9):2283-2296. doi: 10.1016/j.xphs.2018.05.002. Epub 2018 May 12. Review.


Alpha-galactosylceramide (αGalCer) enhances vaccine-induced protection in a model of ricin intoxication.

Yates JL, Leadbetter E, Mantis NJ.

Hum Vaccin Immunother. 2018;14(8):2053-2057. doi: 10.1080/21645515.2018.1461299. Epub 2018 May 14.


Vibrio cholerae O1 secretes an extracellular matrix in response to antibody-mediated agglutination.

Baranova DE, Levinson KJ, Mantis NJ.

PLoS One. 2018 Jan 2;13(1):e0190026. doi: 10.1371/journal.pone.0190026. eCollection 2018.


A Supercluster of Neutralizing Epitopes at the Interface of Ricin's Enzymatic (RTA) and Binding (RTB) Subunits.

Poon AY, Vance DJ, Rong Y, Ehrbar D, Mantis NJ.

Toxins (Basel). 2017 Nov 23;9(12). pii: E378. doi: 10.3390/toxins9120378.


High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine.

Toth RT 4th, Angalakurthi SK, Van Slyke G, Vance DJ, Hickey JM, Joshi SB, Middaugh CR, Volkin DB, Weis DD, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00237-17. doi: 10.1128/CVI.00237-17. Print 2017 Dec.


High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin.

Vance DJ, Tremblay JM, Rong Y, Angalakurthi SK, Volkin DB, Middaugh CR, Weis DD, Shoemaker CB, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00236-17. doi: 10.1128/CVI.00236-17. Print 2017 Dec.


Evaluation of lumazine synthase from Bacillus anthracis as a presentation platform for polyvalent antigen display.

Wei Y, Wahome N, VanSlyke G, Whitaker N, Kumar P, Barta ML, Picking WL, Volkin DB, Mantis NJ, Middaugh CR.

Protein Sci. 2017 Oct;26(10):2059-2072. doi: 10.1002/pro.3243. Epub 2017 Sep 13.


Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.

Bazzoli A, Vance DJ, Rudolph MJ, Rong Y, Angalakurthi SK, Toth RT 4th, Middaugh CR, Volkin DB, Weis DD, Karanicolas J, Mantis NJ.

Proteins. 2017 Nov;85(11):1994-2008. doi: 10.1002/prot.25353. Epub 2017 Aug 4.


Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin's binding subunit.

Rong Y, Van Slyke G, Vance DJ, Westfall J, Ehrbar D, Mantis NJ.

PLoS One. 2017 Jul 10;12(7):e0180999. doi: 10.1371/journal.pone.0180999. eCollection 2017.


Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin's Enzymatic Subunit.

Rudolph MJ, Vance DJ, Cassidy MS, Rong Y, Mantis NJ.

J Biol Chem. 2017 Jan 20;292(3):872-883. doi: 10.1074/jbc.M116.758102. Epub 2016 Nov 30.


Applications in Stimulated Emission Depletion Microscopy: Localization of a Protein Toxin in the Endoplasmic Reticulum Following Retrograde Transport.

Herrera C, Mantis NJ, Cole R.

Microsc Microanal. 2016 Dec;22(6):1113-1119. doi: 10.1017/S1431927616011879. Epub 2016 Nov 2.


A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response.

Jandhyala DM, Wong J, Mantis NJ, Magun BE, Leong JM, Thorpe CM.

Toxins (Basel). 2016 Sep 2;8(9). pii: E259. doi: 10.3390/toxins8090259.


Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.

Van Slyke G, Sully EK, Bohorova N, Bohorov O, Kim D, Pauly MH, Whaley KJ, Zeitlin L, Mantis NJ.

Clin Vaccine Immunol. 2016 Sep 6;23(9):795-9. doi: 10.1128/CVI.00088-16. Print 2016 Sep.


A Bispecific Antibody Promotes Aggregation of Ricin Toxin on Cell Surfaces and Alters Dynamics of Toxin Internalization and Trafficking.

Herrera C, Klokk TI, Cole R, Sandvig K, Mantis NJ.

PLoS One. 2016 Jun 14;11(6):e0156893. doi: 10.1371/journal.pone.0156893. eCollection 2016.


Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.

Rudolph MJ, Vance DJ, Cassidy MS, Rong Y, Shoemaker CB, Mantis NJ.

Proteins. 2016 Aug;84(8):1162-72. doi: 10.1002/prot.25062. Epub 2016 Jun 15.


Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils.

Greene CJ, Hu JC, Vance DJ, Rong Y, Mandell L, King-Lyons N, Masso-Welch P, Mantis NJ, Connell TD.

J Leukoc Biol. 2016 Aug;100(2):361-9. doi: 10.1189/jlb.3A0415-153RR. Epub 2016 Apr 8.


Progress and challenges associated with the development of ricin toxin subunit vaccines.

Vance DJ, Mantis NJ.

Expert Rev Vaccines. 2016 Sep;15(9):1213-22. doi: 10.1586/14760584.2016.1168701. Epub 2016 Apr 6. Review.


Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.

Wahome N, Sully E, Singer C, Thomas JC, Hu L, Joshi SB, Volkin DB, Fang J, Karanicolas J, Jacobs DJ, Mantis NJ, Middaugh CR.

J Pharm Sci. 2016 May;105(5):1603-1613. doi: 10.1016/j.xphs.2016.02.009. Epub 2016 Mar 15.


Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport.

Yermakova A, Klokk TI, O'Hara JM, Cole R, Sandvig K, Mantis NJ.

Sci Rep. 2016 Mar 7;6:22721. doi: 10.1038/srep22721.


Recent advances in the development of vaccines against ricin.

Brey RN 3rd, Mantis NJ, Pincus SH, Vitetta ES, Smith LA, Roy CJ.

Hum Vaccin Immunother. 2016 May 3;12(5):1196-201. doi: 10.1080/21645515.2015.1124202. Epub 2016 Jan 25.


Role of Maternal Dietary Peanut Exposure in Development of Food Allergy and Oral Tolerance.

Järvinen KM, Westfall J, De Jesus M, Mantis NJ, Carroll JA, Metzger DW, Sampson HA, Berin MC.

PLoS One. 2015 Dec 10;10(12):e0143855. doi: 10.1371/journal.pone.0143855. eCollection 2015.


Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.

Vance DJ, Greene CJ, Rong Y, Mandell LM, Connell TD, Mantis NJ.

Clin Vaccine Immunol. 2015 Dec;22(12):1285-93. doi: 10.1128/CVI.00402-15. Epub 2015 Oct 21.


Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies.

Herrera C, Tremblay JM, Shoemaker CB, Mantis NJ.

J Biol Chem. 2015 Nov 13;290(46):27880-9. doi: 10.1074/jbc.M115.658070. Epub 2015 Sep 22.


Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer's patches.

De Jesus M, Rodriguez AE, Yagita H, Ostroff GR, Mantis NJ.

Immunol Lett. 2015 Nov;168(1):64-72. doi: 10.1016/j.imlet.2015.09.008. Epub 2015 Sep 16.


Phenotypic Analysis of a Population of IgA+ Cells in the Follicle-Associated Epithelium of Mouse Peyer's Patches.

Hernandez MO, Mantis NJ.

PLoS One. 2015 Apr 20;10(4):e0124111. doi: 10.1371/journal.pone.0124111. eCollection 2015.


Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide.

Levinson KJ, Giffen SR, Pauly MH, Kim DH, Bohorov O, Bohorova N, Whaley KJ, Zeitlin L, Mantis NJ.

J Immunol Methods. 2015 Jul;422:111-7. doi: 10.1016/j.jim.2015.04.001. Epub 2015 Apr 9.


Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.

Roy CJ, Brey RN, Mantis NJ, Mapes K, Pop IV, Pop LM, Ruback S, Killeen SZ, Doyle-Meyers L, Vinet-Oliphant HS, Didier PJ, Vitetta ES.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3782-7. doi: 10.1073/pnas.1502585112. Epub 2015 Mar 9.


Rapid effects of a protective O-polysaccharide-specific monoclonal IgA on Vibrio cholerae agglutination, motility, and surface morphology.

Levinson KJ, De Jesus M, Mantis NJ.

Infect Immun. 2015 Apr;83(4):1674-83. doi: 10.1128/IAI.02856-14. Epub 2015 Feb 9.


Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants.

Hassett KJ, Vance DJ, Jain NK, Sahni N, Rabia LA, Cousins MC, Joshi S, Volkin DB, Middaugh CR, Mantis NJ, Carpenter JF, Randolph TW.

J Pharm Sci. 2015 Feb;104(2):627-39. doi: 10.1002/jps.24295. Epub 2015 Jan 11.


Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice.

Vance DJ, Rong Y, Brey RN 3rd, Mantis NJ.

Vaccine. 2015 Jan 9;33(3):417-21. doi: 10.1016/j.vaccine.2014.11.036. Epub 2014 Dec 2.


A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.

Sully EK, Whaley K, Bohorova N, Bohorov O, Goodman C, Kim D, Pauly M, Velasco J, Holtsberg FW, Stavale E, Aman MJ, Tangudu C, Uzal FA, Mantis NJ, Zeitlin L.

Toxicon. 2014 Dec 15;92:36-41. doi: 10.1016/j.toxicon.2014.09.006. Epub 2014 Sep 28.


Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells.

Chung AY, Li Q, Blair SJ, De Jesus M, Dennis KL, LeVea C, Yao J, Sun Y, Conway TF, Virtuoso LP, Battaglia NG, Furtado S, Mathiowitz E, Mantis NJ, Khazaie K, Egilmez NK.

Cancer Res. 2014 Oct 1;74(19):5377-85. doi: 10.1158/0008-5472.CAN-14-0918. Epub 2014 Sep 16.


Mice deficient in intestinal epithelium cytochrome P450 reductase are prone to acute toxin-induced mucosal damage.

Ahlawat S, Xie F, Zhu Y, D'Hondt R, Ding X, Zhang QY, Mantis NJ.

Sci Rep. 2014 Jul 3;4:5551. doi: 10.1038/srep05551.


Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB).

Herrera C, Vance DJ, Eisele LE, Shoemaker CB, Mantis NJ.

PLoS One. 2014 Jun 11;9(6):e99788. doi: 10.1371/journal.pone.0099788. eCollection 2014.


Crystal structures of ricin toxin's enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies.

Rudolph MJ, Vance DJ, Cheung J, Franklin MC, Burshteyn F, Cassidy MS, Gary EN, Herrera C, Shoemaker CB, Mantis NJ.

J Mol Biol. 2014 Aug 26;426(17):3057-68. doi: 10.1016/j.jmb.2014.05.026. Epub 2014 Jun 4.


Antibody-mediated inhibition of ricin toxin retrograde transport.

Yermakova A, Klokk TI, Cole R, Sandvig K, Mantis NJ.

MBio. 2014 Apr 8;5(2):e00995. doi: 10.1128/mBio.00995-13.


A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles.

De Jesus M, Ostroff GR, Levitz SM, Bartling TR, Mantis NJ.

PLoS One. 2014 Mar 14;9(3):e91002. doi: 10.1371/journal.pone.0091002. eCollection 2014.


Chimeric plantibody passively protects mice against aerosolized ricin challenge.

Sully EK, Whaley KJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Pauly MH, Velasco J, Hiatt E, Morton J, Swope K, Roy CJ, Zeitlin L, Mantis NJ.

Clin Vaccine Immunol. 2014 May;21(5):777-82. doi: 10.1128/CVI.00003-14. Epub 2014 Feb 26.


Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA).

O'Hara JM, Kasten-Jolly JC, Reynolds CE, Mantis NJ.

Immunol Lett. 2014 Mar-Apr;158(1-2):7-13. doi: 10.1016/j.imlet.2013.11.009. Epub 2013 Nov 21.


Stepwise engineering of heterodimeric single domain camelid VHH antibodies that passively protect mice from ricin toxin.

Vance DJ, Tremblay JM, Mantis NJ, Shoemaker CB.

J Biol Chem. 2013 Dec 20;288(51):36538-47. doi: 10.1074/jbc.M113.519207. Epub 2013 Nov 7.

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