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The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis.

Manthey CL, Moore BA, Chen Y, Loza MJ, Yao X, Liu H, Belkowski SM, Raymond-Parks H, Dunford PJ, Leon F, Towne JE, Plevy SE.

PLoS One. 2019 Nov 11;14(11):e0223918. doi: 10.1371/journal.pone.0223918. eCollection 2019.


Reproducing human and cross-species drug toxicities using a Liver-Chip.

Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, Petropolis DB, Kulkarni G, Rubins JE, Conegliano D, Nawroth J, Simic D, Lam W, Singer M, Barale E, Singh B, Sonee M, Streeter AJ, Manthey C, Jones B, Srivastava A, Andersson LC, Williams D, Park H, Barrile R, Sliz J, Herland A, Haney S, Karalis K, Ingber DE, Hamilton GA.

Sci Transl Med. 2019 Nov 6;11(517). pii: eaax5516. doi: 10.1126/scitranslmed.aax5516.


Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis.

Wittner M, Schlicker V, Libera J, Bockmann JH, Horvatits T, Seiz O, Kummer S, Manthey CF, Hüfner A, Kantowski M, Rösch T, Degen O, Huber S, Eberhard JM, Schulze Zur Wiesch J.

PLoS One. 2019 Jul 29;14(7):e0220008. doi: 10.1371/journal.pone.0220008. eCollection 2019.


Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.

Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki JR, Lohse AW, Flavell RA, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca EJ, Gagliani N, Huber S.

Nat Commun. 2018 Dec 21;9(1):5457. doi: 10.1038/s41467-018-07581-4.


Hepatitis E seroprevalence in the Americas: A systematic review and meta-analysis.

Horvatits T, Ozga AK, Westhölter D, Hartl J, Manthey CF, Lütgehetmann M, Rauch G, Kriston L, Lohse AW, Bendall R, Wedemeyer H, Dalton HR, Pischke S.

Liver Int. 2018 Nov;38(11):1951-1964. doi: 10.1111/liv.13859. Epub 2018 May 3.


Stool cultures at the ICU: get rid of it!

Manthey CF, Dranova D, Christner M, Berneking L, Kluge S, Lohse AW, Fuhrmann V.

Ann Intensive Care. 2018 Jan 18;8(1):10. doi: 10.1186/s13613-018-0358-x.


Therapy for Clostridium difficile infection - any news beyond Metronidazole and Vancomycin?

Manthey CF, Eckmann L, Fuhrmann V.

Expert Rev Clin Pharmacol. 2017 Nov;10(11):1239-1250. doi: 10.1080/17512433.2017.1362978. Epub 2017 Aug 11. Review.


Chytrid parasitism facilitates trophic transfer between bloom-forming cyanobacteria and zooplankton (Daphnia).

Agha R, Saebelfeld M, Manthey C, Rohrlack T, Wolinska J.

Sci Rep. 2016 Oct 13;6:35039. doi: 10.1038/srep35039.


Targeting c-fms kinase attenuates chronic aristolochic acid nephropathy in mice.

Dai XY, Huang XR, Zhou L, Zhang L, Fu P, Manthey C, Nikolic-Paterson DJ, Lan HY.

Oncotarget. 2016 Mar 8;7(10):10841-56. doi: 10.18632/oncotarget.7460.


Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy.

Genovese MC, Hsia E, Belkowski SM, Chien C, Masterson T, Thurmond RL, Manthey CL, Yan XD, Ge T, Franks C, Greenspan A.

J Rheumatol. 2015 Oct;42(10):1752-60. doi: 10.3899/jrheum.141580. Epub 2015 Aug 1.


IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia.

Dann SM, Manthey CF, Le C, Miyamoto Y, Gima L, Abrahim A, Cao AT, Hanson EM, Kolls JK, Raz E, Cong Y, Eckmann L.

Exp Parasitol. 2015 Sep;156:68-78. doi: 10.1016/j.exppara.2015.06.003. Epub 2015 Jun 9.


An unusual case of esophageal ulcer and weight loss.

Manthey CF, Badran AG, Denzer UW.

Gastroenterology. 2015 Jun;148(7):e5-6. doi: 10.1053/j.gastro.2014.11.006. Epub 2015 Apr 30. No abstract available.


Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions.

Manthey CF, Calabio CB, Wosinski A, Hanson EM, Vallance BA, Groisman A, Martín MG, Wang JY, Eckmann L.

Am J Physiol Cell Physiol. 2014 Jul 15;307(2):C180-9. doi: 10.1152/ajpcell.00013.2014. Epub 2014 May 21.


Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors.

Illig CR, Manthey CL, Meegalla SK, Wall MJ, Chen J, Wilson KJ, DesJarlais RL, Ballentine SK, Schubert C, Crysler CS, Chen Y, Molloy CJ, Chaikin MA, Donatelli RR, Yurkow E, Zhou Z, Player MR, Tomczuk BE.

Bioorg Med Chem Lett. 2013 Dec 1;23(23):6363-9. doi: 10.1016/j.bmcl.2013.09.061. Epub 2013 Oct 1.


Human milk oligosaccharides protect against enteropathogenic Escherichia coli attachment in vitro and EPEC colonization in suckling mice.

Manthey CF, Autran CA, Eckmann L, Bode L.

J Pediatr Gastroenterol Nutr. 2014 Feb;58(2):165-8. doi: 10.1097/MPG.0000000000000172.


Trp53 deficiency protects against acute intestinal inflammation.

Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang JY, Eckmann L.

J Immunol. 2013 Jul 15;191(2):837-47. doi: 10.4049/jimmunol.1201716. Epub 2013 Jun 14.


Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis.

Han Y, Ma FY, Tesch GH, Manthey CL, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1043-53. doi: 10.1152/ajprenal.00389.2012. Epub 2013 Feb 13.


Evaluation of the B-SAFE campaign to reduce clinically significant warfarin-drug interactions among fee-for-service Medicare beneficiaries.

Mitchiner JC, Korzeniewski SJ, Betten D, Castle D, Halasyamani L, Burns SM, Callahan C, Manthey C.

Am J Med Qual. 2012 Nov-Dec;27(6):518-23. doi: 10.1177/1062860612438706. Epub 2012 Apr 26.


Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).

Illig CR, Manthey CL, Wall MJ, Meegalla SK, Chen J, Wilson KJ, Ballentine SK, Desjarlais RL, Schubert C, Crysler CS, Chen Y, Molloy CJ, Chaikin MA, Donatelli RR, Yurkow E, Zhou Z, Player MR, Tomczuk BE.

J Med Chem. 2011 Nov 24;54(22):7860-83. doi: 10.1021/jm200900q. Epub 2011 Oct 31.


Matrix metalloproteinase-9 inhibition reduces inflammation and improves motility in murine models of postoperative ileus.

Moore BA, Manthey CL, Johnson DL, Bauer AJ.

Gastroenterology. 2011 Oct;141(4):1283-92, 1292.e1-4. doi: 10.1053/j.gastro.2011.06.035. Epub 2011 Jun 22.


c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat.

Han Y, Ma FY, Tesch GH, Manthey CL, Nikolic-Paterson DJ.

Lab Invest. 2011 Jul;91(7):978-91. doi: 10.1038/labinvest.2011.61. Epub 2011 Apr 25.


Case report of aseptic meningitis in a patient with Crohn's disease under infliximab therapy.

Manthey C, Lohse AW, Pace A.

Inflamm Bowel Dis. 2011 Feb;17(2):E10. doi: 10.1002/ibd.21324. No abstract available.


Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors.

Wilson KJ, Illig CR, Chen J, Wall MJ, Ballentine SK, DesJarlais RL, Chen Y, Schubert C, Donatelli R, Petrounia I, Crysler CS, Molloy CJ, Chaikin MA, Manthey CL, Player MR, Tomczuk BE, Meegalla SK.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3925-9. doi: 10.1016/j.bmcl.2010.05.013. Epub 2010 May 12.


Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells.

Manthey C, Mern DS, Gutmann A, Zielinski AJ, Herz C, Lassmann S, Hasskarl J.

BMC Cell Biol. 2010 Jan 14;11:2. doi: 10.1186/1471-2121-11-2.


JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia.

Manthey CL, Johnson DL, Illig CR, Tuman RW, Zhou Z, Baker JF, Chaikin MA, Donatelli RR, Franks CF, Zeng L, Crysler C, Chen Y, Yurkow EJ, Boczon L, Meegalla SK, Wilson KJ, Wall MJ, Chen J, Ballentine SK, Ott H, Baumann C, Lawrence D, Tomczuk BE, Molloy CJ.

Mol Cancer Ther. 2009 Nov;8(11):3151-61. doi: 10.1158/1535-7163.MCT-09-0255. Epub 2009 Nov 3.


Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.

Huang H, Hutta DA, Rinker JM, Hu H, Parsons WH, Schubert C, DesJarlais RL, Crysler CS, Chaikin MA, Donatelli RR, Chen Y, Cheng D, Zhou Z, Yurkow E, Manthey CL, Player MR.

J Med Chem. 2009 Feb 26;52(4):1081-99. doi: 10.1021/jm801406h.


Targeting renal macrophage accumulation via c-fms kinase reduces tubular apoptosis but fails to modify progressive fibrosis in the obstructed rat kidney.

Ma FY, Liu J, Kitching AR, Manthey CL, Nikolic-Paterson DJ.

Am J Physiol Renal Physiol. 2009 Jan;296(1):F177-85. doi: 10.1152/ajprenal.90498.2008. Epub 2008 Nov 5.


Structure-based optimization of a potent class of arylamide FMS inhibitors.

Meegalla SK, Wall MJ, Chen J, Wilson KJ, Ballentine SK, Desjarlais RL, Schubert C, Crysler CS, Chen Y, Molloy CJ, Chaikin MA, Manthey CL, Player MR, Tomczuk BE, Illig CR.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3632-7. doi: 10.1016/j.bmcl.2008.04.059. Epub 2008 Apr 26.


Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.

Huang H, Hutta DA, Hu H, DesJarlais RL, Schubert C, Petrounia IP, Chaikin MA, Manthey CL, Player MR.

Bioorg Med Chem Lett. 2008 Apr 1;18(7):2355-61. doi: 10.1016/j.bmcl.2008.02.070. Epub 2008 Mar 4.


Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor.

Winters MP, Crysler C, Subasinghe N, Ryan D, Leong L, Zhao S, Donatelli R, Yurkow E, Mazzulla M, Boczon L, Manthey CL, Molloy C, Raymond H, Murray L, McAlonan L, Tomczuk B.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1926-30. doi: 10.1016/j.bmcl.2008.01.127. Epub 2008 Feb 7.


Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors.

Wall MJ, Chen J, Meegalla S, Ballentine SK, Wilson KJ, DesJarlais RL, Schubert C, Chaikin MA, Crysler C, Petrounia IP, Donatelli RR, Yurkow EJ, Boczon L, Mazzulla M, Player MR, Patch RJ, Manthey CL, Molloy C, Tomczuk B, Illig CR.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2097-102. doi: 10.1016/j.bmcl.2008.01.088. Epub 2008 Jan 30.


Pharmacokinetics of TDP223206 following intravenous and oral administration to intact rats and intravenous administration to bile duct-cannulated rats.

Chen Y, Cheng D, Marugan JJ, Manthey C, Tomczuk B, Huebert N.

Biopharm Drug Dispos. 2008 May;29(4):219-30. doi: 10.1002/bdd.601.


Discovery of novel FMS kinase inhibitors as anti-inflammatory agents.

Illig CR, Chen J, Wall MJ, Wilson KJ, Ballentine SK, Rudolph MJ, DesJarlais RL, Chen Y, Schubert C, Petrounia I, Crysler CS, Molloy CJ, Chaikin MA, Manthey CL, Player MR, Tomczuk BE, Meegalla SK.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1642-8. doi: 10.1016/j.bmcl.2008.01.059. Epub 2008 Jan 19.


Identification of novel short chain 4-substituted indoles as potent alphavbeta3 antagonist using structure-based drug design.

Raboisson P, Desjarlais RL, Reed R, Lattanze J, Chaikin M, Manthey CL, Tomczuk BE, Marugán JJ.

Eur J Med Chem. 2007 Mar;42(3):334-43. Epub 2006 Dec 20.


Novel potent and selective alphavbeta3/alphavbeta5 integrin dual antagonists with reduced binding affinity for human serum albumin.

Raboisson P, Manthey CL, Chaikin M, Lattanze J, Crysler C, Leonard K, Pan W, Tomczuk BE, Marugán JJ.

Eur J Med Chem. 2006 Jul;41(7):847-61. Epub 2006 May 11.


A functional radioreceptor assay of alpha-V-beta-3 (alphavbeta3) inhibitors in plasma: application as an ex vivo pharmacodynamic model.

Chaikin MA, Marugan JJ, De Vries GW, Baciu P, Edelman J, Ni M, Tomczuk BE, Pan W, Guo Z, Anaclerio B, Leonard K, Eisennagel SH, Molloy CJ, Manthey CL.

J Biochem Biophys Methods. 2005 Dec 31;65(2-3):107-20. Epub 2005 Nov 21.


Non-peptidic alpha(v)beta3 antagonists containing indol-1-yl propionic acids.

Leonard K, Pan W, Anaclerio B, Gushue JM, Guo Z, DesJarlais RL, Chaikin MA, Lattanze J, Crysler C, Manthey CL, Tomczuk BE, Marugan JJ.

Bioorg Med Chem Lett. 2005 May 16;15(10):2679-84.


2-Hydroxy-4,6-diamino-[1,3,5]triazines: a novel class of VEGF-R2 (KDR) tyrosine kinase inhibitors.

Baindur N, Chadha N, Brandt BM, Asgari D, Patch RJ, Schalk-Hihi C, Carver TE, Petrounia IP, Baumann CA, Ott H, Manthey C, Springer BA, Player MR.

J Med Chem. 2005 Mar 24;48(6):1717-20.


Design, synthesis, and biological evaluation of novel potent and selective alphavbeta3/alphavbeta5 integrin dual inhibitors with improved bioavailability. Selection of the molecular core.

Marugán JJ, Manthey C, Anaclerio B, Lafrance L, Lu T, Markotan T, Leonard KA, Crysler C, Eisennagel S, Dasgupta M, Tomczuk B.

J Med Chem. 2005 Feb 24;48(4):926-34.


Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Grasberger BL, Lu T, Schubert C, Parks DJ, Carver TE, Koblish HK, Cummings MD, LaFrance LV, Milkiewicz KL, Calvo RR, Maguire D, Lattanze J, Franks CF, Zhao S, Ramachandren K, Bylebyl GR, Zhang M, Manthey CL, Petrella EC, Pantoliano MW, Deckman IC, Spurlino JC, Maroney AC, Tomczuk BE, Molloy CJ, Bone RF.

J Med Chem. 2005 Feb 24;48(4):909-12.


Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.

Rudolph MJ, Illig CR, Subasinghe NL, Wilson KJ, Hoffman JB, Randle T, Green D, Molloy CJ, Soll RM, Lewandowski F, Zhang M, Bone R, Spurlino JC, Deckman IC, Manthey C, Sharp C, Maguire D, Grasberger BL, DesJarlais RL, Zhou Z.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):491-5.


Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.

Subasinghe NL, Illig C, Hoffman J, Rudolph MJ, Wilson KJ, Soll R, Randle T, Green D, Lewandowski F, Zhang M, Bone R, Spurlino J, DesJarlais R, Deckman I, Molloy CJ, Manthey C, Zhou Z, Sharp C, Maguire D, Crysler C, Grasberger B.

Bioorg Med Chem Lett. 2001 Jun 4;11(11):1379-82.


Superoxide release and superoxide dismutase expression by human gingival fibroblasts.

Skaleric U, Manthey CM, Mergenhagen SE, Gaspirc B, Wahl SM.

Eur J Oral Sci. 2000 Apr;108(2):130-5.


Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase.

Wang SW, Pawlowski J, Wathen ST, Kinney SD, Lichenstein HS, Manthey CL.

Inflamm Res. 1999 Oct;48(10):533-8.


Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes.

Manthey JA, Grohmann K, Montanari A, Ash K, Manthey CL.

J Nat Prod. 1999 Mar;62(3):441-4.


Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes.

Chang Ms, McNinch J, Elias C 3rd, Manthey CL, Grosshans D, Meng T, Boone T, Andrew DP.

J Biol Chem. 1997 Oct 3;272(40):25229-37.


Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.

Wang XS, Diener K, Manthey CL, Wang S, Rosenzweig B, Bray J, Delaney J, Cole CN, Chan-Hui PY, Mantlo N, Lichenstein HS, Zukowski M, Yao Z.

J Biol Chem. 1997 Sep 19;272(38):23668-74.

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