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Items: 1 to 50 of 236

1.

Mechanism of H2S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes.

Dulac M, Nagarathinam C, Dansette P, Mansuy D, Boucher JL.

Drug Metab Dispos. 2019 Oct;47(10):1061-1065. doi: 10.1124/dmd.119.087205. Epub 2019 Jun 18.

PMID:
31213461
2.

Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways.

Dulac M, Sassi A, Nagarathinan C, Christen MO, Dansette PM, Mansuy D, Boucher JL.

Drug Metab Dispos. 2018 Oct;46(10):1390-1395. doi: 10.1124/dmd.118.082545. Epub 2018 Jul 17.

PMID:
30018103
3.

Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.

Lafite P, André F, Graves JP, Zeldin DC, Dansette PM, Mansuy D.

Int J Mol Sci. 2018 Jul 16;19(7). pii: E2066. doi: 10.3390/ijms19072066.

4.

A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism.

Laskaris P, Vicentefranqueira R, Helynck O, Jouvion G, Calera JA, du Merle L, Suzenet F, Buron F, de Sousa RA, Mansuy D, Cavaillon JM, Latgé JP, Munier-Lehmann H, Ibrahim-Granet O.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02510-17. doi: 10.1128/AAC.02510-17. Print 2018 Jun.

5.

A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties.

Wang Y, Dansette PM, Pigeon P, Top S, McGlinchey MJ, Mansuy D, Jaouen G.

Chem Sci. 2017 Nov 16;9(1):70-78. doi: 10.1039/c7sc04213b. eCollection 2018 Jan 7.

6.

CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56.

Durand CM, Dhers L, Tesson C, Tessa A, Fouillen L, Jacqueré S, Raymond L, Coupry I, Benard G, Darios F, El-Hachimi KH, Astrea G, Rivier F, Banneau G, Pujol C, Lacombe D, Durr A, Babin PJ, Santorelli FM, Pietrancosta N, Boucher JL, Mansuy D, Stevanin G, Goizet C.

Hum Mutat. 2018 Jan;39(1):140-151. doi: 10.1002/humu.23359. Epub 2017 Nov 11.

PMID:
29034544
7.

Membrane-bound human orphan cytochrome P450 2U1: Sequence singularities, construction of a full 3D model, and substrate docking.

Ducassou L, Dhers L, Jonasson G, Pietrancosta N, Boucher JL, Mansuy D, André F.

Biochimie. 2017 Sep;140:166-175. doi: 10.1016/j.biochi.2017.07.007. Epub 2017 Jul 23.

PMID:
28743672
8.

Cytochrome P450 2U1, a very peculiar member of the human P450s family.

Dhers L, Ducassou L, Boucher JL, Mansuy D.

Cell Mol Life Sci. 2017 May;74(10):1859-1869. doi: 10.1007/s00018-016-2443-3. Epub 2017 Jan 12. Review.

PMID:
28083596
9.

Spectral and 3D model studies of the interaction of orphan human cytochrome P450 2U1 with substrates and ligands.

Dhers L, Pietrancosta N, Ducassou L, Ramassamy B, Dairou J, Jaouen M, André F, Mansuy D, Boucher JL.

Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3144-3153. doi: 10.1016/j.bbagen.2016.07.018. Epub 2016 Jul 25.

PMID:
27456766
10.

Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation.

Wang Y, Richard MA, Top S, Dansette PM, Pigeon P, Vessières A, Mansuy D, Jaouen G.

Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10431-4. doi: 10.1002/anie.201603931. Epub 2016 Jun 8.

PMID:
27276169
11.

Bioactivation of clopidogrel and prasugrel: factors determining the stereochemistry of the thiol metabolite double bond.

Dansette PM, Levent D, Hessani A, Mansuy D.

Chem Res Toxicol. 2015 Jun 15;28(6):1338-45. doi: 10.1021/acs.chemrestox.5b00133. Epub 2015 May 21.

PMID:
25970225
12.

Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites.

Richard MA, Hamels D, Pigeon P, Top S, Dansette PM, Lee HZ, Vessières A, Mansuy D, Jaouen G.

ChemMedChem. 2015 Jun;10(6):981-90. doi: 10.1002/cmdc.201500075. Epub 2015 Apr 16.

PMID:
25882581
13.

Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies.

Ducassou L, Jonasson G, Dhers L, Pietrancosta N, Ramassamy B, Xu-Li Y, Loriot MA, Beaune P, Bertho G, Lombard M, Mansuy D, André F, Boucher JL.

Biochim Biophys Acta. 2015 Jul;1850(7):1426-37. doi: 10.1016/j.bbagen.2015.03.014. Epub 2015 Apr 7.

PMID:
25857771
14.

Reactions of amino acids, peptides, and proteins with oxidized metabolites of tris(p-carboxyltetrathiaaryl)methyl radical EPR probes.

Decroos C, Boucher JL, Mansuy D, Xu-Li Y.

Chem Res Toxicol. 2014 Apr 21;27(4):627-36. doi: 10.1021/tx400467p. Epub 2014 Mar 11.

PMID:
24564180
15.

Metabolic stability of superoxide adducts derived from newly developed cyclic nitrone spin traps.

Bézière N, Hardy M, Poulhès F, Karoui H, Tordo P, Ouari O, Frapart YM, Rockenbauer A, Boucher JL, Mansuy D, Peyrot F.

Free Radic Biol Med. 2014 Feb;67:150-8. doi: 10.1016/j.freeradbiomed.2013.10.812. Epub 2013 Oct 24.

PMID:
24161442
16.

Toward stable electron paramagnetic resonance oximetry probes: synthesis, characterization, and metabolic evaluation of new ester derivatives of a tris-(para-carboxyltetrathiaaryl)methyl (TAM) radical.

Decroos C, Balland V, Boucher JL, Bertho G, Xu-Li Y, Mansuy D.

Chem Res Toxicol. 2013 Oct 21;26(10):1561-9. doi: 10.1021/tx400250a. Epub 2013 Sep 26.

PMID:
24010758
17.

[Metabolism of xenobiotics: beneficial and adverse effects].

Mansuy D.

Biol Aujourdhui. 2013;207(1):33-7. doi: 10.1051/jbio/2013003. Epub 2013 May 23. Review. French.

PMID:
23694723
18.

Thiolactone sulfoxides as new reactive metabolites acting as bis-electrophiles: implication in clopidogrel and prasugrel bioactivation.

Dansette PM, Levent D, Hessani A, Bertho G, Mansuy D.

Chem Res Toxicol. 2013 May 20;26(5):794-802. doi: 10.1021/tx400083b. Epub 2013 Apr 9.

PMID:
23527615
19.

First combined in vivo X-ray tomography and high-resolution molecular electron paramagnetic resonance (EPR) imaging of the mouse knee joint taking into account the disappearance kinetics of the EPR probe.

Bézière N, Decroos C, Mkhitaryan K, Kish E, Richard F, Bigot-Marchand S, Durand S, Cloppet F, Chauvet C, Corvol MT, Rannou F, Xu-Li Y, Mansuy D, Peyrot F, Frapart YM.

Mol Imaging. 2012 Jun;11(3):220-8.

PMID:
22554486
20.

Deciphering the activation sequence of ferrociphenol anticancer drug candidates.

Messina P, Labbé E, Buriez O, Hillard EA, Vessières A, Hamels D, Top S, Jaouen G, Frapart YM, Mansuy D, Amatore C.

Chemistry. 2012 May 21;18(21):6581-7. doi: 10.1002/chem.201103378. Epub 2012 Apr 11.

PMID:
22492462
21.

A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2.

Soler N, Craescu CT, Gallay J, Frapart YM, Mansuy D, Raynal B, Baldacci G, Pastore A, Huang ME, Vernis L.

FEBS J. 2012 Jun;279(12):2108-19. doi: 10.1111/j.1742-4658.2012.08597.x. Epub 2012 May 9.

22.

Metabolic activation of prasugrel: nature of the two competitive pathways resulting in the opening of its thiophene ring.

Dansette PM, Rosi J, Debernardi J, Bertho G, Mansuy D.

Chem Res Toxicol. 2012 May 21;25(5):1058-65. doi: 10.1021/tx3000279. Epub 2012 Apr 18.

PMID:
22482514
23.

Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.

Salard-Arnaud I, Stuehr D, Boucher JL, Mansuy D.

J Inorg Biochem. 2012 Jan;106(1):164-71. doi: 10.1016/j.jinorgbio.2011.10.003. Epub 2011 Oct 8.

PMID:
22119809
24.

Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer.

Dansette PM, Rosi J, Bertho G, Mansuy D.

Chem Res Toxicol. 2012 Feb 20;25(2):348-56. doi: 10.1021/tx2004085. Epub 2011 Dec 1.

PMID:
22103858
25.

Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability.

Soler N, Delagoutte E, Miron S, Facca C, Baïlle D, d'Autreaux B, Craescu G, Frapart YM, Mansuy D, Baldacci G, Huang ME, Vernis L.

Mol Microbiol. 2011 Oct;82(1):54-67. doi: 10.1111/j.1365-2958.2011.07788.x. Epub 2011 Sep 8.

26.

Paraoxonase-1 and clopidogrel efficacy.

Dansette PM, Rosi J, Bertho G, Mansuy D.

Nat Med. 2011 Sep 7;17(9):1040-1; author reply 1042-4. doi: 10.1038/nm.2436. No abstract available.

PMID:
21900914
27.

Unprecedented ipso aromatic nucleophilic substitution upon oxidative decarboxylation of tris(p-carboxyltetrathiaaryl)methyl (TAM) radicals: a new access to diversely substituted TAM radicals.

Decroos C, Prangé T, Mansuy D, Boucher JL, Li Y.

Chem Commun (Camb). 2011 Apr 28;47(16):4805-7. doi: 10.1039/c1cc10426h. Epub 2011 Mar 16.

PMID:
21412549
28.
29.

A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis.

Lombard M, Salard I, Sari MA, Mansuy D, Buisson D.

Arch Biochem Biophys. 2011 Apr 1;508(1):54-63. doi: 10.1016/j.abb.2011.01.008. Epub 2011 Jan 15.

PMID:
21241658
30.

Sulfenic acids as reactive intermediates in xenobiotic metabolism.

Mansuy D, Dansette PM.

Arch Biochem Biophys. 2011 Mar 1;507(1):174-85. doi: 10.1016/j.abb.2010.09.015. Epub 2010 Oct 1. Review.

PMID:
20869346
31.

Comparison of wild type neuronal nitric oxide synthase and its Tyr588Phe mutant towards various L-arginine analogues.

Giroud C, Moreau M, Sagami I, Shimizu T, Frapart Y, Mansuy D, Boucher JL.

J Inorg Biochem. 2010 Oct;104(10):1043-50. doi: 10.1016/j.jinorgbio.2010.06.001. Epub 2010 Jun 18.

PMID:
20630600
32.

Oxidative decarboxylation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes by peroxidases and related hemeproteins: intermediate formation and characterization of the corresponding cations.

Decroos C, Li Y, Soltani A, Frapart Y, Mansuy D, Boucher JL.

Arch Biochem Biophys. 2010 Oct 1;502(1):74-80. doi: 10.1016/j.abb.2010.07.002. Epub 2010 Jul 6.

PMID:
20615385
33.

Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel.

Dansette PM, Thébault S, Bertho G, Mansuy D.

Chem Res Toxicol. 2010 Jul 19;23(7):1268-74. doi: 10.1021/tx1001332.

PMID:
20557086
34.

Metabolic stability of superoxide and hydroxyl radical adducts of a cyclic nitrone toward rat liver microsomes and cytosol: A stopped-flow ESR spectroscopy study.

Bézière N, Frapart Y, Rockenbauer A, Boucher JL, Mansuy D, Peyrot F.

Free Radic Biol Med. 2010 Aug 1;49(3):437-46. doi: 10.1016/j.freeradbiomed.2010.04.035. Epub 2010 May 7.

PMID:
20452418
35.

Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols.

Hamels D, Dansette PM, Hillard EA, Top S, Vessières A, Herson P, Jaouen G, Mansuy D.

Angew Chem Int Ed Engl. 2009;48(48):9124-6. doi: 10.1002/anie.200903768. No abstract available.

PMID:
19876986
36.

Oxidative and reductive metabolism of tris(p-carboxyltetrathiaaryl)methyl radicals by liver microsomes.

Decroos C, Li Y, Bertho G, Frapart Y, Mansuy D, Boucher JL.

Chem Res Toxicol. 2009 Jul;22(7):1342-50. doi: 10.1021/tx9001379.

PMID:
19545126
37.

Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-.

Decroos C, Li Y, Bertho G, Frapart Y, Mansuy D, Boucher JL.

Chem Commun (Camb). 2009 Mar 21;(11):1416-8. doi: 10.1039/b819259f. Epub 2009 Jan 22.

PMID:
19259606
38.
39.

Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.

Cottyn B, Acher F, Ramassamy B, Alvey L, Lepoivre M, Frapart Y, Stuehr D, Mansuy D, Boucher JL, Vichard D.

Bioorg Med Chem. 2008 Jun 1;16(11):5962-73. doi: 10.1016/j.bmc.2008.04.056. Epub 2008 Apr 26.

PMID:
18502134
40.

Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases.

Chandor A, Dijols S, Ramassamy B, Frapart Y, Mansuy D, Stuehr D, Helsby N, Boucher JL.

Chem Res Toxicol. 2008 Apr;21(4):836-43. doi: 10.1021/tx7004234. Epub 2008 Mar 28.

PMID:
18370414
41.

Unusual regioselectivity and active site topology of human cytochrome P450 2J2.

Lafite P, André F, Zeldin DC, Dansette PM, Mansuy D.

Biochemistry. 2007 Sep 11;46(36):10237-47. Epub 2007 Aug 17.

42.

Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.

Lafite P, Dijols S, Zeldin DC, Dansette PM, Mansuy D.

Arch Biochem Biophys. 2007 Aug 15;464(2):155-68. Epub 2007 Apr 10.

43.

Analogies and surprising differences between recombinant nitric oxide synthase-like proteins from Staphylococcus aureus and Bacillus anthracis in their interactions with l-arginine analogs and iron ligands.

Salard I, Mercey E, Rekka E, Boucher JL, Nioche P, Mikula I, Martasek P, Raman CS, Mansuy D.

J Inorg Biochem. 2006 Dec;100(12):2024-33. Epub 2006 Sep 28.

PMID:
17084900
44.

Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes.

Moreau M, Boucher JL, Mattioli TA, Stuehr DJ, Mansuy D, Santolini J.

Biochemistry. 2006 Mar 28;45(12):3988-99.

PMID:
16548526
45.

Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.

Lafite P, Dijols S, Buisson D, Macherey AC, Zeldin DC, Dansette PM, Mansuy D.

Bioorg Med Chem Lett. 2006 May 15;16(10):2777-80. Epub 2006 Feb 21.

46.

Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.

Lefèvre-Groboillot D, Boucher JL, Mansuy D, Stuehr DJ.

FEBS J. 2006 Jan;273(1):180-91.

47.
48.

First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives.

Dansette PM, Bertho G, Mansuy D.

Biochem Biophys Res Commun. 2005 Dec 9;338(1):450-5. Epub 2005 Aug 22.

PMID:
16137656
49.

Reduction of ferric haemoproteins by tetrahydropterins: a kinetic study.

Capeillere-Blandin C, Mathieu D, Mansuy D.

Biochem J. 2005 Dec 15;392(Pt 3):583-7.

50.

Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents.

Beranova P, Chalupsky K, Kleschyov AL, Schott C, Boucher JL, Mansuy D, Munzel T, Muller B, Stoclet JC.

Eur J Pharmacol. 2005 Jun 15;516(3):260-7.

PMID:
15964563

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