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Items: 1 to 50 of 111

1.

Actin-tropomyosin distribution in non-muscle cells.

Manstein DJ, Meiring JCM, Hardeman EC, Gunning PW.

J Muscle Res Cell Motil. 2019 May 4. doi: 10.1007/s10974-019-09514-0. [Epub ahead of print]

PMID:
31054005
2.

Phenamacril is a reversible and noncompetitive inhibitor of Fusarium class I myosin.

Wollenberg RD, Taft MH, Giese S, Thiel C, Balázs Z, Giese H, Manstein DJ, Sondergaard TE.

J Biol Chem. 2019 Jan 25;294(4):1328-1337. doi: 10.1074/jbc.RA118.005408. Epub 2018 Nov 30.

PMID:
30504222
3.

Author Correction: Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.

Latham SL, Ehmke N, Reinke PYA, Taft MH, Eicke D, Reindl T, Stenzel W, Lyons MJ, Friez MJ, Lee JA, Hecker R, Frühwald MC, Becker K, Neuhann TM, Horn D, Schrock E, Niehaus I, Sarnow K, Grützmann K, Gawehn L, Klink B, Rump A, Chaponnier C, Figueiredo C, Knöfler R, Manstein DJ, Di Donato N.

Nat Commun. 2018 Nov 19;9(1):4930. doi: 10.1038/s41467-018-07404-6.

4.

Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.

Latham SL, Ehmke N, Reinke PYA, Taft MH, Eicke D, Reindl T, Stenzel W, Lyons MJ, Friez MJ, Lee JA, Hecker R, Frühwald MC, Becker K, Neuhann TM, Horn D, Schrock E, Niehaus I, Sarnow K, Grützmann K, Gawehn L, Klink B, Rump A, Chaponnier C, Figueiredo C, Knöfler R, Manstein DJ, Di Donato N.

Nat Commun. 2018 Oct 12;9(1):4250. doi: 10.1038/s41467-018-06713-0. Erratum in: Nat Commun. 2018 Nov 19;9(1):4930.

5.

Treatments targeting inotropy.

Maack C, Eschenhagen T, Hamdani N, Heinzel FR, Lyon AR, Manstein DJ, Metzger J, Papp Z, Tocchetti CG, Yilmaz MB, Anker SD, Balligand JL, Bauersachs J, Brutsaert D, Carrier L, Chlopicki S, Cleland JG, de Boer RA, Dietl A, Fischmeister R, Harjola VP, Heymans S, Hilfiker-Kleiner D, Holzmeister J, de Keulenaer G, Limongelli G, Linke WA, Lund LH, Masip J, Metra M, Mueller C, Pieske B, Ponikowski P, Ristic A, Ruschitzka F, Seferovic PM, Skouri H, Zimmermann WH, Mebazaa A.

Eur Heart J. 2018 Oct 8. doi: 10.1093/eurheartj/ehy600. [Epub ahead of print]

PMID:
30295807
6.

Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton.

Meiring JCM, Bryce NS, Wang Y, Taft MH, Manstein DJ, Liu Lau S, Stear J, Hardeman EC, Gunning PW.

Curr Biol. 2018 Jul 23;28(14):2331-2337.e5. doi: 10.1016/j.cub.2018.05.053. Epub 2018 Jul 5.

7.

Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.

Chinthalapudi K, Heissler SM, Preller M, Sellers JR, Manstein DJ.

Elife. 2017 Dec 19;6. pii: e32742. doi: 10.7554/eLife.32742.

8.

Three mammalian tropomyosin isoforms have different regulatory effects on nonmuscle myosin-2B and filamentous β-actin in vitro.

Pathan-Chhatbar S, Taft MH, Reindl T, Hundt N, Latham SL, Manstein DJ.

J Biol Chem. 2018 Jan 19;293(3):863-875. doi: 10.1074/jbc.M117.806521. Epub 2017 Nov 30.

9.

Pink-beam serial crystallography.

Meents A, Wiedorn MO, Srajer V, Henning R, Sarrou I, Bergtholdt J, Barthelmess M, Reinke PYA, Dierksmeyer D, Tolstikova A, Schaible S, Messerschmidt M, Ogata CM, Kissick DJ, Taft MH, Manstein DJ, Lieske J, Oberthuer D, Fischetti RF, Chapman HN.

Nat Commun. 2017 Nov 3;8(1):1281. doi: 10.1038/s41467-017-01417-3.

10.

Inward H+ pump xenorhodopsin: Mechanism and alternative optogenetic approach.

Shevchenko V, Mager T, Kovalev K, Polovinkin V, Alekseev A, Juettner J, Chizhov I, Bamann C, Vavourakis C, Ghai R, Gushchin I, Borshchevskiy V, Rogachev A, Melnikov I, Popov A, Balandin T, Rodriguez-Valera F, Manstein DJ, Bueldt G, Bamberg E, Gordeliy V.

Sci Adv. 2017 Sep 22;3(9):e1603187. doi: 10.1126/sciadv.1603187. eCollection 2017 Sep.

11.

N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms.

Zattelman L, Regev R, Ušaj M, Reinke PYA, Giese S, Samson AO, Taft MH, Manstein DJ, Henn A.

J Biol Chem. 2017 Oct 27;292(43):17804-17818. doi: 10.1074/jbc.M117.794008. Epub 2017 Sep 11.

12.

Structural and biochemical studies of sulphotransferase 18 from Arabidopsis thaliana explain its substrate specificity and reaction mechanism.

Hirschmann F, Krause F, Baruch P, Chizhov I, Mueller JW, Manstein DJ, Papenbrock J, Fedorov R.

Sci Rep. 2017 Jun 23;7(1):4160. doi: 10.1038/s41598-017-04539-2.

13.

Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro.

Gateva G, Kremneva E, Reindl T, Kotila T, Kogan K, Gressin L, Gunning PW, Manstein DJ, Michelot A, Lappalainen P.

Curr Biol. 2017 Mar 6;27(5):705-713. doi: 10.1016/j.cub.2017.01.018. Epub 2017 Feb 16.

14.

Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution.

von der Ecken J, Heissler SM, Pathan-Chhatbar S, Manstein DJ, Raunser S.

Nature. 2016 Jun 30;534(7609):724-8. Epub 2016 Jun 20.

PMID:
27324845
15.

Tropomyosin-Mediated Regulation of Cytoplasmic Myosins.

Manstein DJ, Mulvihill DP.

Traffic. 2016 Aug;17(8):872-7. doi: 10.1111/tra.12399. Epub 2016 May 4. Review.

16.

Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2.

Hundt N, Steffen W, Pathan-Chhatbar S, Taft MH, Manstein DJ.

Sci Rep. 2016 Feb 5;6:20554. doi: 10.1038/srep20554.

17.

Crystal structure of the dynamin tetramer.

Reubold TF, Faelber K, Plattner N, Posor Y, Ketel K, Curth U, Schlegel J, Anand R, Manstein DJ, Noé F, Haucke V, Daumke O, Eschenburg S.

Nature. 2015 Sep 17;525(7569):404-8. doi: 10.1038/nature14880. Epub 2015 Aug 24.

PMID:
26302298
18.

The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity.

Lohöfener J, Steinke N, Kay-Fedorov P, Baruch P, Nikulin A, Tishchenko S, Manstein DJ, Fedorov R.

Structure. 2015 May 5;23(5):851-862. doi: 10.1016/j.str.2015.03.012. Epub 2015 Apr 16.

19.

Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion.

Brandstaetter H, Kishi-Itakura C, Tumbarello DA, Manstein DJ, Buss F.

Autophagy. 2014;10(12):2310-23. doi: 10.4161/15548627.2014.984272.

20.

Structure of the F-actin-tropomyosin complex.

von der Ecken J, Müller M, Lehman W, Manstein DJ, Penczek PA, Raunser S.

Nature. 2015 Mar 5;519(7541):114-7. doi: 10.1038/nature14033. Epub 2014 Dec 1.

21.

Crystal structure of the rigor-like human non-muscle myosin-2 motor domain.

Münnich S, Pathan-Chhatbar S, Manstein DJ.

FEBS Lett. 2014 Dec 20;588(24):4754-60. doi: 10.1016/j.febslet.2014.11.007. Epub 2014 Nov 15.

22.

Molecular mechanisms of disease-related human β-actin mutations p.R183W and p.E364K.

Hundt N, Preller M, Swolski O, Ang AM, Mannherz HG, Manstein DJ, Müller M.

FEBS J. 2014 Dec;281(23):5279-91. doi: 10.1111/febs.13068. Epub 2014 Oct 13.

23.

Expression, purification and crystallization of a dye-decolourizing peroxidase from Dictyostelium discoideum.

Rai A, Fedorov R, Manstein DJ.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):252-5. doi: 10.1107/S2053230X14000545. Epub 2014 Jan 22.

24.

Crystal structure of human myosin 1c--the motor in GLUT4 exocytosis: implications for Ca2+ regulation and 14-3-3 binding.

Münnich S, Taft MH, Manstein DJ.

J Mol Biol. 2014 May 15;426(10):2070-81. doi: 10.1016/j.jmb.2014.03.004. Epub 2014 Mar 14.

PMID:
24636949
25.

Small molecule-mediated refolding and activation of myosin motor function.

Radke MB, Taft MH, Stapel B, Hilfiker-Kleiner D, Preller M, Manstein DJ.

Elife. 2014 Feb 11;3:e01603. doi: 10.7554/eLife.01603.

26.

Myosin structure, allostery, and mechano-chemistry.

Preller M, Manstein DJ.

Structure. 2013 Nov 5;21(11):1911-22. doi: 10.1016/j.str.2013.09.015. Review.

27.

Kinetic and thermodynamic analysis of the light-induced processes in plant and cyanobacterial phytochromes.

Chizhov I, Zorn B, Manstein DJ, Gärtner W.

Biophys J. 2013 Nov 5;105(9):2210-20. doi: 10.1016/j.bpj.2013.09.033.

28.

Functional characterization of human myosin-18A and its interaction with F-actin and GOLPH3.

Taft MH, Behrmann E, Munske-Weidemann LC, Thiel C, Raunser S, Manstein DJ.

J Biol Chem. 2013 Oct 18;288(42):30029-41. doi: 10.1074/jbc.M113.497180. Epub 2013 Aug 29.

29.

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human myosin 1c in complex with calmodulin.

Münnich S, Manstein DJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):1020-2. doi: 10.1107/S1744309113020988. Epub 2013 Aug 21.

30.

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML.

Chaturvedi A, Araujo Cruz MM, Jyotsana N, Sharma A, Yun H, Görlich K, Wichmann M, Schwarzer A, Preller M, Thol F, Meyer J, Haemmerle R, Struys EA, Jansen EE, Modlich U, Li Z, Sly LM, Geffers R, Lindner R, Manstein DJ, Lehmann U, Krauter J, Ganser A, Heuser M.

Blood. 2013 Oct 17;122(16):2877-87. doi: 10.1182/blood-2013-03-491571. Epub 2013 Aug 16.

PMID:
23954893
31.

Distinct functional interactions between actin isoforms and nonsarcomeric myosins.

Müller M, Diensthuber RP, Chizhov I, Claus P, Heissler SM, Preller M, Taft MH, Manstein DJ.

PLoS One. 2013 Jul 26;8(7):e70636. doi: 10.1371/journal.pone.0070636. Print 2013.

32.

Functional dissection of the dictyostelium discoideum dynamin B mitochondrial targeting sequence.

Rai A, Tzvetkov N, Manstein DJ.

PLoS One. 2013;8(2):e56975. doi: 10.1371/journal.pone.0056975. Epub 2013 Feb 21.

33.

Kinetic properties and small-molecule inhibition of human myosin-6.

Heissler SM, Selvadurai J, Bond LM, Fedorov R, Kendrick-Jones J, Buss F, Manstein DJ.

FEBS Lett. 2012 Sep 21;586(19):3208-14. doi: 10.1016/j.febslet.2012.07.014. Epub 2012 Jul 31.

34.

Structure of the rigor actin-tropomyosin-myosin complex.

Behrmann E, Müller M, Penczek PA, Mannherz HG, Manstein DJ, Raunser S.

Cell. 2012 Jul 20;150(2):327-38. doi: 10.1016/j.cell.2012.05.037.

35.

Functional characterization of the human α-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy.

Müller M, Mazur AJ, Behrmann E, Diensthuber RP, Radke MB, Qu Z, Littwitz C, Raunser S, Schoenenberger CA, Manstein DJ, Mannherz HG.

Cell Mol Life Sci. 2012 Oct;69(20):3457-79. doi: 10.1007/s00018-012-1030-5. Epub 2012 May 29.

PMID:
22643837
36.

Nonmuscle myosin-2: mix and match.

Heissler SM, Manstein DJ.

Cell Mol Life Sci. 2013 Jan;70(1):1-21. doi: 10.1007/s00018-012-1002-9. Epub 2012 May 8. Review.

37.

Structural basis for the allosteric interference of myosin function by reactive thiol region mutations G680A and G680V.

Preller M, Bauer S, Adamek N, Fujita-Becker S, Fedorov R, Geeves MA, Manstein DJ.

J Biol Chem. 2011 Oct 7;286(40):35051-60. doi: 10.1074/jbc.M111.265298. Epub 2011 Aug 13.

38.

Functional characterization of the human myosin-7a motor domain.

Heissler SM, Manstein DJ.

Cell Mol Life Sci. 2012 Jan;69(2):299-311. doi: 10.1007/s00018-011-0749-8. Epub 2011 Jun 18.

39.

Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.

Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker HJ, Coluccio LM, Manstein DJ.

J Biol Chem. 2011 Aug 26;286(34):29700-8. doi: 10.1074/jbc.M111.239210. Epub 2011 Jun 16.

40.

Inhibition of Myosin ATPase activity by halogenated pseudilins: a structure-activity study.

Preller M, Chinthalapudi K, Martin R, Knolker HJ, Manstein DJ.

J Med Chem. 2011 Jun 9;54(11):3675-85. doi: 10.1021/jm200259f. Epub 2011 May 13.

PMID:
21534527
41.

Acute-phase protein α1-antitrypsin inhibits neutrophil calpain I and induces random migration.

Al-Omari M, Korenbaum E, Ballmaier M, Lehmann U, Jonigk D, Manstein DJ, Welte T, Mahadeva R, Janciauskiene S.

Mol Med. 2011 Sep-Oct;17(9-10):865-74. doi: 10.2119/molmed.2011.00089. Epub 2011 Apr 11.

42.

Comparative kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoforms.

Heissler SM, Manstein DJ.

J Biol Chem. 2011 Jun 17;286(24):21191-202. doi: 10.1074/jbc.M110.212290. Epub 2011 Apr 8.

43.

Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin.

Diensthuber RP, Müller M, Heissler SM, Taft MH, Chizhov I, Manstein DJ.

FEBS Lett. 2011 Mar 9;585(5):767-71. doi: 10.1016/j.febslet.2011.01.042. Epub 2011 Feb 3.

44.

Unusual anchor of a motor complex (MyoD-MLC2) to the plasma membrane of Toxoplasma gondii.

Polonais V, Javier Foth B, Chinthalapudi K, Marq JB, Manstein DJ, Soldati-Favre D, Frénal K.

Traffic. 2011 Mar;12(3):287-300. doi: 10.1111/j.1600-0854.2010.01148.x. Epub 2011 Jan 7.

45.

Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles.

Rai A, Nöthe H, Tzvetkov N, Korenbaum E, Manstein DJ.

Cell Mol Life Sci. 2011 Aug;68(16):2751-67. doi: 10.1007/s00018-010-0590-5. Epub 2010 Nov 18.

46.

Site-directed mutagenesis of the χ subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction.

Naue N, Fedorov R, Pich A, Manstein DJ, Curth U.

Nucleic Acids Res. 2011 Mar;39(4):1398-407. doi: 10.1093/nar/gkq988. Epub 2010 Oct 23.

47.

Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization.

Montessuit S, Somasekharan SP, Terrones O, Lucken-Ardjomande S, Herzig S, Schwarzenbacher R, Manstein DJ, Bossy-Wetzel E, Basañez G, Meda P, Martinou JC.

Cell. 2010 Sep 17;142(6):889-901. doi: 10.1016/j.cell.2010.08.017.

48.

Targeted optimization of a protein nanomachine for operation in biohybrid devices.

Amrute-Nayak M, Diensthuber RP, Steffen W, Kathmann D, Hartmann FK, Fedorov R, Urbanke C, Manstein DJ, Brenner B, Tsiavaliaris G.

Angew Chem Int Ed Engl. 2010;49(2):312-6. doi: 10.1002/anie.200905200. No abstract available.

PMID:
19921669
49.

Total synthesis of pentabromo- and pentachloropseudilin, and synthetic analogues--allosteric inhibitors of myosin ATPase.

Martin R, Jäger A, Böhl M, Richter S, Fedorov R, Manstein DJ, Gutzeit HO, Knölker HJ.

Angew Chem Int Ed Engl. 2009;48(43):8042-6. doi: 10.1002/anie.200903743. No abstract available.

PMID:
19739175
50.

The Ras pathway modulator melophlin A targets dynamins.

Knoth T, Warburg K, Katzka C, Rai A, Wolf A, Brockmeyer A, Janning P, Reubold TF, Eschenburg S, Manstein DJ, Hübel K, Kaiser M, Waldmann H.

Angew Chem Int Ed Engl. 2009;48(39):7240-5. doi: 10.1002/anie.200902023. No abstract available.

PMID:
19722243

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