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Items: 35


Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis.

Urness LD, Wang X, Doan H, Shumway N, Noyes CA, Gutierrez-Magana E, Lu R, Mansour SL.

Development. 2018 Dec 18;145(24). pii: dev170142. doi: 10.1242/dev.170142.


Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins.

Quadros RM, Miura H, Harms DW, Akatsuka H, Sato T, Aida T, Redder R, Richardson GP, Inagaki Y, Sakai D, Buckley SM, Seshacharyulu P, Batra SK, Behlke MA, Zeiner SA, Jacobi AM, Izu Y, Thoreson WB, Urness LD, Mansour SL, Ohtsuka M, Gurumurthy CB.

Genome Biol. 2017 May 17;18(1):92. doi: 10.1186/s13059-017-1220-4.


SHH ventralizes the otocyst by maintaining basal PKA activity and regulating GLI3 signaling.

Ohta S, Wang B, Mansour SL, Schoenwolf GC.

Dev Biol. 2016 Dec 1;420(1):100-109. doi: 10.1016/j.ydbio.2016.10.004. Epub 2016 Oct 5.


BMP regulates regional gene expression in the dorsal otocyst through canonical and non-canonical intracellular pathways.

Ohta S, Wang B, Mansour SL, Schoenwolf GC.

Development. 2016 Jun 15;143(12):2228-37. doi: 10.1242/dev.137133. Epub 2016 May 5.


Fgf10 is required for specification of non-sensory regions of the cochlear epithelium.

Urness LD, Wang X, Shibata S, Ohyama T, Mansour SL.

Dev Biol. 2015 Apr 1;400(1):59-71. doi: 10.1016/j.ydbio.2015.01.015. Epub 2015 Jan 24.


Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis.

Jackson A, Kasah S, Mansour SL, Morrow B, Basson MA.

Dev Dyn. 2014 Sep;243(9):1143-51. doi: 10.1002/dvdy.24147. Epub 2014 Jun 12.


Genetic rescue of Muenke syndrome model hearing loss reveals prolonged FGF-dependent plasticity in cochlear supporting cell fates.

Mansour SL, Li C, Urness LD.

Genes Dev. 2013 Nov 1;27(21):2320-31. doi: 10.1101/gad.228957.113. Epub 2013 Oct 21.


Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development.

Urness LD, Bleyl SB, Wright TJ, Moon AM, Mansour SL.

Dev Biol. 2011 Aug 15;356(2):383-97. doi: 10.1016/j.ydbio.2011.05.671. Epub 2011 Jun 12.


BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst.

Ohta S, Mansour SL, Schoenwolf GC.

Dev Biol. 2010 Nov 15;347(2):369-81. doi: 10.1016/j.ydbio.2010.09.002. Epub 2010 Sep 15.


FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a.

Urness LD, Paxton CN, Wang X, Schoenwolf GC, Mansour SL.

Dev Biol. 2010 Apr 15;340(2):595-604. doi: 10.1016/j.ydbio.2010.02.016. Epub 2010 Feb 18.


Hearing loss in a mouse model of Muenke syndrome.

Mansour SL, Twigg SR, Freeland RM, Wall SA, Li C, Wilkie AO.

Hum Mol Genet. 2009 Jan 1;18(1):43-50. doi: 10.1093/hmg/ddn311. Epub 2008 Sep 25.


Fgf16(IRESCre) mice: a tool to inactivate genes expressed in inner ear cristae and spiral prominence epithelium.

Hatch EP, Urness LD, Mansour SL.

Dev Dyn. 2009 Feb;238(2):358-66. doi: 10.1002/dvdy.21681.


Expression of ERK signaling inhibitors Dusp6, Dusp7, and Dusp9 during mouse ear development.

Urness LD, Li C, Wang X, Mansour SL.

Dev Dyn. 2008 Jan;237(1):163-9.


Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium.

Hatch EP, Noyes CA, Wang X, Wright TJ, Mansour SL.

Development. 2007 Oct;134(20):3615-25. Epub 2007 Sep 12.


Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development.

Li C, Scott DA, Hatch E, Tian X, Mansour SL.

Development. 2007 Jan;134(1):167-76.


FGF8 initiates inner ear induction in chick and mouse.

Ladher RK, Wright TJ, Moon AM, Mansour SL, Schoenwolf GC.

Genes Dev. 2005 Mar 1;19(5):603-13.


Regulation of external genitalia development by concerted actions of FGF ligands and FGF receptors.

Satoh Y, Haraguchi R, Wright TJ, Mansour SL, Partanen J, Hajihosseini MK, Eswarakumar VP, Lonai P, Yamada G.

Anat Embryol (Berl). 2004 Sep;208(6):479-86. Epub 2004 Aug 31.


Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction.

Wright TJ, Ladher R, McWhirter J, Murre C, Schoenwolf GC, Mansour SL.

Dev Biol. 2004 May 1;269(1):264-75.


FGF signaling in ear development and innervation.

Wright TJ, Mansour SL.

Curr Top Dev Biol. 2003;57:225-59. Review. No abstract available.


Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development.

Wright TJ, Hatch EP, Karabagli H, Karabagli P, Schoenwolf GC, Mansour SL.

Dev Dyn. 2003 Oct;228(2):267-72.


Fgf3 and Fgf10 are required for mouse otic placode induction.

Wright TJ, Mansour SL.

Development. 2003 Aug;130(15):3379-90.


Impaired motor coordination in mice that lack punc.

Yang W, Li C, Mansour SL.

Mol Cell Biol. 2001 Sep;21(17):6031-43.


Defective organellar membrane protein trafficking in Ap3b1-deficient cells.

Yang W, Li C, Ward DM, Kaplan J, Mansour SL.

J Cell Sci. 2000 Nov;113 ( Pt 22):4077-86.


Trapping genes expressed in the developing mouse inner ear.

Yang W, Musci TS, Mansour SL.

Hear Res. 1997 Dec;114(1-2):53-61.


Targeted disruption of int-2 (fgf-3) causes developmental defects in the tail and inner ear.

Mansour SL.

Mol Reprod Dev. 1994 Sep;39(1):62-7; discussion 67-8. Review.


Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.

Mansour SL, Thomas KR, Deng CX, Capecchi MR.

Proc Natl Acad Sci U S A. 1990 Oct;87(19):7688-92.


Downstream sequences affect transcription initiation from the adenovirus major late promoter.

Mansour SL, Grodzicker T, Tjian R.

Mol Cell Biol. 1986 Jul;6(7):2684-94.


ASHA Omnibus Survey 1984.

Mansour SL, Lingwall JB.

ASHA. 1985 May;27(5):37-40. No abstract available.


An adenovirus vector system used to express polyoma virus tumor antigens.

Mansour SL, Grodzicker T, Tjian R.

Proc Natl Acad Sci U S A. 1985 Mar;82(5):1359-63.

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