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Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period.

Glimm AM, Sprenger LI, Haugen IK, Mansmann U, Hermann S, Häupl T, Hoff P, Burmester GR, Backhaus M, Le L, Ohrndorf S.

Arthritis Res Ther. 2019 Sep 18;21(1):209. doi: 10.1186/s13075-019-1989-5.


Allelic Imbalance of Recurrently Mutated Genes in Acute Myeloid Leukaemia.

Batcha AMN, Bamopoulos SA, Kerbs P, Kumar A, Jurinovic V, Rothenberg-Thurley M, Ksienzyk B, Philippou-Massier J, Krebs S, Blum H, Schneider S, Konstandin N, Bohlander SK, Heckman C, Kontro M, Hiddemann W, Spiekermann K, Braess J, Metzeler KH, Greif PA, Mansmann U, Herold T.

Sci Rep. 2019 Aug 13;9(1):11796. doi: 10.1038/s41598-019-48167-4.


Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial.

Levin J, Maaß S, Schuberth M, Giese A, Oertel WH, Poewe W, Trenkwalder C, Wenning GK, Mansmann U, Südmeyer M, Eggert K, Mollenhauer B, Lipp A, Löhle M, Classen J, Münchau A, Kassubek J, Gandor F, Berg D, Egert-Schwender S, Eberhardt C, Paul F, Bötzel K, Ertl-Wagner B, Huppertz HJ, Ricard I, Höglinger GU; PROMESA Study Group.

Lancet Neurol. 2019 Aug;18(8):724-735. doi: 10.1016/S1474-4422(19)30141-3. Epub 2019 Jul 2.


No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial.

Dallaku K, Shakur-Still H, Beaumont D, Roberts I, Huque S, Delius M, Holdenrieder S, Gliozheni O, Mansmann U.

Wellcome Open Res. 2019 Feb 5;4:21. doi: 10.12688/wellcomeopenres.14977.1. eCollection 2019.


Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures.

Li J, Halfter K, Zhang M, Saad C, Xu K, Bauer B, Huang Y, Shi L, Mansmann UR.

BMC Cancer. 2019 Jun 17;19(1):600. doi: 10.1186/s12885-019-5804-0.


[Research involving human subjects-principles and challenges for the work of ethics committees].

Pigeot I, Mansmann U, Rauch G.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Jun;62(6):679-681. doi: 10.1007/s00103-019-02961-7. German. No abstract available.


Effectiveness of a complex intervention to improve participation and activities in nursing home residents with joint contractures (JointConEval): study protocol of a multicentre cluster-randomised controlled trial [DRKS-ID:DRKS00015185].

Nguyen N, Thalhammer R, Beutner K, Saal S, Servaty R, Klingshirn H, Icks A, Freyberg K, Vomhof M, Mansmann U, Le L, Müller M, Meyer G.

Trials. 2019 May 29;20(1):305. doi: 10.1186/s13063-019-3384-6.


[Scientific and ethical evaluation of projects in data-driven medicine].

Caliebe A, Scherag A, Strech D, Mansmann U.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Jun;62(6):765-772. doi: 10.1007/s00103-019-02958-2. Review. German.


[The role of biostatistics in institutional review boards].

Schlattmann P, Scherag A, Rauch G, Mansmann U.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2019 Jun;62(6):751-757. doi: 10.1007/s00103-019-02951-9. Review. German.


Angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy compared to best medical treatment: One-year interim results of SPACE-2.

Reiff T, Eckstein HH, Mansmann U, Jansen O, Fraedrich G, Mudra H, Böckler D, Böhm M, Brückmann H, Debus ES, Fiehler J, Lang W, Mathias K, Ringelstein EB, Schmidli J, Stingele R, Zahn R, Zeller T, Hetzel A, Bodechtel U, Binder A, Glahn J, Hacke W, Ringleb PA.

Int J Stroke. 2019 Mar 15:1747493019833017. doi: 10.1177/1747493019833017. [Epub ahead of print]


Added value of biomarkers compared with clinical parameters for the prediction of radiographic spinal progression in axial spondyloarthritis.

Rademacher J, Tietz LM, Le L, Hartl A, Hermann KA, Sieper J, Mansmann U, Rudwaleit M, Poddubnyy D.

Rheumatology (Oxford). 2019 Sep 1;58(9):1556-1564. doi: 10.1093/rheumatology/kez025.


Acupuncture for migraine: a protocol for a meta-analysis and meta-regression of randomised controlled trials.

Gao Z, Giovanardi CM, Li H, Hao C, Li Q, Zhang X, Mansmann U.

BMJ Open. 2019 Feb 22;8(11):e022998. doi: 10.1136/bmjopen-2018-022998.


AutoAnalyze in Systems Biology.

Saad C, Bauer B, Mansmann UR, Li J.

Bioinform Biol Insights. 2019 Jan 9;13:1177932218818458. doi: 10.1177/1177932218818458. eCollection 2019.


Regional Hyperthermia With Neoadjuvant Chemotherapy for Treatment of Soft Tissue Sarcoma-Reply.

Mansmann U, Lindner LH, Issels R.

JAMA Oncol. 2019 Jan 1;5(1):114. doi: 10.1001/jamaoncol.2018.5293. No abstract available.


Late-pregnancy dysglycemia in obese pregnancies after negative testing for gestational diabetes and risk of future childhood overweight: An interim analysis from a longitudinal mother-child cohort study.

Gomes D, von Kries R, Delius M, Mansmann U, Nast M, Stubert M, Langhammer L, Haas NA, Netz H, Obermeier V, Kuhle S, Holdt LM, Teupser D, Hasbargen U, Roscher AA, Ensenauer R.

PLoS Med. 2018 Oct 29;15(10):e1002681. doi: 10.1371/journal.pmed.1002681. eCollection 2018 Oct.


Effect of tranexamic acid on coagulation and fibrinolysis in women with postpartum haemorrhage (WOMAN-ETAC): a single-centre, randomised, double-blind, placebo-controlled trial.

Shakur-Still H, Roberts I, Fawole B, Kuti M, Olayemi OO, Bello A, Huque S, Ogunbode O, Kotila T, Aimakhu C, Okunade OA, Olutogun T, Adetayo CO, Dallaku K, Mansmann U, Hunt BJ, Pepple T, Balogun E.

Wellcome Open Res. 2018 Aug 15;3:100. doi: 10.12688/wellcomeopenres.14722.1. eCollection 2018.


Temporal trends in cardiovascular risk factors and performance of the Framingham Risk Score and the Pooled Cohort Equations.

Rospleszcz S, Thorand B, de Las Heras Gala T, Meisinger C, Holle R, Koenig W, Mansmann U, Peters A.

J Epidemiol Community Health. 2019 Jan;73(1):19-25. doi: 10.1136/jech-2018-211102. Epub 2018 Sep 27.


Effect of a combined brief narrative exposure therapy with case management versus treatment as usual in primary care for patients with traumatic stress sequelae following intensive care medicine: study protocol for a multicenter randomized controlled trial (PICTURE).

Gensichen J, Schultz S, Adrion C, Schmidt K, Schauer M, Lindemann D, Unruh N, Kosilek RP, Schneider A, Scherer M, Bergmann A, Heintze C, Joos S, Briegel J, Scherag A, König HH, Brettschneider C, Schulze TG, Mansmann U, Linde K, Lühmann D, Voigt K, Gehrke-Beck S, Koch R, Zwissler B, Schneider G, Gerlach H, Kluge S, Koch T, Walther A, Atmann O, Oltrogge J, Sauer M, Schnurr J, Elbert T; PICTURE Study Group.

Trials. 2018 Sep 10;19(1):480. doi: 10.1186/s13063-018-2853-7.


A Web-based survey among adults aged 40-54 years was time effective and yielded stable response patterns.

Weigl K, Tikk K, Hoffmeister M, De Toni EN, Hampe J, Kolligs F, Klug SJ, Mansmann U, Nasseh D, Radlovic J, Schwab M, Schweigler D, Stephan AM, Brenner H.

J Clin Epidemiol. 2019 Jan;105:10-18. doi: 10.1016/j.jclinepi.2018.08.021. Epub 2018 Sep 6.


The Trusted Server: A secure computational environment for privacy compliant evaluations on plain personal data.

von Bomhard N, Ahlborn B, Mason C, Mansmann U.

PLoS One. 2018 Sep 6;13(9):e0202752. doi: 10.1371/journal.pone.0202752. eCollection 2018.


Ca2+ and innate immune pathways are activated and differentially expressed in childhood asthma phenotypes.

Boeck A, Landgraf-Rauf K, Vogelsang V, Siemens D, Prazeres da Costa O, Klucker E, von Mutius E, Buch T, Mansmann U, Schaub B.

Pediatr Allergy Immunol. 2018 Dec;29(8):823-833. doi: 10.1111/pai.12971. Epub 2018 Oct 9.


The DNA-polymorphism rs849142 is associated with skin toxicity induced by targeted anti-EGFR therapy using cetuximab.

Froelich MF, Stintzing S, Kumbrink J, Grünewald TGP, Mansmann U, Heinemann V, Kirchner T, Jung A.

Oncotarget. 2018 Jul 13;9(54):30279-30288. doi: 10.18632/oncotarget.25689. eCollection 2018 Jul 13.


Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia.

Schranz K, Hubmann M, Harin E, Vosberg S, Herold T, Metzeler KH, Rothenberg-Thurley M, Janke H, Bräundl K, Ksienzyk B, Batcha AMN, Schaaf S, Schneider S, Bohlander SK, Görlich D, Berdel WE, Wörmann BJ, Braess J, Krebs S, Hiddemann W, Mansmann U, Spiekermann K, Greif PA.

Oncotarget. 2018 Jul 10;9(53):30128-30145. doi: 10.18632/oncotarget.25729. eCollection 2018 Jul 10.


Data Integration for Future Medicine (DIFUTURE).

Prasser F, Kohlbacher O, Mansmann U, Bauer B, Kuhn KA.

Methods Inf Med. 2018 Jul;57(S 01):e57-e65. doi: 10.3414/ME17-02-0022. Epub 2018 Jul 17.


Study protocol of the RaPS study: novel risk adapted prevention strategies for people with a family history of colorectal cancer.

Tikk K, Weigl K, Hoffmeister M, Igel S, Schwab M, Hampe J, Klug SJ, Mansmann U, Kolligs F, Brenner H.

BMC Cancer. 2018 Jul 6;18(1):720. doi: 10.1186/s12885-018-4646-5.


Computational modeling of methionine cycle-based metabolism and DNA methylation and the implications for anti-cancer drug response prediction.

Zhang M, Saad C, Le L, Halfter K, Bauer B, Mansmann UR, Li J.

Oncotarget. 2018 Feb 21;9(32):22546-22558. doi: 10.18632/oncotarget.24547. eCollection 2018 Apr 27.


[Risk Prediction Using Routine Data: Development and Validation of Multivariable Models Predicting 30- and 90-day Mortality after Surgical Treatment of Colorectal Cancer].

Crispin A, Strahwald B, Cheney C, Mansmann U.

Gesundheitswesen. 2018 Nov;80(11):963-973. doi: 10.1055/a-0592-6826. Epub 2018 Jun 4. German.


[Biomarkers and imaging for diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the BMBF consortium ArthroMark].

Häupl T, Skapenko A, Hoppe B, Skriner K, Burkhardt H, Poddubnyy D, Ohrndorf S, Sewerin P, Mansmann U, Stuhlmüller B, Schulze-Koops H, Burmester GR.

Z Rheumatol. 2018 May;77(Suppl 1):16-23. doi: 10.1007/s00393-018-0458-x. Review. German.


Patient trajectories and their impact on mobility, social participation and quality of life in patients with vertigo/dizziness/balance disorders and osteoarthritis (MobilE-TRA): study protocol of an observational, practice-based cohort study.

Kisch R, Bergmann A, Koller D, Leidl R, Mansmann U, Mueller M, Sanftenberg L, Schelling J, Sundmacher L, Voigt K, Grill E.

BMJ Open. 2018 Apr 21;8(4):e022970. doi: 10.1136/bmjopen-2018-022970.


Rheumatoid Arthritis Magnetic Resonance Imaging Score Predicts Therapy Response: Results of the German ArthroMark Cohort.

Sewerin P, Le L, Vordenbäumen S, Schleich C, Sengewein R, Brinks R, Pongratz G, Bleck E, Lesch J, Mansmann U, Schneider M, Ostendorf B.

J Rheumatol. 2018 Jun;45(6):753-759. doi: 10.3899/jrheum.170797. Epub 2018 Apr 1.


[Big data from clinical routine].

Mansmann U.

Z Rheumatol. 2018 Apr;77(3):209-218. doi: 10.1007/s00393-018-0424-7. Review. German.


Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients With Localized High-Risk Soft Tissue Sarcoma: The EORTC 62961-ESHO 95 Randomized Clinical Trial.

Issels RD, Lindner LH, Verweij J, Wessalowski R, Reichardt P, Wust P, Ghadjar P, Hohenberger P, Angele M, Salat C, Vujaskovic Z, Daugaard S, Mella O, Mansmann U, Dürr HR, Knösel T, Abdel-Rahman S, Schmidt M, Hiddemann W, Jauch KW, Belka C, Gronchi A; European Organization for the Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group and the European Society for Hyperthermic Oncology.

JAMA Oncol. 2018 Apr 1;4(4):483-492. doi: 10.1001/jamaoncol.2017.4996. Erratum in: JAMA Oncol. 2018 Apr 1;4(4):590.


Versorgungsforschung – Gegenstand einer neuen Wissenschaft oder transdisziplinäre Aktivität?

Mansmann U.

Gesundheitswesen. 2017 Dec;79(12):1093-1094. doi: 10.1055/s-0043-123502. Epub 2017 Dec 29. German. No abstract available.


A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia.

Herold T, Jurinovic V, Batcha AMN, Bamopoulos SA, Rothenberg-Thurley M, Ksienzyk B, Hartmann L, Greif PA, Phillippou-Massier J, Krebs S, Blum H, Amler S, Schneider S, Konstandin N, Sauerland MC, Görlich D, Berdel WE, Wörmann BJ, Tischer J, Subklewe M, Bohlander SK, Braess J, Hiddemann W, Metzeler KH, Mansmann U, Spiekermann K.

Haematologica. 2018 Mar;103(3):456-465. doi: 10.3324/haematol.2017.178442. Epub 2017 Dec 14.


Neo-adjuvant chemotherapy alone or with regional hyperthermia for soft-tissue sarcoma - Authors' reply.

Issels RD, Lindner LH, Wessalowski R, Mansmann U.

Lancet Oncol. 2017 Nov;18(11):e630. doi: 10.1016/S1470-2045(17)30809-4. Epub 2017 Oct 31. No abstract available.


A Bayesian scoring rule on clustered event data for familial risk assessment - An example from colorectal cancer screening.

Rieger AK, Mansmann UR.

Biom J. 2018 Jan;60(1):115-127. doi: 10.1002/bimj.201600264. Epub 2017 Nov 8.


Evaluation of the IT Infrastructure of the RESIST Study with the Evidence-Based CIPROS Checklist.

Lindoerfer D, Mansmann U.

Stud Health Technol Inform. 2017;243:47-51.


Data for the elaboration of the CIPROS checklist with items for a patient registry software system: Examples and explanations.

Lindoerfer D, Mansmann U.

Data Brief. 2017 Aug 3;14:494-497. doi: 10.1016/j.dib.2017.07.075. eCollection 2017 Oct.


The DGAV risk calculator: development and validation of statistical models for a web-based instrument predicting complications of colorectal cancer surgery.

Crispin A, Klinger C, Rieger A, Strahwald B, Lehmann K, Buhr HJ, Mansmann U.

Int J Colorectal Dis. 2017 Oct;32(10):1385-1397. doi: 10.1007/s00384-017-2869-6. Epub 2017 Aug 10.


Efficient Maximum Likelihood Estimation for Pedigree Data with the Sum-Product Algorithm.

Engelhardt A, Rieger A, Tresch A, Mansmann U.

Hum Hered. 2016;82(1-2):1-15. doi: 10.1159/000475465. Epub 2017 Jul 21.


Enhancing requirements engineering for patient registry software systems with evidence-based components.

Lindoerfer D, Mansmann U.

J Biomed Inform. 2017 Jul;71:147-153. doi: 10.1016/j.jbi.2017.05.013. Epub 2017 May 20.


IT Infrastructure of an Oncological Trial Where Xenografts Inform Individual Second Line Treatment Decision.

Lindoerfer D, Mansmann U.

Stud Health Technol Inform. 2017;235:226-230.


Statistical analysis plan for the WOMAN-ETAPlaT study: Effect of tranexamic acid on platelet function and thrombin generation.

Dallaku K, Shakur H, Edwards P, Beaumont D, Roberts I, Huque S, Delius M, Mansmann U.

Wellcome Open Res. 2016 Dec 15;1:30. doi: 10.12688/wellcomeopenres.10105.2.


Extracorporeal Circulation During Lung Transplantation Procedures: A Meta-Analysis.

Hoechter DJ, Shen YM, Kammerer T, Günther S, Weig T, Schramm R, Hagl C, Born F, Meiser B, Preissler G, Winter H, Czerner S, Zwissler B, Mansmann UU, von Dossow V.

ASAIO J. 2017 Sep/Oct;63(5):551-561. doi: 10.1097/MAT.0000000000000549.


Prefrontal transcranial direct current stimulation (tDCS) as treatment for major depression: study design and methodology of a multicenter triple blind randomized placebo controlled trial (DepressionDC).

Padberg F, Kumpf U, Mansmann U, Palm U, Plewnia C, Langguth B, Zwanzger P, Fallgatter A, Nolden J, Burger M, Keeser D, Rupprecht R, Falkai P, Hasan A, Egert S, Bajbouj M.

Eur Arch Psychiatry Clin Neurosci. 2017 Dec;267(8):751-766. doi: 10.1007/s00406-017-0769-y. Epub 2017 Feb 28.


Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer.

Herbst A, Vdovin N, Gacesa S, Ofner A, Philipp A, Nagel D, Holdt LM, Op den Winkel M, Heinemann V, Stieber P, Graeven U, Reinacher-Schick A, Arnold D, Ricard I, Mansmann U, Hegewisch-Becker S, Kolligs FT.

Int J Cancer. 2017 May 1;140(9):2134-2144. doi: 10.1002/ijc.30625. Epub 2017 Feb 22. Erratum in: Int J Cancer. 2018 Feb 1;142(3):E1.


Effects of tranexamic acid on platelet function and thrombin generation (ETAPlaT): WOMAN trial sub-study.

Dallaku K, Shakur H, Roberts I, Edwards P, Beaumont D, Delius M, Siegmund B, Gliozheni O, Tasha I, Cenameri S, Mansmann U.

Wellcome Open Res. 2016 Dec 15;1:29. doi: 10.12688/wellcomeopenres.9964.1.


Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial.

Feil K, Adrion C, Teufel J, Bösch S, Claassen J, Giordano I, Hengel H, Jacobi H, Klockgether T, Klopstock T, Nachbauer W, Schöls L, Stendel C, Uslar E, van de Warrenburg B, Berger I, Naumann I, Bayer O, Müller HH, Mansmann U, Strupp M.

BMC Neurol. 2017 Jan 10;17(1):7. doi: 10.1186/s12883-016-0786-x.


Erratum to: Health-exploring complexity: an interdisciplinary systems approach HEC2016 : 28 August-2 September 2016, Munich, Germany.

Grill E, Müller M, Mansmann U.

Eur J Epidemiol. 2017 Feb;32(2):167. doi: 10.1007/s10654-016-0208-9. No abstract available.


Laparoscopic versus open distal pancreatectomy-a propensity score-matched analysis from the German StuDoQ|Pancreas registry.

Wellner UF, Lapshyn H, Bartsch DK, Mintziras I, Hopt UT, Wittel U, Krämling HJ, Preissinger-Heinzel H, Anthuber M, Geissler B, Köninger J, Feilhauer K, Hommann M, Peter L, Nüssler NC, Klier T, Mansmann U, Keck T; StuDoQ Pancreas study group and members of StuDoQ|Pancreas registry of the German Society for General and Visceral Surgery (DGAV).

Int J Colorectal Dis. 2017 Feb;32(2):273-280. doi: 10.1007/s00384-016-2693-4. Epub 2016 Nov 4.


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