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Items: 1 to 50 of 111

1.

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.

Acosta MI, Urbach S, Doye A, Ng YW, Boudeau J, Mettouchi A, Debant A, Manser E, Visvikis O, Lemichez E.

Sci Rep. 2018 Jan 23;8(1):1410. doi: 10.1038/s41598-018-19471-2.

2.

Formin DAAM1 Organizes Actin Filaments in the Cytoplasmic Nodal Actin Network.

Luo W, Lieu ZZ, Manser E, Bershadsky AD, Sheetz MP.

PLoS One. 2016 Oct 19;11(10):e0163915. doi: 10.1371/journal.pone.0163915. eCollection 2016.

3.

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale.

Dong JM, Tay FP, Swa HL, Gunaratne J, Leung T, Burke B, Manser E.

Sci Signal. 2016 Jun 14;9(432):rs4. doi: 10.1126/scisignal.aaf3572.

PMID:
27303058
4.

PAK5 is auto-activated by a central domain that promotes kinase oligomerization.

Tabanifar B, Zhao Z, Manser E.

Biochem J. 2016 Jun 15;473(12):1777-89. doi: 10.1042/BCJ20160132. Epub 2016 Apr 19.

PMID:
27095851
5.

An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1.

Baskaran Y, Ang KC, Anekal PV, Chan WL, Grimes JM, Manser E, Robinson RC.

Nat Commun. 2015 Nov 26;6:8681. doi: 10.1038/ncomms9681.

6.

Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1.

Zhao Z, Manser E.

Small GTPases. 2015;6(2):81-8. doi: 10.1080/21541248.2014.1000699. Epub 2015 Jun 19. Review.

7.

The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.

Selamat W, Tay PL, Baskaran Y, Manser E.

PLoS One. 2015 Jun 11;10(6):e0129634. doi: 10.1371/journal.pone.0129634. eCollection 2015.

8.

Arg kinase-binding protein 2 (ArgBP2) interaction with α-actinin and actin stress fibers inhibits cell migration.

Anekal PV, Yong J, Manser E.

J Biol Chem. 2015 Jan 23;290(4):2112-25. doi: 10.1074/jbc.M114.610725. Epub 2014 Nov 26.

9.

Rho GTPases and regulation of cell migration and polarization in human corneal epithelial cells.

Hou A, Toh LX, Gan KH, Lee KJ, Manser E, Tong L.

PLoS One. 2013 Oct 10;8(10):e77107. doi: 10.1371/journal.pone.0077107. eCollection 2013.

10.

NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1.

Wang W, Lim L, Baskaran Y, Manser E, Song J.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):169-74. doi: 10.1016/j.bbrc.2013.07.047. Epub 2013 Jul 20.

PMID:
23876315
11.

The PAK system links Rho GTPase signaling to thrombin-mediated platelet activation.

Aslan JE, Baker SM, Loren CP, Haley KM, Itakura A, Pang J, Greenberg DL, David LL, Manser E, Chernoff J, McCarty OJ.

Am J Physiol Cell Physiol. 2013 Sep;305(5):C519-28. doi: 10.1152/ajpcell.00418.2012. Epub 2013 Jun 19.

12.

PAK family kinases: Physiological roles and regulation.

Zhao ZS, Manser E.

Cell Logist. 2012 Apr 1;2(2):59-68.

13.

The PAKs come of age: Celebrating 18 years of discovery.

Field J, Manser E.

Cell Logist. 2012 Apr 1;2(2):54-58.

14.

The GTPase-deficient Rnd proteins are stabilized by their effectors.

Goh LL, Manser E.

J Biol Chem. 2012 Sep 7;287(37):31311-20. doi: 10.1074/jbc.M111.327056. Epub 2012 Jul 17.

15.

Group I and II mammalian PAKs have different modes of activation by Cdc42.

Baskaran Y, Ng YW, Selamat W, Ling FT, Manser E.

EMBO Rep. 2012 Jun 29;13(7):653-9. doi: 10.1038/embor.2012.75.

16.

PAKs in human disease.

Chan PM, Manser E.

Prog Mol Biol Transl Sci. 2012;106:171-87. doi: 10.1016/B978-0-12-396456-4.00011-0. Review.

PMID:
22340718
17.
18.

PTB domain-directed substrate targeting in a tyrosine kinase from the unicellular choanoflagellate Monosiga brevicollis.

Prieto-Echagüe V, Chan PM, Craddock BP, Manser E, Miller WT.

PLoS One. 2011 Apr 26;6(4):e19296. doi: 10.1371/journal.pone.0019296.

19.

Rho GTPases and their role in organizing the actin cytoskeleton.

Sit ST, Manser E.

J Cell Sci. 2011 Mar 1;124(Pt 5):679-83. doi: 10.1242/jcs.064964. No abstract available.

20.

The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.

Chan W, Sit ST, Manser E.

Biochem J. 2011 Apr 15;435(2):355-64. doi: 10.1042/BJ20102156.

PMID:
21309750
21.

A robust protocol to map binding sites of the 14-3-3 interactome: Cdc25C requires phosphorylation of both S216 and S263 to bind 14-3-3.

Chan PM, Ng YW, Manser E.

Mol Cell Proteomics. 2011 Mar;10(3):M110.005157. doi: 10.1074/mcp.M110.005157. Epub 2010 Dec 28.

22.

Do PAKs make good drug targets?

Zhao ZS, Manser E.

F1000 Biol Rep. 2010 Sep 23;2:70. doi: 10.3410/B2-70.

23.

DAAM1 is a formin required for centrosome re-orientation during cell migration.

Ang SF, Zhao ZS, Lim L, Manser E.

PLoS One. 2010 Sep 29;5(9). pii: e13064. doi: 10.1371/journal.pone.0013064.

24.

The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.

Goh LL, Manser E.

PLoS One. 2010 Aug 25;5(8):e12409. doi: 10.1371/journal.pone.0012409.

25.

Why an A-loop phospho-mimetic fails to activate PAK1: understanding an inaccessible kinase state by molecular dynamics simulations.

Ng YW, Raghunathan D, Chan PM, Baskaran Y, Smith DJ, Lee CH, Verma C, Manser E.

Structure. 2010 Jul 14;18(7):879-90. doi: 10.1016/j.str.2010.04.011.

26.

The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation.

Bahri S, Wang S, Conder R, Choy J, Vlachos S, Dong K, Merino C, Sigrist S, Molnar C, Yang X, Manser E, Harden N.

Development. 2010 Jun;137(12):2023-32. doi: 10.1242/dev.045088.

27.

A functional requirement for PAK1 binding to the KH(2) domain of the fragile X protein-related FXR1.

Say E, Tay HG, Zhao ZS, Baskaran Y, Li R, Lim L, Manser E.

Mol Cell. 2010 Apr 23;38(2):236-49. doi: 10.1016/j.molcel.2010.04.004.

28.

A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly.

Tay HG, Ng YW, Manser E.

PLoS One. 2010 Apr 12;5(4):e10125. doi: 10.1371/journal.pone.0010125.

29.

SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery.

Seet LF, Su R, Barathi VA, Lee WS, Poh R, Heng YM, Manser E, Vithana EN, Aung T, Weaver M, Sage EH, Wong TT.

PLoS One. 2010 Feb 25;5(2):e9415. doi: 10.1371/journal.pone.0009415.

30.

Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.

Robens JM, Yeow-Fong L, Ng E, Hall C, Manser E.

Mol Cell Biol. 2010 Feb;30(3):829-44. doi: 10.1128/MCB.01574-08. Epub 2009 Nov 23.

31.

Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX.

Teng TS, Lin B, Manser E, Ng DC, Cao X.

J Cell Sci. 2009 Nov 15;122(Pt 22):4150-9. doi: 10.1242/jcs.057109. Epub 2009 Oct 27.

32.

Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.

Pao-Chun L, Chan PM, Chan W, Manser E.

J Biol Chem. 2009 Dec 11;284(50):34954-63. doi: 10.1074/jbc.M109.072660. Epub 2009 Oct 8.

33.

Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.

Chan W, Tian R, Lee YF, Sit ST, Lim L, Manser E.

J Biol Chem. 2009 Mar 20;284(12):8185-94. doi: 10.1074/jbc.M806877200. Epub 2009 Jan 14.

34.

The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis.

Bahri SM, Choy JM, Manser E, Lim L, Yang X.

Dev Biol. 2009 Jan 1;325(1):15-23. doi: 10.1016/j.ydbio.2008.09.001. Epub 2008 Sep 13.

35.

Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4 motif: evidence that nuclear paxillin promotes cell proliferation.

Dong JM, Lau LS, Ng YW, Lim L, Manser E.

Biochem J. 2009 Feb 15;418(1):173-84. doi: 10.1042/BJ20080170. Erratum in: Biochem J. 2009 Mar 15;418(3):717.

PMID:
18986306
36.

Bcl-xL and UVRAG cause a monomer-dimer switch in Beclin1.

Noble CG, Dong JM, Manser E, Song H.

J Biol Chem. 2008 Sep 19;283(38):26274-82. doi: 10.1074/jbc.M804723200. Epub 2008 Jul 18.

37.

PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.

Chan PM, Lim L, Manser E.

J Biol Chem. 2008 Sep 5;283(36):24949-61. doi: 10.1074/jbc.M801728200. Epub 2008 Jun 27.

38.

Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways.

Xie Y, Tan EJ, Wee S, Manser E, Lim L, Koh CG.

J Cell Sci. 2008 Feb 15;121(Pt 4):514-21. doi: 10.1242/jcs.013557. Epub 2008 Jan 29.

39.

PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition.

Wang H, Quah SY, Dong JM, Manser E, Tang JP, Zeng Q.

Cancer Res. 2007 Apr 1;67(7):2922-6.

40.

Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.

Weisz Hubsman M, Volinsky N, Manser E, Yablonski D, Aronheim A.

Biochem J. 2007 Jun 15;404(3):487-97.

41.

betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth.

Shin EY, Lee CS, Cho TG, Kim YG, Song S, Juhnn YS, Park SC, Manser E, Kim EG.

J Biol Chem. 2006 Nov 24;281(47):35954-64. Epub 2006 Sep 5.

42.

The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

Zhao ZS, Lim JP, Ng YW, Lim L, Manser E.

Mol Cell. 2005 Oct 28;20(2):237-49.

43.

SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.

Yeow-Fong L, Lim L, Manser E.

FEBS Lett. 2005 Sep 12;579(22):5040-8.

44.
45.

Signaling via a novel integral plasma membrane pool of a serine/threonine protein kinase PRK1 in mammalian cells.

Zhu Y, Stolz DB, Guo F, Ross MA, Watkins SC, Tan BJ, Qi RZ, Manser E, Li QT, Bay BH, Teo TS, Duan W.

FASEB J. 2004 Nov;18(14):1722-4. Epub 2004 Sep 16.

PMID:
15375078
46.

Regulation of smooth muscle contraction by calcium, monomeric GTPases of the Rho subfamily and their effector kinases.

Pfitzer G, Wirth A, Lucius C, Brkic-Koric D, Manser E, de Lanerolle P, Arner A.

Adv Exp Med Biol. 2003;538:89-99; discussion 99. No abstract available.

PMID:
15098657
47.

GIT1 activates p21-activated kinase through a mechanism independent of p21 binding.

Loo TH, Ng YW, Lim L, Manser E.

Mol Cell Biol. 2004 May;24(9):3849-59.

48.

Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase, ACK.

Ahmed I, Calle Y, Sayed MA, Kamal JM, Rengaswamy P, Manser E, Meiners S, Nur-E-Kamal A.

Biochem Biophys Res Commun. 2004 Feb 6;314(2):571-9.

PMID:
14733946
49.

PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.

Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H.

Kidney Int. 2003 Nov;64(5):1733-45.

50.

PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.

Zeng Q, Dong JM, Guo K, Li J, Tan HX, Koh V, Pallen CJ, Manser E, Hong W.

Cancer Res. 2003 Jun 1;63(11):2716-22.

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