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Items: 1 to 50 of 80

1.

A secondary mutation in BRAF confers resistance to RAF inhibition in a BRAF V600E-mutant brain tumor.

Wang J, Yao Z, Jonsson P, Allen AN, Qin ACR, Uddin S, Dunkel IJ, Petriccione M, Manova K, Haque S, Rosenblum MK, Pisapia DJ, Rosen N, Taylor BS, Pratilas CA.

Cancer Discov. 2018 Jun 7. pii: CD-17-1263. doi: 10.1158/2159-8290.CD-17-1263. [Epub ahead of print]

PMID:
29880583
2.

PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence.

Klein ME, Dickson MA, Antonescu C, Qin LX, Dooley SJ, Barlas A, Manova K, Schwartz GK, Crago AM, Singer S, Koff A, Tap WD.

Oncogene. 2018 May 23. doi: 10.1038/s41388-018-0332-y. [Epub ahead of print]

PMID:
29789718
3.

Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.

Bosbach B, Rossi F, Yozgat Y, Loo J, Zhang JQ, Berrozpe G, Warpinski K, Ehlers I, Veach D, Kwok A, Manova K, Antonescu CR, DeMatteo RP, Besmer P.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8448-E8457. doi: 10.1073/pnas.1711449114. Epub 2017 Sep 18.

4.

Iron deposition is associated with differential macrophage infiltration and therapeutic response to iron chelation in prostate cancer.

Leftin A, Zhao H, Turkekul M, de Stanchina E, Manova K, Koutcher JA.

Sci Rep. 2017 Sep 14;7(1):11632. doi: 10.1038/s41598-017-11899-2.

5.

Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission.

Huang G, Kaufman AJ, Xu K, Manova K, Singh B.

J Biol Chem. 2017 Sep 15;292(37):15254-15265. doi: 10.1074/jbc.M117.778530. Epub 2017 Jun 15.

PMID:
28620047
6.

Targeting acid sphingomyelinase with anti-angiogenic chemotherapy.

Jacobi J, García-Barros M, Rao S, Rotolo JA, Thompson C, Mizrachi A, Feldman R, Manova K, Bielawska A, Bielawska J, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

Cell Signal. 2017 Jan;29:52-61. doi: 10.1016/j.cellsig.2016.09.010. Epub 2016 Oct 1.

7.

VEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors.

Röhrig F, Vorlová S, Hoffmann H, Wartenberg M, Escorcia FE, Keller S, Tenspolde M, Weigand I, Gätzner S, Manova K, Penack O, Scheinberg DA, Rosenwald A, Ergün S, Granot Z, Henke E.

Oncogene. 2017 Jan 5;36(1):1-12. doi: 10.1038/onc.2016.182. Epub 2016 Jun 6.

8.

A novel cell-stiffness-fingerprinting analysis by scanning atomic force microscopy: comparison of fibroblasts and diverse cancer cell lines.

Zoellner H, Paknejad N, Manova K, Moore MA.

Histochem Cell Biol. 2015 Dec;144(6):533-42. doi: 10.1007/s00418-015-1363-x. Epub 2015 Sep 10.

9.

Distinct but Spatially Overlapping Intestinal Niches for Vancomycin-Resistant Enterococcus faecium and Carbapenem-Resistant Klebsiella pneumoniae.

Caballero S, Carter R, Ke X, Sušac B, Leiner IM, Kim GJ, Miller L, Ling L, Manova K, Pamer EG.

PLoS Pathog. 2015 Sep 3;11(9):e1005132. doi: 10.1371/journal.ppat.1005132. eCollection 2015 Sep.

10.

CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms.

Meyer SC, Keller MD, Chiu S, Koppikar P, Guryanova OA, Rapaport F, Xu K, Manova K, Pankov D, O'Reilly RJ, Kleppe M, McKenney AS, Shih AH, Shank K, Ahn J, Papalexi E, Spitzer B, Socci N, Viale A, Mandon E, Ebel N, Andraos R, Rubert J, Dammassa E, Romanet V, Dölemeyer A, Zender M, Heinlein M, Rampal R, Weinberg RS, Hoffman R, Sellers WR, Hofmann F, Murakami M, Baffert F, Gaul C, Radimerski T, Levine RL.

Cancer Cell. 2015 Jul 13;28(1):15-28. doi: 10.1016/j.ccell.2015.06.006.

11.

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis.

Chang Q, Bournazou E, Sansone P, Berishaj M, Gao SP, Daly L, Wels J, Theilen T, Granitto S, Zhang X, Cotari J, Alpaugh ML, de Stanchina E, Manova K, Li M, Bonafe M, Ceccarelli C, Taffurelli M, Santini D, Altan-Bonnet G, Kaplan R, Norton L, Nishimoto N, Huszar D, Lyden D, Bromberg J.

Neoplasia. 2013 Jul;15(7):848-62.

12.

GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation.

Madsen LW, Knauf JA, Gotfredsen C, Pilling A, Sjögren I, Andersen S, Andersen L, de Boer AS, Manova K, Barlas A, Vundavalli S, Nyborg NC, Knudsen LB, Moelck AM, Fagin JA.

Endocrinology. 2012 Mar;153(3):1538-47. doi: 10.1210/en.2011-1864. Epub 2012 Jan 10.

13.

Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures.

Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP.

Blood. 2011 Jul 28;118(4):1163-74. doi: 10.1182/blood-2011-04-348557. Epub 2011 Jun 7.

14.

Double in situ detection of sonic hedgehog mRNA and pMAPK protein in examining the cell proliferation signaling pathway in mouse embryo.

Fujisawa S, Turkekul M, Barlas A, Fan N, Manova K.

Methods Mol Biol. 2011;717:257-76. doi: 10.1007/978-1-61779-024-9_15.

PMID:
21370036
15.

Immunohistochemical assessment of signal transduction and cell-cycle networks in neural tumors.

Ciznadija D, Barlas A, Manova K.

Methods Mol Biol. 2011;717:221-31. doi: 10.1007/978-1-61779-024-9_12.

PMID:
21370033
16.

Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib.

Rossi F, Yozgat Y, de Stanchina E, Veach D, Clarkson B, Manova K, Giancotti FG, Antonescu CR, Besmer P.

Mol Cancer Res. 2010 Sep;8(9):1271-83. doi: 10.1158/1541-7786.MCR-10-0065. Epub 2010 Aug 24.

17.

Kit ligand cytoplasmic domain is essential for basolateral sorting in vivo and has roles in spermatogenesis and hematopoiesis.

Deshpande S, Agosti V, Manova K, Moore MA, Hardy MP, Besmer P.

Dev Biol. 2010 Jan 15;337(2):199-210. doi: 10.1016/j.ydbio.2009.10.022. Epub 2009 Oct 27.

18.

Expression of Dazl and Vasa in turtle embryos and ovaries: evidence for inductive specification of germ cells.

Bachvarova RF, Crother BI, Manova K, Chatfield J, Shoemaker CM, Crews DP, Johnson AD.

Evol Dev. 2009 Sep-Oct;11(5):525-34. doi: 10.1111/j.1525-142X.2009.00360.x.

PMID:
19754709
19.

The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies.

Paoluzzi L, Gonen M, Bhagat G, Furman RR, Gardner JR, Scotto L, Gueorguiev VD, Heaney ML, Manova K, O'Connor OA.

Blood. 2008 Oct 1;112(7):2906-16. doi: 10.1182/blood-2007-12-130781. Epub 2008 Jun 30.

20.

Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma.

Paoluzzi L, Gonen M, Gardner JR, Mastrella J, Yang D, Holmlund J, Sorensen M, Leopold L, Manova K, Marcucci G, Heaney ML, O'Connor OA.

Blood. 2008 Jun 1;111(11):5350-8. doi: 10.1182/blood-2007-12-129833. Epub 2008 Feb 21.

21.

Tumor endothelial marker 8 enhances tumor immunity in conjunction with immunization against differentiation Ag.

Felicetti P, Mennecozzi M, Barucca A, Montgomery S, Orlandi F, Manova K, Houghton AN, Gregor PD, Concetti A, Venanzi FM.

Cytotherapy. 2007;9(1):23-34. doi: 10.1080/14653240601048369.

PMID:
18236207
22.

Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo.

Henke E, Perk J, Vider J, de Candia P, Chin Y, Solit DB, Ponomarev V, Cartegni L, Manova K, Rosen N, Benezra R.

Nat Biotechnol. 2008 Jan;26(1):91-100. doi: 10.1038/nbt1366. Epub 2008 Jan 6.

PMID:
18176556
23.

Tumor endothelial marker 8 enhances tumor immunity in conjunction with immnization against differentiation Ag.

Felicetti P, Mennecozzi M, Barucca A, Montgomery S, Orlandi F, Manova K, Houghton AN, Gregor PD, Concetti A, Venanzi FM.

Cytotherapy. 2007;9(1):23-34. Erratum in: Cytotherapy. 2007;9(2):205.

PMID:
17361485
24.

Misexpression of cyclin B3 leads to aberrant spermatogenesis.

Refik-Rogers J, Manova K, Koff A.

Cell Cycle. 2006 Sep;5(17):1966-73. Epub 2006 Sep 1.

PMID:
16929180
25.

Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor.

Rossi F, Ehlers I, Agosti V, Socci ND, Viale A, Sommer G, Yozgat Y, Manova K, Antonescu CR, Besmer P.

Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12843-8. Epub 2006 Aug 14.

26.

A distant upstream locus control region is critical for expression of the Kit receptor gene in mast cells.

Berrozpe G, Agosti V, Tucker C, Blanpain C, Manova K, Besmer P.

Mol Cell Biol. 2006 Aug;26(15):5850-60.

27.

Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene.

Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11746-50. Epub 2005 Aug 8.

28.

Role of nucleophosmin in embryonic development and tumorigenesis.

Grisendi S, Bernardi R, Rossi M, Cheng K, Khandker L, Manova K, Pandolfi PP.

Nature. 2005 Sep 1;437(7055):147-53. Epub 2005 Jul 6.

29.

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A.

Nat Cell Biol. 2005 Jul;7(7):675-85. Epub 2005 Jun 19.

PMID:
15965469
30.

Molecular signaling in intervertebral disk development.

DiPaola CP, Farmer JC, Manova K, Niswander LA.

J Orthop Res. 2005 Sep;23(5):1112-9.

31.
32.

The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development.

Gotoh N, Manova K, Tanaka S, Murohashi M, Hadari Y, Lee A, Hamada Y, Hiroe T, Ito M, Kurihara T, Nakazato H, Shibuya M, Lax I, Lacy E, Schlessinger J.

Mol Cell Biol. 2005 May;25(10):4105-16.

33.

Measurement of apoptosis of intact human islets by confocal optical sectioning and stereologic analysis of YO-PRO-1-stained islets.

Boffa DJ, Waka J, Thomas D, Suh S, Curran K, Sharma VK, Besada M, Muthukumar T, Yang H, Suthanthiran M, Manova K.

Transplantation. 2005 Apr 15;79(7):842-5.

PMID:
15818328
34.

The Sept4 septin locus is required for sperm terminal differentiation in mice.

Kissel H, Georgescu MM, Larisch S, Manova K, Hunnicutt GR, Steller H.

Dev Cell. 2005 Mar;8(3):353-64.

35.

Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.

Shaffer DR, Viale A, Ishiwata R, Leversha M, Olgac S, Manova K, Satagopan J, Scher H, Koff A.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):210-5. Epub 2004 Dec 22.

36.

Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice.

Kelly K, Hutchinson G, Nebenius-Oosthuizen D, Smith AJ, Bartsch JW, Horiuchi K, Rittger A, Manova K, Docherty AJ, Blobel CP.

Dev Dyn. 2005 Jan;232(1):221-31.

37.

Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells.

Fraidenraich D, Stillwell E, Romero E, Wilkes D, Manova K, Basson CT, Benezra R.

Science. 2004 Oct 8;306(5694):247-52.

38.

Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules.

Strope S, Rivi R, Metzger T, Manova K, Lacy E.

Development. 2004 Oct;131(19):4787-95. Epub 2004 Sep 1. Erratum in: Development. 2004 Oct;131(4):5211.

39.

Essential role of Plzf in maintenance of spermatogonial stem cells.

Costoya JA, Hobbs RM, Barna M, Cattoretti G, Manova K, Sukhwani M, Orwig KE, Wolgemuth DJ, Pandolfi PP.

Nat Genet. 2004 Jun;36(6):653-9. Epub 2004 May 23.

40.

Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development.

Agosti V, Corbacioglu S, Ehlers I, Waskow C, Sommer G, Berrozpe G, Kissel H, Tucker CM, Manova K, Moore MA, Rodewald HR, Besmer P.

J Exp Med. 2004 Mar 15;199(6):867-78.

41.

Essential role for ADAM19 in cardiovascular morphogenesis.

Zhou HM, Weskamp G, Chesneau V, Sahin U, Vortkamp A, Horiuchi K, Chiusaroli R, Hahn R, Wilkes D, Fisher P, Baron R, Manova K, Basson CT, Hempstead B, Blobel CP.

Mol Cell Biol. 2004 Jan;24(1):96-104.

42.

Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors.

Ruzinova MB, Schoer RA, Gerald W, Egan JE, Pandolfi PP, Rafii S, Manova K, Mittal V, Benezra R.

Cancer Cell. 2003 Oct;4(4):277-89.

43.

Potential role for ADAM15 in pathological neovascularization in mice.

Horiuchi K, Weskamp G, Lum L, Hammes HP, Cai H, Brodie TA, Ludwig T, Chiusaroli R, Baron R, Preissner KT, Manova K, Blobel CP.

Mol Cell Biol. 2003 Aug;23(16):5614-24.

44.

A role for kit receptor signaling in Leydig cell steroidogenesis.

Rothschild G, Sottas CM, Kissel H, Agosti V, Manova K, Hardy MP, Besmer P.

Biol Reprod. 2003 Sep;69(3):925-32. Epub 2003 May 28.

PMID:
12773427
45.

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase.

Sommer G, Agosti V, Ehlers I, Rossi F, Corbacioglu S, Farkas J, Moore M, Manova K, Antonescu CR, Besmer P.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6706-11. Epub 2003 May 16.

46.

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.

Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A.

Dev Cell. 2003 Apr;4(4):497-508.

47.

Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.

Nguyen TB, Manova K, Capodieci P, Lindon C, Bottega S, Wang XY, Refik-Rogers J, Pines J, Wolgemuth DJ, Koff A.

J Biol Chem. 2002 Nov 1;277(44):41960-9. Epub 2002 Aug 15.

48.

Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal.

Longo L, Vanegas OC, Patel M, Rosti V, Li H, Waka J, Merghoub T, Pandolfi PP, Notaro R, Manova K, Luzzatto L.

EMBO J. 2002 Aug 15;21(16):4229-39.

49.

Genomic instability in mice lacking histone H2AX.

Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A.

Science. 2002 May 3;296(5569):922-7. Epub 2002 Apr 4.

50.

Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.

Weskamp G, Cai H, Brodie TA, Higashyama S, Manova K, Ludwig T, Blobel CP.

Mol Cell Biol. 2002 Mar;22(5):1537-44.

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