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High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors.

Manoharan GB, Kopra K, Eskonen V, Härmä H, Abankwa D.

Anal Biochem. 2019 May 1;572:25-32. doi: 10.1016/j.ab.2019.02.015. Epub 2019 Feb 27.


The role of surgical transcatheter valve implantation for the treatment of severe mitral annular calcification.

Jeganathan R, Imran Hamid U, Johnston N, Owens C, Spence M, Manoharan G, Nzewi O.

J Card Surg. 2019 Apr;34(4):161-166. doi: 10.1111/jocs.14004. Epub 2019 Feb 25.


Myositis Ossificans of the Masseter Muscle.

Kayal L, Manoharan GVMG, Joshi B.

Saudi J Med Med Sci. 2018 May-Aug;6(2):119-120. doi: 10.4103/sjmms.sjmms_100_17. Epub 2018 Apr 16. No abstract available.


Long-Term Durability of Transcatheter Aortic Valve Prostheses.

Blackman DJ, Saraf S, MacCarthy PA, Myat A, Anderson SG, Malkin CJ, Cunnington MS, Somers K, Brennan P, Manoharan G, Parker J, Aldalati O, Brecker SJ, Dowling C, Hoole SP, Dorman S, Mullen M, Kennon S, Jerrum M, Chandrala P, Roberts DH, Tay J, Doshi SN, Ludman PF, Fairbairn TA, Crowe J, Levy RD, Banning AP, Ruparelia N, Spence MS, Hildick-Smith D.

J Am Coll Cardiol. 2019 Feb 12;73(5):537-545. doi: 10.1016/j.jacc.2018.10.078.


1-Year Outcomes With the Evolut R Self-Expanding Transcatheter Aortic Valve: From the International FORWARD Study.

Manoharan G, Van Mieghem NM, Windecker S, Bosmans J, Bleiziffer S, Modine T, Linke A, Scholtz W, Chevalier B, Gooley R, Zeng C, Oh JK, Grube E.

JACC Cardiovasc Interv. 2018 Nov 26;11(22):2326-2334. doi: 10.1016/j.jcin.2018.07.032.


Initial experience of a large, self-expanding, and fully recapturable transcatheter aortic valve: The UK & Ireland Implanters' registry.

Dowling C, Firoozi S, Doyle N, Blackman DJ, Malkin CJ, Cunnington MS, Saraf S, Buch MH, Levy R, Chowdhary S, Spence MS, Manoharan G, Owens CG, Brennan PF, Roberts D, More R, Wiper A, Abdelaziz HK, Mylotte D, Neylon A, Martin N, Mercanti F, Dorman S, Panoulas V, Dalby M, Kashyap MN, Kabir T, Kovac J, Kontoprias K, Malik IS, Ghada MW, Sen S, Ruparelia N, Demir OM, Frame A, Uren NG, Anderson R, Rajathurai T, Tapp L, Deegan L, Grech E, Hall I, Neville M, Rampat R, Hildick-Smith D, Mullen M, Kennon S, Chandrala P, Doshi S, Brecker SJ.

Catheter Cardiovasc Interv. 2019 Mar 1;93(4):751-757. doi: 10.1002/ccd.27934. Epub 2018 Nov 5.


Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2.

Vahter J, Viht K, Uri A, Manoharan GB, Enkvist E.

Bioorg Med Chem. 2018 Oct 1;26(18):5062-5068. doi: 10.1016/j.bmc.2018.09.003. Epub 2018 Sep 5.


Distal fibula oblique fracture fixation using one-third tubular plate with and without lag screw - A biomechanical study of stability.

Manoharan G, Singh R, Kuiper JH, Nokes LDM.

J Orthop. 2018 May 7;15(2):549-552. doi: 10.1016/j.jor.2018.05.011. eCollection 2018 Jun.


Molecular characterization of two alkylresorcylic acid synthases from Sordariomycetes fungi.

Ramakrishnan D, Tiwari MK, Manoharan G, Sairam T, Thangamani R, Lee JK, Marimuthu J.

Enzyme Microb Technol. 2018 Aug;115:16-22. doi: 10.1016/j.enzmictec.2018.04.006. Epub 2018 Apr 14.


Face and Construct Validity of a Novel Virtual Reality-Based Bimanual Laparoscopic Force-Skills Trainer With Haptics Feedback.

Prasad R, Muniyandi M, Manoharan G, Chandramohan SM.

Surg Innov. 2018 Oct;25(5):499-514. doi: 10.1177/1553350618773666. Epub 2018 May 29.


Incidence of new-onset left bundle branch block and predictors of new permanent pacemaker following transcatheter aortic valve replacement with the Portico™ valve.

Walther T, Manoharan G, Linke A, Möllmann H, Holzhey D, Worthley SG, Kim WK, Schäfer U.

Eur J Cardiothorac Surg. 2018 Sep 1;54(3):467-474. doi: 10.1093/ejcts/ezy078.


Treatment of Aortic Stenosis With a Self-Expanding, Resheathable Transcatheter Valve: One-Year Results of the International Multicenter Portico Transcatheter Aortic Valve Implantation System Study.

Linke A, Holzhey D, Möllmann H, Manoharan G, Schäfer U, Frerker C, Worthley SG, van Boven AJ, Redwood S, Kovac J, Butter C, Søndergaard L, Lauten A, Schymik G, Walther T.

Circ Cardiovasc Interv. 2018 Feb;11(2):e005206. doi: 10.1161/CIRCINTERVENTIONS.117.005206.


Uncemented Thompson's hemiarthroplasty: safe, palliative and cost-effective surgery in the infirm patient-a consecutive series of 1445 cases.

Manoharan G, Chatterton BD, Moores TS, Roberts PJ.

Eur J Orthop Surg Traumatol. 2018 Aug;28(6):1103-1109. doi: 10.1007/s00590-018-2144-8. Epub 2018 Feb 8.


Crouzon syndrome - A rare case report.

Kalanjiam V, Manoharan GVMG.

Int J Health Sci (Qassim). 2017 Sep-Oct;11(4):74-75.


10-year results of the Birmingham Hip Resurfacing: a non-designer case series.

Hunter TJA, Moores TS, Morley D, Manoharan G, Collier SG, Shaylor PJ.

Hip Int. 2018 Jan;28(1):50-52. doi: 10.5301/hipint.5000518.


Implantation and 30-Day Follow-Up on All 4 Valve Sizes Within the Portico Transcatheter Aortic Bioprosthetic Family.

Möllmann H, Linke A, Holzhey DM, Walther T, Manoharan G, Schäfer U, Heinz-Kuck K, Van Boven AJ, Redwood SR, Kovac J, Butter C, Søndergaard L, Lauten A, Schymik G, Worthley SG.

JACC Cardiovasc Interv. 2017 Aug 14;10(15):1538-1547. doi: 10.1016/j.jcin.2017.05.021.


Clinical Outcomes With a Repositionable Self-Expanding Transcatheter Aortic Valve Prosthesis: The International FORWARD Study.

Grube E, Van Mieghem NM, Bleiziffer S, Modine T, Bosmans J, Manoharan G, Linke A, Scholtz W, Tchétché D, Finkelstein A, Trillo R, Fiorina C, Walton A, Malkin CJ, Oh JK, Qiao H, Windecker S; FORWARD Study Investigators.

J Am Coll Cardiol. 2017 Aug 15;70(7):845-853. doi: 10.1016/j.jacc.2017.06.045.


An Unusual Radiographic Presentation of Aneurysmal Bone Cyst of the Zygoma: A Rare Case Report.

Manoharan GMG, Khobre P, Balaji J, Singh M.

J Clin Diagn Res. 2017 May;11(5):ZD06-ZD08. doi: 10.7860/JCDR/2017/26457.9869. Epub 2017 May 1.


Conduction Abnormalities and Permanent Pacemaker Implantation After Transcatheter Aortic Valve Replacement Using the Repositionable LOTUS Device: The United Kingdom Experience.

Rampat R, Khawaja MZ, Hilling-Smith R, Byrne J, MacCarthy P, Blackman DJ, Krishnamurthy A, Gunarathne A, Kovac J, Banning A, Kharbanda R, Firoozi S, Brecker S, Redwood S, Bapat V, Mullen M, Aggarwal S, Manoharan G, Spence MS, Khogali S, Dooley M, Cockburn J, de Belder A, Trivedi U, Hildick-Smith D.

JACC Cardiovasc Interv. 2017 Jun 26;10(12):1247-1253. doi: 10.1016/j.jcin.2017.03.044.


Repositionable percutaneous aortic valve implantation with the LOTUS valve: 30-day and 1-year outcomes in 250 high-risk surgical patients.

Meredith IT, Dumonteil N, Blackman DJ, Tchétché D, Walters DL, Hildick-Smith D, Manoharan G, Harnek J, Worthley SG, Rioufol G, Lefèvre T, Modine T, Van Mieghem NM, Feldman T, Allocco DJ, Dawkins KD.

EuroIntervention. 2017 Sep 20;13(7):788-795. doi: 10.4244/EIJ-D-16-01024.


Matched Comparison of Self-Expanding Transcatheter Heart Valves for the Treatment of Failed Aortic Surgical Bioprosthesis: Insights From the Valve-in-Valve International Data Registry (VIVID).

Alnasser S, Cheema AN, Simonato M, Barbanti M, Edwards J, Kornowski R, Horlick E, Wijeysundera HC, Testa L, Bedogni F, Amrane H, Walther T, Pelletier M, Latib A, Laborde JC, Hildick-Smith D, Kim WK, Tchetche D, Agrifoglio M, Sinning JM, van Boven AJ, Kefer J, Frerker C, van Mieghem NM, Linke A, Worthley S, Asgar A, Sgroi C, Aziz M, Danenberg HD, Labinaz M, Manoharan G, Cheung A, Webb JG, Dvir D; Valve-in-Valve International Data Registry Investigators.

Circ Cardiovasc Interv. 2017 Apr;10(4). pii: e004392. doi: 10.1161/CIRCINTERVENTIONS.116.004392.


Impact of Technological Changes on TAVI Outcomes-For Better, for Worse or No Change?

Manoharan G.

Rev Esp Cardiol (Engl Ed). 2017 Sep;70(9):694-695. doi: 10.1016/j.rec.2017.03.003. Epub 2017 Apr 5. English, Spanish. No abstract available.


Florid Osseous Dysplasia-Report of Two Cases and Review of Literature.

Mahalingam G, Manoharan GV.

J Clin Diagn Res. 2017 Jan;11(1):ZD21-ZD24. doi: 10.7860/JCDR/2017/22532.9204. Epub 2017 Jan 1.


Comparison of clinical outcomes after multivessel versus single-vessel stenting with the zotarolimus-eluting stent in the RESOLUTE Global Clinical Trial Program.

Manoharan G, Belardi JA, Du Z, Lee M, Qiao S, Serruys PW, Windecker S, Xu B, Yeung A.

EuroIntervention. 2017 Jan 20;12(13):1605-1613. doi: 10.4244/EIJ-D-16-00079.


TAVI with current CE-marked devices: strategies for optimal sizing and valve delivery.

van Gils L, Tchetche D, Latib A, Sgroi C, Manoharan G, Möllmann H, Van Mieghem NM.

EuroIntervention. 2016 Sep 18;12(Y):Y22-7. doi: 10.4244/EIJV12SYA6. Review.


Multicentre clinical study evaluating a novel resheathable annular functioning self-expanding transcatheter aortic valve system: safety and performance results at 30 days with the Portico system.

Manoharan G, Linke A, Moellmann H, Redwood S, Frerker C, Kovac J, Walther T.

EuroIntervention. 2016 Aug 20;12(6):768-74. doi: 10.4244/EIJV12I6A125.


Transcatheter Aortic Valve Replacement Using the Portico System: 10 Things to Remember.

Tzikas A, Amrane H, Bedogni F, Brambilla N, Kefer J, Manoharan G, Makkar R, Möllman H, Rodés-Cabau J, Schäfer U, Settergren M, Spargias K, van Boven A, Walther T, Worthley SG, Sondergaard L.

J Interv Cardiol. 2016 Oct;29(5):523-529. doi: 10.1111/joic.12322. Epub 2016 Aug 5. Review.


Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.

Ivan T, Enkvist E, Viira B, Manoharan GB, Raidaru G, Pflug A, Alam KA, Zaccolo M, Engh RA, Uri A.

Bioconjug Chem. 2016 Aug 17;27(8):1900-10. doi: 10.1021/acs.bioconjchem.6b00293. Epub 2016 Jul 20.


Intracardiac impedance response during acute AF internal cardioversion using novel rectilinear and capacitor-discharge waveforms.

Rababah AS, Walsh SJ, Manoharan G, Walsh PR, Escalona OJ.

Physiol Meas. 2016 Jul;37(7):1129-45. doi: 10.1088/0967-3334/37/7/1129. Epub 2016 Jun 21.


Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.

Santio NM, Landor SK, Vahtera L, Ylä-Pelto J, Paloniemi E, Imanishi SY, Corthals G, Varjosalo M, Manoharan GB, Uri A, Lendahl U, Sahlgren C, Koskinen PJ.

Oncotarget. 2016 Jul 12;7(28):43220-43238. doi: 10.18632/oncotarget.9215.


Objective Assessment of Laparoscopic Force and Psychomotor Skills in a Novel Virtual Reality-Based Haptic Simulator.

Prasad MS, Manivannan M, Manoharan G, Chandramohan SM.

J Surg Educ. 2016 Sep-Oct;73(5):858-69. doi: 10.1016/j.jsurg.2016.04.009. Epub 2016 Jun 3.


High Risk Aortic Valve Replacement - The Challenges of Multiple Treatment Strategies with an Evolving Technology.

Booth K, Beattie R, McBride M, Manoharan G, Spence M, Jones JM.

Ulster Med J. 2016 Jan;85(1):18-22.


Trends in antibiotic resistance in bacterial keratitis isolates from South India.

Lalitha P, Manoharan G, Karpagam R, Prajna NV, Srinivasan M, Mascarenhas J, Das M, Porco TC, Lietman TM, Cevallos V, Keenan JD.

Br J Ophthalmol. 2017 Feb;101(2):108-113. doi: 10.1136/bjophthalmol-2016-308487. Epub 2016 Apr 29.


1-Year Outcomes With the Fully Repositionable and Retrievable Lotus Transcatheter Aortic Replacement Valve in 120 High-Risk Surgical Patients With Severe Aortic Stenosis: Results of the REPRISE II Study.

Meredith IT, Walters DL, Dumonteil N, Worthley SG, Tchétché D, Manoharan G, Blackman DJ, Rioufol G, Hildick-Smith D, Whitbourn RJ, Lefèvre T, Lange R, Müller R, Redwood S, Feldman TE, Allocco DJ, Dawkins KD.

JACC Cardiovasc Interv. 2016 Feb 22;9(4):376-384. doi: 10.1016/j.jcin.2015.10.024.


Transcatheter Aortic Valve Replacement Using the Repositionable LOTUS Valve: United Kingdom Experience.

Rampat R, Khawaja MZ, Byrne J, MacCarthy P, Blackman DJ, Krishnamurthy A, Gunarathne A, Kovac J, Banning A, Kharbanda R, Firoozi S, Brecker S, Redwood S, Bapat V, Mullen M, Aggarwal S, Manoharan G, Spence MS, Khogali S, Dooley M, Cockburn J, de Belder A, Trivedi U, Hildick-Smith D.

JACC Cardiovasc Interv. 2016 Feb 22;9(4):367-372. doi: 10.1016/j.jcin.2015.12.012.


Combining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases.

Manoharan GB, Enkvist E, Uri A.

Biophys Chem. 2016 Apr;211:39-48. doi: 10.1016/j.bpc.2016.01.004. Epub 2016 Jan 25.


Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial.

van Nunen LX, Zimmermann FM, Tonino PA, Barbato E, Baumbach A, Engstrøm T, Klauss V, MacCarthy PA, Manoharan G, Oldroyd KG, Ver Lee PN, Van't Veer M, Fearon WF, De Bruyne B, Pijls NH; FAME Study Investigators.

Lancet. 2015 Nov 7;386(10006):1853-60. doi: 10.1016/S0140-6736(15)00057-4. Epub 2015 Aug 30.


Treatment of Symptomatic Severe Aortic Stenosis With a Novel Resheathable Supra-Annular Self-Expanding Transcatheter Aortic Valve System.

Manoharan G, Walton AS, Brecker SJ, Pasupati S, Blackman DJ, Qiao H, Meredith IT.

JACC Cardiovasc Interv. 2015 Aug 24;8(10):1359-67. doi: 10.1016/j.jcin.2015.05.015.


Blood metal ions after hybrid metal-on-polyethylene Exeter-Trident total hip replacement.

Singh R, Manoharan G, Craig P, Collier S, Shaylor P, Sinha A.

J Orthop Traumatol. 2016 Jun;17(2):149-53. doi: 10.1007/s10195-015-0369-4. Epub 2015 Jul 24.


Macronodular tuberculosis of the liver: a tumour masquerade.

Rammohan A, Sathyanesan J, Palaniappan R, Manoharan G.

Trop Gastroenterol. 2014 Jul-Sep;35(3):180-2. No abstract available.


A pathway to earlier discharge following TAVI: Assessment of safety and resource utilization.

Noad RL, Johnston N, McKinley A, Dougherty M, Nzewi OC, Jeganathan R, Manoharan G, Spence MS.

Catheter Cardiovasc Interv. 2016 Jan 1;87(1):134-42. doi: 10.1002/ccd.26005. Epub 2015 May 23.


Efficacy of RADPAD® protection drape in reducing radiation exposure to the primary operator during Transcatheter Aortic Valve Implantation (TAVI).

Sharma D, Ramsewak A, Manoharan G, Spence MS.

Minerva Cardioangiol. 2016 Feb;64(1):41-6. Epub 2015 Apr 22.


FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases.

Manoharan GB, Enkvist E, Kasari M, Viht K, Zenn M, Prinz A, Filhol O, Herberg FW, Uri A.

Anal Biochem. 2015 Jul 15;481:10-7. doi: 10.1016/j.ab.2015.04.009. Epub 2015 Apr 10.


Transcatheter aortic valve replacement for severe symptomatic aortic stenosis using a repositionable valve system: 30-day primary endpoint results from the REPRISE II study.

Meredith Am IT, Walters DL, Dumonteil N, Worthley SG, Tchétché D, Manoharan G, Blackman DJ, Rioufol G, Hildick-Smith D, Whitbourn RJ, Lefèvre T, Lange R, Müller R, Redwood S, Allocco DJ, Dawkins KD.

J Am Coll Cardiol. 2014 Sep 30;64(13):1339-48. doi: 10.1016/j.jacc.2014.05.067.


Fractional flow reserve-guided PCI for stable coronary artery disease.

De Bruyne B, Fearon WF, Pijls NH, Barbato E, Tonino P, Piroth Z, Jagic N, Mobius-Winckler S, Rioufol G, Witt N, Kala P, MacCarthy P, Engström T, Oldroyd K, Mavromatis K, Manoharan G, Verlee P, Frobert O, Curzen N, Johnson JB, Limacher A, Nüesch E, Jüni P; FAME 2 Trial Investigators.

N Engl J Med. 2014 Sep 25;371(13):1208-17. doi: 10.1056/NEJMoa1408758. Epub 2014 Sep 1. Erratum in: N Engl J Med. 2014 Oct 9;371(15):1465.


Trends in bacterial and fungal keratitis in South India, 2002-2012.

Lalitha P, Prajna NV, Manoharan G, Srinivasan M, Mascarenhas J, Das M, D'Silva SS, Porco TC, Keenan JD.

Br J Ophthalmol. 2015 Feb;99(2):192-4. doi: 10.1136/bjophthalmol-2014-305000. Epub 2014 Aug 20.


Laparoscopic excision of large ciliated hepatic foregut cyst.

Saravanan J, Manoharan G, Jeswanth S, Ravichandran P.

J Minim Access Surg. 2014 Jul;10(3):151-3. doi: 10.4103/0972-9941.134879.


Acute spontaneous atraumatic bilateral anterior dislocation of the shoulder joint with Hill-Sachs lesions: first reported case and review of literature.

Manoharan G, Singh R, Ahmed B, Kathuria V.

BMJ Case Rep. 2014 Jun 3;2014. pii: bcr2013202847. doi: 10.1136/bcr-2013-202847. Review.


Nintendo Wii related Achilles tendon rupture: first reported case and literature review of motion sensing video game injuries.

Singh R, Manoharan G, Moores TS, Patel A.

BMJ Case Rep. 2014 May 14;2014. pii: bcr2013202657. doi: 10.1136/bcr-2013-202657. Review.


Benzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases.

Ekambaram R, Enkvist E, Manoharan Gb, Ugandi M, Kasari M, Viht K, Knapp S, Issinger OG, Uri A.

Chem Commun (Camb). 2014 Apr 21;50(31):4096-8. doi: 10.1039/c3cc49198f.


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