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Items: 1 to 50 of 442

1.

Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions.

Nishikawa M, Yasuda K, Takamatsu M, Abe K, Okamoto K, Horibe K, Mano H, Nakagawa K, Tsugawa N, Hirota Y, Horie T, Hinoi E, Okano T, Ikushiro S, Sakaki T.

Sci Rep. 2020 Mar 30;10(1):5677. doi: 10.1038/s41598-020-62048-1.

2.

Clinical Application of Next-generation Sequencing for the Diagnosis of Lung Squamous Cell Carcinoma: Is It Primary or Secondary?

Aizawa H, Karasaki T, Nagayama K, Shinozaki-Ushiku A, Aburatani H, Mano H, Nakajima J.

Intern Med. 2020 Feb 12. doi: 10.2169/internalmedicine.3682-19. [Epub ahead of print]

3.

Identification of Novel CD74-NRG2α Fusion From Comprehensive Profiling of Lung Adenocarcinoma in Japanese Never or Light Smokers.

Kohsaka S, Hayashi T, Nagano M, Ueno T, Kojima S, Kawazu M, Shiraishi Y, Kishikawa S, Suehara Y, Takahashi F, Takahashi K, Suzuki K, Takamochi K, Mano H.

J Thorac Oncol. 2020 Feb 6. pii: S1556-0864(20)30098-8. doi: 10.1016/j.jtho.2020.01.021. [Epub ahead of print]

4.

Mesenchymal Tumors with RREB1-MRTFB Fusion Involving the Mediastinum: Extra-Glossal Ectomesenchymal Chondromyxoid Tumors?

Makise N, Mori T, Kobayashi H, Nakagawa K, Ryo E, Nakajima J, Kohsaka S, Mano H, Aburatani H, Yoshida A, Ushiku T.

Histopathology. 2020 Jan 28. doi: 10.1111/his.14080. [Epub ahead of print]

PMID:
31991003
5.

Does a sum of toxic units exceeding 1 imply adverse impacts on macroinvertebrate assemblages? A field study in a northern Japanese river receiving treated mine discharge.

Iwasaki Y, Fujisawa M, Ogino T, Mano H, Shinohara N, Masunaga S, Kamo M.

Environ Monit Assess. 2020 Jan 3;192(2):83. doi: 10.1007/s10661-019-8047-2.

PMID:
31900674
6.

Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter.

Hasegawa N, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Akaike K, Okubo T, Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H, Kohsaka S.

Sci Rep. 2019 Dec 27;9(1):20047. doi: 10.1038/s41598-019-56377-z.

7.

Spinal solitary fibrous tumor of the neck: Next-generation sequencing-based analysis of genomic aberrations.

Ando M, Kobayashi H, Shinozaki-Ushiku A, Chikuda H, Matsubayashi Y, Yoshida M, Saito Y, Kohsaka S, Oda K, Miyagawa K, Aburatani H, Mano H, Yamasoba T.

Auris Nasus Larynx. 2019 Dec 23. pii: S0385-8146(19)30932-0. doi: 10.1016/j.anl.2019.12.001. [Epub ahead of print]

PMID:
31879078
8.

Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations.

Inoue S, Hirota Y, Ueno T, Fukui Y, Yoshida E, Hayashi T, Kojima S, Takeyama R, Hashimoto T, Kiyono T, Ikemura M, Taguchi A, Tanaka T, Tanaka Y, Sakata S, Takeuchi K, Muraoka A, Osuka S, Saito T, Oda K, Osuga Y, Terao Y, Kawazu M, Mano H.

Nat Commun. 2019 Dec 19;10(1):5785. doi: 10.1038/s41467-019-13708-y.

9.

Narrower QRS may be enough to respond to cardiac resynchronization therapy in lightweight patients.

Nakai T, Mano H, Ikeya Y, Aizawa Y, Kurokawa S, Ohkubo K, Nagashima K, Watanabe I, Okumura Y.

Heart Vessels. 2019 Nov 27. doi: 10.1007/s00380-019-01541-8. [Epub ahead of print]

PMID:
31776736
10.

Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation.

Hayakawa D, Takahashi F, Mitsuishi Y, Tajima K, Hidayat M, Winardi W, Ihara H, Kanamori K, Matsumoto N, Asao T, Ko R, Shukuya T, Takamochi K, Hayashi T, Suehara Y, Takeda Nakamura I, Ueno T, Kohsaka S, Mano H, Takahashi K.

Thorac Cancer. 2020 Jan;11(1):140-149. doi: 10.1111/1759-7714.13255. Epub 2019 Nov 22.

11.

Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish.

Mano H, Asaoka Y, Kojima D, Fukada Y.

Commun Biol. 2019 Oct 7;2:364. doi: 10.1038/s42003-019-0613-1. eCollection 2019.

12.

Collagen-derived dipeptide prolyl hydroxyproline directly binds to Foxg1 to change its conformation and inhibit the interaction with Runx2.

Nomura K, Kimira Y, Osawa Y, Shimizu J, Kataoka-Matsushita A, Mano H.

Biosci Biotechnol Biochem. 2019 Nov;83(11):2027-2033. doi: 10.1080/09168451.2019.1642099. Epub 2019 Jul 19.

PMID:
31322484
13.

Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma.

Yoshimoto T, Matsubara D, Soda M, Ueno T, Amano Y, Kihara A, Sakatani T, Nakano T, Shibano T, Endo S, Hagiwara K, Fukayama M, Denda-Nagai K, Irimura T, Mano H, Niki T.

Cancer Sci. 2019 Sep;110(9):3006-3011. doi: 10.1111/cas.14129. Epub 2019 Aug 16.

14.

Genomic profiles of colorectal carcinoma with liver metastases and newly identified fusion genes.

Oga T, Yamashita Y, Soda M, Kojima S, Ueno T, Kawazu M, Suzuki N, Nagano H, Hazama S, Izumiya M, Koike K, Mano H.

Cancer Sci. 2019 Sep;110(9):2973-2981. doi: 10.1111/cas.14127. Epub 2019 Jul 30.

15.

Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing.

Kage H, Kohsaka S, Shinozaki-Ushiku A, Hiraishi Y, Sato J, Nagayama K, Ushiku T, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T.

Cancer Sci. 2019 Aug;110(8):2652-2657. doi: 10.1111/cas.14112. Epub 2019 Jun 21.

16.

Identification of candidates for driver oncogenes in scirrhous-type gastric cancer cell lines.

Sai E, Miwa Y, Takeyama R, Kojima S, Ueno T, Yashiro M, Seto Y, Mano H.

Cancer Sci. 2019 Aug;110(8):2643-2651. doi: 10.1111/cas.14111. Epub 2019 Jul 15.

17.

Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens.

Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H.

Cancer Sci. 2019 Apr;110(4):1464-1479. doi: 10.1111/cas.13968. Epub 2019 Mar 5.

18.

A germline HLTF mutation in familial MDS induces DNA damage accumulation through impaired PCNA polyubiquitination.

Takaoka K, Kawazu M, Koya J, Yoshimi A, Masamoto Y, Maki H, Toya T, Kobayashi T, Nannya Y, Arai S, Ueno T, Ueno H, Suzuki K, Harada H, Manabe A, Hayashi Y, Mano H, Kurokawa M.

Leukemia. 2019 Jul;33(7):1773-1782. doi: 10.1038/s41375-019-0385-0. Epub 2019 Jan 29.

PMID:
30696947
19.

Spontaneous Transdifferentiation from Small Cell Lung Carcinoma to Squamous Cell Carcinoma.

Watanabe K, Kage H, Shinozaki-Ushiku A, Kohsaka S, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T.

J Thorac Oncol. 2019 Feb;14(2):e31-e34. doi: 10.1016/j.jtho.2018.10.159. No abstract available.

20.

MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration.

Mori N, Mochizuki T, Yamazaki F, Takei S, Mano H, Matsugi T, Setou M.

PLoS One. 2019 Jan 25;14(1):e0211376. doi: 10.1371/journal.pone.0211376. eCollection 2019.

21.

Differential regulation of CpG island methylation within divergent and unidirectional promoters in colorectal cancer.

Namba S, Sato K, Kojima S, Ueno T, Yamamoto Y, Tanaka Y, Inoue S, Nagae G, Iinuma H, Hazama S, Ishihara S, Aburatani H, Mano H, Kawazu M.

Cancer Sci. 2019 Mar;110(3):1096-1104. doi: 10.1111/cas.13937. Epub 2019 Mar 2.

22.

Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO).

Kinoshita Y, Takashi Y, Ito N, Ikegawa S, Mano H, Ushiku T, Fukayama M, Nangaku M, Fukumoto S.

Bone Rep. 2018 Dec 31;10:100192. doi: 10.1016/j.bonr.2018.100192. eCollection 2019 Jun.

23.

Body knowledge in children with congenital lower limb deficiency.

Mano H, Fujiwara S, Haga N.

Pediatr Int. 2019 Feb;61(2):158-165. doi: 10.1111/ped.13757. Epub 2019 Feb 7.

PMID:
30565809
24.

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.

Li JF, Dai YT, Lilljebjörn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11711-E11720. doi: 10.1073/pnas.1814397115. Epub 2018 Nov 28.

25.

Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity.

Hirano D, Hayakawa F, Yasuda T, Tange N, Yamamoto H, Kojima Y, Morishita T, Imoto N, Tsuzuki S, Mano H, Naoe T, Kiyoi H.

Oncogene. 2019 Mar;38(13):2263-2274. doi: 10.1038/s41388-018-0573-9. Epub 2018 Nov 26.

PMID:
30478446
26.

Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia.

Matsuo H, Yoshida K, Fukumura K, Nakatani K, Noguchi Y, Takasaki S, Noura M, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Okada A, Nannya Y, Takeda J, Ueno H, Shiba N, Yamato G, Handa H, Ono Y, Hiramoto N, Ishikawa T, Usuki K, Ishiyama K, Miyawaki S, Itonaga H, Miyazaki Y, Kawamura M, Yamaguchi H, Kiyokawa N, Tomizawa D, Taga T, Tawa A, Hayashi Y, Mano H, Miyano S, Kamikubo Y, Ogawa S, Adachi S.

Blood Adv. 2018 Nov 13;2(21):2879-2889. doi: 10.1182/bloodadvances.2018019398.

27.

Classification and characterisation of brain network changes in chronic back pain: A multicenter study.

Mano H, Kotecha G, Leibnitz K, Matsubara T, Sprenger C, Nakae A, Shenker N, Shibata M, Voon V, Yoshida W, Lee M, Yanagida T, Kawato M, Rosa MJ, Seymour B.

Version 2. Wellcome Open Res. 2018 Oct 10 [revised 2018 Jan 1];3:19. doi: 10.12688/wellcomeopenres.14069.2. eCollection 2018.

28.

Fusion Kinases Identified by Genomic Analyses of Sporadic Microsatellite Instability-High Colorectal Cancers.

Sato K, Kawazu M, Yamamoto Y, Ueno T, Kojima S, Nagae G, Abe H, Soda M, Oga T, Kohsaka S, Sai E, Yamashita Y, Iinuma H, Fukayama M, Aburatani H, Watanabe T, Mano H.

Clin Cancer Res. 2019 Jan 1;25(1):378-389. doi: 10.1158/1078-0432.CCR-18-1574. Epub 2018 Oct 2.

29.

Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator.

Mano H, Takano M, Ikushiro S, Kittaka A, Sakaki T.

Biochem Biophys Res Commun. 2018 Oct 28;505(2):460-465. doi: 10.1016/j.bbrc.2018.09.122. Epub 2018 Sep 26.

PMID:
30268505
30.

Anterior cingulate cortex connectivity is associated with suppression of behaviour in a rat model of chronic pain.

Morris LS, Sprenger C, Koda K, de la Mora DM, Yamada T, Mano H, Kashiwagi Y, Yoshioka Y, Morioka Y, Seymour B.

Brain Neurosci Adv. 2018 Jun 5;2:2398212818779646. doi: 10.1177/2398212818779646. eCollection 2018.

31.

Development of a highly sensitive and reliable enzyme-linked immunosorbent assay for MUC5AC in human tears extracted from Schirmer strips.

Miyake H, Mori N, Mano H, Imanaka T, Nakamura M.

Clin Ophthalmol. 2018 Aug 29;12:1571-1580. doi: 10.2147/OPTH.S170552. eCollection 2018.

32.

Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation.

Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N.

J Cell Biol. 2018 Nov 5;217(11):3817-3828. doi: 10.1083/jcb.201804132. Epub 2018 Aug 9.

33.

Congenital limb deficiency in Japan: a cross-sectional nationwide survey on its epidemiology.

Mano H, Fujiwara S, Takamura K, Kitoh H, Takayama S, Ogata T, Hashimoto S, Haga N.

BMC Musculoskelet Disord. 2018 Jul 27;19(1):262. doi: 10.1186/s12891-018-2195-3.

34.

Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.

Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T.

Nat Commun. 2018 Jul 16;9(1):2733. doi: 10.1038/s41467-018-05085-9.

35.

Novel split luciferase-based biosensors for evaluation of vitamin D receptor ligands and their application to estimate CYP27B1 activity in living cells.

Mano H, Ikushiro S, Sakaki T.

J Steroid Biochem Mol Biol. 2018 Oct;183:221-227. doi: 10.1016/j.jsbmb.2018.06.017. Epub 2018 Jul 9.

PMID:
30004013
36.

High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2.

Nagano M, Kohsaka S, Ueno T, Kojima S, Saka K, Iwase H, Kawazu M, Mano H.

Clin Cancer Res. 2018 Oct 15;24(20):5112-5122. doi: 10.1158/1078-0432.CCR-18-0991. Epub 2018 Jul 2.

37.

Mutant p53-Expressing Cells Undergo Necroptosis via Cell Competition with the Neighboring Normal Epithelial Cells.

Watanabe H, Ishibashi K, Mano H, Kitamoto S, Sato N, Hoshiba K, Kato M, Matsuzawa F, Takeuchi Y, Shirai T, Ishikawa S, Morioka Y, Imagawa T, Sakaguchi K, Yonezawa S, Kon S, Fujita Y.

Cell Rep. 2018 Jun 26;23(13):3721-3729. doi: 10.1016/j.celrep.2018.05.081.

38.

Spontaneous Transformation from EGFR and ALK Wild-Type Lung Adenocarcinoma to Neuroendocrine Carcinoma.

Kage H, Kohsaka S, Shinozaki-Ushiku A, Ushiku T, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T.

J Thorac Oncol. 2018 Jul;13(7):e126-e128. doi: 10.1016/j.jtho.2018.02.029. No abstract available.

39.

Ethical concerns on sharing genomic data including patients' family members.

Takashima K, Maru Y, Mori S, Mano H, Noda T, Muto K.

BMC Med Ethics. 2018 Jun 18;19(1):61. doi: 10.1186/s12910-018-0310-5.

40.

Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia.

Tanaka Y, Kawazu M, Yasuda T, Tamura M, Hayakawa F, Kojima S, Ueno T, Kiyoi H, Naoe T, Mano H.

Haematologica. 2018 Nov;103(11):e522-e526. doi: 10.3324/haematol.2017.183152. Epub 2018 May 17. No abstract available.

41.

Impact of Sinus Node Recovery Time after Long-Standing Atrial Fibrillation Termination on the Long-Term Outcome of Catheter Ablation.

Yamaguchi N, Okumura Y, Watanabe I, Nagashima K, Takahashi K, Iso K, Watanabe R, Arai M, Mano H, Kogawa R, Kurokawa S, Ohkubo K, Nakai T, Hirayama A, Sonoda K, Tosaka T.

Int Heart J. 2018 May 30;59(3):497-502. doi: 10.1536/ihj.17-097. Epub 2018 May 9.

42.

Hot Balloon Versus Cryoballoon Ablation for Atrial Fibrillation: Lesion Characteristics and Middle-Term Outcomes.

Nagashima K, Okumura Y, Watanabe I, Nakahara S, Hori Y, Iso K, Watanabe R, Arai M, Wakamatsu Y, Kurokawa S, Mano H, Nakai T, Ohkubo K, Hirayama A.

Circ Arrhythm Electrophysiol. 2018 May;11(5):e005861. doi: 10.1161/CIRCEP.117.005861. Erratum in: Circ Arrhythm Electrophysiol. 2018 Aug;11(8):e000028.

PMID:
29700055
43.

Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells.

Takahashi K, Ehata S, Koinuma D, Morishita Y, Soda M, Mano H, Miyazono K.

Oncogene. 2018 May;37(21):2757-2772. doi: 10.1038/s41388-018-0144-0. Epub 2018 Mar 7.

44.

The control of tonic pain by active relief learning.

Zhang S, Mano H, Lee M, Yoshida W, Kawato M, Robbins TW, Seymour B.

Elife. 2018 Feb 27;7. pii: e31949. doi: 10.7554/eLife.31949.

45.

Integrated molecular profiling of juvenile myelomonocytic leukemia.

Murakami N, Okuno Y, Yoshida K, Shiraishi Y, Nagae G, Suzuki K, Narita A, Sakaguchi H, Kawashima N, Wang X, Xu Y, Chiba K, Tanaka H, Hama A, Sanada M, Ito M, Hirayama M, Watanabe A, Ueno T, Kojima S, Aburatani H, Mano H, Miyano S, Ogawa S, Takahashi Y, Muramatsu H.

Blood. 2018 Apr 5;131(14):1576-1586. doi: 10.1182/blood-2017-07-798157. Epub 2018 Feb 2.

PMID:
29437595
46.

Mechanistic Insights Into Durable Pulmonary Vein Isolation Achieved by Second-Generation Cryoballoon Ablation.

Okumura Y, Watanabe I, Iso K, Takahashi K, Nagashima K, Sonoda K, Mano H, Yamaguchi N, Kogawa R, Watanabe R, Arai M, Ohkubo K, Kurokawa S, Nakai T, Hirayama A.

J Atr Fibrillation. 2017 Apr 30;9(6):1538. doi: 10.4022/jafib.1538. eCollection 2017 Apr-May.

47.

Collagen-derived dipeptide prolyl-hydroxyproline promotes osteogenic differentiation through Foxg1.

Kimira Y, Odaira H, Nomura K, Taniuchi Y, Inoue N, Nakatani S, Shimizu J, Wada M, Mano H.

Cell Mol Biol Lett. 2017 Dec 1;22:27. doi: 10.1186/s11658-017-0060-2. eCollection 2017.

48.

Identification of a novel fusion gene HMGA2-EGFR in glioblastoma.

Komuro A, Raja E, Iwata C, Soda M, Isogaya K, Yuki K, Ino Y, Morikawa M, Todo T, Aburatani H, Suzuki H, Ranjit M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K, Koinuma D.

Int J Cancer. 2018 Apr 15;142(8):1627-1639. doi: 10.1002/ijc.31179. Epub 2017 Dec 11.

49.

A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer.

Kohsaka S, Nagano M, Ueno T, Suehara Y, Hayashi T, Shimada N, Takahashi K, Suzuki K, Takamochi K, Takahashi F, Mano H.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaan6566. doi: 10.1126/scitranslmed.aan6566.

PMID:
29141884
50.

Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique.

Mano H, Ikushiro S, Saito N, Kittaka A, Sakaki T.

J Steroid Biochem Mol Biol. 2018 Apr;178:55-59. doi: 10.1016/j.jsbmb.2017.10.024. Epub 2017 Nov 1.

PMID:
29101064

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