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Items: 21

1.

Stabilization and characterization of cytotoxic Aβ40 oligomers isolated from an aggregation reaction in the presence of zinc ions.

Mannini B, Habchi J, Chia SKR, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M.

ACS Chem Neurosci. 2018 Jul 9. doi: 10.1021/acschemneuro.8b00141. [Epub ahead of print]

PMID:
29986583
2.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Jun 28. doi: 10.1021/acschembio.8b00466. [Epub ahead of print]

PMID:
29953201
3.

Toxic HypF-N Oligomers Selectively Bind the Plasma Membrane to Impair Cell Adhesion Capability.

Oropesa-Nuñez R, Keshavan S, Dante S, Diaspro A, Mannini B, Capitini C, Cecchi C, Stefani M, Chiti F, Canale C.

Biophys J. 2018 Mar 27;114(6):1357-1367. doi: 10.1016/j.bpj.2018.02.003.

PMID:
29590593
4.

Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles.

Perni M, Aprile FA, Casford S, Mannini B, Sormanni P, Dobson CM, Vendruscolo M.

Sci Rep. 2017 Nov 8;7(1):15045. doi: 10.1038/s41598-017-13755-9.

5.

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity.

Mannini B, Chiti F.

Front Mol Neurosci. 2017 Apr 5;10:98. doi: 10.3389/fnmol.2017.00098. eCollection 2017. Review.

6.

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.

Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E200-E208. doi: 10.1073/pnas.1615613114. Epub 2016 Dec 23.

7.

Bis(indolyl)phenylmethane derivatives are effective small molecules for inhibition of amyloid fibril formation by hen lysozyme.

Ramshini H, Mannini B, Khodayari K, Ebrahim-Habibi A, Moghaddasi AS, Tayebee R, Chiti F.

Eur J Med Chem. 2016 Nov 29;124:361-371. doi: 10.1016/j.ejmech.2016.08.056. Epub 2016 Aug 26.

PMID:
27597412
8.

Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations.

Cappelli S, Penco A, Mannini B, Cascella R, Wilson MR, Ecroyd H, Li X, Buxbaum JN, Dobson CM, Cecchi C, Relini A, Chiti F.

Biol Chem. 2016 May;397(5):401-15. doi: 10.1515/hsz-2015-0250.

PMID:
26812789
9.

SERS Detection of Amyloid Oligomers on Metallorganic-Decorated Plasmonic Beads.

Guerrini L, Arenal R, Mannini B, Chiti F, Pini R, Matteini P, Alvarez-Puebla RA.

ACS Appl Mater Interfaces. 2015 May 13;7(18):9420-8. doi: 10.1021/acsami.5b01056. Epub 2015 May 1.

PMID:
25897657
10.

Toxicity of protein oligomers is rationalized by a function combining size and surface hydrophobicity.

Mannini B, Mulvihill E, Sgromo C, Cascella R, Khodarahmi R, Ramazzotti M, Dobson CM, Cecchi C, Chiti F.

ACS Chem Biol. 2014 Oct 17;9(10):2309-17. doi: 10.1021/cb500505m. Epub 2014 Aug 11.

PMID:
25079908
11.

Transthyretin suppresses the toxicity of oligomers formed by misfolded proteins in vitro.

Cascella R, Conti S, Mannini B, Li X, Buxbaum JN, Tiribilli B, Chiti F, Cecchi C.

Biochim Biophys Acta. 2013 Dec;1832(12):2302-14. doi: 10.1016/j.bbadis.2013.09.011. Epub 2013 Sep 25.

12.

Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N.

Tatini F, Pugliese AM, Traini C, Niccoli S, Maraula G, Ed Dami T, Mannini B, Scartabelli T, Pedata F, Casamenti F, Chiti F.

Neurobiol Aging. 2013 Sep;34(9):2100-9. doi: 10.1016/j.neurobiolaging.2013.03.020. Epub 2013 Apr 18.

PMID:
23601807
13.

Salt anions promote the conversion of HypF-N into amyloid-like oligomers and modulate the structure of the oligomers and the monomeric precursor state.

Campioni S, Mannini B, López-Alonso JP, Shalova IN, Penco A, Mulvihill E, Laurents DV, Relini A, Chiti F.

J Mol Biol. 2012 Dec 7;424(3-4):132-49. doi: 10.1016/j.jmb.2012.09.023. Epub 2012 Oct 3.

PMID:
23041425
14.

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.

Mannini B, Cascella R, Zampagni M, van Waarde-Verhagen M, Meehan S, Roodveldt C, Campioni S, Boninsegna M, Penco A, Relini A, Kampinga HH, Dobson CM, Wilson MR, Cecchi C, Chiti F.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12479-84. doi: 10.1073/pnas.1117799109. Epub 2012 Jul 16.

15.

Glycosaminoglycans (GAGs) suppress the toxicity of HypF-N prefibrillar aggregates.

Saridaki T, Zampagni M, Mannini B, Evangelisti E, Taddei N, Cecchi C, Chiti F.

J Mol Biol. 2012 Aug 24;421(4-5):616-30. doi: 10.1016/j.jmb.2012.02.007. Epub 2012 Feb 9.

PMID:
22326346
16.

The induction of α-helical structure in partially unfolded HypF-N does not affect its aggregation propensity.

Ahmad B, Vigliotta I, Tatini F, Campioni S, Mannini B, Winkelmann J, Tiribilli B, Chiti F.

Protein Eng Des Sel. 2011 Jul;24(7):553-63. doi: 10.1093/protein/gzr018. Epub 2011 Apr 25.

PMID:
21518735
17.

Large proteins have a great tendency to aggregate but a low propensity to form amyloid fibrils.

Ramshini H, Parrini C, Relini A, Zampagni M, Mannini B, Pesce A, Saboury AA, Nemat-Gorgani M, Chiti F.

PLoS One. 2011 Jan 13;6(1):e16075. doi: 10.1371/journal.pone.0016075.

18.

A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells.

Zampagni M, Cascella R, Casamenti F, Grossi C, Evangelisti E, Wright D, Becatti M, Liguri G, Mannini B, Campioni S, Chiti F, Cecchi C.

J Cell Mol Med. 2011 Oct;15(10):2106-16. doi: 10.1111/j.1582-4934.2010.01239.x.

19.

Low-level expression of a folding-incompetent protein in Escherichia coli: search for the molecular determinants of protein aggregation in vivo.

Winkelmann J, Calloni G, Campioni S, Mannini B, Taddei N, Chiti F.

J Mol Biol. 2010 May 14;398(4):600-13. doi: 10.1016/j.jmb.2010.03.030. Epub 2010 Mar 25.

PMID:
20346957
20.

A causative link between the structure of aberrant protein oligomers and their toxicity.

Campioni S, Mannini B, Zampagni M, Pensalfini A, Parrini C, Evangelisti E, Relini A, Stefani M, Dobson CM, Cecchi C, Chiti F.

Nat Chem Biol. 2010 Feb;6(2):140-7. doi: 10.1038/nchembio.283. Epub 2010 Jan 10.

PMID:
20081829
21.

[Osteoarthritis caused by Brucella melitensis: isolation of the microorganism from the synovial fluid].

Gori E, Mannini B, Pazzaglia R, Bertini V, Fioriti M, Casadei BM.

Pediatr Med Chir. 1993 Nov-Dec;15(6):625-7. Italian.

PMID:
8197028

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