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Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling.

Manning JR, Thapa D, Zhang M, Stoner MW, Traba J, Corey C, Shiva S, Sack MN, Scott I.

Biochem J. 2019 Jun 19;476(12):1713-1724. doi: 10.1042/BCJ20190302.


Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions.

Thapa D, Zhang M, Manning JR, Guimarães DA, Stoner MW, Lai YC, Shiva S, Scott I.

Physiol Rep. 2019 Apr;7(8):e14054. doi: 10.14814/phy2.14054.


Adropin reduces blood glucose levels in mice by limiting hepatic glucose production.

Thapa D, Xie B, Manning JR, Zhang M, Stoner MW, Huckestein BR, Edmunds LR, Zhang X, Dedousis NL, O'Doherty RM, Jurczak MJ, Scott I.

Physiol Rep. 2019 Apr;7(8):e14043. doi: 10.14814/phy2.14043.


Adropin treatment restores cardiac glucose oxidation in pre-diabetic obese mice.

Thapa D, Xie B, Zhang M, Stoner MW, Manning JR, Huckestein BR, Edmunds LR, Mullett SJ, McTiernan CF, Wendell SG, Jurczak MJ, Scott I.

J Mol Cell Cardiol. 2019 Apr;129:174-178. doi: 10.1016/j.yjmcc.2019.02.012. Epub 2019 Feb 26.


Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury.

Manning JR, Thapa D, Zhang M, Stoner MW, Traba J, McTiernan CF, Corey C, Shiva S, Sack MN, Scott I.

J Mol Cell Cardiol. 2019 Apr;129:69-78. doi: 10.1016/j.yjmcc.2019.02.009. Epub 2019 Feb 15.


Uncommon Neonatal Skin Lesions.

Manning JR, Lee DH.

Pediatr Ann. 2019 Jan 1;48(1):e30-e35. doi: 10.3928/19382359-20181212-02. Review.


The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.

Thapa D, Wu K, Stoner MW, Xie B, Zhang M, Manning JR, Lu Z, Li JH, Chen Y, Gucek M, Playford MP, Mehta NN, Harmon D, O'Doherty RM, Jurczak MJ, Sack MN, Scott I.

J Biol Chem. 2018 Nov 16;293(46):17676-17684. doi: 10.1074/jbc.AC118.005462. Epub 2018 Oct 15.


Preparation of Functional Silica Using a Bioinspired Method.

Manning JRH, Routoula E, Patwardhan SV.

J Vis Exp. 2018 Aug 1;(138). doi: 10.3791/57730.


Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Orally Bioavailable and Brain Penetrant Mutant IDH1 Inhibitors.

Zhao Q, Manning JR, Sutton J, Costales A, Sendzik M, Shafer CM, Levell JR, Liu G, Caferro T, Cho YS, Palermo M, Chenail G, Dooley J, Villalba B, Farsidjani A, Chen J, Dodd S, Gould T, Liang G, Slocum K, Pu M, Firestone B, Growney J, Heimbach T, Pagliarini R.

ACS Med Chem Lett. 2018 Jun 11;9(7):746-751. doi: 10.1021/acsmedchemlett.8b00182. eCollection 2018 Jul 12.


Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway.

Thapa D, Stoner MW, Zhang M, Xie B, Manning JR, Guimaraes D, Shiva S, Jurczak MJ, Scott I.

Redox Biol. 2018 Sep;18:25-32. doi: 10.1016/j.redox.2018.06.003. Epub 2018 Jun 9.


Rad GTPase deletion attenuates post-ischemic cardiac dysfunction and remodeling.

Manning JR, Chelvarajan L, Levitan BM, Withers CN, Nagareddy PR, Haggerty CM, Fornwalt BK, Gao E, Tripathi H, Abdel-Latif A, Andres DA, Satin J.

JACC Basic Transl Sci. 2018 Feb;3(1):83-96. doi: 10.1016/j.jacbts.2017.09.004.


Is automatic speech-to-text transcription ready for use in psychological experiments?

Ziman K, Heusser AC, Fitzpatrick PC, Field CE, Manning JR.

Behav Res Methods. 2018 Dec;50(6):2597-2605. doi: 10.3758/s13428-018-1037-4.


A probabilistic approach to discovering dynamic full-brain functional connectivity patterns.

Manning JR, Zhu X, Willke TL, Ranganath R, Stachenfeld K, Hasson U, Blei DM, Norman KA.

Neuroimage. 2018 Oct 15;180(Pt A):243-252. doi: 10.1016/j.neuroimage.2018.01.071. Epub 2018 Feb 12. Review.


Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.

Ruetz T, Pfisterer U, Di Stefano B, Ashmore J, Beniazza M, Tian TV, Kaemena DF, Tosti L, Tan W, Manning JR, Chantzoura E, Ottosson DR, Collombet S, Johnsson A, Cohen E, Yusa K, Linnarsson S, Graf T, Parmar M, Kaji K.

Cell Stem Cell. 2017 Dec 7;21(6):791-805.e9. doi: 10.1016/j.stem.2017.10.013. Epub 2017 Nov 22.


Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor.

Cho YS, Levell JR, Liu G, Caferro T, Sutton J, Shafer CM, Costales A, Manning JR, Zhao Q, Sendzik M, Shultz M, Chenail G, Dooley J, Villalba B, Farsidjani A, Chen J, Kulathila R, Xie X, Dodd S, Gould T, Liang G, Heimbach T, Slocum K, Firestone B, Pu M, Pagliarini R, Growney JD.

ACS Med Chem Lett. 2017 Sep 18;8(10):1116-1121. doi: 10.1021/acsmedchemlett.7b00342. eCollection 2017 Oct 12.


Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart.

Thapa D, Zhang M, Manning JR, Guimarães DA, Stoner MW, O'Doherty RM, Shiva S, Scott I.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H265-H274. doi: 10.1152/ajpheart.00752.2016. Epub 2017 May 19.


An Eco-Friendly, Tunable and Scalable Method for Producing Porous Functional Nanomaterials Designed Using Molecular Interactions.

Manning JRH, Yip TWS, Centi A, Jorge M, Patwardhan SV.

ChemSusChem. 2017 Apr 22;10(8):1683-1691. doi: 10.1002/cssc.201700027. Epub 2017 Mar 29.


Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia.

Moore JK, MacKinnon AC, Man TY, Manning JR, Forbes SJ, Simpson KJ.

Aliment Pharmacol Ther. 2017 Feb;45(3):443-454. doi: 10.1111/apt.13878. Epub 2016 Nov 28.


Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart.

Levitan BM, Manning JR, Withers CN, Smith JD, Shaw RM, Andres DA, Sorrell VL, Satin J.

J Cardiovasc Transl Res. 2016 Dec;9(5-6):432-444. Epub 2016 Oct 31.


Erratum to: Fibrinogen production is enhanced in an in-vitro model of non-alcoholic fatty liver disease: an isolated risk factor for cardiovascular events?

Yeung EN, Treskes P, Martin SF, Manning JR, Dunbar DR, Rogers SM, Le Bihan T, Lockman KA, Morley SD, Hayes PC, Nelson LJ, Plevris JN.

Lipids Health Dis. 2016 Aug 1;15(1):125. No abstract available.


A neural signature of contextually mediated intentional forgetting.

Manning JR, Hulbert JC, Williams J, Piloto L, Sahakyan L, Norman KA.

Psychon Bull Rev. 2016 Oct;23(5):1534-1542.


Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes.

Betz BB, Jenks SJ, Cronshaw AD, Lamont DJ, Cairns C, Manning JR, Goddard J, Webb DJ, Mullins JJ, Hughes J, McLachlan S, Strachan MWJ, Price JF, Conway BR.

Kidney Int. 2016 May;89(5):1125-1135. doi: 10.1016/j.kint.2016.01.015. Epub 2016 Mar 7.


Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation.

Khulan B, Liu L, Rose CM, Boyle AK, Manning JR, Drake AJ.

Epigenetics. 2016;11(2):103-9. doi: 10.1080/15592294.2016.1144006. Epub 2016 Feb 18.


Epigenomic profiling of preterm infants reveals DNA methylation differences at sites associated with neural function.

Sparrow S, Manning JR, Cartier J, Anblagan D, Bastin ME, Piyasena C, Pataky R, Moore EJ, Semple SI, Wilkinson AG, Evans M, Drake AJ, Boardman JP.

Transl Psychiatry. 2016 Jan 19;6:e716. doi: 10.1038/tp.2015.210.


Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging.

Manning JR, Withers CN, Levitan B, Smith JD, Andres DA, Satin J.

Am J Physiol Heart Circ Physiol. 2015 Oct;309(8):H1336-45. doi: 10.1152/ajpheart.00389.2015. Epub 2015 Sep 14.


Fibrinogen production is enhanced in an in-vitro model of non-alcoholic fatty liver disease: an isolated risk factor for cardiovascular events?

Yeung EN, Treskes P, Martin SF, Manning JR, Dunbar DR, Rogers SM, Le Bihan T, Lockman KA, Morley SD, Hayes PC, Nelson LJ, Plevris JN.

Lipids Health Dis. 2015 Aug 10;14:86. doi: 10.1186/s12944-015-0069-3. Erratum in: Lipids Health Dis. 2016;15(1):125.


Genome-wide mRNA expression profiling in vastus lateralis of COPD patients with low and normal fat free mass index and healthy controls.

Rabinovich RA, Drost E, Manning JR, Dunbar DR, Díaz-Ramos M, Lakhdar R, Bastos R, MacNee W.

Respir Res. 2015 Jan 8;16:1. doi: 10.1186/s12931-014-0139-5.


Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α.

Rog-Zielinska EA, Craig MA, Manning JR, Richardson RV, Gowans GJ, Dunbar DR, Gharbi K, Kenyon CJ, Holmes MC, Hardie DG, Smith GL, Chapman KE.

Cell Death Differ. 2015 Jul;22(7):1106-16. doi: 10.1038/cdd.2014.181. Epub 2014 Oct 31.


Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state.

Khulan B, Manning JR, Dunbar DR, Seckl JR, Raikkonen K, Eriksson JG, Drake AJ.

Transl Psychiatry. 2014 Sep 23;4:e448. doi: 10.1038/tp.2014.94.


Tight blood glycaemic and blood pressure control in experimental diabetic nephropathy reduces extracellular matrix production without regression of fibrosis.

Conway BR, Betz B, Sheldrake TA, Manning JR, Dunbar DR, Dobyns A, Hughes J, Mullins JJ.

Nephrology (Carlton). 2014 Dec;19(12):802-13. doi: 10.1111/nep.12335.


Unsupervised learning of cone spectral classes from natural images.

Benson NC, Manning JR, Brainard DH.

PLoS Comput Biol. 2014 Jun 26;10(6):e1003652. doi: 10.1371/journal.pcbi.1003652. eCollection 2014 Jun.


Topographic factor analysis: a Bayesian model for inferring brain networks from neural data.

Manning JR, Ranganath R, Norman KA, Blei DM.

PLoS One. 2014 May 7;9(5):e94914. doi: 10.1371/journal.pone.0094914. eCollection 2014.


MAGELLAN: a cognitive map-based model of human wayfinding.

Manning JR, Lew TF, Li N, Sekuler R, Kahana MJ.

J Exp Psychol Gen. 2014 Jun;143(3):1314-1330. doi: 10.1037/a0035542. Epub 2014 Feb 3.


Rad GTPase deletion increases L-type calcium channel current leading to increased cardiac contraction.

Manning JR, Yin G, Kaminski CN, Magyar J, Feng HZ, Penn J, Sievert G, Thompson K, Jin JP, Andres DA, Satin J.

J Am Heart Assoc. 2013 Dec 12;2(6):e000459. doi: 10.1161/JAHA.113.000459.


Quantitative phosphoproteomics using acetone-based peptide labeling: method evaluation and application to a cardiac ischemia/reperfusion model.

Wijeratne AB, Manning JR, Schultz Jel J, Greis KD.

J Proteome Res. 2013 Oct 4;12(10):4268-79. doi: 10.1021/pr400835k. Epub 2013 Sep 24.


Low molecular weight fibroblast growth factor-2 signals via protein kinase C and myofibrillar proteins to protect against postischemic cardiac dysfunction.

Manning JR, Perkins SO, Sinclair EA, Gao X, Zhang Y, Newman G, Pyle WG, Schultz Jel J.

Am J Physiol Heart Circ Physiol. 2013 May 15;304(10):H1382-96. doi: 10.1152/ajpheart.00613.2012. Epub 2013 Mar 11.


Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.

Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, Hartland SN, Snowdon VK, Cappon A, Gordon-Walker TT, Williams MJ, Dunbar DR, Manning JR, van Rooijen N, Fallowfield JA, Forbes SJ, Iredale JP.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):E3186-95. doi: 10.1073/pnas.1119964109. Epub 2012 Oct 24.


The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre.

Bellamy CO, Maxwell RS, Prost S, Azodo IA, Powell JJ, Manning JR.

Histopathology. 2013 Feb;62(3):431-45. doi: 10.1111/his.12011. Epub 2012 Sep 28.


Spontaneously reactivated patterns in frontal and temporal lobe predict semantic clustering during memory search.

Manning JR, Sperling MR, Sharan A, Rosenberg EA, Kahana MJ.

J Neurosci. 2012 Jun 27;32(26):8871-8. doi: 10.1523/JNEUROSCI.5321-11.2012.


Interpreting semantic clustering effects in free recall.

Manning JR, Kahana MJ.

Memory. 2012 Jul;20(5):511-7. doi: 10.1080/09658211.2012.683010. Epub 2012 May 30.


Fibroblast growth factor-2-induced cardioprotection against myocardial infarction occurs via the interplay between nitric oxide, protein kinase signaling, and ATP-sensitive potassium channels.

Manning JR, Carpenter G, Porter DR, House SL, Pietras DA, Doetschman T, Schultz Jel J.

Growth Factors. 2012 Apr;30(2):124-39. doi: 10.3109/08977194.2012.656759. Epub 2012 Feb 6. Erratum in: Growth Factors. 2012 Dec;30(6):418.


Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy.

Conway BR, Rennie J, Bailey MA, Dunbar DR, Manning JR, Bellamy CO, Hughes J, Mullins JJ.

J Am Soc Nephrol. 2012 Mar;23(3):405-11. doi: 10.1681/ASN.2011060577. Epub 2011 Dec 22.


Oscillatory patterns in temporal lobe reveal context reinstatement during memory search.

Manning JR, Polyn SM, Baltuch GH, Litt B, Kahana MJ.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12893-7. doi: 10.1073/pnas.1015174108. Epub 2011 Jul 7.


Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK-Belgian Study).

Fox KA, Carruthers KF, Dunbar DR, Graham C, Manning JR, De Raedt H, Buysschaert I, Lambrechts D, Van de Werf F.

Eur Heart J. 2010 Nov;31(22):2755-64. doi: 10.1093/eurheartj/ehq326. Epub 2010 Aug 30.


In silico structure-function analysis of pathological variation in the HSD11B2 gene sequence.

Manning JR, Bailey MA, Soares DC, Dunbar DR, Mullins JJ.

Physiol Genomics. 2010 Aug;42(3):319-30. doi: 10.1152/physiolgenomics.00053.2010. Epub 2010 Jun 22.


Asymmetric construction of rings A-D of daphnicyclidin-type alkaloids.

Dunn TB, Ellis JM, Kofink CC, Manning JR, Overman LE.

Org Lett. 2009 Dec 17;11(24):5658-61. doi: 10.1021/ol902373m.


Broadband shifts in local field potential power spectra are correlated with single-neuron spiking in humans.

Manning JR, Jacobs J, Fried I, Kahana MJ.

J Neurosci. 2009 Oct 28;29(43):13613-20. doi: 10.1523/JNEUROSCI.2041-09.2009.


Automated seeding of specialised wiki knowledgebases with BioKb.

Manning JR, Hedley A, Mullins JJ, Dunbar DR.

BMC Bioinformatics. 2009 Sep 16;10:291. doi: 10.1186/1471-2105-10-291.


Optimal design of photoreceptor mosaics: why we do not see color at night.

Manning JR, Brainard DH.

Vis Neurosci. 2009 Jan-Feb;26(1):5-19. doi: 10.1017/S095252380808084X. Epub 2009 Feb 5.


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