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Items: 47

1.

Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity.

Payne HL, French RL, Guo CC, Nguyen-Vu TB, Manninen T, Raymond JL.

Elife. 2019 May 3;8. pii: e37102. doi: 10.7554/eLife.37102.

2.

Challenges in Reproducibility, Replicability, and Comparability of Computational Models and Tools for Neuronal and Glial Networks, Cells, and Subcellular Structures.

Manninen T, Aćimović J, Havela R, Teppola H, Linne ML.

Front Neuroinform. 2018 May 1;12:20. doi: 10.3389/fninf.2018.00020. eCollection 2018.

3.

Computational Models for Calcium-Mediated Astrocyte Functions.

Manninen T, Havela R, Linne ML.

Front Comput Neurosci. 2018 Apr 4;12:14. doi: 10.3389/fncom.2018.00014. eCollection 2018. Review.

4.

Reproducibility and Comparability of Computational Models for Astrocyte Calcium Excitability.

Manninen T, Havela R, Linne ML.

Front Neuroinform. 2017 Feb 21;11:11. doi: 10.3389/fninf.2017.00011. eCollection 2017.

5.

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M.

Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015.

PMID:
26819196
6.

Gene expression profiles in human and mouse primary cells provide new insights into the differential actions of vitamin D3 metabolites.

Tuohimaa P, Wang JH, Khan S, Kuuslahti M, Qian K, Manninen T, Auvinen P, Vihinen M, Lou YR.

PLoS One. 2013 Oct 8;8(10):e75338. doi: 10.1371/journal.pone.0075338. eCollection 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/9cb2000b-a962-453c-ad8b-088f91095f6d.

7.

Leukemia prediction using sparse logistic regression.

Manninen T, Huttunen H, Ruusuvuori P, Nykter M.

PLoS One. 2013 Aug 30;8(8):e72932. doi: 10.1371/journal.pone.0072932. eCollection 2013.

8.

Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.

Hämäläinen RH, Manninen T, Koivumäki H, Kislin M, Otonkoski T, Suomalainen A.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):E3622-30. doi: 10.1073/pnas.1311660110. Epub 2013 Sep 3.

9.

Dominance of Lactobacillus acidophilus in the facultative jejunal Lactobacillus microbiota of fistulated beagles.

Tang Y, Manninen TJ, Saris PE.

Appl Environ Microbiol. 2012 Oct;78(19):7156-9. doi: 10.1128/AEM.01975-12. Epub 2012 Jul 27.

10.

New mutation of mitochondrial DNAJC19 causing dilated and noncompaction cardiomyopathy, anemia, ataxia, and male genital anomalies.

Ojala T, Polinati P, Manninen T, Hiippala A, Rajantie J, Karikoski R, Suomalainen A, Tyni T.

Pediatr Res. 2012 Oct;72(4):432-7. doi: 10.1038/pr.2012.92. Epub 2012 Jul 13.

PMID:
22797137
11.

Small molecule inhibitors promote efficient generation of induced pluripotent stem cells from human skeletal myoblasts.

Trokovic R, Weltner J, Manninen T, Mikkola M, Lundin K, Hämäläinen R, Suomalainen A, Otonkoski T.

Stem Cells Dev. 2013 Jan 1;22(1):114-23. doi: 10.1089/scd.2012.0157. Epub 2012 Jul 30.

PMID:
22671711
12.

Computational study of noise in a large signal transduction network.

Intosalmi J, Manninen T, Ruohonen K, Linne ML.

BMC Bioinformatics. 2011 Jun 21;12:252. doi: 10.1186/1471-2105-12-252.

13.

Modeling signal transduction leading to synaptic plasticity: evaluation and comparison of five models.

Manninen T, Hituri K, Toivari E, Linne ML.

EURASIP J Bioinform Syst Biol. 2011;2011:797250. doi: 10.1155/2011/797250. Epub 2011 Mar 29.

14.

Effects of transmitters and amyloid-beta peptide on calcium signals in rat cortical astrocytes: Fura-2AM measurements and stochastic model simulations.

Toivari E, Manninen T, Nahata AK, Jalonen TO, Linne ML.

PLoS One. 2011 Mar 29;6(3):e17914. doi: 10.1371/journal.pone.0017914.

15.

Postsynaptic signal transduction models for long-term potentiation and depression.

Manninen T, Hituri K, Kotaleski JH, Blackwell KT, Linne ML.

Front Comput Neurosci. 2010 Dec 13;4:152. doi: 10.3389/fncom.2010.00152. eCollection 2010.

16.

Gimap3 regulates tissue-specific mitochondrial DNA segregation.

Jokinen R, Marttinen P, Sandell HK, Manninen T, Teerenhovi H, Wai T, Teoli D, Loredo-Osti JC, Shoubridge EA, Battersby BJ.

PLoS Genet. 2010 Oct 14;6(10):e1001161. doi: 10.1371/journal.pgen.1001161.

17.

Effects of latanoprost in iris bioidentification.

Lamminen H, Voipio V, Manninen T, Huttunen H.

Acta Ophthalmol. 2009 Aug;87(5):529-31. doi: 10.1111/j.1755-3768.2008.01496.x. Epub 2009 Apr 27.

18.

Progestins regulate genes that can elicit both proliferative and antiproliferative effects in breast cancer cells.

Purmonen S, Manninen T, Pennanen P, Ylikomi T.

Oncol Rep. 2008 Jun;19(6):1627-34.

PMID:
18497975
19.

Distribution of lipid nanocapsules in different cochlear cell populations after round window membrane permeation.

Zou J, Saulnier P, Perrier T, Zhang Y, Manninen T, Toppila E, Pyykkö I.

J Biomed Mater Res B Appl Biomater. 2008 Oct;87(1):10-8. doi: 10.1002/jbm.b.31058.

PMID:
18437698
20.

Discrete stochastic simulation of cell signaling: comparison of computational tools.

Manninen T, Mäkiraatikka E, Ylipää A, Pettinen A, Leinonen K, Linne ML.

Conf Proc IEEE Eng Med Biol Soc. 2006;1:2013-6.

PMID:
17945691
21.

Alteration of the canine small-intestinal lactic acid bacterium microbiota by feeding of potential probiotics.

Manninen TJ, Rinkinen ML, Beasley SS, Saris PE.

Appl Environ Microbiol. 2006 Oct;72(10):6539-43.

22.

Developing Itô stochastic differential equation models for neuronal signal transduction pathways.

Manninen T, Linne ML, Ruohonen K.

Comput Biol Chem. 2006 Aug;30(4):280-91.

PMID:
16880117
23.

Lactic acid bacteria isolated from canine faeces.

Beasley SS, Manninen TJ, Saris PE.

J Appl Microbiol. 2006 Jul;101(1):131-8.

24.

Interaction of nuclear receptors with hsp90 in living cells.

Manninen T, Purmonen S, Ylikomi T.

J Steroid Biochem Mol Biol. 2005 Jun;96(1):13-8.

PMID:
15908199
25.

Mice with Ppt1Deltaex4 mutation replicate the INCL phenotype and show an inflammation-associated loss of interneurons.

Jalanko A, Vesa J, Manninen T, von Schantz C, Minye H, Fabritius AL, Salonen T, Rapola J, Gentile M, Kopra O, Peltonen L.

Neurobiol Dis. 2005 Feb;18(1):226-41.

PMID:
15649713
26.

A mouse model for Finnish variant late infantile neuronal ceroid lipofuscinosis, CLN5, reveals neuropathology associated with early aging.

Kopra O, Vesa J, von Schantz C, Manninen T, Minye H, Fabritius AL, Rapola J, van Diggelen OP, Saarela J, Jalanko A, Peltonen L.

Hum Mol Genet. 2004 Dec 1;13(23):2893-906. Epub 2004 Sep 30.

PMID:
15459177
27.

Simulation tools for biochemical networks: evaluation of performance and usability.

Pettinen A, Aho T, Smolander OP, Manninen T, Saarinen A, Taattola KL, Yli-Harja O, Linne ML.

Bioinformatics. 2005 Feb 1;21(3):357-63. Epub 2004 Sep 9.

PMID:
15358616
28.

Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells.

Miettinen S, Ahonen MH, Lou YR, Manninen T, Tuohimaa P, Syvälä H, Ylikomi T.

Int J Cancer. 2004 Jan 20;108(3):367-73.

29.

Regulation of nuclear receptor and cofactor expression in breast cancer cell lines.

Vienonen A, Miettinen S, Manninen T, Altucci L, Wilhelm E, Ylikomi T.

Eur J Endocrinol. 2003 Apr;148(4):469-79.

PMID:
12656669
30.

Progestin and G protein-coupled receptor 30 inhibit mitogen-activated protein kinase activity in MCF-7 breast cancer cells.

Ahola TM, Alkio N, Manninen T, Ylikomi T.

Endocrinology. 2002 Dec;143(12):4620-6.

PMID:
12446589
31.

G protein-coupled receptor 30 is critical for a progestin-induced growth inhibition in MCF-7 breast cancer cells.

Ahola TM, Manninen T, Alkio N, Ylikomi T.

Endocrinology. 2002 Sep;143(9):3376-84.

PMID:
12193550
32.

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.

Paloneva J, Manninen T, Christman G, Hovanes K, Mandelin J, Adolfsson R, Bianchin M, Bird T, Miranda R, Salmaggi A, Tranebjaerg L, Konttinen Y, Peltonen L.

Am J Hum Genet. 2002 Sep;71(3):656-62. Epub 2002 Jun 21. Erratum in: Am J Hum Genet. 2003 Jan;72(1):225..

33.

The C-terminal half of Hsp90 is responsible for its cytoplasmic localization.

Passinen S, Valkila J, Manninen T, Syvälä H, Ylikomi T.

Eur J Biochem. 2001 Oct;268(20):5337-42.

34.

Heat shock protein 90 and the nuclear transport of progesterone receptor.

Haverinen M, Passinen S, Syvälä H, Pasanen S, Manninen T, Tuohimaa P, Ylikomi T.

Cell Stress Chaperones. 2001 Jul;6(3):256-62.

35.

Localization of glucocorticoid receptor interacting protein 1 in murine tissues using two novel polyclonal antibodies.

Puustinen R, Sarvilinna N, Manninen T, Tuohimaa P, Ylikomi T.

Eur J Endocrinol. 2001 Sep;145(3):323-33.

PMID:
11517014
36.

Detection of progesterone receptor forms A and B by immunohistochemical analysis.

Mote PA, Johnston JF, Manninen T, Tuohimaa P, Clarke CL.

J Clin Pathol. 2001 Aug;54(8):624-30.

37.

Vitamin D and prostate cancer.

Tuohimaa P, Lyakhovich A, Aksenov N, Pennanen P, Syvälä H, Lou YR, Ahonen M, Hasan T, Pasanen P, Bläuer M, Manninen T, Miettinen S, Vilja P, Ylikomi T.

J Steroid Biochem Mol Biol. 2001 Jan-Mar;76(1-5):125-34.

PMID:
11384870
38.

A comparison of the hemodynamic effects of paracervical block and epidural anesthesia for labor analgesia.

Manninen T, Aantaa R, Salonen M, Pirhonen J, Palo P.

Acta Anaesthesiol Scand. 2000 Apr;44(4):441-5.

PMID:
10757578
39.

Distribution of progesterone receptor in female mouse tissues.

Uotinen N, Puustinen R, Pasanen S, Manninen T, Kivineva M, Syvälä H, Tuohimaa P, Ylikomi T.

Gen Comp Endocrinol. 1999 Sep;115(3):429-41.

PMID:
10480995
40.

Mice with an aspartylglucosaminuria mutation similar to humans replicate the pathophysiology in patients.

Jalanko A, Tenhunen K, McKinney CE, LaMarca ME, Rapola J, Autti T, Joensuu R, Manninen T, Sipilä I, Ikonen S, Riekkinen P Jr, Ginns EI, Peltonen L.

Hum Mol Genet. 1998 Feb;7(2):265-72.

PMID:
9425233
41.

Molecular cloning, chromosomal assignment, and expression of the mouse aspartylglucosaminidase gene.

Tenhunen K, Laan M, Manninen T, Palotie A, Peltonen L, Jalanko A.

Genomics. 1995 Nov 20;30(2):244-50.

PMID:
8586423
43.

Quantitative determination of rare mRNA species by PCR and solid-phase minisequencing.

Ikonen E, Manninen T, Peltonen L, Syvänen AC.

PCR Methods Appl. 1992 May;1(4):234-40.

44.

Convenient and quantitative determination of the frequency of a mutant allele using solid-phase minisequencing: application to aspartylglucosaminuria in Finland.

Syvänen AC, Ikonen E, Manninen T, Bengtström M, Söderlund H, Aula P, Peltonen L.

Genomics. 1992 Mar;12(3):590-5.

PMID:
1559710
45.

Spectrum of mutations in aspartylglucosaminuria.

Ikonen E, Aula P, Grön K, Tollersrud O, Halila R, Manninen T, Syvänen AC, Peltonen L.

Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11222-6.

46.

Infantile form of neuronal ceroid lipofuscinosis (CLN1) maps to the short arm of chromosome 1.

Järvelä I, Schleutker J, Haataja L, Santavuori P, Puhakka L, Manninen T, Palotie A, Sandkuijl LA, Renlund M, White R, et al.

Genomics. 1991 Jan;9(1):170-3.

PMID:
1672288
47.

Infantile neuronal ceroid-lipofuscinosis is not an allelic form of Batten disease: exclusion of chromosome 16 region with linkage analyses.

Jokiaho I, Puhakka L, Santavuori P, Manninen T, Nyman K, Peltonen L.

Genomics. 1990 Oct;8(2):391-3.

PMID:
2249855

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