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Items: 1 to 50 of 398

1.

Potent inhibitors of equine steroid isomerase EcaGST A3-3.

Lindström H, Mazari AMA, Musdal Y, Mannervik B.

PLoS One. 2019 Mar 21;14(3):e0214160. doi: 10.1371/journal.pone.0214160. eCollection 2019.

2.

Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic.

Huenchuguala S, Sjödin B, Mannervik B, Segura-Aguilar J.

Neurotox Res. 2019 Feb;35(2):432-440. doi: 10.1007/s12640-018-9969-0. Epub 2018 Oct 20.

PMID:
30343424
3.

Synthesis and activity mechanism of some novel 2-substituted benzothiazoles as hGSTP1-1 enzyme inhibitors.

Bolelli K, Musdal Y, Aki-Yalcin E, Mannervik B, Yalcin I.

SAR QSAR Environ Res. 2017 Nov;28(11):927-940. doi: 10.1080/1062936X.2017.1402820.

PMID:
29206502
4.

Characterization of equine GST A3-3 as a steroid isomerase.

Lindström H, Peer SM, Ing NH, Mannervik B.

J Steroid Biochem Mol Biol. 2018 Apr;178:117-126. doi: 10.1016/j.jsbmb.2017.11.011. Epub 2017 Nov 24.

PMID:
29180167
5.

Exploring sequence-function space of a poplar glutathione transferase using designed information-rich gene variants.

Musdal Y, Govindarajan S, Mannervik B.

Protein Eng Des Sel. 2017 Aug 1;30(8):543-549. doi: 10.1093/protein/gzx045.

6.

Design and synthesis of 2-substituted-5-(4-trifluoromethylphenyl-sulphonamido)benzoxazole derivatives as human GST P1-1 inhibitors.

Ertan-Bolelli T, Bolelli K, Musdal Y, Yildiz I, Aki-Yalcin E, Mannervik B, Yalcin I.

Artif Cells Nanomed Biotechnol. 2018 May;46(3):510-517. doi: 10.1080/21691401.2017.1324464. Epub 2017 May 14.

PMID:
28503938
7.

Expression of a Drosophila glutathione transferase in Arabidopsis confers the ability to detoxify the environmental pollutant, and explosive, 2,4,6-trinitrotoluene.

Tzafestas K, Razalan MM, Gyulev I, Mazari AM, Mannervik B, Rylott EL, Bruce NC.

New Phytol. 2017 Apr;214(1):294-303. doi: 10.1111/nph.14326. Epub 2016 Dec 6.

8.

Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase.

Cebula M, Turan IS, Sjödin B, Thulasingam M, Brock J, Chmyrov V, Widengren J, Abe H, Mannervik B, Haeggström JZ, Rinaldo-Matthis A, Akkaya EU, Morgenstern R.

Sci Rep. 2016 Dec 5;6:38316. doi: 10.1038/srep38316.

9.

Evolution of Negative Cooperativity in Glutathione Transferase Enabled Preservation of Enzyme Function.

Bocedi A, Fabrini R, Lo Bello M, Caccuri AM, Federici G, Mannervik B, Cornish-Bowden A, Ricci G.

J Biol Chem. 2016 Dec 23;291(52):26739-26749. doi: 10.1074/jbc.M116.749507. Epub 2016 Nov 4.

10.

Drosophila GSTs display outstanding catalytic efficiencies with the environmental pollutants 2,4,6-trinitrotoluene and 2,4-dinitrotoluene.

Mazari AMA, Mannervik B.

Biochem Biophys Rep. 2015 Dec 4;5:141-145. doi: 10.1016/j.bbrep.2015.12.003. eCollection 2016 Mar.

11.

Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.

Scian M, Le Trong I, Mazari AM, Mannervik B, Atkins WM, Stenkamp RE.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2089-98. doi: 10.1107/S1399004715013929. Epub 2015 Sep 26.

12.

On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells.

Brunnström Å, Tryselius Y, Feltenmark S, Andersson E, Leksell H, James A, Mannervik B, Dahlén B, Claesson HE.

Prostaglandins Other Lipid Mediat. 2015 Sep;121(Pt A):83-90. doi: 10.1016/j.prostaglandins.2015.04.010. Epub 2015 May 27.

PMID:
26026713
13.

Substrate specificities of two tau class glutathione transferases inducible by 2,4,6-trinitrotoluene in poplar.

Musdal Y, Mannervik B.

Biochim Biophys Acta. 2015 Sep;1850(9):1877-83. doi: 10.1016/j.bbagen.2015.05.015. Epub 2015 May 27.

PMID:
26026470
14.

Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds.

Mazari AM, Hegazy UM, Mannervik B.

Chem Biol Interact. 2015 Mar 5;229:91-9. doi: 10.1016/j.cbi.2015.01.014. Epub 2015 Jan 17.

PMID:
25603235
15.

Evolution of the active site of human glutathione transferase A2-2 for enhanced activity with dietary isothiocyanates.

Zhang W, Dourado DF, Mannervik B.

Biochim Biophys Acta. 2015 Apr;1850(4):742-9. doi: 10.1016/j.bbagen.2014.12.021. Epub 2014 Dec 24.

PMID:
25542299
16.

Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity.

Cuevas C, Huenchuguala S, Muñoz P, Villa M, Paris I, Mannervik B, Segura-Aguilar J.

Neurotox Res. 2015 Apr;27(3):217-28. doi: 10.1007/s12640-014-9500-1. Epub 2014 Nov 18.

PMID:
25403520
17.

Overexpression of glutathione transferase E7 in Drosophila differentially impacts toxicity of organic isothiocyanates in males and females.

Mazari AM, Dahlberg O, Mannervik B, Mannervik M.

PLoS One. 2014 Oct 16;9(10):e110103. doi: 10.1371/journal.pone.0110103. eCollection 2014.

18.

Glutathione transferases in the bioactivation of azathioprine.

Modén O, Mannervik B.

Adv Cancer Res. 2014;122:199-244. doi: 10.1016/B978-0-12-420117-0.00006-2.

PMID:
24974183
19.

Mapping of amino acid substitutions conferring herbicide resistance in wheat glutathione transferase.

Govindarajan S, Mannervik B, Silverman JA, Wright K, Regitsky D, Hegazy U, Purcell TJ, Welch M, Minshull J, Gustafsson C.

ACS Synth Biol. 2015 Mar 20;4(3):221-7. doi: 10.1021/sb500242x. Epub 2014 Jun 13.

20.

Isomerization of Δ5-androstene-3,17-dione into Δ4-androstene-3,17-dione catalyzed by human glutathione transferase A3-3: a computational study identifies a dual role for glutathione.

Dourado DF, Fernandes PA, Mannervik B, Ramos MJ.

J Phys Chem A. 2014 Aug 7;118(31):5790-800. doi: 10.1021/jp410810q. Epub 2014 Apr 28.

PMID:
24739064
21.

Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction.

Huenchuguala S, Muñoz P, Zavala P, Villa M, Cuevas C, Ahumada U, Graumann R, Nore BF, Couve E, Mannervik B, Paris I, Segura-Aguilar J.

Autophagy. 2014 Apr;10(4):618-30. doi: 10.4161/auto.27720. Epub 2014 Jan 14.

22.

Glutathione transferases immobilized on nanoporous alumina: flow system kinetics, screening, and stability.

Kjellander M, Mazari AM, Boman M, Mannervik B, Johansson G.

Anal Biochem. 2014 Feb 1;446:59-63. doi: 10.1016/j.ab.2013.10.004. Epub 2013 Oct 21.

PMID:
24157647
23.

Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions.

Shibata A, Nakano Y, Ito M, Araki M, Zhang J, Yoshida Y, Shuto S, Mannervik B, Morgenstern R, Ito Y, Abe H.

Analyst. 2013 Nov 12;138(24):7326-30. doi: 10.1039/c3an01339a. Erratum in: Analyst. 2014 Sep 7;139(17):4382. Mogenstern, Ralf [corrected to Morgenstern, Ralf].

PMID:
24151635
24.

Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA).

Dourado DF, Fernandes PA, Ramos MJ, Mannervik B.

Biochemistry. 2013 Nov 12;52(45):8069-78. doi: 10.1021/bi4005705. Epub 2013 Oct 28.

PMID:
24066958
25.

FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.

Musdal Y, Hegazy UM, Aksoy Y, Mannervik B.

Chem Biol Interact. 2013 Sep 5;205(1):53-62. doi: 10.1016/j.cbi.2013.06.003. Epub 2013 Jun 13.

PMID:
23769903
26.

Enzymatic detoxication, conformational selection, and the role of molten globule active sites.

Honaker MT, Acchione M, Zhang W, Mannervik B, Atkins WM.

J Biol Chem. 2013 Jun 21;288(25):18599-611. doi: 10.1074/jbc.M112.445767. Epub 2013 May 6.

27.

Hidden allostery in human glutathione transferase p1-1 unveiled by unnatural amino acid substitutions and inhibition studies.

Hegazy UM, Musdal Y, Mannervik B.

J Mol Biol. 2013 May 13;425(9):1509-14. doi: 10.1016/j.jmb.2013.01.038. Epub 2013 Feb 8.

PMID:
23399543
28.

An improved dual-tube megaprimer approach for multi-site saturation mutagenesis.

Zhang W, Mannervik B.

World J Microbiol Biotechnol. 2013 Apr;29(4):667-72. doi: 10.1007/s11274-012-1222-z. Epub 2012 Dec 7.

PMID:
23225176
29.

Evolution of broad spectrum β-lactam resistance in an engineered metallo-β-lactamase.

Sun S, Zhang W, Mannervik B, Andersson DI.

J Biol Chem. 2013 Jan 25;288(4):2314-24. doi: 10.1074/jbc.M112.430199. Epub 2012 Dec 3.

30.

Universal caging group for the in-cell detection of glutathione transferase applied to 19F NMR and bioluminogenic probes.

Ito M, Shibata A, Zhang J, Hiroshima M, Sako Y, Nakano Y, Kojima-Aikawa K, Mannervik B, Shuto S, Ito Y, Morgenstern R, Abe H.

Chembiochem. 2012 Jul 9;13(10):1428-32. doi: 10.1002/cbic.201200242. Epub 2012 Jun 11. No abstract available.

PMID:
22689392
31.

Multidimensional epistasis and fitness landscapes in enzyme evolution.

Zhang W, Dourado DF, Fernandes PA, Ramos MJ, Mannervik B.

Biochem J. 2012 Jul 1;445(1):39-46. doi: 10.1042/BJ20120136.

PMID:
22533640
32.

Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine.

Zhang W, Modén O, Tars K, Mannervik B.

Chem Biol. 2012 Mar 23;19(3):414-21. doi: 10.1016/j.chembiol.2012.01.021.

33.

Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine.

Modén O, Zhang W, Mannervik B.

Protein Eng Des Sel. 2012 Apr;25(4):189-97. doi: 10.1093/protein/gzs006. Epub 2012 Feb 14.

PMID:
22334756
34.

Five decades with glutathione and the GSTome.

Mannervik B.

J Biol Chem. 2012 Feb 24;287(9):6072-83. doi: 10.1074/jbc.X112.342675. Epub 2012 Jan 13.

35.

Engineering GST M2-2 for high activity with indene 1,2-oxide and indication of an H-site residue sustaining catalytic promiscuity.

Norrgård MA, Mannervik B.

J Mol Biol. 2011 Sep 9;412(1):111-20. doi: 10.1016/j.jmb.2011.07.039. Epub 2011 Jul 29.

PMID:
21821040
36.

Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy.

Zhang J, Shibata A, Ito M, Shuto S, Ito Y, Mannervik B, Abe H, Morgenstern R.

J Am Chem Soc. 2011 Sep 7;133(35):14109-19. doi: 10.1021/ja205500y. Epub 2011 Aug 15.

PMID:
21786801
37.

Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface.

Josephy PD, Pan D, Ianni MD, Mannervik B.

Arch Biochem Biophys. 2011 Sep 15;513(2):87-93. doi: 10.1016/j.abb.2011.07.003. Epub 2011 Jul 14.

PMID:
21781954
38.

Cys-X scanning for expansion of active-site residues and modulation of catalytic functions in a glutathione transferase.

Norrgård MA, Hellman U, Mannervik B.

J Biol Chem. 2011 May 13;286(19):16871-8. doi: 10.1074/jbc.M111.230078. Epub 2011 Mar 23.

39.

Experimental conditions affecting functional comparison of highly active glutathione transferases.

Fedulova N, Mannervik B.

Anal Biochem. 2011 Jun 1;413(1):16-23. doi: 10.1016/j.ab.2011.01.041. Epub 2011 Feb 2.

PMID:
21295006
40.

Quantitative and selective polymerase chain reaction analysis of highly similar human alpha-class glutathione transferases.

Larsson E, Mannervik B, Raffalli-Mathieu F.

Anal Biochem. 2011 May 1;412(1):96-101. doi: 10.1016/j.ab.2011.01.024. Epub 2011 Jan 24.

PMID:
21272561
41.

Characterization of porcine alpha-class glutathione transferase A1-1.

Fedulova N, Raffalli-Mathieu F, Mannervik B.

Arch Biochem Biophys. 2011 Mar 15;507(2):205-11. doi: 10.1016/j.abb.2010.12.015. Epub 2010 Dec 21.

PMID:
21172301
42.

Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.

Brunnström A, Hamberg M, Griffiths WJ, Mannervik B, Claesson HE.

Lipids. 2011 Jan;46(1):69-79. doi: 10.1007/s11745-010-3485-1. Epub 2010 Oct 29.

PMID:
21046276
43.

Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization.

Fedulova N, Raffalli-Mathieu F, Mannervik B.

Biochem J. 2010 Oct 1;431(1):159-67. doi: 10.1042/BJ20100839.

PMID:
20673231
44.

A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.

Runarsdottir A, Mannervik B.

J Mol Biol. 2010 Aug 20;401(3):451-64. doi: 10.1016/j.jmb.2010.06.033. Epub 2010 Jun 23.

PMID:
20600121
45.

Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.

Zhang W, Modén O, Mannervik B.

Chem Biol Interact. 2010 Jul 30;186(2):110-7. doi: 10.1016/j.cbi.2010.04.028. Epub 2010 Apr 29.

PMID:
20434437
46.

The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution.

Mannervik B, Runarsdottir A.

FEBS Lett. 2010 Jun 18;584(12):2565-71. doi: 10.1016/j.febslet.2010.04.024. Epub 2010 Apr 18. Review.

47.

Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents.

Larsson AK, Shokeer A, Mannervik B.

Arch Biochem Biophys. 2010 May;497(1-2):28-34. doi: 10.1016/j.abb.2010.03.001. Epub 2010 Mar 4.

PMID:
20211594
48.

Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1.

Shokeer A, Mannervik B.

Biochim Biophys Acta. 2010 Apr;1800(4):466-73. doi: 10.1016/j.bbagen.2010.01.003. Epub 2010 Jan 25.

PMID:
20097269
49.

Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal.

Balogh LM, Le Trong I, Kripps KA, Shireman LM, Stenkamp RE, Zhang W, Mannervik B, Atkins WM.

Biochemistry. 2010 Feb 23;49(7):1541-8. doi: 10.1021/bi902038u.

50.

Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.

Tars K, Olin B, Mannervik B.

J Mol Biol. 2010 Mar 19;397(1):332-40. doi: 10.1016/j.jmb.2010.01.023. Epub 2010 Jan 18.

PMID:
20083122

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