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Items: 1 to 50 of 56

1.

Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes.

Joshi K, Elso C, Motazedian A, Labonne T, Schiesser JV, Cameron F, Mannering SI, Elefanty AG, Stanley EG.

Diabetologia. 2019 Sep 12. doi: 10.1007/s00125-019-04988-6. [Epub ahead of print]

PMID:
31511930
2.

Quantification of Proliferating Human Antigen-specific CD4+ T Cells using Carboxyfluorescein Succinimidyl Ester.

Di Carluccio AR, Tresoldi E, So M, Mannering SI.

J Vis Exp. 2019 Jun 4;(148). doi: 10.3791/59545.

PMID:
31233024
3.

Divergent SATB1 expression across human life span and tissue compartments.

Nüssing S, Koay HF, Sant S, Loudovaris T, Mannering SI, Lappas M, D Udekem Y, Konstantinov IE, Berzins SP, Rimmelzwaan GF, Turner SJ, Clemens EB, Godfrey DI, Nguyen TH, Kedzierska K.

Immunol Cell Biol. 2019 May;97(5):498-511. doi: 10.1111/imcb.12233. Epub 2019 Feb 25.

4.

Human CD8+ T cell cross-reactivity across influenza A, B and C viruses.

Koutsakos M, Illing PT, Nguyen THO, Mifsud NA, Crawford JC, Rizzetto S, Eltahla AA, Clemens EB, Sant S, Chua BY, Wong CY, Allen EK, Teng D, Dash P, Boyd DF, Grzelak L, Zeng W, Hurt AC, Barr I, Rockman S, Jackson DC, Kotsimbos TC, Cheng AC, Richards M, Westall GP, Loudovaris T, Mannering SI, Elliott M, Tangye SG, Wakim LM, Rossjohn J, Vijaykrishna D, Luciani F, Thomas PG, Gras S, Purcell AW, Kedzierska K.

Nat Immunol. 2019 May;20(5):613-625. doi: 10.1038/s41590-019-0320-6. Epub 2019 Feb 18.

PMID:
30778243
5.

IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4+ T Cell Migration.

Scott NA, Zhao Y, Krishnamurthy B, Mannering SI, Kay TWH, Thomas HE.

Front Immunol. 2018 Nov 28;9:2800. doi: 10.3389/fimmu.2018.02800. eCollection 2018.

6.

Neoepitopes: a new take on beta cell autoimmunity in type 1 diabetes.

Mannering SI, Di Carluccio AR, Elso CM.

Diabetologia. 2019 Mar;62(3):351-356. doi: 10.1007/s00125-018-4760-6. Epub 2018 Nov 6. Review.

PMID:
30402774
7.

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes.

So M, Elso CM, Tresoldi E, Pakusch M, Pathiraja V, Wentworth JM, Harrison LC, Krishnamurthy B, Thomas HE, Rodda C, Cameron FJ, McMahon J, Kay TWH, Mannering SI.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10732-10737. doi: 10.1073/pnas.1809208115. Epub 2018 Oct 1.

8.

Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection.

Sant S, Grzelak L, Wang Z, Pizzolla A, Koutsakos M, Crowe J, Loudovaris T, Mannering SI, Westall GP, Wakim LM, Rossjohn J, Gras S, Richards M, Xu J, Thomas PG, Loh L, Nguyen THO, Kedzierska K.

Front Immunol. 2018 Jun 27;9:1453. doi: 10.3389/fimmu.2018.01453. eCollection 2018.

9.

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity.

Koutsakos M, Wheatley AK, Loh L, Clemens EB, Sant S, Nüssing S, Fox A, Chung AW, Laurie KL, Hurt AC, Rockman S, Lappas M, Loudovaris T, Mannering SI, Westall GP, Elliot M, Tangye SG, Wakim LM, Kent SJ, Nguyen THO, Kedzierska K.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaan8405. doi: 10.1126/scitranslmed.aan8405.

PMID:
29444980
10.

Shuffling peptides to create T-cell epitopes: does the immune system play cards?

Mannering SI, So M, Elso CM, Kay TWH.

Immunol Cell Biol. 2018 Jan;96(1):34-40. doi: 10.1111/imcb.1015. Epub 2017 Dec 7. Review.

PMID:
29359347
11.

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles.

Pizzolla A, Nguyen TH, Sant S, Jaffar J, Loudovaris T, Mannering SI, Thomas PG, Westall GP, Kedzierska K, Wakim LM.

J Clin Invest. 2018 Feb 1;128(2):721-733. doi: 10.1172/JCI96957. Epub 2018 Jan 8.

12.

Deciphering the Pathogenesis of Human Type 1 Diabetes (T1D) by Interrogating T Cells from the "Scene of the Crime".

Kent SC, Mannering SI, Michels AW, Babon JAB.

Curr Diab Rep. 2017 Sep 2;17(10):95. doi: 10.1007/s11892-017-0915-y. Review.

13.

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice.

Trivedi PM, Graham KL, Scott NA, Jenkins MR, Majaw S, Sutherland RM, Fynch S, Lew AM, Burns CJ, Krishnamurthy B, Brodnicki TC, Mannering SI, Kay TW, Thomas HE.

Diabetes. 2017 Jun;66(6):1650-1660. doi: 10.2337/db16-1250. Epub 2017 Mar 14.

14.

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.

Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K.

Science. 2016 Feb 12;351(6274):711-4. doi: 10.1126/science.aad2791.

15.

The case for an autoimmune aetiology of type 1 diabetes.

Mannering SI, Pathiraja V, Kay TW.

Clin Exp Immunol. 2016 Jan;183(1):8-15. doi: 10.1111/cei.12699. Epub 2015 Oct 21. Review.

16.

Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.

Zhao Y, Scott NA, Quah HS, Krishnamurthy B, Bond F, Loudovaris T, Mannering SI, Kay TW, Thomas HE.

Eur J Immunol. 2015 Sep;45(9):2494-503. doi: 10.1002/eji.201445378. Epub 2015 May 28.

17.

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

Jenkins MR, Rudd-Schmidt JA, Lopez JA, Ramsbottom KM, Mannering SI, Andrews DM, Voskoboinik I, Trapani JA.

J Exp Med. 2015 Mar 9;212(3):307-17. doi: 10.1084/jem.20140964. Epub 2015 Mar 2.

18.

Proinsulin-specific, HLA-DQ8, and HLA-DQ8-transdimer-restricted CD4+ T cells infiltrate islets in type 1 diabetes.

Pathiraja V, Kuehlich JP, Campbell PD, Krishnamurthy B, Loudovaris T, Coates PT, Brodnicki TC, O'Connell PJ, Kedzierska K, Rodda C, Bergman P, Hill E, Purcell AW, Dudek NL, Thomas HE, Kay TW, Mannering SI.

Diabetes. 2015 Jan;64(1):172-82. doi: 10.2337/db14-0858. Epub 2014 Aug 25.

19.

Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis.

Wang N, Elso CM, Mackin L, Mannering SI, Strugnell RA, Wijburg OL, Brodnicki TC.

Immunogenetics. 2014 Aug;66(7-8):501-6. doi: 10.1007/s00251-014-0782-5. Epub 2014 Jun 7.

PMID:
24906421
20.

Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

Lopez JA, Jenkins MR, Rudd-Schmidt JA, Brennan AJ, Danne JC, Mannering SI, Trapani JA, Voskoboinik I.

J Immunol. 2013 Sep 1;191(5):2328-34. doi: 10.4049/jimmunol.1301205. Epub 2013 Jul 24.

21.

Ara h 1 CD4+ T cell epitope-based peptides: candidates for a peanut allergy therapeutic.

Prickett SR, Voskamp AL, Phan T, Dacumos-Hill A, Mannering SI, Rolland JM, O'Hehir RE.

Clin Exp Allergy. 2013 Jun;43(6):684-97. doi: 10.1111/cea.12113.

22.

Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease.

Broughton SE, Petersen J, Theodossis A, Scally SW, Loh KL, Thompson A, van Bergen J, Kooy-Winkelaar Y, Henderson KN, Beddoe T, Tye-Din JA, Mannering SI, Purcell AW, McCluskey J, Anderson RP, Koning F, Reid HH, Rossjohn J.

Immunity. 2012 Oct 19;37(4):611-21. doi: 10.1016/j.immuni.2012.07.013. Epub 2012 Oct 11.

23.

Extraction of tissue antigens for functional assays.

Necula A, Chand R, Albatat B, Mannering SI.

J Vis Exp. 2012 Sep 10;(67). pii: 4230. doi: 10.3791/4230.

24.

Residual methylprednisolone suppresses human T-cell responses to spleen, but not islet, extracts from deceased organ donors.

Joffe M, Necula AS, Chand R, McWhinney BC, Krishnamurthy B, Loudovaris T, Goodman D, Thomas HE, Kay TW, Mannering SI.

Int Immunol. 2012 Jul;24(7):447-53. doi: 10.1093/intimm/dxs042. Epub 2012 Feb 29.

PMID:
22378502
25.

Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease.

Graham KL, Sutherland RM, Mannering SI, Zhao Y, Chee J, Krishnamurthy B, Thomas HE, Lew AM, Kay TW.

Rev Diabet Stud. 2012 Winter;9(4):148-68. doi: 10.1900/RDS.2012.9.148. Epub 2012 Dec 28. Review.

26.

An improved method for growing and analysing human antigen-specific CD4+ T-cell clones.

Ciantar JP, Mannering SI.

Diabetes Metab Res Rev. 2011 Nov;27(8):906-12. doi: 10.1002/dmrr.1271.

PMID:
22069283
27.

Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1 diabetic patients and controls.

Brooks-Worrell B, Tree T, Mannering SI, Durinovic-Bello I, James E, Gottlieb P, Wong S, Zhou Z, Yang L, Cilio CM, Reichow J, Menart B, Rutter R, Schreiner R, Pham M, Petrich de Marquesini L, Lou O, Scotto M, Mallone R, Schloot NC; T-Cell Workshop Committee, Immunology of Diabetes Society.

Diabetes Metab Res Rev. 2011 Nov;27(8):737-45. doi: 10.1002/dmrr.1245.

PMID:
22069253
28.

Human dendritic cell subsets from spleen and blood are similar in phenotype and function but modified by donor health status.

Mittag D, Proietto AI, Loudovaris T, Mannering SI, Vremec D, Shortman K, Wu L, Harrison LC.

J Immunol. 2011 Jun 1;186(11):6207-17. doi: 10.4049/jimmunol.1002632. Epub 2011 Apr 22.

29.

Generation and expansion of regulatory human CD4(+) T-cell clones specific for pancreatic islet autoantigens.

Dromey JA, Lee BH, Yu H, Young HE, Thearle DJ, Jensen KP, Mannering SI, Harrison LC.

J Autoimmun. 2011 Feb;36(1):47-55. doi: 10.1016/j.jaut.2010.10.005. Epub 2010 Nov 2.

PMID:
21050716
30.

Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society.

Mallone R, Mannering SI, Brooks-Worrell BM, Durinovic-Belló I, Cilio CM, Wong FS, Schloot NC; T-Cell Workshop Committee, Immunology of Diabetes Society.

Clin Exp Immunol. 2011 Jan;163(1):33-49. doi: 10.1111/j.1365-2249.2010.04272.x. Epub 2010 Oct 5. Review.

31.

Current approaches to measuring human islet-antigen specific T cell function in type 1 diabetes.

Mannering SI, Wong FS, Durinovic-Belló I, Brooks-Worrell B, Tree TI, Cilio CM, Schloot NC, Mallone R; Immunology of Diabetes Society T-Cell Workshop Committee.

Clin Exp Immunol. 2010 Nov;162(2):197-209. doi: 10.1111/j.1365-2249.2010.04237.x. Epub 2010 Sep 15. Review.

32.

Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.

Tye-Din JA, Stewart JA, Dromey JA, Beissbarth T, van Heel DA, Tatham A, Henderson K, Mannering SI, Gianfrani C, Jewell DP, Hill AV, McCluskey J, Rossjohn J, Anderson RP.

Sci Transl Med. 2010 Jul 21;2(41):41ra51. doi: 10.1126/scitranslmed.3001012.

33.

A method for extracting tissue proteins for use in lymphocyte function assays.

Moon HC, Joffe M, Thomas HE, Kay TW, Mannering SI.

J Immunol Methods. 2010 Jul 31;359(1-2):56-60. doi: 10.1016/j.jim.2010.05.002. Epub 2010 May 12.

PMID:
20470778
34.

Insulin teaches a new lesson in tolerance.

Kay TW, Krishnamurthy B, Brodnicki TC, Mannering SI.

EMBO J. 2009 Sep 16;28(18):2687-8. doi: 10.1038/emboj.2009.251. No abstract available.

35.

The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes.

Mannering SI, Pang SH, Williamson NA, Naselli G, Reynolds EC, O'Brien-Simpson NM, Purcell AW, Harrison LC.

Clin Exp Immunol. 2009 May;156(2):226-31. doi: 10.1111/j.1365-2249.2009.03907.x. Epub 2009 Mar 9.

36.

Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates.

Brady JL, Mannering SI, Kireta S, Coates PT, Proietto AI, Cowan PJ, D'Apice AJ, Lew AM.

Immunol Cell Biol. 2009 Jul;87(5):413-8. doi: 10.1038/icb.2009.4. Epub 2009 Feb 10.

PMID:
19204736
37.

Cytotoxic T-lymphocyte-mediated killing of human pancreatic islet cells in vitro.

Campbell PD, Estella E, Dudek NL, Jhala G, Thomas HE, Kay TW, Mannering SI.

Hum Immunol. 2008 Sep;69(9):543-51. doi: 10.1016/j.humimm.2008.06.008. Epub 2008 Jul 17.

PMID:
18639598
38.

T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQB1*0201.

Dudek NL, Maier S, Chen ZJ, Mudd PA, Mannering SI, Jackson DC, Zeng W, Keech CL, Hamlin K, Pan ZJ, Davis-Schwarz K, Workman-Azbill J, Bachmann M, McCluskey J, Farris AD.

Arthritis Rheum. 2007 Oct;56(10):3387-98.

39.

A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.

Henderson KN, Tye-Din JA, Reid HH, Chen Z, Borg NA, Beissbarth T, Tatham A, Mannering SI, Purcell AW, Dudek NL, van Heel DA, McCluskey J, Rossjohn J, Anderson RP.

Immunity. 2007 Jul;27(1):23-34. Epub 2007 Jul 12.

40.

Recent insights into CD4+ T-cell specificity and function in type 1 diabetes.

Mannering SI, Brodnicki TC.

Expert Rev Clin Immunol. 2007 Jul;3(4):557-64. doi: 10.1586/1744666X.3.4.557.

PMID:
20477160
41.

Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes.

Every AL, Kramer DR, Mannering SI, Lew AM, Harrison LC.

J Immunol. 2006 Apr 15;176(8):4608-15.

42.

The insulin A-chain epitope recognized by human T cells is posttranslationally modified.

Mannering SI, Harrison LC, Williamson NA, Morris JS, Thearle DJ, Jensen KP, Kay TW, Rossjohn J, Falk BA, Nepom GT, Purcell AW.

J Exp Med. 2005 Nov 7;202(9):1191-7. Epub 2005 Oct 31.

43.

An efficient method for cloning human autoantigen-specific T cells.

Mannering SI, Dromey JA, Morris JS, Thearle DJ, Jensen KP, Harrison LC.

J Immunol Methods. 2005 Mar;298(1-2):83-92.

PMID:
15847799
44.

CD4+ T cell proliferation in response to GAD and proinsulin in healthy, pre-diabetic, and diabetic donors.

Mannering SI, Morris JS, Stone NL, Jensen KP, VAN Endert PM, Harrison LC.

Ann N Y Acad Sci. 2004 Dec;1037:16-21.

PMID:
15699488
45.

TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death.

Zhan Y, Funda DP, Every AL, Fundova P, Purton JF, Liddicoat DR, Cole TJ, Godfrey DI, Brady JL, Mannering SI, Harrison LC, Lew AM.

Int Immunol. 2004 Sep;16(9):1315-21. Epub 2004 Jul 19.

PMID:
15262900
46.

A sensitive method for detecting proliferation of rare autoantigen-specific human T cells.

Mannering SI, Morris JS, Jensen KP, Purcell AW, Honeyman MC, van Endert PM, Harrison LC.

J Immunol Methods. 2003 Dec;283(1-2):173-83.

PMID:
14659909
47.

Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin.

Chang L, Kjer-Nielsen L, Flynn S, Brooks AG, Mannering SI, Honeyman MC, Harrison LC, McCluskey J, Purcell AW.

Tissue Antigens. 2003 Nov;62(5):408-17.

PMID:
14617048
48.

Human T-cells recognise N-terminally Fmoc-modified peptide.

Mannering SI, Purcell AW, Honeyman MC, McCluskey J, Harrison LC.

Vaccine. 2003 Sep 8;21(25-26):3638-46.

PMID:
12922093
49.

Proinsulin-a pathogenic autoantigen in type 1 diabetes.

Narendran P, Mannering SI, Harrison LC.

Autoimmun Rev. 2003 Jun;2(4):204-10. Review.

PMID:
12848947
50.

T-cell activation, proliferation and apoptosis in primary Listeria monocytogenes infection.

Mannering SI, Zhong J, Cheers C.

Immunology. 2002 May;106(1):87-95.

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