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Items: 45

1.

Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes.

de Vries R, Jacobs F, Mannens G, Snoeys J, Cuyckens F, Chien C, Ward P.

Drug Metab Dispos. 2019 May;47(5):453-464. doi: 10.1124/dmd.118.084517. Epub 2019 Feb 20.

PMID:
30787101
2.

Dose- and Time-dependency of the Toxicity and Pharmacokinetic Profiles of Bedaquiline and Its N-desmethyl Metabolite in Dogs.

Smyej I, De Jonghe S, Looszova A, Mannens G, Verhaeghe T, Thijssen S, Starckx S, Lampo A, Rouan MC.

Toxicol Pathol. 2017 Jul;45(5):663-675. doi: 10.1177/0192623317723085. Epub 2017 Aug 9.

PMID:
28789609
3.

Synthesis, in vitro and in vivo small-animal SPECT evaluation of novel technetium labeled bile acid analogues to study (altered) hepatic transporter function.

Neyt S, Vliegen M, Verreet B, De Lombaerde S, Braeckman K, Vanhove C, Huisman MT, Dumolyn C, Kersemans K, Hulpia F, Van Calenbergh S, Mannens G, De Vos F.

Nucl Med Biol. 2016 Oct;43(10):642-9. doi: 10.1016/j.nucmedbio.2016.07.001. Epub 2016 Jul 12.

PMID:
27513813
4.

Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.

T'jollyn H, Snoeys J, Van Bocxlaer J, De Bock L, Annaert P, Van Peer A, Allegaert K, Mannens G, Vermeulen A, Boussery K.

Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):537-543. doi: 10.1007/s13318-016-0355-0.

PMID:
27317395
5.

Best practices for metabolite quantification in drug development: updated recommendation from the European Bioanalysis Forum.

Timmerman P, Blech S, White S, Green M, Delatour C, McDougall S, Mannens G, Smeraglia J, Williams S, Young G.

Bioanalysis. 2016 Jun;8(12):1297-305. doi: 10.4155/bio-2016-0103. Epub 2016 May 24.

6.

Evaluation of the Pharmacokinetics and Renal Excretion of Simeprevir in Subjects with Renal Impairment.

Ouwerkerk-Mahadevan S, Beumont-Mauviel M, Mortier S, Peeters M, Verloes R, Truyers C, Mannens G, Wynant I, Simion A.

Drugs R D. 2015 Sep;15(3):261-70. doi: 10.1007/s40268-015-0101-0.

7.

Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.

T'jollyn H, Snoeys J, Vermeulen A, Michelet R, Cuyckens F, Mannens G, Van Peer A, Annaert P, Allegaert K, Van Bocxlaer J, Boussery K.

AAPS J. 2015 Nov;17(6):1376-87. doi: 10.1208/s12248-015-9803-z. Epub 2015 Jul 25.

8.

Absorption, metabolism, and excretion of oral ¹⁴C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men.

Scheers E, Leclercq L, de Jong J, Bode N, Bockx M, Laenen A, Cuyckens F, Skee D, Murphy J, Sukbuntherng J, Mannens G.

Drug Metab Dispos. 2015 Feb;43(2):289-97. doi: 10.1124/dmd.114.060061. Epub 2014 Dec 8.

PMID:
25488930
9.

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.

T'jollyn H, Snoeys J, Colin P, Van Bocxlaer J, Annaert P, Cuyckens F, Vermeulen A, Van Peer A, Allegaert K, Mannens G, Boussery K.

Pharm Res. 2015 Jan;32(1):260-74. doi: 10.1007/s11095-014-1460-x. Epub 2014 Jul 22.

PMID:
25048637
10.

In vivo visualization and quantification of (Disturbed) Oatp-mediated hepatic uptake and Mrp2-mediated biliary excretion of 99mTc-mebrofenin in mice.

Neyt S, Huisman MT, Vanhove C, De Man H, Vliegen M, Moerman L, Dumolyn C, Mannens G, De Vos F.

J Nucl Med. 2013 Apr;54(4):624-30. doi: 10.2967/jnumed.112.108233. Epub 2013 Feb 25.

11.

A phase I, open-label, single-dose, mass balance study of 14C-labeled abiraterone acetate in healthy male subjects.

Acharya M, Gonzalez M, Mannens G, De Vries R, Lopez C, Griffin T, Tran N.

Xenobiotica. 2013 Apr;43(4):379-89. doi: 10.3109/00498254.2012.721022. Epub 2012 Sep 28.

PMID:
23020788
12.

Pharmacokinetics, metabolism and excretion of 14C-monoethyl phthalate (MEP) and 14C-diethyl phthalate (DEP) after single oral and IV administration in the juvenile dog.

Kao ML, Ruoff B, Bower N, Aoki T, Smart C, Mannens G.

Xenobiotica. 2012 Apr;42(4):389-97. doi: 10.3109/00498254.2011.627478. Epub 2011 Nov 4.

PMID:
22054055
13.

Evaluation of three state-of-the-art metabolite prediction software packages (Meteor, MetaSite, and StarDrop) through independent and synergistic use.

T'jollyn H, Boussery K, Mortishire-Smith RJ, Coe K, De Boeck B, Van Bocxlaer JF, Mannens G.

Drug Metab Dispos. 2011 Nov;39(11):2066-75. doi: 10.1124/dmd.111.039982. Epub 2011 Aug 10.

PMID:
21832003
14.

Clinical pharmacology of alcaftadine, a novel antihistamine for the prevention of allergic conjunctivitis.

Bohets H, McGowan C, Mannens G, Schroeder N, Edwards-Swanson K, Shapiro A.

J Ocul Pharmacol Ther. 2011 Apr;27(2):187-95. doi: 10.1089/jop.2010.0153. Epub 2011 Feb 12.

PMID:
21314437
15.

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Vermeir M, Hemeryck A, Cuyckens F, Francesch A, Bockx M, Van Houdt J, Steemans K, Mannens G, Avilés P, De Coster R.

Biochem Pharmacol. 2009 May 15;77(10):1642-54. doi: 10.1016/j.bcp.2009.02.020. Epub 2009 Mar 10.

PMID:
19426702
16.

Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical development.

Leclercq L, Cuyckens F, Mannens GS, de Vries R, Timmerman P, Evans DC.

Chem Res Toxicol. 2009 Feb;22(2):280-93. doi: 10.1021/tx800432c. Review.

PMID:
19183054
17.

Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects.

Vermeir M, Lachau-Durand S, Mannens G, Cuyckens F, van Hoof B, Raoof A.

Drug Metab Dispos. 2009 Apr;37(4):809-20. doi: 10.1124/dmd.108.024109. Epub 2009 Jan 8.

PMID:
19131522
18.

The ontogeny of drug metabolizing enzymes and transporters in the rat.

de Zwart L, Scholten M, Monbaliu JG, Annaert PP, Van Houdt JM, Van den Wyngaert I, De Schaepdrijver LM, Bailey GP, Coogan TP, Coussement WC, Mannens GS.

Reprod Toxicol. 2008 Nov-Dec;26(3-4):220-30. doi: 10.1016/j.reprotox.2008.09.010. Epub 2008 Oct 7.

PMID:
18926897
19.

Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men.

Cirillo I, Mannens G, Janssen C, Vermeir M, Cuyckens F, Desai-Krieger D, Vaccaro N, Kao LM, Devineni D, Redman R, Turner K.

Antimicrob Agents Chemother. 2008 Oct;52(10):3478-83. doi: 10.1128/AAC.00424-08. Epub 2008 Jul 21.

20.

Absorption, metabolism, and excretion of paliperidone, a new monoaminergic antagonist, in humans.

Vermeir M, Naessens I, Remmerie B, Mannens G, Hendrickx J, Sterkens P, Talluri K, Boom S, Eerdekens M, van Osselaer N, Cleton A.

Drug Metab Dispos. 2008 Apr;36(4):769-79. doi: 10.1124/dmd.107.018275. Epub 2008 Jan 28.

PMID:
18227146
21.

Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs.

Mamidi RN, Mannens G, Annaert P, Hendrickx J, Goris I, Bockx M, Janssen CG, Kao M, Kelley MF, Meuldermans W.

Drug Metab Dispos. 2007 Apr;35(4):566-75. Epub 2007 Jan 12.

PMID:
17220243
22.

The absorption, metabolism, and excretion of the novel neuromodulator RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-) in humans.

Mannens GS, Hendrickx J, Janssen CG, Chien S, Van Hoof B, Verhaeghe T, Kao M, Kelley MF, Goris I, Bockx M, Verreet B, Bialer M, Meuldermans W.

Drug Metab Dispos. 2007 Apr;35(4):554-65. Epub 2006 Aug 25.

PMID:
16936066
23.

Cell-based models to study hepatic drug metabolism and enzyme induction in humans.

Vermeir M, Annaert P, Mamidi RN, Roymans D, Meuldermans W, Mannens G.

Expert Opin Drug Metab Toxicol. 2005 Jun;1(1):75-90. Review.

PMID:
16922654
24.

Toxicokinetics and metabolism.

Coecke S, Blaauboer BJ, Elaut G, Freeman S, Freidig A, Gensmantel N, Hoet P, Kapoulas VM, Ladstetter B, Langley G, Leahy D, Mannens G, Meneguz A, Monshouwer M, Nemery B, Pelkonen O, Pfaller W, Prieto P, Proctor N, Rogiers V, Rostami-Hodjegan A, Sabbioni E, Steiling W, van de Sandt JJ.

Altern Lab Anim. 2005 Jul;33 Suppl 1:147-75. No abstract available.

PMID:
16194147
25.

Expression and induction potential of cytochromes P450 in human cryopreserved hepatocytes.

Roymans D, Annaert P, Van Houdt J, Weygers A, Noukens J, Sensenhauser C, Silva J, Van Looveren C, Hendrickx J, Mannens G, Meuldermans W.

Drug Metab Dispos. 2005 Jul;33(7):1004-16. Epub 2005 Mar 31.

PMID:
15802389
26.

Determination of cytochrome P450 1A2 and cytochrome P450 3A4 induction in cryopreserved human hepatocytes.

Roymans D, Van Looveren C, Leone A, Parker JB, McMillian M, Johnson MD, Koganti A, Gilissen R, Silber P, Mannens G, Meuldermans W.

Biochem Pharmacol. 2004 Feb 1;67(3):427-37.

PMID:
15037195
27.

Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.

Angibaud P, Bourdrez X, End DW, Freyne E, Janicot M, Lezouret P, Ligny Y, Mannens G, Damsch S, Mevellec L, Meyer C, Muller P, Pilatte I, Poncelet V, Roux B, Smets G, Van Dun J, Van Remoortere P, Venet M, Wouters W.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4365-9.

PMID:
14643327
28.

4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.

Angibaud P, Saha AK, Bourdrez X, End DW, Freyne E, Lezouret P, Mannens G, Mevellec L, Meyer C, Pilatte I, Poncelet V, Roux B, Smets G, Van Dun J, Venet M, Wouters W.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4361-4.

PMID:
14643326
29.

5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.

Angibaud P, Bourdrez X, Devine A, End DW, Freyne E, Ligny Y, Muller P, Mannens G, Pilatte I, Poncelet V, Skrzat S, Smets G, Van Dun J, Van Remoortere P, Venet M, Wouters W.

Bioorg Med Chem Lett. 2003 May 5;13(9):1543-7.

PMID:
12699751
30.

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes.

Bahadur N, Leathart JB, Mutch E, Steimel-Crespi D, Dunn SA, Gilissen R, Houdt JV, Hendrickx J, Mannens G, Bohets H, Williams FM, Armstrong M, Crespi CL, Daly AK.

Biochem Pharmacol. 2002 Dec 1;64(11):1579-89.

PMID:
12429347
31.

Rapid permeability screening in drug discovery to predict human intestinal absorption.

Mannens GS, Bohets H, Verboven P, Steemans K, Lavrijsen K, Meuldermans W.

Ernst Schering Res Found Workshop. 2002;(37):49-67. Review. No abstract available.

PMID:
11975200
32.

The metabolism and excretion of galantamine in rats, dogs, and humans.

Mannens GS, Snel CA, Hendrickx J, Verhaeghe T, Le Jeune L, Bode W, van Beijsterveldt L, Lavrijsen K, Leempoels J, Van Osselaer N, Van Peer A, Meuldermans W.

Drug Metab Dispos. 2002 May;30(5):553-63.

PMID:
11950787
33.

Strategies for absorption screening in drug discovery and development.

Bohets H, Annaert P, Mannens G, Van Beijsterveldt L, Anciaux K, Verboven P, Meuldermans W, Lavrijsen K.

Curr Top Med Chem. 2001 Nov;1(5):367-83. Review.

PMID:
11899103
34.
35.

Influence of age, renal and liver impairment on the pharmacokinetics of risperidone in man.

Snoeck E, Van Peer A, Sack M, Horton M, Mannens G, Woestenborghs R, Meibach R, Heykants J.

Psychopharmacology (Berl). 1995 Dec;122(3):223-9.

PMID:
8748391
36.

Itraconazole and hydroxyitraconazole serum concentrations are reduced more than tenfold by phenytoin.

Ducharme MP, Slaughter RL, Warbasse LH, Chandrasekar PH, Van de Velde V, Mannens G, Edwards DJ.

Clin Pharmacol Ther. 1995 Dec;58(6):617-24.

PMID:
8529326
37.

Plasma protein binding of risperidone and its distribution in blood.

Mannens G, Meuldermans W, Snoeck E, Heykants J.

Psychopharmacology (Berl). 1994 May;114(4):566-72.

PMID:
7531854
38.

The pharmacokinetics of risperidone in humans: a summary.

Heykants J, Huang ML, Mannens G, Meuldermans W, Snoeck E, Van Beijsterveldt L, Van Peer A, Woestenborghs R.

J Clin Psychiatry. 1994 May;55 Suppl:13-7.

PMID:
7520903
39.

The metabolism and excretion of risperidone after oral administration in rats and dogs.

Meuldermans W, Hendrickx J, Mannens G, Lavrijsen K, Janssen C, Bracke J, Le Jeune L, Lauwers W, Heykants J.

Drug Metab Dispos. 1994 Jan-Feb;22(1):129-38.

PMID:
7512019
40.

Absorption, metabolism, and excretion of risperidone in humans.

Mannens G, Huang ML, Meuldermans W, Hendrickx J, Woestenborghs R, Heykants J.

Drug Metab Dispos. 1993 Nov-Dec;21(6):1134-41.

PMID:
7507814
41.

Enzymatic synthesis of 11C-N-acetyl-D-glucosamine.

Mannens GS, Slegers G, Goethals P, Claeys A.

Acta Radiol Suppl. 1991;376:106. No abstract available.

PMID:
1687190
43.
44.

Immobilization of acetylcoenzyme A synthetase and the preparation of an enzyme reactor for the synthesis of [11C]acetylcoenzyme A.

Mannens G, Slegers G, Lambrecht R, Claeys A.

Biochim Biophys Acta. 1988 Apr 15;959(3):214-9.

PMID:
2895670
45.

Direct assay for phosphotransacetylase and acetyl-coenzyme A carboxylase by high-performance liquid chromatography.

De Spiegeleer B, Mannens G, Slegers G, Van den Bossche W, Claeys A.

Anal Biochem. 1986 Oct;158(1):195-200.

PMID:
2879484

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