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Items: 28

1.

Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.

Moya IM, Castaldo SA, Van den Mooter L, Soheily S, Sansores-Garcia L, Jacobs J, Mannaerts I, Xie J, Verboven E, Hillen H, Algueró-Nadal A, Karaman R, Van Haele M, Kowalczyk W, De Waegeneer M, Verhulst S, Karras P, van Huffel L, Zender L, Marine JC, Roskams T, Johnson R, Aerts S, van Grunsven LA, Halder G.

Science. 2019 Nov 22;366(6468):1029-1034. doi: 10.1126/science.aaw9886.

PMID:
31754005
2.

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.

Bonnardel J, T'Jonck W, Gaublomme D, Browaeys R, Scott CL, Martens L, Vanneste B, De Prijck S, Nedospasov SA, Kremer A, Van Hamme E, Borghgraef P, Toussaint W, De Bleser P, Mannaerts I, Beschin A, van Grunsven LA, Lambrecht BN, Taghon T, Lippens S, Elewaut D, Saeys Y, Guilliams M.

Immunity. 2019 Oct 15;51(4):638-654.e9. doi: 10.1016/j.immuni.2019.08.017. Epub 2019 Sep 24.

3.

A PDGFRβ-based score predicts significant liver fibrosis in patients with chronic alcohol abuse, NAFLD and viral liver disease.

Lambrecht J, Verhulst S, Mannaerts I, Sowa JP, Best J, Canbay A, Reynaert H, van Grunsven LA.

EBioMedicine. 2019 May;43:501-512. doi: 10.1016/j.ebiom.2019.04.036. Epub 2019 Apr 27.

4.

Unfolded protein response is an early, non-critical event during hepatic stellate cell activation.

Mannaerts I, Thoen LFR, Eysackers N, Cubero FJ, Batista Leite S, Coldham I, Colle I, Trautwein C, van Grunsven LA.

Cell Death Dis. 2019 Feb 4;10(2):98. doi: 10.1038/s41419-019-1327-5.

5.

P311, Friend, or Foe of Tissue Fibrosis?

Stradiot L, Mannaerts I, van Grunsven LA.

Front Pharmacol. 2018 Oct 12;9:1151. doi: 10.3389/fphar.2018.01151. eCollection 2018. Review.

6.

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.

Coll M, Perea L, Boon R, Leite SB, Vallverdú J, Mannaerts I, Smout A, El Taghdouini A, Blaya D, Rodrigo-Torres D, Graupera I, Aguilar-Bravo B, Chesne C, Najimi M, Sokal E, Lozano JJ, van Grunsven LA, Verfaillie CM, Sancho-Bru P.

Cell Stem Cell. 2018 Jul 5;23(1):101-113.e7. doi: 10.1016/j.stem.2018.05.027. Epub 2018 Jun 28.

7.

Prospects in non-invasive assessment of liver fibrosis: Liquid biopsy as the future gold standard?

Lambrecht J, Verhulst S, Mannaerts I, Reynaert H, van Grunsven LA.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1024-1036. doi: 10.1016/j.bbadis.2018.01.009. Epub 2018 Jan 9. Review.

8.

Protective effect of genetic deletion of pannexin1 in experimental mouse models of acute and chronic liver disease.

Willebrords J, Maes M, Pereira IVA, da Silva TC, Govoni VM, Lopes VV, Crespo Yanguas S, Shestopalov VI, Nogueira MS, de Castro IA, Farhood A, Mannaerts I, van Grunsven L, Akakpo J, Lebofsky M, Jaeschke H, Cogliati B, Vinken M.

Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):819-830. doi: 10.1016/j.bbadis.2017.12.013. Epub 2017 Dec 12.

9.

Functionality based method for simultaneous isolation of rodent hepatic sinusoidal cells.

Stradiot L, Verhulst S, Roosens T, Øie CI, Moya IM, Halder G, Mannaerts I, van Grunsven LA.

Biomaterials. 2017 Sep;139:91-101. doi: 10.1016/j.biomaterials.2017.05.047. Epub 2017 May 30.

PMID:
28595132
10.

Circulating ECV-Associated miRNAs as Potential Clinical Biomarkers in Early Stage HBV and HCV Induced Liver Fibrosis.

Lambrecht J, Jan Poortmans P, Verhulst S, Reynaert H, Mannaerts I, van Grunsven LA.

Front Pharmacol. 2017 Feb 9;8:56. doi: 10.3389/fphar.2017.00056. eCollection 2017.

11.

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis.

Verbeke L, Mannaerts I, Schierwagen R, Govaere O, Klein S, Vander Elst I, Windmolders P, Farre R, Wenes M, Mazzone M, Nevens F, van Grunsven LA, Trebicka J, Laleman W.

Sci Rep. 2016 Sep 16;6:33453. doi: 10.1038/srep33453.

12.

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro.

Leite SB, Roosens T, El Taghdouini A, Mannaerts I, Smout AJ, Najimi M, Sokal E, Noor F, Chesne C, van Grunsven LA.

Biomaterials. 2016 Feb;78:1-10. doi: 10.1016/j.biomaterials.2015.11.026. Epub 2015 Nov 17.

PMID:
26618472
13.

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells.

El Taghdouini A, Sørensen AL, Reiner AH, Coll M, Verhulst S, Mannaerts I, Øie CI, Smedsrød B, Najimi M, Sokal E, Luttun A, Sancho-Bru P, Collas P, van Grunsven LA.

Oncotarget. 2015 Sep 29;6(29):26729-45. doi: 10.18632/oncotarget.4925.

14.

The role of miRNAs in stress-responsive hepatic stellate cells during liver fibrosis.

Lambrecht J, Mannaerts I, van Grunsven LA.

Front Physiol. 2015 Jul 28;6:209. doi: 10.3389/fphys.2015.00209. eCollection 2015. Review.

15.

Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells.

Coll M, El Taghdouini A, Perea L, Mannaerts I, Vila-Casadesús M, Blaya D, Rodrigo-Torres D, Affò S, Morales-Ibanez O, Graupera I, Lozano JJ, Najimi M, Sokal E, Lambrecht J, Ginès P, van Grunsven LA, Sancho-Bru P.

Sci Rep. 2015 Jun 22;5:11549. doi: 10.1038/srep11549.

16.

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation.

Mannaerts I, Leite SB, Verhulst S, Claerhout S, Eysackers N, Thoen LF, Hoorens A, Reynaert H, Halder G, van Grunsven LA.

J Hepatol. 2015 Sep;63(3):679-88. doi: 10.1016/j.jhep.2015.04.011. Epub 2015 Apr 20.

PMID:
25908270
17.

Inhibitory effect of dietary capsaicin on liver fibrosis in mice.

Bitencourt S, Stradiot L, Verhulst S, Thoen L, Mannaerts I, van Grunsven LA.

Mol Nutr Food Res. 2015 Jun;59(6):1107-16. doi: 10.1002/mnfr.201400649. Epub 2015 Apr 29.

PMID:
25755097
18.

P311 modulates hepatic stellate cells migration.

Guimarães EL, Stradiot L, Mannaerts I, Schroyen B, van Grunsven LA.

Liver Int. 2015 Apr;35(4):1253-64. doi: 10.1111/liv.12691. Epub 2014 Oct 10.

PMID:
25243526
19.

Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration.

Mannaerts I, Schroyen B, Verhulst S, Van Lommel L, Schuit F, Nyssen M, van Grunsven LA.

PLoS One. 2013 Dec 17;8(12):e84071. doi: 10.1371/journal.pone.0084071. eCollection 2013.

20.

In vivo hepatocyte MR imaging using lactose functionalized magnetoliposomes.

Ketkar-Atre A, Struys T, Dresselaers T, Hodenius M, Mannaerts I, Ni Y, Lambrichts I, Van Grunsven LA, De Cuyper M, Himmelreich U.

Biomaterials. 2014 Jan;35(3):1015-24. doi: 10.1016/j.biomaterials.2013.10.029. Epub 2013 Nov 5.

PMID:
24210051
21.

Syncoilin is an intermediate filament protein in activated hepatic stellate cells.

Van Rossen E, Liu Z, Blijweert D, Eysackers N, Mannaerts I, Schroyen B, El Taghdouini A, Edwards B, Davies KE, Sokal E, Najimi M, Reynaert H, van Grunsven LA.

Histochem Cell Biol. 2014 Jan;141(1):85-99. doi: 10.1007/s00418-013-1142-5. Epub 2013 Sep 17.

PMID:
24043511
22.

Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells.

Bitencourt S, Mesquita F, Basso B, Schmid J, Ferreira G, Rizzo L, Bauer M, Bartrons R, Ventura F, Rosa JL, Mannaerts I, van Grunsven LA, Oliveira J.

Cell Biochem Biophys. 2014 Mar;68(2):387-96. doi: 10.1007/s12013-013-9719-0.

PMID:
23955514
23.

Comparison of trichostatin A and valproic acid treatment regimens in a mouse model of kidney fibrosis.

Van Beneden K, Geers C, Pauwels M, Mannaerts I, Wissing KM, Van den Branden C, van Grunsven LA.

Toxicol Appl Pharmacol. 2013 Sep 1;271(2):276-84. doi: 10.1016/j.taap.2013.05.013. Epub 2013 May 22.

PMID:
23707763
24.

Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29.

Mannaerts I, Eysackers N, Onyema OO, Van Beneden K, Valente S, Mai A, Odenthal M, van Grunsven LA.

PLoS One. 2013;8(1):e55786. doi: 10.1371/journal.pone.0055786. Epub 2013 Jan 31.

25.

HDAC inhibitors in experimental liver and kidney fibrosis.

Van Beneden K, Mannaerts I, Pauwels M, Van den Branden C, van Grunsven LA.

Fibrogenesis Tissue Repair. 2013 Jan 2;6(1):1. doi: 10.1186/1755-1536-6-1.

26.

Valproic acid attenuates proteinuria and kidney injury.

Van Beneden K, Geers C, Pauwels M, Mannaerts I, Verbeelen D, van Grunsven LA, Van den Branden C.

J Am Soc Nephrol. 2011 Oct;22(10):1863-75. doi: 10.1681/ASN.2010111196. Epub 2011 Aug 25.

27.

A role for autophagy during hepatic stellate cell activation.

Thoen LF, Guimarães EL, Dollé L, Mannaerts I, Najimi M, Sokal E, van Grunsven LA.

J Hepatol. 2011 Dec;55(6):1353-60. doi: 10.1016/j.jhep.2011.07.010. Epub 2011 Jul 29.

PMID:
21803012
28.

Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo.

Mannaerts I, Nuytten NR, Rogiers V, Vanderkerken K, van Grunsven LA, Geerts A.

Hepatology. 2010 Feb;51(2):603-14. doi: 10.1002/hep.23334.

PMID:
19957378

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