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A Functional Assay to Assess Toxicity During Murine B Cell Development In Vitro.

Guilbert C, Chou H, Bolt AM, Wu TH, Luo VM, Orthwein A, Mann KK.

Curr Protoc Toxicol. 2020 Mar;83(1):e91. doi: 10.1002/cptx.91.


Addressing K/L-edge overlap in elemental analysis from micro-X-ray fluorescence: bioimaging of tungsten and zinc in bone tissue using synchrotron radiation and laser ablation inductively coupled plasma mass spectrometry.

VanderSchee CR, Kuter D, Chou H, Jackson BP, Mann KK, Bohle DS.

Anal Bioanal Chem. 2020 Jan;412(2):259-265. doi: 10.1007/s00216-019-02244-9. Epub 2019 Nov 27.


Tungsten Blocks Murine B Lymphocyte Differentiation and Proliferation Through Downregulation of IL-7 Receptor/Pax5 Signaling.

Wu TH, Bolt AM, Chou H, Plourde D, De Jay N, Guilbert C, Young YK, Kleinman CL, Mann KK.

Toxicol Sci. 2019 Jul 1;170(1):45-56. doi: 10.1093/toxsci/kfz080.


Using the Apolipoprotein E Knock-Out Mouse Model to Define Atherosclerotic Plaque Changes Induced by Low Dose Arsenic.

Makhani K, Chiavatti C, Plourde D, Negro Silva LF, Lemaire M, Lemarié CA, Lehoux S, Mann KK.

Toxicol Sci. 2018 Nov 1;166(1):213-218. doi: 10.1093/toxsci/kfy201.


Blaschkoid distribution of composite syringocystadenoma papilliferum and tubular apocrine adenoma without naevus sebaceous.

Khullar G, Sharma S, Ramesh V, Mann KK.

Clin Exp Dermatol. 2019 Jun;44(4):438-440. doi: 10.1111/ced.13753. Epub 2018 Sep 25. No abstract available.


SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.

Findlay S, Heath J, Luo VM, Malina A, Morin T, Coulombe Y, Djerir B, Li Z, Samiei A, Simo-Cheyou E, Karam M, Bagci H, Rahat D, Grapton D, Lavoie EG, Dove C, Khaled H, Kuasne H, Mann KK, Klein KO, Greenwood CM, Tabach Y, Park M, Côté JF, Masson JY, Maréchal A, Orthwein A.

EMBO J. 2018 Sep 14;37(18). pii: e100158. doi: 10.15252/embj.2018100158. Epub 2018 Aug 28.


Single-agent panobinostat for relapsed/refractory diffuse large B-cell lymphoma: clinical outcome and correlation with genomic data. A phase 2 study of the Fondazione Italiana Linfomi.

Zaja F, Salvi F, Rossi M, Sabattini E, Evangelista A, Ciccone G, Angelucci E, Gaidano G, Zanni M, Ladetto M, Chiappella A, Vitolo U, Zinzani PL, Califano C, Tucci A, Patti C, Pileri SA, Lenti V, Piccaluga PP, Cavallo F, Volpetti S, Perali G, Assouline S, Mann KK, Morin R, Alcaide M, Bushell K, Fanin R, Levis A.

Leuk Lymphoma. 2018 Dec;59(12):2904-2910. doi: 10.1080/10428194.2018.1452208. Epub 2018 Apr 4.


Metabolomic Profiling Reveals Cellular Reprogramming of B-Cell Lymphoma by a Lysine Deacetylase Inhibitor through the Choline Pathway.

Pera B, Krumsiek J, Assouline SE, Marullo R, Patel J, Phillip JM, Román L, Mann KK, Cerchietti L.

EBioMedicine. 2018 Feb;28:80-89. doi: 10.1016/j.ebiom.2018.01.014. Epub 2018 Jan 31.


The genomic landscape of two Burkitt lymphoma cases and derived cell lines: comparison between primary and relapse samples.

Wever CM, Geoffrion D, Grande BM, Yu S, Alcaide M, Lemaire M, Riazalhosseini Y, Hébert J, Gavino C, Vinh DC, Petrogiannis-Haliotis T, Dmitrienko S, Mann KK, Morin RD, Johnson NA.

Leuk Lymphoma. 2018 Sep;59(9):2159-2174. doi: 10.1080/10428194.2017.1413186. Epub 2018 Jan 3.


Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis.

Dahabieh MS, Ha Z, Di Pietro E, Nichol JN, Bolt AM, Goncalves C, Dupéré-Richer D, Pettersson F, Mann KK, Braverman NE, Del Rincón SV, Miller WH Jr.

Cell Death Differ. 2017 Nov;24(11):1912-1924. doi: 10.1038/cdd.2017.115. Epub 2017 Jul 21.


Effects of Inorganic Arsenic, Methylated Arsenicals, and Arsenobetaine on Atherosclerosis in the Mouse Model and the Role of As3mt-Mediated Methylation.

Negro Silva LF, Lemaire M, Lemarié CA, Plourde D, Bolt AM, Chiavatti C, Bohle DS, Slavkovich V, Graziano JH, Lehoux S, Mann KK.

Environ Health Perspect. 2017 Jul 5;125(7):077001. doi: 10.1289/EHP806.


From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development.

Baker AH, Wu TH, Bolt AM, Gerstenfeld LC, Mann KK, Schlezinger JJ.

Toxicol Sci. 2017 Jul 1;158(1):63-75. doi: 10.1093/toxsci/kfx067.


The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.

Ahn R, Sabourin V, Bolt AM, Hébert S, Totten S, De Jay N, Festa MC, Young YK, Im YK, Pawson T, Koromilas AE, Muller WJ, Mann KK, Kleinman CL, Ursini-Siegel J.

Nat Commun. 2017 Mar 9;8:14638. doi: 10.1038/ncomms14638.


Isolation of Immune Cells for Adoptive Transfer.

Barhoumi T, Paradis P, Mann KK, Schiffrin EL.

Methods Mol Biol. 2017;1527:321-344. doi: 10.1007/978-1-4939-6625-7_25.


Tungsten: an Emerging Toxicant, Alone or in Combination.

Bolt AM, Mann KK.

Curr Environ Health Rep. 2016 Dec;3(4):405-415. doi: 10.1007/s40572-016-0106-z. Review.


Analyzing the Tumor Microenvironment by Flow Cytometry.

Young YK, Bolt AM, Ahn R, Mann KK.

Methods Mol Biol. 2016;1458:95-110. doi: 10.1007/978-1-4939-3801-8_8.


Multiplex Droplet Digital PCR Quantification of Recurrent Somatic Mutations in Diffuse Large B-Cell and Follicular Lymphoma.

Alcaide M, Yu S, Bushell K, Fornika D, Nielsen JS, Nelson BH, Mann KK, Assouline S, Johnson NA, Morin RD.

Clin Chem. 2016 Sep;62(9):1238-47. doi: 10.1373/clinchem.2016.255315. Epub 2016 Jul 20.


Increased protein processing gene signature in HDACi-resistant cells predicts response to proteasome inhibitors.

Dupéré-Richer D, Kinal M, Pettersson F, Emond A, Calvo-Vidal MN, Nichol JN, Guilbert C, Plourde D, Klein Oros K, Nielsen TH, Ezponda T, Licht JD, Johnson NA, Assouline S, Cerchietti L, Miller WH Jr, Mann KK.

Leuk Lymphoma. 2017 Jan;58(1):218-221. Epub 2016 May 17. No abstract available.


Phase 2 study of panobinostat with or without rituximab in relapsed diffuse large B-cell lymphoma.

Assouline SE, Nielsen TH, Yu S, Alcaide M, Chong L, MacDonald D, Tosikyan A, Kukreti V, Kezouh A, Petrogiannis-Haliotis T, Albuquerque M, Fornika D, Alamouti S, Froment R, Greenwood CM, Oros KK, Camglioglu E, Sharma A, Christodoulopoulos R, Rousseau C, Johnson N, Crump M, Morin RD, Mann KK.

Blood. 2016 Jul 14;128(2):185-94. doi: 10.1182/blood-2016-02-699520. Epub 2016 May 10.


Tungsten Promotes Sex-Specific Adipogenesis in the Bone by Altering Differentiation of Bone Marrow-Resident Mesenchymal Stromal Cells.

Bolt AM, Grant MP, Wu TH, Flores Molina M, Plourde D, Kelly AD, Negro Silva LF, Lemaire M, Schlezinger JJ, Mwale F, Mann KK.

Toxicol Sci. 2016 Apr;150(2):333-46. doi: 10.1093/toxsci/kfw008. Epub 2016 Feb 9.


Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.

Morin RD, Assouline S, Alcaide M, Mohajeri A, Johnston RL, Chong L, Grewal J, Yu S, Fornika D, Bushell K, Nielsen TH, Petrogiannis-Haliotis T, Crump M, Tosikyan A, Grande BM, MacDonald D, Rousseau C, Bayat M, Sesques P, Froment R, Albuquerque M, Monczak Y, Oros KK, Greenwood C, Riazalhosseini Y, Arseneault M, Camlioglu E, Constantin A, Pan-Hammarstrom Q, Peng R, Mann KK, Johnson NA.

Clin Cancer Res. 2016 May 1;22(9):2290-300. doi: 10.1158/1078-0432.CCR-15-2123. Epub 2015 Dec 8.


High-selenium lentil diet protects against arsenic-induced atherosclerosis in a mouse model.

Krohn RM, Lemaire M, Negro Silva LF, Lemarié C, Bolt A, Mann KK, Smits JE.

J Nutr Biochem. 2016 Jan;27:9-15. doi: 10.1016/j.jnutbio.2015.07.003. Epub 2015 Jul 26.


Arsenic Exposure Increases Monocyte Adhesion to the Vascular Endothelium, a Pro-Atherogenic Mechanism.

Lemaire M, Negro Silva LF, Lemarié CA, Bolt AM, Flores Molina M, Krohn RM, Smits JE, Lehoux S, Mann KK.

PLoS One. 2015 Sep 2;10(9):e0136592. doi: 10.1371/journal.pone.0136592. eCollection 2015.


Chronic Exposure to Bisphenol A Reduces Successful Cardiac Remodeling After an Experimental Myocardial Infarction in Male C57bl/6n Mice.

Patel BB, Kasneci A, Bolt AM, Di Lalla V, Di Iorio MR, Raad M, Mann KK, Chalifour LE.

Toxicol Sci. 2015 Jul;146(1):101-15. doi: 10.1093/toxsci/kfv073. Epub 2015 Apr 9.


Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE-/- Mice.

Ebrahimian T, Simon D, Lemarié CA, Simeone S, Heidari M, Mann KK, Wassmann S, Lehoux S.

Arterioscler Thromb Vasc Biol. 2015 May;35(5):1190-7. doi: 10.1161/ATVBAHA.114.305071. Epub 2015 Mar 12.


Methods for sample acquisition and processing of serial blood and tumor biopsies for multicenter diffuse large B-cell lymphoma clinical trials.

Nielsen TH, Diaz Z, Christodoulopoulos R, Charbonneau F, Qureshi S, Rousseau C, Benlimame N, Camlioglu E, Constantin AM, Oros KK, Krumsiek J, Crump M, Morin RD, Cerchietti L, Johnson NA, Petrogiannis-Haliotis T, Miller WH Jr, Assouline SE, Mann KK.

Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2688-93. doi: 10.1158/1055-9965.EPI-14-0549.


Tungsten targets the tumor microenvironment to enhance breast cancer metastasis.

Bolt AM, Sabourin V, Molina MF, Police AM, Negro Silva LF, Plourde D, Lemaire M, Ursini-Siegel J, Mann KK.

Toxicol Sci. 2015 Jan;143(1):165-77. doi: 10.1093/toxsci/kfu219. Epub 2014 Oct 15.


Genetic deletion of LXRα prevents arsenic-enhanced atherosclerosis, but not arsenic-altered plaque composition.

Lemaire M, Lemarié CA, Flores Molina M, Guilbert C, Lehoux S, Mann KK.

Toxicol Sci. 2014 Dec;142(2):477-88. doi: 10.1093/toxsci/kfu197. Epub 2014 Sep 30.


The novel arsenical darinaparsin is transported by cystine importing systems.

Garnier N, Redstone GG, Dahabieh MS, Nichol JN, del Rincon SV, Gu Y, Bohle DS, Sun Y, Conklin DS, Mann KK, Miller WH Jr.

Mol Pharmacol. 2014 Apr;85(4):576-85. doi: 10.1124/mol.113.089433. Epub 2014 Jan 15.


Arsenic trioxide overcomes rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancer.

Guilbert C, Annis MG, Dong Z, Siegel PM, Miller WH Jr, Mann KK.

PLoS One. 2013 Dec 31;8(12):e85995. doi: 10.1371/journal.pone.0085995. eCollection 2013.


The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-κB and is aberrantly regulated in acute myeloid leukemia.

Hariri F, Arguello M, Volpon L, Culjkovic-Kraljacic B, Nielsen TH, Hiscott J, Mann KK, Borden KL.

Leukemia. 2013 Oct;27(10):2047-55. doi: 10.1038/leu.2013.73. Epub 2013 Mar 7.


The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells.

Garnier N, Petruccelli LA, Molina MF, Kourelis M, Kwan S, Diaz Z, Schipper HM, Gupta A, del Rincon SV, Mann KK, Miller WH Jr.

Leukemia. 2013 Nov;27(11):2220-8. doi: 10.1038/leu.2013.54. Epub 2013 Feb 21.


Monitoring Response and Resistance to the Novel Arsenical Darinaparsin in an AML Patient.

Nielsen TH, Johnson N, Garnier N, Kwan S, Yao L, Cocolakis E, Hébert J, Morgan RA, Paquet E, Callahan KP, Jordan CT, Assouline S, Miller WH Jr, Mann KK.

Front Pharmacol. 2013 Feb 12;4:9. doi: 10.3389/fphar.2013.00009. eCollection 2013.


In vivo tungsten exposure alters B-cell development and increases DNA damage in murine bone marrow.

Kelly AD, Lemaire M, Young YK, Eustache JH, Guilbert C, Molina MF, Mann KK.

Toxicol Sci. 2013 Feb;131(2):434-46. doi: 10.1093/toxsci/kfs324. Epub 2012 Nov 14.


Exposure to tungsten induces DNA damage and apoptosis in developing B lymphocytes.

Guilbert C, Kelly AD, Petruccelli LA, Lemaire M, Mann KK.

Leukemia. 2011 Dec;25(12):1900-4. doi: 10.1038/leu.2011.160. Epub 2011 Jun 24. No abstract available.


Organotins are potent activators of PPARγ and adipocyte differentiation in bone marrow multipotent mesenchymal stromal cells.

Yanik SC, Baker AH, Mann KK, Schlezinger JJ.

Toxicol Sci. 2011 Aug;122(2):476-88. doi: 10.1093/toxsci/kfr140. Epub 2011 May 27.


Exposure to moderate arsenic concentrations increases atherosclerosis in ApoE-/- mouse model.

Lemaire M, Lemarié CA, Molina MF, Schiffrin EL, Lehoux S, Mann KK.

Toxicol Sci. 2011 Jul;122(1):211-21. doi: 10.1093/toxsci/kfr097. Epub 2011 Apr 21.


The role of CaMKII in calcium-activated death pathways in bone marrow B cells.

Bissonnette SL, Haas A, Mann KK, Schlezinger JJ.

Toxicol Sci. 2010 Nov;118(1):108-18. doi: 10.1093/toxsci/kfq256. Epub 2010 Sep 1.


Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro.

Padovani AM, Molina MF, Mann KK.

Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36. doi: 10.1161/ATVBAHA.110.205500. Epub 2010 Mar 25.


Darinaparsin: a novel organic arsenical with promising anticancer activity.

Mann KK, Wallner B, Lossos IS, Miller WH Jr.

Expert Opin Investig Drugs. 2009 Nov;18(11):1727-34. doi: 10.1517/13543780903282759. Review.


Retinoids inhibit measles virus through a type I IFN-dependent bystander effect.

Trottier C, Colombo M, Mann KK, Miller WH Jr, Ward BJ.

FASEB J. 2009 Sep;23(9):3203-12. doi: 10.1096/fj.09-129288. Epub 2009 May 15.


A novel arsenical has antitumor activity toward As2O3-resistant and MRP1/ABCC1-overexpressing cell lines.

Diaz Z, Mann KK, Marcoux S, Kourelis M, Colombo M, Komarnitsky PB, Miller WH Jr.

Leukemia. 2008 Oct;22(10):1853-63. doi: 10.1038/leu.2008.194. Epub 2008 Jul 17. Erratum in: Leukemia. 2009 Feb;23(2):431.


Arsenic trioxide decreases AKT protein in a caspase-dependent manner.

Mann KK, Colombo M, Miller WH Jr.

Mol Cancer Ther. 2008 Jun;7(6):1680-7. doi: 10.1158/1535-7163.MCT-07-2164.


Retinoids inhibit measles virus in vitro via nuclear retinoid receptor signaling pathways.

Trottier C, Chabot S, Mann KK, Colombo M, Chatterjee A, Miller WH Jr, Ward BJ.

Antiviral Res. 2008 Oct;80(1):45-53. doi: 10.1016/j.antiviral.2008.04.003. Epub 2008 May 19.


Trolox enhances the anti-lymphoma effects of arsenic trioxide, while protecting against liver toxicity.

Diaz Z, Laurenzana A, Mann KK, Bismar TA, Schipper HM, Miller WH Jr.

Leukemia. 2007 Oct;21(10):2117-27. Epub 2007 Aug 9.


Arsenic trioxide inhibits nuclear receptor function via SEK1/JNK-mediated RXRalpha phosphorylation.

Mann KK, Padovani AM, Guo Q, Colosimo AL, Lee HY, Kurie JM, Miller WH Jr.

J Clin Invest. 2005 Oct;115(10):2924-33. Epub 2005 Sep 22.


Antimony trioxide-induced apoptosis is dependent on SEK1/JNK signaling.

Mann KK, Davison K, Colombo M, Colosimo AL, Diaz Z, Padovani AM, Guo Q, Scrivens PJ, Gao W, Mader S, Miller WH Jr.

Toxicol Lett. 2006 Jan 5;160(2):158-70. Epub 2005 Aug 19.


Trolox selectively enhances arsenic-mediated oxidative stress and apoptosis in APL and other malignant cell lines.

Diaz Z, Colombo M, Mann KK, Su H, Smith KN, Bohle DS, Schipper HM, Miller WH Jr.

Blood. 2005 Feb 1;105(3):1237-45. Epub 2004 Oct 5.


Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells.

Xiao S, Zhang X, Mann KK, Jodo S, Li L, Jarjour WN, Marshak-Rothstein A, Sherr DH, Ju ST.

Int Immunol. 2004 May;16(5):759-66. Epub 2004 Apr 13.


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